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The map label for this gene is hflK [H]

Identifier: 59712928

GI number: 59712928

Start: 2607823

End: 2609028

Strand: Reverse

Name: hflK [H]

Synonym: VF_2321

Alternate gene names: 59712928

Gene position: 2609028-2607823 (Counterclockwise)

Preceding gene: 59712929

Following gene: 59712927

Centisome position: 90.04

GC content: 40.46

Gene sequence:

>1206_bases
ATGGCGTGGAATGAGCCTGGAAATAACAACAATAACGGCGGCGATAAAGACCCTTGGGGTAATAAAAATCGCGGTGGCCG
TGATCAAGGTCCACCAGATCTTGATGAGGTGTTTAACAAGTTAAGCCAGAAGCTAAGCGGTAAGTTTGGTGGTGGTAATA
ACGGTGGAAACAATAAAGGTGGCAGTGGTTTACCTTCATTTGGTAATGGTGGCGCAGTTGGTTTAGGACTAATTGCAGTT
GTCGCTATTGCGATTTGGGTATTCTCTGGTTTCTATACTATTGGTGAAAGTGACCGAGGCGTTGTATTACGTTTTGGCCA
ATACGATCGTATGGTTGATCCAGGTCTAAACTGGAAACCAACCTTTATTGATCAAGTGACACCAGTAAACATTCAGTCTA
TTCGTTCTTTAAACTCAAAAGGTTTAATGCTAACGAAAGATGAAAACGTAGTTACTGTTGAGATGGGTGTTCAATACCGT
GTTGCTGATGCTCATAAATATCTTTATACCGTAACGAATGCTGATGACAGCTTACGTCAAGCGACAGATTCTGCATTACG
TGCTGTTATTGGTGATGCAAAAATGGATGACATCTTGACCAGTGGTCGTCAAGAGATCCGTCAACGTACTCAAGAAACAC
TGAATCGTATTATTGATAAATACGACATGGGTTTAATTGTCGTTGATGTGAACTTCCAATCAGCTCGTCCACCTGAACAA
GTAAAAGCGTCATTTGATGATGCAATTGCAGCTCGAGAAGATGAAGAGCGTTTCATTCGTGAAGCTGAAGCGTACAGTAA
TGACATTCTTCCAAAAGCGACAGGTCGTGCTGAACGTTTGAAGAAAGAAGCTCAAGGTTATACTGAACGTAAAGTTAACG
AAGCAATTGGTCAAATTGCACAGTTTGAAAAACTATTGCCTGAATACAATAAAGCGCCAGAAGTAACTCGTACTCGTTTG
TACCTTGATACTATGGAACGTGTATACAGCAATACAAGTAAGGTTTTGATCGATTCAGAATCAAATGGAAATCTTTTATA
CCTTCCATTAGATAAAATTACGGGTAATCAACAAGGAGCGACAAACGTATCTCCTAAGACGTCAACATCGTCTTCAAAAG
ATTACACGATTGAATTAGAGAAAAAGAACCAACCAACTACTACGAACTCTACTGGCCGTAACTCAACACGTGAAGGGAGA
TATTAA

Upstream 100 bases:

>100_bases
TAAGTTGGAAAAACGTGAAGATGCTCCCTTAAGTGATTTTATTATTACTAAAGAGAGTGCATAGAATTCTTTATCTTCAT
AATTATCATGGAGTTTTCTA

Downstream 100 bases:

>100_bases
TCATGCGTAAGTTAATGATCCCAACACTTATCGTTGTTGTTGCTATTTTCCTGATGTCACTGTTTGTGATTCCAGAAGGT
GAGCGCGGTATTGTTACTCG

Product: modulator for HflB protease specific for phage lambda cII repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MAWNEPGNNNNNGGDKDPWGNKNRGGRDQGPPDLDEVFNKLSQKLSGKFGGGNNGGNNKGGSGLPSFGNGGAVGLGLIAV
VAIAIWVFSGFYTIGESDRGVVLRFGQYDRMVDPGLNWKPTFIDQVTPVNIQSIRSLNSKGLMLTKDENVVTVEMGVQYR
VADAHKYLYTVTNADDSLRQATDSALRAVIGDAKMDDILTSGRQEIRQRTQETLNRIIDKYDMGLIVVDVNFQSARPPEQ
VKASFDDAIAAREDEERFIREAEAYSNDILPKATGRAERLKKEAQGYTERKVNEAIGQIAQFEKLLPEYNKAPEVTRTRL
YLDTMERVYSNTSKVLIDSESNGNLLYLPLDKITGNQQGATNVSPKTSTSSSKDYTIELEKKNQPTTTNSTGRNSTREGR
Y

Sequences:

>Translated_401_residues
MAWNEPGNNNNNGGDKDPWGNKNRGGRDQGPPDLDEVFNKLSQKLSGKFGGGNNGGNNKGGSGLPSFGNGGAVGLGLIAV
VAIAIWVFSGFYTIGESDRGVVLRFGQYDRMVDPGLNWKPTFIDQVTPVNIQSIRSLNSKGLMLTKDENVVTVEMGVQYR
VADAHKYLYTVTNADDSLRQATDSALRAVIGDAKMDDILTSGRQEIRQRTQETLNRIIDKYDMGLIVVDVNFQSARPPEQ
VKASFDDAIAAREDEERFIREAEAYSNDILPKATGRAERLKKEAQGYTERKVNEAIGQIAQFEKLLPEYNKAPEVTRTRL
YLDTMERVYSNTSKVLIDSESNGNLLYLPLDKITGNQQGATNVSPKTSTSSSKDYTIELEKKNQPTTTNSTGRNSTREGR
Y
>Mature_400_residues
AWNEPGNNNNNGGDKDPWGNKNRGGRDQGPPDLDEVFNKLSQKLSGKFGGGNNGGNNKGGSGLPSFGNGGAVGLGLIAVV
AIAIWVFSGFYTIGESDRGVVLRFGQYDRMVDPGLNWKPTFIDQVTPVNIQSIRSLNSKGLMLTKDENVVTVEMGVQYRV
ADAHKYLYTVTNADDSLRQATDSALRAVIGDAKMDDILTSGRQEIRQRTQETLNRIIDKYDMGLIVVDVNFQSARPPEQV
KASFDDAIAAREDEERFIREAEAYSNDILPKATGRAERLKKEAQGYTERKVNEAIGQIAQFEKLLPEYNKAPEVTRTRLY
LDTMERVYSNTSKVLIDSESNGNLLYLPLDKITGNQQGATNVSPKTSTSSSKDYTIELEKKNQPTTTNSTGRNSTREGRY

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=363, Percent_Identity=56.7493112947658, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1786697, Length=218, Percent_Identity=26.1467889908257, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 44252; Mature: 44121

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWNEPGNNNNNGGDKDPWGNKNRGGRDQGPPDLDEVFNKLSQKLSGKFGGGNNGGNNKG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
GSGLPSFGNGGAVGLGLIAVVAIAIWVFSGFYTIGESDRGVVLRFGQYDRMVDPGLNWKP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCCCCCCC
TFIDQVTPVNIQSIRSLNSKGLMLTKDENVVTVEMGVQYRVADAHKYLYTVTNADDSLRQ
CHHCCCCCCCHHHHHHCCCCCEEEECCCCEEEEEECCEEEEECCCEEEEEEECCCHHHHH
ATDSALRAVIGDAKMDDILTSGRQEIRQRTQETLNRIIDKYDMGLIVVDVNFQSARPPEQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHH
VKASFDDAIAAREDEERFIREAEAYSNDILPKATGRAERLKKEAQGYTERKVNEAIGQIA
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
QFEKLLPEYNKAPEVTRTRLYLDTMERVYSNTSKVLIDSESNGNLLYLPLDKITGNQQGA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEHHHHCCCCCCC
TNVSPKTSTSSSKDYTIELEKKNQPTTTNSTGRNSTREGRY
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AWNEPGNNNNNGGDKDPWGNKNRGGRDQGPPDLDEVFNKLSQKLSGKFGGGNNGGNNKG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
GSGLPSFGNGGAVGLGLIAVVAIAIWVFSGFYTIGESDRGVVLRFGQYDRMVDPGLNWKP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEEEECCCCCCCCCCCCCCC
TFIDQVTPVNIQSIRSLNSKGLMLTKDENVVTVEMGVQYRVADAHKYLYTVTNADDSLRQ
CHHCCCCCCCHHHHHHCCCCCEEEECCCCEEEEEECCEEEEECCCEEEEEEECCCHHHHH
ATDSALRAVIGDAKMDDILTSGRQEIRQRTQETLNRIIDKYDMGLIVVDVNFQSARPPEQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHH
VKASFDDAIAAREDEERFIREAEAYSNDILPKATGRAERLKKEAQGYTERKVNEAIGQIA
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
QFEKLLPEYNKAPEVTRTRLYLDTMERVYSNTSKVLIDSESNGNLLYLPLDKITGNQQGA
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEHHHHCCCCCCC
TNVSPKTSTSSSKDYTIELEKKNQPTTTNSTGRNSTREGRY
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]