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The map label for this gene is phoR [H]

Identifier: 59712594

GI number: 59712594

Start: 2220630

End: 2221925

Strand: Reverse

Name: phoR [H]

Synonym: VF_1987

Alternate gene names: 59712594

Gene position: 2221925-2220630 (Counterclockwise)

Preceding gene: 59712595

Following gene: 59712593

Centisome position: 76.68

GC content: 39.27

Gene sequence:

>1296_bases
ATGGTTGAGCGTCTTTCATGGAAAAAATTGATTGGAGAATTGGTTTTTTTCTATGTTCCTTGGGTTATTGTAGGGTATCT
ATTTGATGCGCTATGGCCATTGCTGTTCCTTGCCTCCTTTATTTTATTAATTTGGCATCTTCATAACCAAATTAAGATGT
CACGTTGGTTACATGAAGGCCGAAAGGCGACACCTCCATCAGCATCTGGTAGTTGGGAACCTATTTTTGATGAGACGTAT
CGTCTGCAAAAAAGACATAAGAAGCGTCGCAAAGAGTTATCTGGTTTGATCCGTCGATTCCGTCAAGGTGCAGAAGCCTT
ACCAGATGCGGTAGTGGTTTTTCGCCACGAAGGAAATATCGTTTGGTGTAACACATTAGCACAATCTCTTCTTGGTTTTC
GTTGGCCTGATGATTCTGGTCAACCGATCACTAATTTAATTAGAACGCCTGATTTTGTGCAGTATTTGATGGGTCAACAT
TTTGATTTTCCATTGGATATGAAATCACCAATCAATAGTGATAAAACGTTAGAAATACGTATTGCACCATACAGTGATGG
TGAATATCTAATGGTGGTACGTGACGTTTCTCAAATTAAGCAACTTGAAGGCATGCGTCGTAACTTCTTTGCTAACGTAT
CTCATGAATTACGTACACCAATGACGGTTCTTCGCGGTTATTTGGAAATGTCGGAAGATCCTGACATGTTAGTTGGACCT
ATGTGGAATCGTGCGCATGGTGTAATGACTGAGCAGTTGTCTCGTATGGAAGGCTTAGTCGAACAACTATTAACTTTATC
TAAAATAGAAGCAGCAGCAACATCAATGCTAGAAGATCGTGTAGATGTTCCTTCAATGTTGGATATTTTAGAGAAAGAAG
CCGTAGCGCTAAGCGGCGAAAGAAATCATAAAATCACCTTTAATGTTGATCATAATCTCAAAGTTAAAGGTGATGAAGAT
CAATTACGTAGTGCTATTTCAAATTTAGTGTATAACGCCGTAAAACACACAACAGATGGTGCTGAAATTATTGTTGATTG
GCAATCAACATTCAGTGGTGCTGAGCTAAAAGTTACCGATAGTGGACAAGGGATAGAGCCGCAACATATTCCTCGTTTGA
CGGAACGTTTCTATCGTGTAGATAAAGCACGTTCTAGAGAAACGGGTGGTAGTGGATTAGGGCTAGCAATTGTTAAGCAT
GCGCTTAGTCATCATGACTCTCAGCTTGAAATAAAAAGTAAGTTAGGAAAAGGCAGTACTTTCTCATTTACATTACCTAA
AAAACTCATTCTTTAA

Upstream 100 bases:

>100_bases
AAGTAGAAGGTCATGATCGTTTAGTTCAAACGGTTCGTGGTGCGGGCTATCGCTTCTCTGTACAAGCGTCATAATTTAAT
TATTGTAAGGTATAAAGGTA

Downstream 100 bases:

>100_bases
GTAAGTACAGAATCATGATTAATATGCAAAGTAGAATTATAAAGTGGTTTAAGGGATTCTTCCCTGTAGGATTACTTTGG
TTGTGCTTTGCAAATAATGG

Product: phosphate regulon sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MVERLSWKKLIGELVFFYVPWVIVGYLFDALWPLLFLASFILLIWHLHNQIKMSRWLHEGRKATPPSASGSWEPIFDETY
RLQKRHKKRRKELSGLIRRFRQGAEALPDAVVVFRHEGNIVWCNTLAQSLLGFRWPDDSGQPITNLIRTPDFVQYLMGQH
FDFPLDMKSPINSDKTLEIRIAPYSDGEYLMVVRDVSQIKQLEGMRRNFFANVSHELRTPMTVLRGYLEMSEDPDMLVGP
MWNRAHGVMTEQLSRMEGLVEQLLTLSKIEAAATSMLEDRVDVPSMLDILEKEAVALSGERNHKITFNVDHNLKVKGDED
QLRSAISNLVYNAVKHTTDGAEIIVDWQSTFSGAELKVTDSGQGIEPQHIPRLTERFYRVDKARSRETGGSGLGLAIVKH
ALSHHDSQLEIKSKLGKGSTFSFTLPKKLIL

Sequences:

>Translated_431_residues
MVERLSWKKLIGELVFFYVPWVIVGYLFDALWPLLFLASFILLIWHLHNQIKMSRWLHEGRKATPPSASGSWEPIFDETY
RLQKRHKKRRKELSGLIRRFRQGAEALPDAVVVFRHEGNIVWCNTLAQSLLGFRWPDDSGQPITNLIRTPDFVQYLMGQH
FDFPLDMKSPINSDKTLEIRIAPYSDGEYLMVVRDVSQIKQLEGMRRNFFANVSHELRTPMTVLRGYLEMSEDPDMLVGP
MWNRAHGVMTEQLSRMEGLVEQLLTLSKIEAAATSMLEDRVDVPSMLDILEKEAVALSGERNHKITFNVDHNLKVKGDED
QLRSAISNLVYNAVKHTTDGAEIIVDWQSTFSGAELKVTDSGQGIEPQHIPRLTERFYRVDKARSRETGGSGLGLAIVKH
ALSHHDSQLEIKSKLGKGSTFSFTLPKKLIL
>Mature_431_residues
MVERLSWKKLIGELVFFYVPWVIVGYLFDALWPLLFLASFILLIWHLHNQIKMSRWLHEGRKATPPSASGSWEPIFDETY
RLQKRHKKRRKELSGLIRRFRQGAEALPDAVVVFRHEGNIVWCNTLAQSLLGFRWPDDSGQPITNLIRTPDFVQYLMGQH
FDFPLDMKSPINSDKTLEIRIAPYSDGEYLMVVRDVSQIKQLEGMRRNFFANVSHELRTPMTVLRGYLEMSEDPDMLVGP
MWNRAHGVMTEQLSRMEGLVEQLLTLSKIEAAATSMLEDRVDVPSMLDILEKEAVALSGERNHKITFNVDHNLKVKGDED
QLRSAISNLVYNAVKHTTDGAEIIVDWQSTFSGAELKVTDSGQGIEPQHIPRLTERFYRVDKARSRETGGSGLGLAIVKH
ALSHHDSQLEIKSKLGKGSTFSFTLPKKLIL

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=432, Percent_Identity=58.5648148148148, Blast_Score=486, Evalue=1e-139,
Organism=Escherichia coli, GI1788393, Length=251, Percent_Identity=29.0836653386454, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1786783, Length=263, Percent_Identity=31.5589353612167, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI145693157, Length=344, Percent_Identity=24.1279069767442, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788713, Length=241, Percent_Identity=28.6307053941909, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789149, Length=346, Percent_Identity=26.3005780346821, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=30.6034482758621, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=26.3636363636364, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788549, Length=350, Percent_Identity=22.5714285714286, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790346, Length=217, Percent_Identity=25.8064516129032, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790551, Length=246, Percent_Identity=29.6747967479675, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789403, Length=213, Percent_Identity=29.5774647887324, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789808, Length=233, Percent_Identity=27.0386266094421, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI48994928, Length=391, Percent_Identity=24.8081841432225, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788279, Length=243, Percent_Identity=27.9835390946502, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=230, Percent_Identity=28.2608695652174, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=26.1802575107296, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=27.5862068965517, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49277; Mature: 49277

Theoretical pI: Translated: 8.44; Mature: 8.44

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVERLSWKKLIGELVFFYVPWVIVGYLFDALWPLLFLASFILLIWHLHNQIKMSRWLHEG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RKATPPSASGSWEPIFDETYRLQKRHKKRRKELSGLIRRFRQGAEALPDAVVVFRHEGNI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCE
VWCNTLAQSLLGFRWPDDSGQPITNLIRTPDFVQYLMGQHFDFPLDMKSPINSDKTLEIR
EEHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEE
IAPYSDGEYLMVVRDVSQIKQLEGMRRNFFANVSHELRTPMTVLRGYLEMSEDPDMLVGP
EEECCCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHCCCCCCEEECC
MWNRAHGVMTEQLSRMEGLVEQLLTLSKIEAAATSMLEDRVDVPSMLDILEKEAVALSGE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
RNHKITFNVDHNLKVKGDEDQLRSAISNLVYNAVKHTTDGAEIIVDWQSTFSGAELKVTD
CCCEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEC
SGQGIEPQHIPRLTERFYRVDKARSRETGGSGLGLAIVKHALSHHDSQLEIKSKLGKGST
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCE
FSFTLPKKLIL
EEEECCHHHCC
>Mature Secondary Structure
MVERLSWKKLIGELVFFYVPWVIVGYLFDALWPLLFLASFILLIWHLHNQIKMSRWLHEG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RKATPPSASGSWEPIFDETYRLQKRHKKRRKELSGLIRRFRQGAEALPDAVVVFRHEGNI
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCE
VWCNTLAQSLLGFRWPDDSGQPITNLIRTPDFVQYLMGQHFDFPLDMKSPINSDKTLEIR
EEHHHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEE
IAPYSDGEYLMVVRDVSQIKQLEGMRRNFFANVSHELRTPMTVLRGYLEMSEDPDMLVGP
EEECCCCCEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHHHHHCCCCCCEEECC
MWNRAHGVMTEQLSRMEGLVEQLLTLSKIEAAATSMLEDRVDVPSMLDILEKEAVALSGE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCC
RNHKITFNVDHNLKVKGDEDQLRSAISNLVYNAVKHTTDGAEIIVDWQSTFSGAELKVTD
CCCEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEEEC
SGQGIEPQHIPRLTERFYRVDKARSRETGGSGLGLAIVKHALSHHDSQLEIKSKLGKGST
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHCCCCCE
FSFTLPKKLIL
EEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3550103; 9278503; 2187152; 8391104 [H]