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The map label for this gene is cadB [H]

Identifier: 59712665

GI number: 59712665

Start: 2291602

End: 2292936

Strand: Reverse

Name: cadB [H]

Synonym: VF_2058

Alternate gene names: 59712665

Gene position: 2292936-2291602 (Counterclockwise)

Preceding gene: 59712667

Following gene: 59712664

Centisome position: 79.13

GC content: 42.55

Gene sequence:

>1335_bases
ATGGAATCGAATACAAAAAAAATTGGCTTAATTGCCTGTACAGGTGTTGTAGCCGGCAACATGATGGGGAGTGGTATTGC
ACTATTACCTTCTTCATTAGCAGCGGTTGGTTCAGTATCTATTTTTAGTTGGATTATCTGTTTGGTAGGTGCGTTAAGTT
TGGCCTTTGTTTTTGCTCGCTTAGCGACGAAAAACCCTCAAGAAGGTGGTCCAATCGCTTATGCAGGTGAAGTATCTCCT
GTATTTGGTTTCCAAACCGGTGTGCTTTACTACCACGCAAACTGGATTGGTAACTTAGCTATCGCTATTACTGGTGTATC
TTACTTATCTGTTTTCTTCCCTGCGTTGAATGACCCTATCCCTGCAGCTGCTGCGACGATTGCATCGGTATGGTTATTTA
CCTTAGTTAACTTACTAGGTGGTAGTTGGGTAAGTCGTCTATGTACATTAGGTTTAGGTCTTATCCTTATTCCTGTTGTT
GGTACGGCGATTGTTGGTTGGGGACACTTTGACTCGACACTATATAGTCAAAACTGGAATGTATCTTCAGGTACAAGTAC
TCACGCTATTATTAGTGCTGTTCTTATCTGTTTATGGTCATTTGTTGGTGTTGAATCAGCAGCAGTATCATCAGGTATGG
TTAAAAATCCAAAACGCACCGTTCCTCTAGCAACAATGCTAGGTACAGCGATTGCCGGTGTGATTTATATTCTATCAACT
CAAGTAATCAGCGGTATGTTCCCTGCTGCAGAAGTAGCGGCATCTGGTGCTCCATTTGCTCTAGCAACCACTGAGATCTT
CGGTAGCTGGTCAGCGCCATTTGTTGCAGCTTTCACAGCATTAGCGTGTTTCACTTCTCTAGGTTCTTGGATGATGTTGG
TAGGTGAAGCCGGTAAACGTGCAGCTCACGATGGTAACTTCCCTAAAATCTACGGCGAAACAGATAAAAATGGTGTAGCG
AAAAAAGGTCTAATCCTAGCTTCACTTAAAATGACAGCACTGATGGTTGCACTAACTGTATTCAGTTCTCAATCAGCTCA
CACTGCTGACTTATTTAATCAGTTAACGACTGATGCCGTACTACTAACAATGCTTCCTTACTTCTACTCAAGCATTAACT
TAATTCGTTTCGAAGGTATGACAACACGCAGCGGCTTTACCATGTTCTTCTCAGGTATTGCTTGTGTGTTCTGCATGATT
GCACTGGCTGGTGCAGAAGGTGCAACACTAACTGCAACCTTTATCGTGTCACTTGTCATCCTTATGTTCTACGCAAAAAA
AATGGGTCTGAAACAATCAGAGCAACATGTAACTGCAGAAGCAGTAGCCCATTAA

Upstream 100 bases:

>100_bases
AGTTTGCATGACCTGCTTCAAATAACATCTCGCTTCCTTAAAGAAAAAATTTCGTATAACGGGTAAAAAAATTGCCCATT
CGATGATCCTTGGAGATGTT

Downstream 100 bases:

>100_bases
TGTCACTCGATAGCGTAAACAGTTAACGCTACCAACTTAGTAAGTTTTACCCCTAGCGGCGCTCCACTACCTCACCATCA
AAATGATGGGGAGCGCCTCT

Product: lysine/cadaverine antiporter

Products: cadaverine [Cytoplasm]; L-lysine [Cytoplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MESNTKKIGLIACTGVVAGNMMGSGIALLPSSLAAVGSVSIFSWIICLVGALSLAFVFARLATKNPQEGGPIAYAGEVSP
VFGFQTGVLYYHANWIGNLAIAITGVSYLSVFFPALNDPIPAAAATIASVWLFTLVNLLGGSWVSRLCTLGLGLILIPVV
GTAIVGWGHFDSTLYSQNWNVSSGTSTHAIISAVLICLWSFVGVESAAVSSGMVKNPKRTVPLATMLGTAIAGVIYILST
QVISGMFPAAEVAASGAPFALATTEIFGSWSAPFVAAFTALACFTSLGSWMMLVGEAGKRAAHDGNFPKIYGETDKNGVA
KKGLILASLKMTALMVALTVFSSQSAHTADLFNQLTTDAVLLTMLPYFYSSINLIRFEGMTTRSGFTMFFSGIACVFCMI
ALAGAEGATLTATFIVSLVILMFYAKKMGLKQSEQHVTAEAVAH

Sequences:

>Translated_444_residues
MESNTKKIGLIACTGVVAGNMMGSGIALLPSSLAAVGSVSIFSWIICLVGALSLAFVFARLATKNPQEGGPIAYAGEVSP
VFGFQTGVLYYHANWIGNLAIAITGVSYLSVFFPALNDPIPAAAATIASVWLFTLVNLLGGSWVSRLCTLGLGLILIPVV
GTAIVGWGHFDSTLYSQNWNVSSGTSTHAIISAVLICLWSFVGVESAAVSSGMVKNPKRTVPLATMLGTAIAGVIYILST
QVISGMFPAAEVAASGAPFALATTEIFGSWSAPFVAAFTALACFTSLGSWMMLVGEAGKRAAHDGNFPKIYGETDKNGVA
KKGLILASLKMTALMVALTVFSSQSAHTADLFNQLTTDAVLLTMLPYFYSSINLIRFEGMTTRSGFTMFFSGIACVFCMI
ALAGAEGATLTATFIVSLVILMFYAKKMGLKQSEQHVTAEAVAH
>Mature_444_residues
MESNTKKIGLIACTGVVAGNMMGSGIALLPSSLAAVGSVSIFSWIICLVGALSLAFVFARLATKNPQEGGPIAYAGEVSP
VFGFQTGVLYYHANWIGNLAIAITGVSYLSVFFPALNDPIPAAAATIASVWLFTLVNLLGGSWVSRLCTLGLGLILIPVV
GTAIVGWGHFDSTLYSQNWNVSSGTSTHAIISAVLICLWSFVGVESAAVSSGMVKNPKRTVPLATMLGTAIAGVIYILST
QVISGMFPAAEVAASGAPFALATTEIFGSWSAPFVAAFTALACFTSLGSWMMLVGEAGKRAAHDGNFPKIYGETDKNGVA
KKGLILASLKMTALMVALTVFSSQSAHTADLFNQLTTDAVLLTMLPYFYSSINLIRFEGMTTRSGFTMFFSGIACVFCMI
ALAGAEGATLTATFIVSLVILMFYAKKMGLKQSEQHVTAEAVAH

Specific function: Probable cadaverine/lysine antiporter or part of it [H]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI115648063, Length=328, Percent_Identity=26.8292682926829, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI115648022, Length=328, Percent_Identity=26.8292682926829, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI186910308, Length=325, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI186910306, Length=325, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI186910304, Length=325, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790575, Length=442, Percent_Identity=66.7420814479638, Blast_Score=598, Evalue=1e-172,
Organism=Escherichia coli, GI2367353, Length=428, Percent_Identity=38.5514018691589, Blast_Score=290, Evalue=9e-80,
Organism=Escherichia coli, GI1786908, Length=381, Percent_Identity=33.5958005249344, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1787890, Length=387, Percent_Identity=26.8733850129199, Blast_Score=82, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221331183, Length=326, Percent_Identity=26.6871165644172, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17647653, Length=326, Percent_Identity=26.6871165644172, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24664379, Length=326, Percent_Identity=26.6871165644172, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004754 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 46394; Mature: 46394

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESNTKKIGLIACTGVVAGNMMGSGIALLPSSLAAVGSVSIFSWIICLVGALSLAFVFAR
CCCCCCEEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATKNPQEGGPIAYAGEVSPVFGFQTGVLYYHANWIGNLAIAITGVSYLSVFFPALNDPI
HHCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCHHHCHHHHHHHHHHHHHHHHHCCCCC
PAAAATIASVWLFTLVNLLGGSWVSRLCTLGLGLILIPVVGTAIVGWGHFDSTLYSQNWN
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCC
VSSGTSTHAIISAVLICLWSFVGVESAAVSSGMVKNPKRTVPLATMLGTAIAGVIYILST
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QVISGMFPAAEVAASGAPFALATTEIFGSWSAPFVAAFTALACFTSLGSWMMLVGEAGKR
HHHHCCCCHHHHHCCCCCEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AAHDGNFPKIYGETDKNGVAKKGLILASLKMTALMVALTVFSSQSAHTADLFNQLTTDAV
CCCCCCCCEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LLTMLPYFYSSINLIRFEGMTTRSGFTMFFSGIACVFCMIALAGAEGATLTATFIVSLVI
HHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LMFYAKKMGLKQSEQHVTAEAVAH
HHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MESNTKKIGLIACTGVVAGNMMGSGIALLPSSLAAVGSVSIFSWIICLVGALSLAFVFAR
CCCCCCEEEEEEEHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATKNPQEGGPIAYAGEVSPVFGFQTGVLYYHANWIGNLAIAITGVSYLSVFFPALNDPI
HHCCCCCCCCCEEEECCCCCCCCCCCCEEEEECCHHHCHHHHHHHHHHHHHHHHHCCCCC
PAAAATIASVWLFTLVNLLGGSWVSRLCTLGLGLILIPVVGTAIVGWGHFDSTLYSQNWN
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCC
VSSGTSTHAIISAVLICLWSFVGVESAAVSSGMVKNPKRTVPLATMLGTAIAGVIYILST
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QVISGMFPAAEVAASGAPFALATTEIFGSWSAPFVAAFTALACFTSLGSWMMLVGEAGKR
HHHHCCCCHHHHHCCCCCEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
AAHDGNFPKIYGETDKNGVAKKGLILASLKMTALMVALTVFSSQSAHTADLFNQLTTDAV
CCCCCCCCEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LLTMLPYFYSSINLIRFEGMTTRSGFTMFFSGIACVFCMIALAGAEGATLTATFIVSLVI
HHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LMFYAKKMGLKQSEQHVTAEAVAH
HHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: cadaverine [Cytoplasm]; Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: cadaverine [Cytoplasm] + Proton [Periplasm] + L-lysine [Periplasm] = cadaverine [Cytoplasm] + L-lysine [Cytoplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]