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The map label for this gene is degP [H]

Identifier: 59712832

GI number: 59712832

Start: 2495391

End: 2496758

Strand: Direct

Name: degP [H]

Synonym: VF_2225

Alternate gene names: 59712832

Gene position: 2495391-2496758 (Clockwise)

Preceding gene: 59712831

Following gene: 59712833

Centisome position: 86.12

GC content: 39.62

Gene sequence:

>1368_bases
ATGAAAAAACCTTTGCTCGTTTTAGGTGCTTTAACTTTAAGCATCAGTGCCATCCTTACCCCTATTCAATCACAGGCAGC
CTTACCTATTGCAGTTGATTCACAACAGCTGCCAAGTCTTGCTCCTATGTTAGAAAAGATCACACCAGCAGTAGTCAGTA
TCGCTGTAGAAGGTACTCAAGTATCTAAACGTCATATACCTGAACAATTTCGTTTTTTCTTTGGCCCAGACTTCCCCTCT
GAACAAGTTCAAGAGCAGCCATTTAGAGGTCTCGGTTCTGGCGTTATTGTTGATGCAAAAAAAGGATATATTGTTACCAA
CCACCATGTAATTAATAACGCTGAAAAAATATTAGTTCAATTACACGATGGACGTGAATATACCGCAGAGTTGATTGGTA
GCGATGAATTGTCTGATATCGCTTTACTAAAACTTGAAGAGGCAAAAAACTTAACCGAAATAAAATTAGCGGATTCAGAT
AATTTACGTGTCGGAGATTTTAGTGTTGCCATTGGTAACCCTTTTGGCCTTGGTCAAACCGTAACCTCTGGTATTATTTC
AGCTTTAGGCCGCAGTGGATTAAACCTAGATAACTTTGAAAACTTTATTCAAACGGATGCAGCTATCAATAGTGGTAACT
CTGGTGGTGCTCTTGTCAATCTAAATGGCGACTTAATTGGTATTAACACCGCAATATTGGGGCCTAATGGCGGCAACGTA
GGCATTGGCTTTGCGATCCCATCAAATATGGTTCGTAATTTATCAGAGCAGATTTTAGAGTTTGGCCATGTTAAGCGCGG
TATTCTTGGTGTTCAAGGTGGAGAATTAACACCAGAGCTAGCTGAAGCATTCGACTATGAAACCAACCATGGTGCTTTTG
TTAGTCAGGTAGTTCCAGACAGTGCCGCTGATAAAGCCGGAATTCAAGCGGGTGATATACTTATCTCTATAAACGGCAAA
AAAATCCAAACTTTCGGTGAGTTACGAGCCAAAGTCGCCACTTTAGGTGCAGGTAAAAAAGTGACCTTAGGCTTGATTCG
TGATGGAAAAGAAAAAACAGTTACCGCAACACTAAAAGAAGCGGAACAAATTAAAGCACAAGCTGAAAACCTTCATAATG
GATTAAAAGGAGCGGAACTACAAAACACCACTCAATCAGATCCAGTTAAAGGCGTGAAGATCAGTAATGTAGAAAAAACA
TCCATGGCACAACGTTACGGTTTACAAAAAGACGATATTATTATCGGTGTTAACCGCAAACCGGTGAAAAATTTACAGCA
ATTTAGAAAATTACTTGAAAGTAAACCGCCTGTACTTGCATTGAATATTCAACGTGGTGAACACACGCTTTATCTAGTAA
TTAAGTAA

Upstream 100 bases:

>100_bases
AAAGAAGATAAAATCGCTTAAAACCCGAAGTTATCAATGAACTTTCTCAAAGGTTTTTGAGTCGAATAAGTACACTTTGT
TTAATTAAGAGTACATTTCG

Downstream 100 bases:

>100_bases
CCTAGAAGCAAGCACTCATTCTTTGAGTGCTTGCTTCTCCATCCTCTACTTTTTAACTAGATTCAATGTTATCCTAATCA
ATTATTCTTTTTATTCATCA

Product: serine endoprotease DegP (protease Do), periplasmic

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKKPLLVLGALTLSISAILTPIQSQAALPIAVDSQQLPSLAPMLEKITPAVVSIAVEGTQVSKRHIPEQFRFFFGPDFPS
EQVQEQPFRGLGSGVIVDAKKGYIVTNHHVINNAEKILVQLHDGREYTAELIGSDELSDIALLKLEEAKNLTEIKLADSD
NLRVGDFSVAIGNPFGLGQTVTSGIISALGRSGLNLDNFENFIQTDAAINSGNSGGALVNLNGDLIGINTAILGPNGGNV
GIGFAIPSNMVRNLSEQILEFGHVKRGILGVQGGELTPELAEAFDYETNHGAFVSQVVPDSAADKAGIQAGDILISINGK
KIQTFGELRAKVATLGAGKKVTLGLIRDGKEKTVTATLKEAEQIKAQAENLHNGLKGAELQNTTQSDPVKGVKISNVEKT
SMAQRYGLQKDDIIIGVNRKPVKNLQQFRKLLESKPPVLALNIQRGEHTLYLVIK

Sequences:

>Translated_455_residues
MKKPLLVLGALTLSISAILTPIQSQAALPIAVDSQQLPSLAPMLEKITPAVVSIAVEGTQVSKRHIPEQFRFFFGPDFPS
EQVQEQPFRGLGSGVIVDAKKGYIVTNHHVINNAEKILVQLHDGREYTAELIGSDELSDIALLKLEEAKNLTEIKLADSD
NLRVGDFSVAIGNPFGLGQTVTSGIISALGRSGLNLDNFENFIQTDAAINSGNSGGALVNLNGDLIGINTAILGPNGGNV
GIGFAIPSNMVRNLSEQILEFGHVKRGILGVQGGELTPELAEAFDYETNHGAFVSQVVPDSAADKAGIQAGDILISINGK
KIQTFGELRAKVATLGAGKKVTLGLIRDGKEKTVTATLKEAEQIKAQAENLHNGLKGAELQNTTQSDPVKGVKISNVEKT
SMAQRYGLQKDDIIIGVNRKPVKNLQQFRKLLESKPPVLALNIQRGEHTLYLVIK
>Mature_455_residues
MKKPLLVLGALTLSISAILTPIQSQAALPIAVDSQQLPSLAPMLEKITPAVVSIAVEGTQVSKRHIPEQFRFFFGPDFPS
EQVQEQPFRGLGSGVIVDAKKGYIVTNHHVINNAEKILVQLHDGREYTAELIGSDELSDIALLKLEEAKNLTEIKLADSD
NLRVGDFSVAIGNPFGLGQTVTSGIISALGRSGLNLDNFENFIQTDAAINSGNSGGALVNLNGDLIGINTAILGPNGGNV
GIGFAIPSNMVRNLSEQILEFGHVKRGILGVQGGELTPELAEAFDYETNHGAFVSQVVPDSAADKAGIQAGDILISINGK
KIQTFGELRAKVATLGAGKKVTLGLIRDGKEKTVTATLKEAEQIKAQAENLHNGLKGAELQNTTQSDPVKGVKISNVEKT
SMAQRYGLQKDDIIIGVNRKPVKNLQQFRKLLESKPPVLALNIQRGEHTLYLVIK

Specific function: Protease with a shared specificity with degP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=339, Percent_Identity=36.283185840708, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4506141, Length=298, Percent_Identity=37.5838926174497, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI24308541, Length=301, Percent_Identity=34.8837209302326, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI7019477, Length=315, Percent_Identity=34.6031746031746, Blast_Score=142, Evalue=7e-34,
Organism=Escherichia coli, GI1789629, Length=457, Percent_Identity=56.4551422319475, Blast_Score=505, Evalue=1e-144,
Organism=Escherichia coli, GI1786356, Length=457, Percent_Identity=56.0175054704595, Blast_Score=503, Evalue=1e-143,
Organism=Escherichia coli, GI1789630, Length=276, Percent_Identity=44.5652173913043, Blast_Score=214, Evalue=9e-57,
Organism=Saccharomyces cerevisiae, GI6324206, Length=376, Percent_Identity=25.2659574468085, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24646839, Length=340, Percent_Identity=33.2352941176471, Blast_Score=142, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 48603; Mature: 48603

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPLLVLGALTLSISAILTPIQSQAALPIAVDSQQLPSLAPMLEKITPAVVSIAVEGTQ
CCCCEEEEHHHHHHHHHHHCCHHCCCCCEEEECCHHCCHHHHHHHHHCCEEEEEEECCCC
VSKRHIPEQFRFFFGPDFPSEQVQEQPFRGLGSGVIVDAKKGYIVTNHHVINNAEKILVQ
CHHHCCCHHHHEEECCCCCHHHHHHCCHHCCCCCEEEECCCCEEEECCEECCCCEEEEEE
LHDGREYTAELIGSDELSDIALLKLEEAKNLTEIKLADSDNLRVGDFSVAIGNPFGLGQT
EECCCHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEEEEEEECCCCCCCHH
VTSGIISALGRSGLNLDNFENFIQTDAAINSGNSGGALVNLNGDLIGINTAILGPNGGNV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEEEECCCCCCE
GIGFAIPSNMVRNLSEQILEFGHVKRGILGVQGGELTPELAEAFDYETNHGAFVSQVVPD
EEEEECCHHHHHHHHHHHHHHHHHHHCEEECCCCCCCHHHHHHHCCCCCCCCEEHHHCCC
SAADKAGIQAGDILISINGKKIQTFGELRAKVATLGAGKKVTLGLIRDGKEKTVTATLKE
CCCHHCCCCCCCEEEEECCCEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEHHHHH
AEQIKAQAENLHNGLKGAELQNTTQSDPVKGVKISNVEKTSMAQRYGLQKDDIIIGVNRK
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHCCCCCCEEEECCCC
PVKNLQQFRKLLESKPPVLALNIQRGEHTLYLVIK
CHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEC
>Mature Secondary Structure
MKKPLLVLGALTLSISAILTPIQSQAALPIAVDSQQLPSLAPMLEKITPAVVSIAVEGTQ
CCCCEEEEHHHHHHHHHHHCCHHCCCCCEEEECCHHCCHHHHHHHHHCCEEEEEEECCCC
VSKRHIPEQFRFFFGPDFPSEQVQEQPFRGLGSGVIVDAKKGYIVTNHHVINNAEKILVQ
CHHHCCCHHHHEEECCCCCHHHHHHCCHHCCCCCEEEECCCCEEEECCEECCCCEEEEEE
LHDGREYTAELIGSDELSDIALLKLEEAKNLTEIKLADSDNLRVGDFSVAIGNPFGLGQT
EECCCHHHHHHCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEEEEEEECCCCCCCHH
VTSGIISALGRSGLNLDNFENFIQTDAAINSGNSGGALVNLNGDLIGINTAILGPNGGNV
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEEEEECCCCCCE
GIGFAIPSNMVRNLSEQILEFGHVKRGILGVQGGELTPELAEAFDYETNHGAFVSQVVPD
EEEEECCHHHHHHHHHHHHHHHHHHHCEEECCCCCCCHHHHHHHCCCCCCCCEEHHHCCC
SAADKAGIQAGDILISINGKKIQTFGELRAKVATLGAGKKVTLGLIRDGKEKTVTATLKE
CCCHHCCCCCCCEEEEECCCEEHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEHHHHH
AEQIKAQAENLHNGLKGAELQNTTQSDPVKGVKISNVEKTSMAQRYGLQKDDIIIGVNRK
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHCCCCCCEEEECCCC
PVKNLQQFRKLLESKPPVLALNIQRGEHTLYLVIK
CHHHHHHHHHHHHCCCCEEEEEEECCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8576051; 9278503 [H]