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The map label for this gene is aroK [H]

Identifier: 59712899

GI number: 59712899

Start: 2574908

End: 2575426

Strand: Reverse

Name: aroK [H]

Synonym: VF_2292

Alternate gene names: 59712899

Gene position: 2575426-2574908 (Counterclockwise)

Preceding gene: 59712900

Following gene: 59712898

Centisome position: 88.88

GC content: 42.0

Gene sequence:

>519_bases
ATGGCTGAAAAACGAAATATTTTCCTTGTTGGCCCAATGGGCGCCGGCAAAAGCACAATTGGTAGACACTTAGCTCAACA
ACTTCATATGGAGTTTCTTGATTCTGATACGGTAATCGAAGAACGCACAGGCGCAGATATTGCTTGGGTTTTCGATGTTG
AAGGTGAAGAAGGTTTCCGCAAACGTGAAGAAGGTGTGATTAACGATCTTACTCAAGAGCAAGGTATTGTTCTTGCGACG
GGTGGTGGCTCTGTAATTAGTAAAGAGAGTCGTAATCGTTTATCTGCTCGTGGTGTTGTTGTATATCTTGAAACTACAAT
TGAGAAGCAGTTAGCACGCACACAACGTGATAAAAAACGTCCACTGCTTCAAACTGATGAGCCTCGTGAAGTGTTAGAAG
CACTAGCGAAAGAACGTAACGCACTTTATGAAGAAGTGTCTGATTACGTTGTTCGTACCGATGATCAAAGTGCAAAAGTA
GTTGCAAACCAAATCATTCAAATGCTTGAAGAGCGTTAA

Upstream 100 bases:

>100_bases
TCACGAAATATCTGTGAGGAATATGGTGCCACAGGCGAGCGTCTATTAAAGAGACAACTGTTGGCAATGTCGTTAATGAA
CTTTGCATAATTTCTGAAAA

Downstream 100 bases:

>100_bases
TTTAAGCAATTAATAGATATAAAGTGGGAACGAATCATGGAAACGATTCATGTAGATTTAGCAGAACGTAGCTATCCCAT
CTCTATCGGCGCCGAGTTGT

Product: shikimate kinase I

Products: NA

Alternate protein names: SK [H]

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MAEKRNIFLVGPMGAGKSTIGRHLAQQLHMEFLDSDTVIEERTGADIAWVFDVEGEEGFRKREEGVINDLTQEQGIVLAT
GGGSVISKESRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLQTDEPREVLEALAKERNALYEEVSDYVVRTDDQSAKV
VANQIIQMLEER

Sequences:

>Translated_172_residues
MAEKRNIFLVGPMGAGKSTIGRHLAQQLHMEFLDSDTVIEERTGADIAWVFDVEGEEGFRKREEGVINDLTQEQGIVLAT
GGGSVISKESRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLQTDEPREVLEALAKERNALYEEVSDYVVRTDDQSAKV
VANQIIQMLEER
>Mature_171_residues
AEKRNIFLVGPMGAGKSTIGRHLAQQLHMEFLDSDTVIEERTGADIAWVFDVEGEEGFRKREEGVINDLTQEQGIVLATG
GGSVISKESRNRLSARGVVVYLETTIEKQLARTQRDKKRPLLQTDEPREVLEALAKERNALYEEVSDYVVRTDDQSAKVV
ANQIIQMLEER

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate [H]

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family [H]

Homologues:

Organism=Escherichia coli, GI87082255, Length=171, Percent_Identity=82.4561403508772, Blast_Score=284, Evalue=2e-78,
Organism=Escherichia coli, GI1786587, Length=159, Percent_Identity=30.8176100628931, Blast_Score=89, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6320332, Length=154, Percent_Identity=33.1168831168831, Blast_Score=68, Evalue=8e-13,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000623
- InterPro:   IPR023000 [H]

Pfam domain/function: PF01202 SKI [H]

EC number: =2.7.1.71 [H]

Molecular weight: Translated: 19372; Mature: 19241

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKRNIFLVGPMGAGKSTIGRHLAQQLHMEFLDSDTVIEERTGADIAWVFDVEGEEGFR
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCEEEEEECCCCHHHH
KREEGVINDLTQEQGIVLATGGGSVISKESRNRLSARGVVVYLETTIEKQLARTQRDKKR
HHHHHHHHHHHHHCCEEEEECCCCEECHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHCC
PLLQTDEPREVLEALAKERNALYEEVSDYVVRTDDQSAKVVANQIIQMLEER
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AEKRNIFLVGPMGAGKSTIGRHLAQQLHMEFLDSDTVIEERTGADIAWVFDVEGEEGFR
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCEEEEEECCCCHHHH
KREEGVINDLTQEQGIVLATGGGSVISKESRNRLSARGVVVYLETTIEKQLARTQRDKKR
HHHHHHHHHHHHHCCEEEEECCCCEECHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHCC
PLLQTDEPREVLEALAKERNALYEEVSDYVVRTDDQSAKVVANQIIQMLEER
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA