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The map label for this gene is dapA [H]

Identifier: 59712525

GI number: 59712525

Start: 2147415

End: 2148296

Strand: Reverse

Name: dapA [H]

Synonym: VF_1918

Alternate gene names: 59712525

Gene position: 2148296-2147415 (Counterclockwise)

Preceding gene: 59712528

Following gene: 59712524

Centisome position: 74.14

GC content: 41.5

Gene sequence:

>882_bases
ATGTTCTCAGGTAGCATTGTCGCTTTAGTTACACCATTGGATACTGATGGTGAAGTAGATTACAACAGTTTAAAAAGCCT
TGTTGATTACCACATTAAAGCGGGCACAAATGGTATTGTGGCTGTTGGTACAACAGGAGAATCAGCGACATTAAGTGTAG
AAGAGCATGTCAAATTAGTTATGAAGACCCTTGAGTTCGCTGATGGCCGAATTCCTGTAATTGCAGGAACGGGTGCAAAT
GCAACTCATGAAGCGGTGACATTTAGTAAGCTTTTCCATGATTCTGGTGTTGCTGGTTGTTTAAGTGTTACGCCTTATTA
CAATAAACCGACTCAAGAAGGTTTGTTCCAGCACTATAAAGCGATCTCTGAAGCAACAGATATTCCTCAAATTCTTTATA
ATGTACCAGGACGTACAGCAGTAGACCTTCTTCCTGAAACGGTCGCGCGTCTTGCTGAGCTTGATAACATTGTTGCATTA
AAAGATGCGACAGGTGATTTAGACCGCGTGGCGATTACTCGTGAACTTTGTGGTGAAAACTTTATCCAACTAAGTGGTGA
TGATGCTACTGCGCTTGATTTTGTTAAATTGGGTGGCCATGGTGTTATCTCTGTAACGTCAAACATTGCAGCAAAAGACA
TGGCGACCATGTTTGCTTTAGCTGCTCAAGGTAAGTTTGAAGAAGCTGAAATCATTAACCAACGTTTAATGCCGTTACAT
AATGATTTATTTGTTGAAGCTAACCCAATTCCGGTTAAATGGGCGGCACATCGTTTAGGTATGATTACTCATTCGGATAT
TCGTTTACCATTAACGGAATTAAGTCTGTCAGCACAGCCAACGGTAGAGCAAGCGCTGAAAAGTGCGGGTTTGTTGAAGT
AG

Upstream 100 bases:

>100_bases
ACCAGATAACACATCATGGTCAAGGATGGTGATTCTTTACGATGAAGTTAATTGAGTAACAGAACCAATATTGTAGCAGC
AGATAGAAAGGGAGAAGGAT

Downstream 100 bases:

>100_bases
TAGGATAGAAAATGAAAGTGAAGACTCGCTTTGTTGTTGGATCATTAATGATTGCTGTTTTATCAGCATGTTCAAGTAGT
CCAACAGAGCGTCGCCAAGC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MFSGSIVALVTPLDTDGEVDYNSLKSLVDYHIKAGTNGIVAVGTTGESATLSVEEHVKLVMKTLEFADGRIPVIAGTGAN
ATHEAVTFSKLFHDSGVAGCLSVTPYYNKPTQEGLFQHYKAISEATDIPQILYNVPGRTAVDLLPETVARLAELDNIVAL
KDATGDLDRVAITRELCGENFIQLSGDDATALDFVKLGGHGVISVTSNIAAKDMATMFALAAQGKFEEAEIINQRLMPLH
NDLFVEANPIPVKWAAHRLGMITHSDIRLPLTELSLSAQPTVEQALKSAGLLK

Sequences:

>Translated_293_residues
MFSGSIVALVTPLDTDGEVDYNSLKSLVDYHIKAGTNGIVAVGTTGESATLSVEEHVKLVMKTLEFADGRIPVIAGTGAN
ATHEAVTFSKLFHDSGVAGCLSVTPYYNKPTQEGLFQHYKAISEATDIPQILYNVPGRTAVDLLPETVARLAELDNIVAL
KDATGDLDRVAITRELCGENFIQLSGDDATALDFVKLGGHGVISVTSNIAAKDMATMFALAAQGKFEEAEIINQRLMPLH
NDLFVEANPIPVKWAAHRLGMITHSDIRLPLTELSLSAQPTVEQALKSAGLLK
>Mature_293_residues
MFSGSIVALVTPLDTDGEVDYNSLKSLVDYHIKAGTNGIVAVGTTGESATLSVEEHVKLVMKTLEFADGRIPVIAGTGAN
ATHEAVTFSKLFHDSGVAGCLSVTPYYNKPTQEGLFQHYKAISEATDIPQILYNVPGRTAVDLLPETVARLAELDNIVAL
KDATGDLDRVAITRELCGENFIQLSGDDATALDFVKLGGHGVISVTSNIAAKDMATMFALAAQGKFEEAEIINQRLMPLH
NDLFVEANPIPVKWAAHRLGMITHSDIRLPLTELSLSAQPTVEQALKSAGLLK

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=290, Percent_Identity=27.5862068965517, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI13540533, Length=246, Percent_Identity=26.0162601626016, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=64.3835616438356, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI87082415, Length=296, Percent_Identity=29.3918918918919, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1786463, Length=244, Percent_Identity=29.5081967213115, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789620, Length=231, Percent_Identity=29.004329004329, Blast_Score=94, Evalue=9e-21,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31325; Mature: 31325

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSGSIVALVTPLDTDGEVDYNSLKSLVDYHIKAGTNGIVAVGTTGESATLSVEEHVKLV
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEHHHHHHHH
MKTLEFADGRIPVIAGTGANATHEAVTFSKLFHDSGVAGCLSVTPYYNKPTQEGLFQHYK
HHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
AISEATDIPQILYNVPGRTAVDLLPETVARLAELDNIVALKDATGDLDRVAITRELCGEN
HHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCC
FIQLSGDDATALDFVKLGGHGVISVTSNIAAKDMATMFALAAQGKFEEAEIINQRLMPLH
EEEECCCCCHHHHHEEECCCEEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
NDLFVEANPIPVKWAAHRLGMITHSDIRLPLTELSLSAQPTVEQALKSAGLLK
CCEEEECCCCCCHHHHHHHCCEECCCCCCCHHHHCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MFSGSIVALVTPLDTDGEVDYNSLKSLVDYHIKAGTNGIVAVGTTGESATLSVEEHVKLV
CCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEHHHHHHHH
MKTLEFADGRIPVIAGTGANATHEAVTFSKLFHDSGVAGCLSVTPYYNKPTQEGLFQHYK
HHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHH
AISEATDIPQILYNVPGRTAVDLLPETVARLAELDNIVALKDATGDLDRVAITRELCGEN
HHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCC
FIQLSGDDATALDFVKLGGHGVISVTSNIAAKDMATMFALAAQGKFEEAEIINQRLMPLH
EEEECCCCCHHHHHEEECCCEEEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCC
NDLFVEANPIPVKWAAHRLGMITHSDIRLPLTELSLSAQPTVEQALKSAGLLK
CCEEEECCCCCCHHHHHHHCCEECCCCCCCHHHHCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA