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The map label for this gene is cadA [H]

Identifier: 59712664

GI number: 59712664

Start: 2289343

End: 2291481

Strand: Reverse

Name: cadA [H]

Synonym: VF_2057

Alternate gene names: 59712664

Gene position: 2291481-2289343 (Counterclockwise)

Preceding gene: 59712665

Following gene: 59712663

Centisome position: 79.08

GC content: 39.6

Gene sequence:

>2139_bases
ATGAATATTTTTGCTATCCTAAATCACTCAGGTGTTTTCTTTAAAGAAGAGCCAGTTCGCGAATTGCATGCTTCTTTAGA
AAAAGCAGGCTACAAAGTGGTTTACCCAGTAGATGCACAAGATCTATATAAAATGATTGAAATGAACCCACGTATTTGTG
GTGTGTTATTTGACTGGGATAAATACTCACTAGATTTATGTTCTGAAATTAATGCGTTGAATGAAAAACTGCCGCTATAT
GCATTTGCAAACCAACATTCAACATTAGATATTTCATTAACTGATTTACGTCTAAATCTACACTTCTTTGAATATGCGTT
AGATATGGCTGACGACATCGCTCTGAAAATTAATCAAGCGACTGAAGAGTACAAAGATCAGATCATGCCTCCGTTTACTA
AGGCATTATTCAAATACGTAGAAGAGGGTAAATATACTTTCTGTACTCCTGGCCACATGGGCGGTACGGCTTTCCAAAAA
AGTCCAGCGGGCAGCATCTTCTATGATTTCTACGGTCCAAACGCATTTAAAGCGGACGTATCAATCTCAATGCCTGAACT
AGGTTCATTACTTGATCACTCTGGTCCTCATAAAGAAGCTGAAGAGTACATTGCTCGTACGTTTAATGCAGATAGCTCTT
ACATCGTAACTAACGGTACTTCTACATCAAACAAAATTGTAGGCATGTACTCAGCACCAGCAGGAAGTACAGTGCTTGTT
GACCGTAACTGTCACAAATCACTGACTCACATGATGATGATGAGTGATGTAACACCTATTTATTTCCGTCCAACACGTAA
TGCTTACGGTATTTTAGGTGGCATCCCACAAAGCGAATTTACTCGTGAAGTGATTGAGCAAAAAGTAGCAGCAACACCAA
ACGCAACCATGCCAGGTTATGCGGTTATTACTAACTCAACTTACGATGGTCTTCTGTATAACACTCAATACATTAAAGAA
ACGCTAGATACTAAATACATCCACTTTGATAGTGCTTGGGTTCCTTACACTAACTTCAACAAAATTTATGAAGGTAAGTG
TGGTATGAGTGGCGAAGCAATGCCAGGTAAAGTGTTCTACGAAACACAATCAACTCATAAATTACTGGCTGCGTTCTCTC
AAGCATCAATGATCCACGTAAAAGGTGAATTTGATAAAGAATCATTCAATGAAGCGTTCATGATGCACACATCAACATCA
CCTCAATACGGTATTGTTGCATCAACTGAAACTGCTGCGGCAATGATGCGTGGTAATACAGGTAAGAAACTGATCCAAGA
CTCAATTGACCGTGCGATTCGTTTCCGTAAAGAGATCAAACGTCTTCAAAGTGAAAGTGACAGCTGGTTCTTTGATGTAT
GGCAACCAGAAAACATCGATACAACTGAATGTTGGAAACTGGATCCAAAAGATTCATGGCACGGCTTCAAGGACATCGAT
GATGATCACATGTACCTTGATCCAATCAAAGTAACGCTATTAACTCCAGGAATGAACGAAAATAGCGAAATGAGCGAGAC
TGGTATTCCTGCATCAATCGTTGCTAAATACTTAGATGAACGCGGTATCGTAGTAGAGAAAACAGGTCCATATAACTTAT
TGTTCCTATTCTCTATCGGTATTGATAAATCAAAAGCAATGCAATTACTACGTGCATTAACGGACTTTAAACGTGGCTTC
GATCTTAACTTAACAGTGAAAAACTTCCTTCCTTCACTGTACAACGAAGATCCAAGTTTCTATGAAGGTATGCGAGTACA
AGAACTGGCACAAGGCATTCACGATTTAACTCGTAAATACCGTTTACCAGAACTGATGTTTAAAGCATTCGATGTACTTC
CTGAACTAAAAGTAACACCACATGCAGCATGGCAAGAAGAGCTTCGCGGTAACGTAGAAGAAGTGCCTCTAGCTGATTTA
GTAGACCGTGTAAGTGCGAATATGATCCTACCTTACCCACCGGGTGTGCCTCTAGTACTTCCTGGTGAAATGGTAACAGC
TGAATCTCGCCCAGTACTTGATTTCTTAGAAATGCTATGTGAAATCGGCGCTCACTACCCAGGTTTTGAGACTGATATTC
ACGGTGTATATGCTCAAAAAGATGGCAGTTACACAGTGAAAGTACTAAAACAAAATTAA

Upstream 100 bases:

>100_bases
AGTTAACGCTACCAACTTAGTAAGTTTTACCCCTAGCGGCGCTCCACTACCTCACCATCAAAATGATGGGGAGCGCCTCT
CTTCGTCTTGGAGATATAAA

Downstream 100 bases:

>100_bases
GCCCTAGGGTTTTGATGGAATATCGTTTATTTTAGGGCACGGAAGCCCTTACTCTATTTTAAATTATGGTGATGTTATGA
AACGTATTCTTTCCATTCAG

Product: lysine decarboxylase 1

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 712; Mature: 712

Protein sequence:

>712_residues
MNIFAILNHSGVFFKEEPVRELHASLEKAGYKVVYPVDAQDLYKMIEMNPRICGVLFDWDKYSLDLCSEINALNEKLPLY
AFANQHSTLDISLTDLRLNLHFFEYALDMADDIALKINQATEEYKDQIMPPFTKALFKYVEEGKYTFCTPGHMGGTAFQK
SPAGSIFYDFYGPNAFKADVSISMPELGSLLDHSGPHKEAEEYIARTFNADSSYIVTNGTSTSNKIVGMYSAPAGSTVLV
DRNCHKSLTHMMMMSDVTPIYFRPTRNAYGILGGIPQSEFTREVIEQKVAATPNATMPGYAVITNSTYDGLLYNTQYIKE
TLDTKYIHFDSAWVPYTNFNKIYEGKCGMSGEAMPGKVFYETQSTHKLLAAFSQASMIHVKGEFDKESFNEAFMMHTSTS
PQYGIVASTETAAAMMRGNTGKKLIQDSIDRAIRFRKEIKRLQSESDSWFFDVWQPENIDTTECWKLDPKDSWHGFKDID
DDHMYLDPIKVTLLTPGMNENSEMSETGIPASIVAKYLDERGIVVEKTGPYNLLFLFSIGIDKSKAMQLLRALTDFKRGF
DLNLTVKNFLPSLYNEDPSFYEGMRVQELAQGIHDLTRKYRLPELMFKAFDVLPELKVTPHAAWQEELRGNVEEVPLADL
VDRVSANMILPYPPGVPLVLPGEMVTAESRPVLDFLEMLCEIGAHYPGFETDIHGVYAQKDGSYTVKVLKQN

Sequences:

>Translated_712_residues
MNIFAILNHSGVFFKEEPVRELHASLEKAGYKVVYPVDAQDLYKMIEMNPRICGVLFDWDKYSLDLCSEINALNEKLPLY
AFANQHSTLDISLTDLRLNLHFFEYALDMADDIALKINQATEEYKDQIMPPFTKALFKYVEEGKYTFCTPGHMGGTAFQK
SPAGSIFYDFYGPNAFKADVSISMPELGSLLDHSGPHKEAEEYIARTFNADSSYIVTNGTSTSNKIVGMYSAPAGSTVLV
DRNCHKSLTHMMMMSDVTPIYFRPTRNAYGILGGIPQSEFTREVIEQKVAATPNATMPGYAVITNSTYDGLLYNTQYIKE
TLDTKYIHFDSAWVPYTNFNKIYEGKCGMSGEAMPGKVFYETQSTHKLLAAFSQASMIHVKGEFDKESFNEAFMMHTSTS
PQYGIVASTETAAAMMRGNTGKKLIQDSIDRAIRFRKEIKRLQSESDSWFFDVWQPENIDTTECWKLDPKDSWHGFKDID
DDHMYLDPIKVTLLTPGMNENSEMSETGIPASIVAKYLDERGIVVEKTGPYNLLFLFSIGIDKSKAMQLLRALTDFKRGF
DLNLTVKNFLPSLYNEDPSFYEGMRVQELAQGIHDLTRKYRLPELMFKAFDVLPELKVTPHAAWQEELRGNVEEVPLADL
VDRVSANMILPYPPGVPLVLPGEMVTAESRPVLDFLEMLCEIGAHYPGFETDIHGVYAQKDGSYTVKVLKQN
>Mature_712_residues
MNIFAILNHSGVFFKEEPVRELHASLEKAGYKVVYPVDAQDLYKMIEMNPRICGVLFDWDKYSLDLCSEINALNEKLPLY
AFANQHSTLDISLTDLRLNLHFFEYALDMADDIALKINQATEEYKDQIMPPFTKALFKYVEEGKYTFCTPGHMGGTAFQK
SPAGSIFYDFYGPNAFKADVSISMPELGSLLDHSGPHKEAEEYIARTFNADSSYIVTNGTSTSNKIVGMYSAPAGSTVLV
DRNCHKSLTHMMMMSDVTPIYFRPTRNAYGILGGIPQSEFTREVIEQKVAATPNATMPGYAVITNSTYDGLLYNTQYIKE
TLDTKYIHFDSAWVPYTNFNKIYEGKCGMSGEAMPGKVFYETQSTHKLLAAFSQASMIHVKGEFDKESFNEAFMMHTSTS
PQYGIVASTETAAAMMRGNTGKKLIQDSIDRAIRFRKEIKRLQSESDSWFFDVWQPENIDTTECWKLDPKDSWHGFKDID
DDHMYLDPIKVTLLTPGMNENSEMSETGIPASIVAKYLDERGIVVEKTGPYNLLFLFSIGIDKSKAMQLLRALTDFKRGF
DLNLTVKNFLPSLYNEDPSFYEGMRVQELAQGIHDLTRKYRLPELMFKAFDVLPELKVTPHAAWQEELRGNVEEVPLADL
VDRVSANMILPYPPGVPLVLPGEMVTAESRPVLDFLEMLCEIGAHYPGFETDIHGVYAQKDGSYTVKVLKQN

Specific function: Appears To Play A Role In pH Homeostasis By Consuming Protons And Neutralizing The Acidic By-Products Of Carbohydrate Fermentation. [C]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1790573, Length=711, Percent_Identity=75.3867791842475, Blast_Score=1159, Evalue=0.0,
Organism=Escherichia coli, GI1786384, Length=710, Percent_Identity=69.0140845070423, Blast_Score=1077, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=735, Percent_Identity=36.1904761904762, Blast_Score=483, Evalue=1e-137,
Organism=Escherichia coli, GI87082193, Length=619, Percent_Identity=35.0565428109855, Blast_Score=348, Evalue=7e-97,
Organism=Escherichia coli, GI1786909, Length=628, Percent_Identity=34.0764331210191, Blast_Score=330, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 80453; Mature: 80453

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00703 OKR_DC_1 ; PS00867 CPSASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIFAILNHSGVFFKEEPVRELHASLEKAGYKVVYPVDAQDLYKMIEMNPRICGVLFDWD
CEEEEEEECCCCEECCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCEEEEEECCC
KYSLDLCSEINALNEKLPLYAFANQHSTLDISLTDLRLNLHFFEYALDMADDIALKINQA
CCCHHHHHHHHHHHHCCCEEEEECCCCEEEEEEEEEEEEHHHHHHHHHCCCCEEEEECHH
TEEYKDQIMPPFTKALFKYVEEGKYTFCTPGHMGGTAFQKSPAGSIFYDFYGPNAFKADV
HHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEECE
SISMPELGSLLDHSGPHKEAEEYIARTFNADSSYIVTNGTSTSNKIVGMYSAPAGSTVLV
EECCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEEECCCCCEEEE
DRNCHKSLTHMMMMSDVTPIYFRPTRNAYGILGGIPQSEFTREVIEQKVAATPNATMPGY
ECCHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCE
AVITNSTYDGLLYNTQYIKETLDTKYIHFDSAWVPYTNFNKIYEGKCGMSGEAMPGKVFY
EEEECCCCCCEEECHHHHHHHHCCEEEEECCCCCCCCCCCCEECCCCCCCCCCCCCEEEE
ETQSTHKLLAAFSQASMIHVKGEFDKESFNEAFMMHTSTSPQYGIVASTETAAAMMRGNT
ECCHHHHHHHHHHCCCEEEEECCCCHHHCCCEEEEEECCCCCCCEEECCHHHHHHHCCCC
GKKLIQDSIDRAIRFRKEIKRLQSESDSWFFDVWQPENIDTTECWKLDPKDSWHGFKDID
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCCCC
DDHMYLDPIKVTLLTPGMNENSEMSETGIPASIVAKYLDERGIVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKSKAMQLLRALTDFKRGFDLNLTVKNFLPSLYNEDPSFYEGMRVQELAQGIHDLTRKY
CCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHH
RLPELMFKAFDVLPELKVTPHAAWQEELRGNVEEVPLADLVDRVSANMILPYPPGVPLVL
CCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCEEEECCCCCCEEE
PGEMVTAESRPVLDFLEMLCEIGAHYPGFETDIHGVYAQKDGSYTVKVLKQN
CCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEEECC
>Mature Secondary Structure
MNIFAILNHSGVFFKEEPVRELHASLEKAGYKVVYPVDAQDLYKMIEMNPRICGVLFDWD
CEEEEEEECCCCEECCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCEEEEEECCC
KYSLDLCSEINALNEKLPLYAFANQHSTLDISLTDLRLNLHFFEYALDMADDIALKINQA
CCCHHHHHHHHHHHHCCCEEEEECCCCEEEEEEEEEEEEHHHHHHHHHCCCCEEEEECHH
TEEYKDQIMPPFTKALFKYVEEGKYTFCTPGHMGGTAFQKSPAGSIFYDFYGPNAFKADV
HHHHHHHCCCHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEECE
SISMPELGSLLDHSGPHKEAEEYIARTFNADSSYIVTNGTSTSNKIVGMYSAPAGSTVLV
EECCHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCEEEEEEECCCCCEEEE
DRNCHKSLTHMMMMSDVTPIYFRPTRNAYGILGGIPQSEFTREVIEQKVAATPNATMPGY
ECCHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCCCCCE
AVITNSTYDGLLYNTQYIKETLDTKYIHFDSAWVPYTNFNKIYEGKCGMSGEAMPGKVFY
EEEECCCCCCEEECHHHHHHHHCCEEEEECCCCCCCCCCCCEECCCCCCCCCCCCCEEEE
ETQSTHKLLAAFSQASMIHVKGEFDKESFNEAFMMHTSTSPQYGIVASTETAAAMMRGNT
ECCHHHHHHHHHHCCCEEEEECCCCHHHCCCEEEEEECCCCCCCEEECCHHHHHHHCCCC
GKKLIQDSIDRAIRFRKEIKRLQSESDSWFFDVWQPENIDTTECWKLDPKDSWHGFKDID
CHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCCCCCCCCCCCCC
DDHMYLDPIKVTLLTPGMNENSEMSETGIPASIVAKYLDERGIVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKSKAMQLLRALTDFKRGFDLNLTVKNFLPSLYNEDPSFYEGMRVQELAQGIHDLTRKY
CCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHH
RLPELMFKAFDVLPELKVTPHAAWQEELRGNVEEVPLADLVDRVSANMILPYPPGVPLVL
CCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHCCCEEEECCCCCCEEE
PGEMVTAESRPVLDFLEMLCEIGAHYPGFETDIHGVYAQKDGSYTVKVLKQN
CCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]