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The map label for this gene is dxr

Identifier: 59712563

GI number: 59712563

Start: 2186491

End: 2187693

Strand: Reverse

Name: dxr

Synonym: VF_1956

Alternate gene names: 59712563

Gene position: 2187693-2186491 (Counterclockwise)

Preceding gene: 59712564

Following gene: 59712562

Centisome position: 75.5

GC content: 41.06

Gene sequence:

>1203_bases
ATGCGCAAGTTAACCATTTTAGGAGCGACAGGCTCTATTGGTAGTAGCACACTATCAGTCGCAAAACAAAATTCCGATCA
ATTTGAAGTTGTAGCATTAGGTGCAGGTACTAATGTCGATAAAATGTTGGAGCTATGCCTTGAATGGAAACCAAAGTACG
TTGCAATGGCAACTCAACCTGCTGCTGATGAGTTAAAAGAACTATTATCAGCTCACGCGATTAATGCTGAAGTATTCTCA
GGTGAAGATGGCTTATGTCATATTGCGCAACTTGACGAAGTTGATACTGTTATGGCTGCAATTGTAGGGGCTGCAGGGCT
TCTACCTACCATGTCGGCAGTTAAAGCTGGTAAACGTATTTTGCTTGCTAATAAAGAAGCTTTGGTCATGTCTGGGCAGC
TATTTATTGATGCGGTTGAAAAGTACGGTGCTGAATTACTGCCAGTGGATAGTGAACATAACGCTATCTTTCAGTGTTTA
CCGCAATCAATTCAAACCAATTTAGGTCGTTGCGATTTAGAAGAGCACGGCGTTAGTTCTATTTTATTAACTGGTTCTGG
TGGTCCTTTTCGTTATACCGATGTATCAGAGCTTGAAGCTGTAACGCCTGAAATGGCAATTGCGCACCCTAATTGGTCTA
TGGGGCCAAAGATCTCTGTCGATTCAGCGACGATGATGAACAAAGGCCTTGAGTATATTGAGGCTCGTTGGTTATTCAAT
GCGAGTAAAGATCAATTAAAGGTTGTTATTCATCCGCAATCAGTAATTCATTCAATGGTTCAATATAAAGACGGCTCTGT
GTTGGCACAAATGGGACTGCCAGATATGAGAACACCTATTGCGTGTACTATGTCTTATCCAAAAAGAGTTGATGCAGGTG
TTGAACCTTTAGATTTTACTAAAGTTGGAGAGTTTACGTTTATTGCTCCTGATTTTGCTCGTTATCCTTGTTTGAAACTA
GCCATTGATGCGTGCTATTTAGGACAACATGCAACTACGGGGCTAAATGCTGCGAACGAGCAAGCTGTTGCTGCCTTTTT
AGCCAATAAAATAAAATTTACAGATATCGCTCGAATTAATGAGGCTGTTTTGCATAAAGTCTGTGCAAACTTCCAAAACC
TTGAGCTAGATAGCTTGGAAAGCCTGATTGACCTAGATAGAATGGCGCGTCGTTATGCCGATGAGGCAATTAATAAGGTT
TAA

Upstream 100 bases:

>100_bases
TTAGGTATTTGACGACAAATACCATATCCATTTTTAAGTTATGCGGTAGATAGGATTATCTGCCGTTTTTCTATCTTTAA
ACCACCATGGTCATTTCATT

Downstream 100 bases:

>100_bases
TTATGTCAGAACTTCTATGGAATTTAGCATCATTCATTATTGCACTAGGTATTCTTGTTGCAGTGCATGAATTTGGCCAC
TTCTGGGTAGCGCGCCGTTG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MRKLTILGATGSIGSSTLSVAKQNSDQFEVVALGAGTNVDKMLELCLEWKPKYVAMATQPAADELKELLSAHAINAEVFS
GEDGLCHIAQLDEVDTVMAAIVGAAGLLPTMSAVKAGKRILLANKEALVMSGQLFIDAVEKYGAELLPVDSEHNAIFQCL
PQSIQTNLGRCDLEEHGVSSILLTGSGGPFRYTDVSELEAVTPEMAIAHPNWSMGPKISVDSATMMNKGLEYIEARWLFN
ASKDQLKVVIHPQSVIHSMVQYKDGSVLAQMGLPDMRTPIACTMSYPKRVDAGVEPLDFTKVGEFTFIAPDFARYPCLKL
AIDACYLGQHATTGLNAANEQAVAAFLANKIKFTDIARINEAVLHKVCANFQNLELDSLESLIDLDRMARRYADEAINKV

Sequences:

>Translated_400_residues
MRKLTILGATGSIGSSTLSVAKQNSDQFEVVALGAGTNVDKMLELCLEWKPKYVAMATQPAADELKELLSAHAINAEVFS
GEDGLCHIAQLDEVDTVMAAIVGAAGLLPTMSAVKAGKRILLANKEALVMSGQLFIDAVEKYGAELLPVDSEHNAIFQCL
PQSIQTNLGRCDLEEHGVSSILLTGSGGPFRYTDVSELEAVTPEMAIAHPNWSMGPKISVDSATMMNKGLEYIEARWLFN
ASKDQLKVVIHPQSVIHSMVQYKDGSVLAQMGLPDMRTPIACTMSYPKRVDAGVEPLDFTKVGEFTFIAPDFARYPCLKL
AIDACYLGQHATTGLNAANEQAVAAFLANKIKFTDIARINEAVLHKVCANFQNLELDSLESLIDLDRMARRYADEAINKV
>Mature_400_residues
MRKLTILGATGSIGSSTLSVAKQNSDQFEVVALGAGTNVDKMLELCLEWKPKYVAMATQPAADELKELLSAHAINAEVFS
GEDGLCHIAQLDEVDTVMAAIVGAAGLLPTMSAVKAGKRILLANKEALVMSGQLFIDAVEKYGAELLPVDSEHNAIFQCL
PQSIQTNLGRCDLEEHGVSSILLTGSGGPFRYTDVSELEAVTPEMAIAHPNWSMGPKISVDSATMMNKGLEYIEARWLFN
ASKDQLKVVIHPQSVIHSMVQYKDGSVLAQMGLPDMRTPIACTMSYPKRVDAGVEPLDFTKVGEFTFIAPDFARYPCLKL
AIDACYLGQHATTGLNAANEQAVAAFLANKIKFTDIARINEAVLHKVCANFQNLELDSLESLIDLDRMARRYADEAINKV

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=400, Percent_Identity=61, Blast_Score=478, Evalue=1e-136,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_VIBF1 (Q5E3E5)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_205339.1
- ProteinModelPortal:   Q5E3E5
- SMR:   Q5E3E5
- STRING:   Q5E3E5
- GeneID:   3279228
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_1956
- NMPDR:   fig|312309.3.peg.1956
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q5E3E5
- ProtClustDB:   PRK05447
- BioCyc:   VFIS312309:VF1956-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 43336; Mature: 43336

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00435 PEROXIDASE_1

Important sites: BINDING 125-125 BINDING 152-152 BINDING 186-186 BINDING 209-209 BINDING 231-231

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKLTILGATGSIGSSTLSVAKQNSDQFEVVALGAGTNVDKMLELCLEWKPKYVAMATQP
CCEEEEEECCCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCC
AADELKELLSAHAINAEVFSGEDGLCHIAQLDEVDTVMAAIVGAAGLLPTMSAVKAGKRI
CHHHHHHHHHHHCCCCEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKEALVMSGQLFIDAVEKYGAELLPVDSEHNAIFQCLPQSIQTNLGRCDLEEHGVSS
EEECCCEEEEECHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCEE
ILLTGSGGPFRYTDVSELEAVTPEMAIAHPNWSMGPKISVDSATMMNKGLEYIEARWLFN
EEEECCCCCEECCCHHHHHHCCCCCEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHEEC
ASKDQLKVVIHPQSVIHSMVQYKDGSVLAQMGLPDMRTPIACTMSYPKRVDAGVEPLDFT
CCCCCEEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCCHHHCCCCCCCCCE
KVGEFTFIAPDFARYPCLKLAIDACYLGQHATTGLNAANEQAVAAFLANKIKFTDIARIN
ECCCEEEECCCHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHH
EAVLHKVCANFQNLELDSLESLIDLDRMARRYADEAINKV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRKLTILGATGSIGSSTLSVAKQNSDQFEVVALGAGTNVDKMLELCLEWKPKYVAMATQP
CCEEEEEECCCCCCCHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCC
AADELKELLSAHAINAEVFSGEDGLCHIAQLDEVDTVMAAIVGAAGLLPTMSAVKAGKRI
CHHHHHHHHHHHCCCCEEECCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKEALVMSGQLFIDAVEKYGAELLPVDSEHNAIFQCLPQSIQTNLGRCDLEEHGVSS
EEECCCEEEEECHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHCCCEE
ILLTGSGGPFRYTDVSELEAVTPEMAIAHPNWSMGPKISVDSATMMNKGLEYIEARWLFN
EEEECCCCCEECCCHHHHHHCCCCCEEECCCCCCCCEEECCHHHHHHHHHHHHHHHHEEC
ASKDQLKVVIHPQSVIHSMVQYKDGSVLAQMGLPDMRTPIACTMSYPKRVDAGVEPLDFT
CCCCCEEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEECCCHHHCCCCCCCCCE
KVGEFTFIAPDFARYPCLKLAIDACYLGQHATTGLNAANEQAVAAFLANKIKFTDIARIN
ECCCEEEECCCHHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHH
EAVLHKVCANFQNLELDSLESLIDLDRMARRYADEAINKV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA