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The map label for this gene is hflC [H]

Identifier: 59712927

GI number: 59712927

Start: 2606936

End: 2607820

Strand: Reverse

Name: hflC [H]

Synonym: VF_2320

Alternate gene names: 59712927

Gene position: 2607820-2606936 (Counterclockwise)

Preceding gene: 59712928

Following gene: 59712926

Centisome position: 90.0

GC content: 39.55

Gene sequence:

>885_bases
ATGCGTAAGTTAATGATCCCAACACTTATCGTTGTTGTTGCTATTTTCCTGATGTCACTGTTTGTGATTCCAGAAGGTGA
GCGCGGTATTGTTACTCGTTTTGGTCGTTTGATTAAAGAAGATAACAACATTACACGTATTTACGAACCTGGTCTGCACT
TTAAAATGCCACTGTTCGATCGTGTAAACACGTTAGATGCTCGTATTCAAACAATGGATGATCAATCAGACCGTTTCGTA
ACGTCAGAGAAAAAAGACGTTATCATCGACTCATATGTTAAGTGGAAGATTAAAGACTTTGGTCAATTCTACCTAGCAAC
AGGTGGTGGTAATATCCTAACGGCGGAAGCGTTATTACAACGCCGTGTATCTGATGGTTTACGTGCTGAGATTGGTAGCA
CGACAGTAAAAGAGCTTGTTTCTGAAAAACGTGAAGAAGTAATGAATACCGTACTTCTAGACTCGCAAGATGGAACGGGC
GATTTAGGGATTGAGGTAATTGATTTACGAATTAAGAAAATCAACTTACCAGAAGAAATCTCTGAATCTATTTACCGTCG
TATGCGTGCAGAGCGTGAAGCCGTTGCTCGTAAACTACGTTCCCAAGGTCGTGAGAAAGCCGAAGTAATTCGTGCTCAAT
CAGAACTTGAAGTAGCGACAATTATTGCTGAAGCAGATAAAACAGCACGAATTACTCGTGGTAATGCGGACGCAAAAGTC
GCTAAATTGTATGCAGATGCATTTAATAAAGAGCCTGAGTTCTTTAGCTTCATTCGTTCATTAAGAGCGTATGAAAAATC
ATTCAACAGTAAGAGTGATATCTTAGTACTTGATCCTAAGACTGACTTCTTTAAGTACATGAATGATTCAAAAGGCGGAA
AGTAA

Upstream 100 bases:

>100_bases
CGTCTTCAAAAGATTACACGATTGAATTAGAGAAAAAGAACCAACCAACTACTACGAACTCTACTGGCCGTAACTCAACA
CGTGAAGGGAGATATTAATC

Downstream 100 bases:

>100_bases
ACATTCATTTGTTTAATTAACGTATAAAATAACAAGGTCCTTCGGGGCCTTGTTTTGTATTTAGCGTATAGAAATTGAAT
CGAATTAAGGATTGGCAATG

Product: modulator for HflB protease specific for phage lambda cII repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MRKLMIPTLIVVVAIFLMSLFVIPEGERGIVTRFGRLIKEDNNITRIYEPGLHFKMPLFDRVNTLDARIQTMDDQSDRFV
TSEKKDVIIDSYVKWKIKDFGQFYLATGGGNILTAEALLQRRVSDGLRAEIGSTTVKELVSEKREEVMNTVLLDSQDGTG
DLGIEVIDLRIKKINLPEEISESIYRRMRAEREAVARKLRSQGREKAEVIRAQSELEVATIIAEADKTARITRGNADAKV
AKLYADAFNKEPEFFSFIRSLRAYEKSFNSKSDILVLDPKTDFFKYMNDSKGGK

Sequences:

>Translated_294_residues
MRKLMIPTLIVVVAIFLMSLFVIPEGERGIVTRFGRLIKEDNNITRIYEPGLHFKMPLFDRVNTLDARIQTMDDQSDRFV
TSEKKDVIIDSYVKWKIKDFGQFYLATGGGNILTAEALLQRRVSDGLRAEIGSTTVKELVSEKREEVMNTVLLDSQDGTG
DLGIEVIDLRIKKINLPEEISESIYRRMRAEREAVARKLRSQGREKAEVIRAQSELEVATIIAEADKTARITRGNADAKV
AKLYADAFNKEPEFFSFIRSLRAYEKSFNSKSDILVLDPKTDFFKYMNDSKGGK
>Mature_294_residues
MRKLMIPTLIVVVAIFLMSLFVIPEGERGIVTRFGRLIKEDNNITRIYEPGLHFKMPLFDRVNTLDARIQTMDDQSDRFV
TSEKKDVIIDSYVKWKIKDFGQFYLATGGGNILTAEALLQRRVSDGLRAEIGSTTVKELVSEKREEVMNTVLLDSQDGTG
DLGIEVIDLRIKKINLPEEISESIYRRMRAEREAVARKLRSQGREKAEVIRAQSELEVATIIAEADKTARITRGNADAKV
AKLYADAFNKEPEFFSFIRSLRAYEKSFNSKSDILVLDPKTDFFKYMNDSKGGK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=326, Percent_Identity=50.6134969325153, Blast_Score=323, Evalue=1e-89,
Organism=Escherichia coli, GI1786697, Length=294, Percent_Identity=23.1292517006803, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI193209764, Length=195, Percent_Identity=24.6153846153846, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17569493, Length=191, Percent_Identity=24.6073298429319, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 33486; Mature: 33486

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLMIPTLIVVVAIFLMSLFVIPEGERGIVTRFGRLIKEDNNITRIYEPGLHFKMPLFD
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEECCHHH
RVNTLDARIQTMDDQSDRFVTSEKKDVIIDSYVKWKIKDFGQFYLATGGGNILTAEALLQ
HHHHHHHHHHHCCCCCCCEECCCCCCEEEHHHHHEEEECCCEEEEEECCCCEEHHHHHHH
RRVSDGLRAEIGSTTVKELVSEKREEVMNTVLLDSQDGTGDLGIEVIDLRIKKINLPEEI
HHHHCCHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCHHHH
SESIYRRMRAEREAVARKLRSQGREKAEVIRAQSELEVATIIAEADKTARITRGNADAKV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHH
AKLYADAFNKEPEFFSFIRSLRAYEKSFNSKSDILVLDPKTDFFKYMNDSKGGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCCCC
>Mature Secondary Structure
MRKLMIPTLIVVVAIFLMSLFVIPEGERGIVTRFGRLIKEDNNITRIYEPGLHFKMPLFD
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCEECCHHH
RVNTLDARIQTMDDQSDRFVTSEKKDVIIDSYVKWKIKDFGQFYLATGGGNILTAEALLQ
HHHHHHHHHHHCCCCCCCEECCCCCCEEEHHHHHEEEECCCEEEEEECCCCEEHHHHHHH
RRVSDGLRAEIGSTTVKELVSEKREEVMNTVLLDSQDGTGDLGIEVIDLRIKKINLPEEI
HHHHCCHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCHHHH
SESIYRRMRAEREAVARKLRSQGREKAEVIRAQSELEVATIIAEADKTARITRGNADAKV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHH
AKLYADAFNKEPEFFSFIRSLRAYEKSFNSKSDILVLDPKTDFFKYMNDSKGGK
HHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]