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The map label for this gene is flrB [H]

Identifier: 59712462

GI number: 59712462

Start: 2086982

End: 2088043

Strand: Reverse

Name: flrB [H]

Synonym: VF_1855

Alternate gene names: 59712462

Gene position: 2088043-2086982 (Counterclockwise)

Preceding gene: 59712463

Following gene: 59712461

Centisome position: 72.06

GC content: 41.53

Gene sequence:

>1062_bases
ATGCAGGGTAATTCTGAGGGTGAATTAAACTCACCTCTTGGCACAGTAGAAGAGCAAAATACACGATATAAGCAAGTGCT
AGATGTTATGCCAGCTGGTGTTATTTTACTTGATACACAAGGTATGGTGTGTGAAGTCAATCCAGAAGCAATTAAGCTTT
TAGGTCTACCTCTATTGGGAGAGCGTTGGTTTGAAGTCATTCAACGATCGTTTGATCCAAGAGAAGATGATGGTCATGAG
ATCTCATTGCGTAATGGACGCAAAGTTCGATTGGCAATTTCGGCATCAGAAACAGGTCAACTAATACTGATCACTGATCT
GACTGAAACGCGTTTATTGCAATCTCGTGTGAGTGATCTTCAACGACTATCTTCATTAGGTAAGATGGTTGCATCGTTAG
CTCACCAAGTGAGAACACCGCTGTCGAGTGCGATGTTGTACGCCTCAAACTTAGGATCACCAAATTTACCAGCCGCAACA
CATAAACGTTTTCAAACCAAATTGGTTGATCGCCTTCATGATCTAGAAAAGCAAGTGAATGACATGCTTCTCTTTGCTAA
AGGCGGTGATAATAAAGTTGTTAAGCCATTCACAATAGGTGACTTGGTTGCTGAATATCGTCCAATGGTTGAAACCGCTC
TGCAATCAAATCAAGTCGATTACTACTTAGAAGTCGAACATGAAGATACAGTGCTAATGGGCAACGCCAATGCCATTGCT
AGCGCTATTAGTAATTTGATCATGAATGCCATTCAAGTGATAGGGAAGGGATGTCAAATAGACGTCTTTTTCAGACCTGT
GAATGGGTTTTTAAAAATATCGGTGCAAGATAATGGCCCCGGTATACCACTAGAGTTACAAGACAAAATAATGGAACCAT
TTTTTACTACTCGCTCTCAAGGCACAGGTCTTGGTCTTGCGGTTGTACAAATGGTTTGTCGAGCTCACAAAGGACAACTT
GAATTGTATTCAGAACCGGATGATGGCGCATGTTTTACCATGTCAATTCCACTATCAGCAACCCCAACAGACAGCCTAGC
TCAAACAGAATCTGGAGAATAA

Upstream 100 bases:

>100_bases
TCAAGCTTACATGTGCAGTGTAAGTTATTGATAATAAATACCAAAAGGGCTGGCATGTAAAATGCATCAGCCCTTTTGTT
GTTTTGGCGGGAATAAAATT

Downstream 100 bases:

>100_bases
ATCATGGCACAAAGCAAAGTATTAATTGTCGAGGATGATGAAGGTTTACGTGAAGCCTTGATCGACACGCTAGAGTTAGC
TGGTTACGAGTGGGTAGAAG

Product: sensory histidine kinase FlrB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MQGNSEGELNSPLGTVEEQNTRYKQVLDVMPAGVILLDTQGMVCEVNPEAIKLLGLPLLGERWFEVIQRSFDPREDDGHE
ISLRNGRKVRLAISASETGQLILITDLTETRLLQSRVSDLQRLSSLGKMVASLAHQVRTPLSSAMLYASNLGSPNLPAAT
HKRFQTKLVDRLHDLEKQVNDMLLFAKGGDNKVVKPFTIGDLVAEYRPMVETALQSNQVDYYLEVEHEDTVLMGNANAIA
SAISNLIMNAIQVIGKGCQIDVFFRPVNGFLKISVQDNGPGIPLELQDKIMEPFFTTRSQGTGLGLAVVQMVCRAHKGQL
ELYSEPDDGACFTMSIPLSATPTDSLAQTESGE

Sequences:

>Translated_353_residues
MQGNSEGELNSPLGTVEEQNTRYKQVLDVMPAGVILLDTQGMVCEVNPEAIKLLGLPLLGERWFEVIQRSFDPREDDGHE
ISLRNGRKVRLAISASETGQLILITDLTETRLLQSRVSDLQRLSSLGKMVASLAHQVRTPLSSAMLYASNLGSPNLPAAT
HKRFQTKLVDRLHDLEKQVNDMLLFAKGGDNKVVKPFTIGDLVAEYRPMVETALQSNQVDYYLEVEHEDTVLMGNANAIA
SAISNLIMNAIQVIGKGCQIDVFFRPVNGFLKISVQDNGPGIPLELQDKIMEPFFTTRSQGTGLGLAVVQMVCRAHKGQL
ELYSEPDDGACFTMSIPLSATPTDSLAQTESGE
>Mature_353_residues
MQGNSEGELNSPLGTVEEQNTRYKQVLDVMPAGVILLDTQGMVCEVNPEAIKLLGLPLLGERWFEVIQRSFDPREDDGHE
ISLRNGRKVRLAISASETGQLILITDLTETRLLQSRVSDLQRLSSLGKMVASLAHQVRTPLSSAMLYASNLGSPNLPAAT
HKRFQTKLVDRLHDLEKQVNDMLLFAKGGDNKVVKPFTIGDLVAEYRPMVETALQSNQVDYYLEVEHEDTVLMGNANAIA
SAISNLIMNAIQVIGKGCQIDVFFRPVNGFLKISVQDNGPGIPLELQDKIMEPFFTTRSQGTGLGLAVVQMVCRAHKGQL
ELYSEPDDGACFTMSIPLSATPTDSLAQTESGE

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=330, Percent_Identity=28.4848484848485, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1790436, Length=249, Percent_Identity=30.9236947791165, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI1790346, Length=231, Percent_Identity=26.8398268398268, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI145693157, Length=224, Percent_Identity=30.8035714285714, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1786600, Length=354, Percent_Identity=24.0112994350282, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786912, Length=225, Percent_Identity=26.2222222222222, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790300, Length=346, Percent_Identity=24.8554913294798, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081816, Length=231, Percent_Identity=31.1688311688312, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=25.5605381165919, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1789149, Length=251, Percent_Identity=25.4980079681275, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI48994928, Length=248, Percent_Identity=25.8064516129032, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87082128, Length=242, Percent_Identity=25.2066115702479, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38697; Mature: 38697

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGNSEGELNSPLGTVEEQNTRYKQVLDVMPAGVILLDTQGMVCEVNPEAIKLLGLPLLG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEECHHHEEHCCCCHHH
ERWFEVIQRSFDPREDDGHEISLRNGRKVRLAISASETGQLILITDLTETRLLQSRVSDL
HHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHH
QRLSSLGKMVASLAHQVRTPLSSAMLYASNLGSPNLPAATHKRFQTKLVDRLHDLEKQVN
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DMLLFAKGGDNKVVKPFTIGDLVAEYRPMVETALQSNQVDYYLEVEHEDTVLMGNANAIA
HEEEEEECCCCCEECCEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECHHHHH
SAISNLIMNAIQVIGKGCQIDVFFRPVNGFLKISVQDNGPGIPLELQDKIMEPFFTTRSQ
HHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCCCCCCEEHHHHHHHHHHHCCCC
GTGLGLAVVQMVCRAHKGQLELYSEPDDGACFTMSIPLSATPTDSLAQTESGE
CCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MQGNSEGELNSPLGTVEEQNTRYKQVLDVMPAGVILLDTQGMVCEVNPEAIKLLGLPLLG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEECHHHEEHCCCCHHH
ERWFEVIQRSFDPREDDGHEISLRNGRKVRLAISASETGQLILITDLTETRLLQSRVSDL
HHHHHHHHHHCCCCCCCCCEEEECCCCEEEEEEEECCCCCEEEEECCHHHHHHHHHHHHH
QRLSSLGKMVASLAHQVRTPLSSAMLYASNLGSPNLPAATHKRFQTKLVDRLHDLEKQVN
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DMLLFAKGGDNKVVKPFTIGDLVAEYRPMVETALQSNQVDYYLEVEHEDTVLMGNANAIA
HEEEEEECCCCCEECCEEHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEECHHHHH
SAISNLIMNAIQVIGKGCQIDVFFRPVNGFLKISVQDNGPGIPLELQDKIMEPFFTTRSQ
HHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCCCCCCEEHHHHHHHHHHHCCCC
GTGLGLAVVQMVCRAHKGQLELYSEPDDGACFTMSIPLSATPTDSLAQTESGE
CCCHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEECCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503 [H]