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The map label for this gene is cytR [H]

Identifier: 59712882

GI number: 59712882

Start: 2557876

End: 2558883

Strand: Direct

Name: cytR [H]

Synonym: VF_2275

Alternate gene names: 59712882

Gene position: 2557876-2558883 (Clockwise)

Preceding gene: 59712881

Following gene: 59712883

Centisome position: 88.28

GC content: 41.47

Gene sequence:

>1008_bases
ATGGCGACAATGAAGGACGTTGCTTTATCGGCAGGAGTGTCAACAGCAACGGTATCACGAGCACTAATGACACCAGAAAA
AGTATCATTATCCACTCGTAAGCGCGTTGAAGATGCAGTATTAGAAACGGGTTACTCACCAACTACGTTAACTCGAACAT
TACGACGCAATGAGTCAAAAACCATTGTGACGATTGTTCCTGATATTTGCGATCCTTACTTTAGTGACATTATTCGCGGT
ATTGAAGATGCTGCCGTTGAAAATGGTTATGTCATTTTAGTAGGCGACAGCAGTCAGCAAAAAAAACGTGAACACTCCTT
TGTAAACCTTGTGTATACCAAGCAAGTTGATGGCATGGTATTACTTGGTTCAGACCTCCCTTTTAACGTTAGTCGCCAAG
AACAAAAAAATTTACCGCCTCTTGTAATGGCGTGTGAATATGCACCAGAATTAGAACTACCAACCGTTCATATCGATAAC
CTTACAGCCGCCTATGAAGCAGTTAACTACCTAACTAAACTAGGGCATAAAAACATCGCAGAATTATCTGGTCCTGAGAG
CTCCGCGCTCTGTCAGTTCAGACATCAAGGTTACCAACAAGCACTTCGCCGTGCGGGTATCACCATGAATGCCTCTTATG
TGCAATATGGTGATTTCACTTTCGAAGCAGGGGCAAAAGCAATAACTCAACTTCTTTCTCTTTCAACACCACCGACTGCT
GTCTTTTGTCATAACGATATTATGGCAATCGGAGCAATTCAAAAAGCGAAACAAATGGGTTTTAGAGTGCCTCAAGACAT
TTCTATCATGGGATTTGATGATATTGAATTCTCTCAATATTGTGATCCTGCATTAACCACGATTTCCCAGCCTCGTTATG
AAATAGGTCGTCAATCTATGTTAATGCTACTTGACCTATTAAAAGGCCATGATGTTCGTTCTGGTTCACGATTACTCGAA
TCCTCATTGATTGTTAGAGAGAGTACGGCGTCCCCAAAAAACAAATAA

Upstream 100 bases:

>100_bases
ACGAGCCGTATTTAAATCTTTATTTTATGAATAAAATATCTTCTTATTCAAATAGAGCAATCGTTTACTTTAAGATAAAA
GTATTAGGGAGAAGATAATT

Downstream 100 bases:

>100_bases
AACGTCTCGATTCATTCTTTAAGCCACGTTAACGCCAAAAAGTCATAACTCTAGACAATCAATTTGTCTAAATAGTGACT
TTTTGCGTACTTTTTTACAC

Product: DNA-binding transcriptional regulator CytR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MATMKDVALSAGVSTATVSRALMTPEKVSLSTRKRVEDAVLETGYSPTTLTRTLRRNESKTIVTIVPDICDPYFSDIIRG
IEDAAVENGYVILVGDSSQQKKREHSFVNLVYTKQVDGMVLLGSDLPFNVSRQEQKNLPPLVMACEYAPELELPTVHIDN
LTAAYEAVNYLTKLGHKNIAELSGPESSALCQFRHQGYQQALRRAGITMNASYVQYGDFTFEAGAKAITQLLSLSTPPTA
VFCHNDIMAIGAIQKAKQMGFRVPQDISIMGFDDIEFSQYCDPALTTISQPRYEIGRQSMLMLLDLLKGHDVRSGSRLLE
SSLIVRESTASPKNK

Sequences:

>Translated_335_residues
MATMKDVALSAGVSTATVSRALMTPEKVSLSTRKRVEDAVLETGYSPTTLTRTLRRNESKTIVTIVPDICDPYFSDIIRG
IEDAAVENGYVILVGDSSQQKKREHSFVNLVYTKQVDGMVLLGSDLPFNVSRQEQKNLPPLVMACEYAPELELPTVHIDN
LTAAYEAVNYLTKLGHKNIAELSGPESSALCQFRHQGYQQALRRAGITMNASYVQYGDFTFEAGAKAITQLLSLSTPPTA
VFCHNDIMAIGAIQKAKQMGFRVPQDISIMGFDDIEFSQYCDPALTTISQPRYEIGRQSMLMLLDLLKGHDVRSGSRLLE
SSLIVRESTASPKNK
>Mature_334_residues
ATMKDVALSAGVSTATVSRALMTPEKVSLSTRKRVEDAVLETGYSPTTLTRTLRRNESKTIVTIVPDICDPYFSDIIRGI
EDAAVENGYVILVGDSSQQKKREHSFVNLVYTKQVDGMVLLGSDLPFNVSRQEQKNLPPLVMACEYAPELELPTVHIDNL
TAAYEAVNYLTKLGHKNIAELSGPESSALCQFRHQGYQQALRRAGITMNASYVQYGDFTFEAGAKAITQLLSLSTPPTAV
FCHNDIMAIGAIQKAKQMGFRVPQDISIMGFDDIEFSQYCDPALTTISQPRYEIGRQSMLMLLDLLKGHDVRSGSRLLES
SLIVRESTASPKNK

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=328, Percent_Identity=62.8048780487805, Blast_Score=454, Evalue=1e-129,
Organism=Escherichia coli, GI1787948, Length=333, Percent_Identity=35.1351351351351, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1790194, Length=307, Percent_Identity=36.4820846905537, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI1789202, Length=332, Percent_Identity=30.7228915662651, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788474, Length=334, Percent_Identity=30.5389221556886, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1789068, Length=339, Percent_Identity=30.6784660766962, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI48994940, Length=310, Percent_Identity=27.741935483871, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786540, Length=343, Percent_Identity=31.4868804664723, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1787580, Length=314, Percent_Identity=27.7070063694268, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1790715, Length=314, Percent_Identity=28.343949044586, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1787906, Length=307, Percent_Identity=28.6644951140065, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789456, Length=325, Percent_Identity=24.9230769230769, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1790689, Length=321, Percent_Identity=25.8566978193146, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1786268, Length=309, Percent_Identity=21.6828478964401, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790192, Length=284, Percent_Identity=25.7042253521127, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36936; Mature: 36805

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATMKDVALSAGVSTATVSRALMTPEKVSLSTRKRVEDAVLETGYSPTTLTRTLRRNESK
CCCHHHHHHHCCCHHHHHHHHHCCCHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
TIVTIVPDICDPYFSDIIRGIEDAAVENGYVILVGDSSQQKKREHSFVNLVYTKQVDGMV
EEEEECCHHCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHEEEEEEECCCCEE
LLGSDLPFNVSRQEQKNLPPLVMACEYAPELELPTVHIDNLTAAYEAVNYLTKLGHKNIA
EECCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCHH
ELSGPESSALCQFRHQGYQQALRRAGITMNASYVQYGDFTFEAGAKAITQLLSLSTPPTA
HCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCEEEECCEEHHHHHHHHHHHHHCCCCCCE
VFCHNDIMAIGAIQKAKQMGFRVPQDISIMGFDDIEFSQYCDPALTTISQPRYEIGRQSM
EEECCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHCCHHHHHCCCCHHHHHHHHH
LMLLDLLKGHDVRSGSRLLESSLIVRESTASPKNK
HHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCCC
>Mature Secondary Structure 
ATMKDVALSAGVSTATVSRALMTPEKVSLSTRKRVEDAVLETGYSPTTLTRTLRRNESK
CCHHHHHHHCCCHHHHHHHHHCCCHHHCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
TIVTIVPDICDPYFSDIIRGIEDAAVENGYVILVGDSSQQKKREHSFVNLVYTKQVDGMV
EEEEECCHHCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHEEEEEEECCCCEE
LLGSDLPFNVSRQEQKNLPPLVMACEYAPELELPTVHIDNLTAAYEAVNYLTKLGHKNIA
EECCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCHH
ELSGPESSALCQFRHQGYQQALRRAGITMNASYVQYGDFTFEAGAKAITQLLSLSTPPTA
HCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCEEEECCEEHHHHHHHHHHHHHCCCCCCE
VFCHNDIMAIGAIQKAKQMGFRVPQDISIMGFDDIEFSQYCDPALTTISQPRYEIGRQSM
EEECCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHCCHHHHHCCCCHHHHHHHHH
LMLLDLLKGHDVRSGSRLLESSLIVRESTASPKNK
HHHHHHHHCCCCCHHHHHHHHHHHEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]