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The map label for this gene is hpt [H]

Identifier: 59712783

GI number: 59712783

Start: 2445632

End: 2446162

Strand: Reverse

Name: hpt [H]

Synonym: VF_2176

Alternate gene names: 59712783

Gene position: 2446162-2445632 (Counterclockwise)

Preceding gene: 59712785

Following gene: 59712782

Centisome position: 84.42

GC content: 36.16

Gene sequence:

>531_bases
ATGAAACATACAGTAGAGGTAATGATCTCTGAGCAAGAGGTCAACCAACGTGTAAAAGAACTAGGTCAACAAATTTCAGA
ACACTATAAAGATTCTGAAGGATTAGTAATGGTTGGCTTATTACGAGGTTCATTCGTATTCATGGCTGATTTAGCGCGAG
CTATTGATGTGCCAATGACTGTAGACTTTATGACAGCATCAAGTTACGGCAACAGTATGGAAAGTACTCGTGATGTACGA
ATCTTAAAAGATTTAGATGATGACATCAAAGGTAAGGATGTTCTTCTAGTAGAAGATATTATTGATACTGGTAATACGCT
AAGTAAAGTTTGCGAGATTTTATCTATTCGTGAACCAAACTCAATTACGATTTGTACATTACTTGATAAACCTTCTCGTC
GTGAAGTTGAAGTAAATGTGGATTGGATTGGTTTTTCAATTCCTGACGAATTTGTTGTTGGTGTGGGTATTGATTATGCT
CAGAAGTACCGTAACTTATCGTATATCGGAAAAGTTGTACCGCAAGAATAA

Upstream 100 bases:

>100_bases
GAAAAACTTTTATAATTACTCACGTTTCATTTTCTATTTTGCTGTAAACTGTGCAGGTCTAATCCTACTCTTAGTAGGTT
CAACGAATAAGTGAGATAGT

Downstream 100 bases:

>100_bases
TTTGAGAACGGGTGTTCACGCATAACCGTTCTCTAATCTTAACGCTTAATCATGCTATTAAGTAGAAGAATAAAGCCAAA
GATCCTTTATGTTCTTTGGC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MKHTVEVMISEQEVNQRVKELGQQISEHYKDSEGLVMVGLLRGSFVFMADLARAIDVPMTVDFMTASSYGNSMESTRDVR
ILKDLDDDIKGKDVLLVEDIIDTGNTLSKVCEILSIREPNSITICTLLDKPSRREVEVNVDWIGFSIPDEFVVGVGIDYA
QKYRNLSYIGKVVPQE

Sequences:

>Translated_176_residues
MKHTVEVMISEQEVNQRVKELGQQISEHYKDSEGLVMVGLLRGSFVFMADLARAIDVPMTVDFMTASSYGNSMESTRDVR
ILKDLDDDIKGKDVLLVEDIIDTGNTLSKVCEILSIREPNSITICTLLDKPSRREVEVNVDWIGFSIPDEFVVGVGIDYA
QKYRNLSYIGKVVPQE
>Mature_176_residues
MKHTVEVMISEQEVNQRVKELGQQISEHYKDSEGLVMVGLLRGSFVFMADLARAIDVPMTVDFMTASSYGNSMESTRDVR
ILKDLDDDIKGKDVLLVEDIIDTGNTLSKVCEILSIREPNSITICTLLDKPSRREVEVNVDWIGFSIPDEFVVGVGIDYA
QKYRNLSYIGKVVPQE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine [H]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=174, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI9910262, Length=173, Percent_Identity=31.7919075144509, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI87081689, Length=174, Percent_Identity=73.5632183908046, Blast_Score=262, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI17510817, Length=177, Percent_Identity=38.4180790960452, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 19805; Mature: 19805

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHTVEVMISEQEVNQRVKELGQQISEHYKDSEGLVMVGLLRGSFVFMADLARAIDVPMT
CCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHCCCEE
VDFMTASSYGNSMESTRDVRILKDLDDDIKGKDVLLVEDIIDTGNTLSKVCEILSIREPN
EEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEHHHCCCHHHHHHHHHHHCCCCC
SITICTLLDKPSRREVEVNVDWIGFSIPDEFVVGVGIDYAQKYRNLSYIGKVVPQE
CEEEEEEECCCCCCEEEEEEEEEEECCCCHHEEECCCHHHHHHCCHHHHHHCCCCC
>Mature Secondary Structure
MKHTVEVMISEQEVNQRVKELGQQISEHYKDSEGLVMVGLLRGSFVFMADLARAIDVPMT
CCCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHCCCEE
VDFMTASSYGNSMESTRDVRILKDLDDDIKGKDVLLVEDIIDTGNTLSKVCEILSIREPN
EEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEHHHCCCHHHHHHHHHHHCCCCC
SITICTLLDKPSRREVEVNVDWIGFSIPDEFVVGVGIDYAQKYRNLSYIGKVVPQE
CEEEEEEECCCCCCEEEEEEEEEEECCCCHHEEECCCHHHHHHCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2388850 [H]