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The map label for this gene is yeaP [H]

Identifier: 59712969

GI number: 59712969

Start: 2650097

End: 2651092

Strand: Direct

Name: yeaP [H]

Synonym: VF_2362

Alternate gene names: 59712969

Gene position: 2650097-2651092 (Clockwise)

Preceding gene: 59712964

Following gene: 59712971

Centisome position: 91.46

GC content: 35.44

Gene sequence:

>996_bases
ATGATCTACATGGATGTTTATATGAATAGCTACTTTCCTCATAATTTAGATACAGAAAACAGCATCATTGACTTATCAAA
GTGGCAGGAACTTGCTGATTTGATCGTCGATATATTTGGTGCTGATTGCGGAGCGATCATTAAATTTACCGGGCATTCAT
TTACCACCATGCTTAGTAGTCGCAACGAAGCGAGCTTTCTACACCAAGGAACAGAATGGTCTAGTGATAGTAAAAGTTTT
TGTCGTACGATAATAAAAACAGGCAAGCCTTTATATATTGCAAATGCAGTTGAAGATGAATATTGGTTTGATGCACCTCC
CGTCGTTAATGGACCAGTTCGTTCATATTGTGGTGTTCCAATATTTTCTCCTGATGGCAGTATTTACGGAACCATTTGTG
CAATCGACACGAAAAGCACTCGTTATGAAGACGCCTTAACCAAACTGCTTCTGCATTTATCAAAACTCATCACTTCCGAT
TTAAAAATAGCAGAAAAAGCGGAACAACACAGATTGATGGCTCTCACAGACCAAACGACGGGTTTGTTAAATCGAAGAGG
GCTTAATGTCCTTAGTGAACAAAAATTTAAAGACGCTAAAAGAAATCAAGATCATATTGGCGTGTTATATCTTGATATAG
ATAACTTAAAAATTATCAATGACAATTTTGGTCATCTAGCTGGAGATAAGTGCATTAAATTACTTGCTACTATCCTAAAA
AAAATGGTCAGACAATCAGACTTAATAGCACGTATCGGTGGTGATGAATTTACCGTACTTGCTTTAATTAACAGTGAAAA
TACAAATGAATTAGACCACTTATCCATGCGTATACGTGAAGTTTATCAAAACGAAATTAAAGATAATGCTGAATTAAATA
TGAGCAATATTAGTATAGGTCAGCATCTTGTCTCTTATGATTCAAATGCCTCTCTAAAAGAAATGTTAGCTAAAGCAGAT
TCGCTCATGTACCAAGAGAAAATTGATAAATCATAA

Upstream 100 bases:

>100_bases
TTATTTTCTAAACTACTCAATAAACCAAACCATTTTAAGTACAGTGATTTACATCATTGCAATTCATAAATGATAGCTTT
AGAAATAAGATGCCGTACTA

Downstream 100 bases:

>100_bases
AGTAATATTTAAATGCCCATCCCAACTTGGAAATAAAGAGCTGTATCTTCTTCGCTAAACGCTAAATCGATCCCTGTTTT
CATACCATAGCGACGAGCAA

Product: GGDEF domain-containing protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MIYMDVYMNSYFPHNLDTENSIIDLSKWQELADLIVDIFGADCGAIIKFTGHSFTTMLSSRNEASFLHQGTEWSSDSKSF
CRTIIKTGKPLYIANAVEDEYWFDAPPVVNGPVRSYCGVPIFSPDGSIYGTICAIDTKSTRYEDALTKLLLHLSKLITSD
LKIAEKAEQHRLMALTDQTTGLLNRRGLNVLSEQKFKDAKRNQDHIGVLYLDIDNLKIINDNFGHLAGDKCIKLLATILK
KMVRQSDLIARIGGDEFTVLALINSENTNELDHLSMRIREVYQNEIKDNAELNMSNISIGQHLVSYDSNASLKEMLAKAD
SLMYQEKIDKS

Sequences:

>Translated_331_residues
MIYMDVYMNSYFPHNLDTENSIIDLSKWQELADLIVDIFGADCGAIIKFTGHSFTTMLSSRNEASFLHQGTEWSSDSKSF
CRTIIKTGKPLYIANAVEDEYWFDAPPVVNGPVRSYCGVPIFSPDGSIYGTICAIDTKSTRYEDALTKLLLHLSKLITSD
LKIAEKAEQHRLMALTDQTTGLLNRRGLNVLSEQKFKDAKRNQDHIGVLYLDIDNLKIINDNFGHLAGDKCIKLLATILK
KMVRQSDLIARIGGDEFTVLALINSENTNELDHLSMRIREVYQNEIKDNAELNMSNISIGQHLVSYDSNASLKEMLAKAD
SLMYQEKIDKS
>Mature_331_residues
MIYMDVYMNSYFPHNLDTENSIIDLSKWQELADLIVDIFGADCGAIIKFTGHSFTTMLSSRNEASFLHQGTEWSSDSKSF
CRTIIKTGKPLYIANAVEDEYWFDAPPVVNGPVRSYCGVPIFSPDGSIYGTICAIDTKSTRYEDALTKLLLHLSKLITSD
LKIAEKAEQHRLMALTDQTTGLLNRRGLNVLSEQKFKDAKRNQDHIGVLYLDIDNLKIINDNFGHLAGDKCIKLLATILK
KMVRQSDLIARIGGDEFTVLALINSENTNELDHLSMRIREVYQNEIKDNAELNMSNISIGQHLVSYDSNASLKEMLAKAD
SLMYQEKIDKS

Specific function: Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger (Probable). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2199

COG function: function code T; FOG: GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI87081977, Length=261, Percent_Identity=30.2681992337165, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786584, Length=167, Percent_Identity=32.3353293413174, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787262, Length=192, Percent_Identity=29.6875, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787541, Length=175, Percent_Identity=32, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI145693134, Length=187, Percent_Identity=31.0160427807487, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI87081974, Length=86, Percent_Identity=39.5348837209302, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081881, Length=183, Percent_Identity=27.8688524590164, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787816, Length=153, Percent_Identity=30.0653594771242, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787802, Length=174, Percent_Identity=29.8850574712644, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788381, Length=216, Percent_Identity=26.8518518518519, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI87082007, Length=155, Percent_Identity=27.741935483871, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR003018 [H]

Pfam domain/function: PF01590 GAF; PF00990 GGDEF [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 37304; Mature: 37304

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYMDVYMNSYFPHNLDTENSIIDLSKWQELADLIVDIFGADCGAIIKFTGHSFTTMLSS
CEEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHC
RNEASFLHQGTEWSSDSKSFCRTIIKTGKPLYIANAVEDEYWFDAPPVVNGPVRSYCGVP
CCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHCCCE
IFSPDGSIYGTICAIDTKSTRYEDALTKLLLHLSKLITSDLKIAEKAEQHRLMALTDQTT
EECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHH
GLLNRRGLNVLSEQKFKDAKRNQDHIGVLYLDIDNLKIINDNFGHLAGDKCIKLLATILK
HHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEECCEEEECCCCCCCHHHHHHHHHHHHHH
KMVRQSDLIARIGGDEFTVLALINSENTNELDHLSMRIREVYQNEIKDNAELNMSNISIG
HHHHHHHHHEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEECHHHHH
QHLVSYDSNASLKEMLAKADSLMYQEKIDKS
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIYMDVYMNSYFPHNLDTENSIIDLSKWQELADLIVDIFGADCGAIIKFTGHSFTTMLSS
CEEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHC
RNEASFLHQGTEWSSDSKSFCRTIIKTGKPLYIANAVEDEYWFDAPPVVNGPVRSYCGVP
CCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHCCCE
IFSPDGSIYGTICAIDTKSTRYEDALTKLLLHLSKLITSDLKIAEKAEQHRLMALTDQTT
EECCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECHHH
GLLNRRGLNVLSEQKFKDAKRNQDHIGVLYLDIDNLKIINDNFGHLAGDKCIKLLATILK
HHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEEECCEEEECCCCCCCHHHHHHHHHHHHHH
KMVRQSDLIARIGGDEFTVLALINSENTNELDHLSMRIREVYQNEIKDNAELNMSNISIG
HHHHHHHHHEEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCEEECHHHHH
QHLVSYDSNASLKEMLAKADSLMYQEKIDKS
HHHHHCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]