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The map label for this gene is flrC [H]

Identifier: 59712461

GI number: 59712461

Start: 2085545

End: 2086978

Strand: Reverse

Name: flrC [H]

Synonym: VF_1854

Alternate gene names: 59712461

Gene position: 2086978-2085545 (Counterclockwise)

Preceding gene: 59712462

Following gene: 59712460

Centisome position: 72.03

GC content: 42.61

Gene sequence:

>1434_bases
ATGGCACAAAGCAAAGTATTAATTGTCGAGGATGATGAAGGTTTACGTGAAGCCTTGATCGACACGCTAGAGTTAGCTGG
TTACGAGTGGGTAGAAGCCGATAGCGCAGAAACAGCATTACTTATTTTGAAGAAAGAGCCCGTTGATATTGTTGTTTCTG
ATGTTCAAATGGCAGGCATGGGTGGATTGGCTTTATTGCGCAGTATTAAATTGAATTGGCCGAATCTTCCGGTTCTTTTA
ATGACGGCTTACGCCAATATTGAAGATGCGGTTTCTGCAATGAAAGACGGTGCTATTGATTATATGGCTAAGCCATTTGC
ACCAGAAGTATTACTGAATATGGTCAGCCGTTATGCACCAGTGAAAACTGAGCAAACGGGTGATGCTATCGTTGCTGATG
AAAAGAGTCTTAAGCTACTTAAATTAGCTGATAAAGTCGCACGTACAGACGCTAACGTGATGGTGCTTGGTCCTAGTGGT
TCAGGTAAAGAAGTCATGTCACGCTACATCCACAATAATTCACAACGAAGTGAAGGCCCATTTGTTGCCATTAACTGTGC
TGCTATTCCTGACAACATGTTAGAAGCTACATTATTTGGTTATGAAAAAGGTGCCTTTACAGGGGCAGTTCAAGCCTGTC
CGGGGAAATTTGAACAAGCTCAAGGTGGTACTATTTTACTGGATGAGATCAGTGAAATGGATCTTAACCTACAAGCTAAG
TTACTGCGTGTATTGCAAGAACGTGAAGTTGAACGTTTAGGTGGTCGTAAGAGCATTAAGTTGGATGTACGTATCTTAGC
AACCAGTAACCGTGATCTGAAAAAGTACGTCGAAGAAGGCAACTTCCGTGAAGATTTATATTACCGCTTAAACGTATTCC
CAATTGCATGGCCGCCATTGAAAGATCGTAAAGGTGATATTGCACCGATAGCTCAACACTTAGTAGAGCGTCACTGTCAA
AAACAAGGTTTACCAGTTCCTAGTTTTAGTGCAGAAGCGACTCAAAAACTAGAAGCATACCCATGGCCGGGTAACGTTCG
TGAATTAGATAACGTCGTTCAGCGTGCGCTTATTCTTGCAGAAGAACATACGATCACTGCGGATGATGTTTTATTAGAAG
GGGTTGATTGGGCAGATGCGGACGGCTTACAACAAGTAGTAAGTGGTGAAGCGCCAACAATTAGACCAGAGCAACAAGTA
CCGTCAATAAACGAGACAGGTGCACCAGCAACGTCTGAAGAAAGTGAGGTTTTGGTTGCATCTAGTGGTTTAGGTGGTGA
ACTTCGAGAACAAGAATTTATCATTATCCTTGAAACCATAAAAGCCTGTGATGGGAAGCGAAAAGATGTCGCTGAAAAAC
TAGGTATTAGCCCAAGAACGTTACGTTACAAGCTAGCGAAGATGCGTGATGCTGGAATAGATATCCCAAGTTAA

Upstream 100 bases:

>100_bases
GTATTCAGAACCGGATGATGGCGCATGTTTTACCATGTCAATTCCACTATCAGCAACCCCAACAGACAGCCTAGCTCAAA
CAGAATCTGGAGAATAAATC

Downstream 100 bases:

>100_bases
AACAATGAGTTATCGTTATTGATATATTGGTATGTAAATTGCTTTATATACTTCGGGTCGTAAAATTAAGTCAAGAAGTT
GACTGGGTCGGAGAATAGAA

Product: two-component response regulator FlrC

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MAQSKVLIVEDDEGLREALIDTLELAGYEWVEADSAETALLILKKEPVDIVVSDVQMAGMGGLALLRSIKLNWPNLPVLL
MTAYANIEDAVSAMKDGAIDYMAKPFAPEVLLNMVSRYAPVKTEQTGDAIVADEKSLKLLKLADKVARTDANVMVLGPSG
SGKEVMSRYIHNNSQRSEGPFVAINCAAIPDNMLEATLFGYEKGAFTGAVQACPGKFEQAQGGTILLDEISEMDLNLQAK
LLRVLQEREVERLGGRKSIKLDVRILATSNRDLKKYVEEGNFREDLYYRLNVFPIAWPPLKDRKGDIAPIAQHLVERHCQ
KQGLPVPSFSAEATQKLEAYPWPGNVRELDNVVQRALILAEEHTITADDVLLEGVDWADADGLQQVVSGEAPTIRPEQQV
PSINETGAPATSEESEVLVASSGLGGELREQEFIIILETIKACDGKRKDVAEKLGISPRTLRYKLAKMRDAGIDIPS

Sequences:

>Translated_477_residues
MAQSKVLIVEDDEGLREALIDTLELAGYEWVEADSAETALLILKKEPVDIVVSDVQMAGMGGLALLRSIKLNWPNLPVLL
MTAYANIEDAVSAMKDGAIDYMAKPFAPEVLLNMVSRYAPVKTEQTGDAIVADEKSLKLLKLADKVARTDANVMVLGPSG
SGKEVMSRYIHNNSQRSEGPFVAINCAAIPDNMLEATLFGYEKGAFTGAVQACPGKFEQAQGGTILLDEISEMDLNLQAK
LLRVLQEREVERLGGRKSIKLDVRILATSNRDLKKYVEEGNFREDLYYRLNVFPIAWPPLKDRKGDIAPIAQHLVERHCQ
KQGLPVPSFSAEATQKLEAYPWPGNVRELDNVVQRALILAEEHTITADDVLLEGVDWADADGLQQVVSGEAPTIRPEQQV
PSINETGAPATSEESEVLVASSGLGGELREQEFIIILETIKACDGKRKDVAEKLGISPRTLRYKLAKMRDAGIDIPS
>Mature_476_residues
AQSKVLIVEDDEGLREALIDTLELAGYEWVEADSAETALLILKKEPVDIVVSDVQMAGMGGLALLRSIKLNWPNLPVLLM
TAYANIEDAVSAMKDGAIDYMAKPFAPEVLLNMVSRYAPVKTEQTGDAIVADEKSLKLLKLADKVARTDANVMVLGPSGS
GKEVMSRYIHNNSQRSEGPFVAINCAAIPDNMLEATLFGYEKGAFTGAVQACPGKFEQAQGGTILLDEISEMDLNLQAKL
LRVLQEREVERLGGRKSIKLDVRILATSNRDLKKYVEEGNFREDLYYRLNVFPIAWPPLKDRKGDIAPIAQHLVERHCQK
QGLPVPSFSAEATQKLEAYPWPGNVRELDNVVQRALILAEEHTITADDVLLEGVDWADADGLQQVVSGEAPTIRPEQQVP
SINETGAPATSEESEVLVASSGLGGELREQEFIIILETIKACDGKRKDVAEKLGISPRTLRYKLAKMRDAGIDIPS

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=488, Percent_Identity=38.7295081967213, Blast_Score=331, Evalue=5e-92,
Organism=Escherichia coli, GI1788905, Length=375, Percent_Identity=41.8666666666667, Blast_Score=287, Evalue=1e-78,
Organism=Escherichia coli, GI1790437, Length=474, Percent_Identity=36.7088607594937, Blast_Score=284, Evalue=8e-78,
Organism=Escherichia coli, GI1790299, Length=479, Percent_Identity=32.9853862212944, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI87082117, Length=349, Percent_Identity=38.9684813753582, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI1789087, Length=353, Percent_Identity=39.6600566572238, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082152, Length=241, Percent_Identity=46.0580912863071, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1789233, Length=337, Percent_Identity=38.5756676557863, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI87081872, Length=248, Percent_Identity=39.5161290322581, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1787583, Length=305, Percent_Identity=36.3934426229508, Blast_Score=195, Evalue=7e-51,
Organism=Escherichia coli, GI1786524, Length=235, Percent_Identity=42.9787234042553, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789828, Length=243, Percent_Identity=36.2139917695473, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI87081858, Length=238, Percent_Identity=31.0924369747899, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1786599, Length=127, Percent_Identity=29.9212598425197, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788394, Length=129, Percent_Identity=29.4573643410853, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787375, Length=105, Percent_Identity=35.2380952380952, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52274; Mature: 52143

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQSKVLIVEDDEGLREALIDTLELAGYEWVEADSAETALLILKKEPVDIVVSDVQMAGM
CCCCCEEEEECCCHHHHHHHHHHHHCCCCEEECCCCCEEEEEEECCCCEEEEECHHHCCC
GGLALLRSIKLNWPNLPVLLMTAYANIEDAVSAMKDGAIDYMAKPFAPEVLLNMVSRYAP
CHHHHHHHHHCCCCCCCEEEEEHHCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHCC
VKTEQTGDAIVADEKSLKLLKLADKVARTDANVMVLGPSGSGKEVMSRYIHNNSQRSEGP
CCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCC
FVAINCAAIPDNMLEATLFGYEKGAFTGAVQACPGKFEQAQGGTILLDEISEMDLNLQAK
EEEEEEEECCCHHHHHHHHCCCCCCCCCHHHHCCCCCHHCCCCEEEEECHHCCCCCHHHH
LLRVLQEREVERLGGRKSIKLDVRILATSNRDLKKYVEEGNFREDLYYRLNVFPIAWPPL
HHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHHCCCCCCCEEEEEEEEEEECCCC
KDRKGDIAPIAQHLVERHCQKQGLPVPSFSAEATQKLEAYPWPGNVRELDNVVQRALILA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
EEHTITADDVLLEGVDWADADGLQQVVSGEAPTIRPEQQVPSINETGAPATSEESEVLVA
HCCCCCHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEE
SSGLGGELREQEFIIILETIKACDGKRKDVAEKLGISPRTLRYKLAKMRDAGIDIPS
ECCCCCCCCCCCEEEEEEHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
AQSKVLIVEDDEGLREALIDTLELAGYEWVEADSAETALLILKKEPVDIVVSDVQMAGM
CCCCEEEEECCCHHHHHHHHHHHHCCCCEEECCCCCEEEEEEECCCCEEEEECHHHCCC
GGLALLRSIKLNWPNLPVLLMTAYANIEDAVSAMKDGAIDYMAKPFAPEVLLNMVSRYAP
CHHHHHHHHHCCCCCCCEEEEEHHCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHCC
VKTEQTGDAIVADEKSLKLLKLADKVARTDANVMVLGPSGSGKEVMSRYIHNNSQRSEGP
CCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCC
FVAINCAAIPDNMLEATLFGYEKGAFTGAVQACPGKFEQAQGGTILLDEISEMDLNLQAK
EEEEEEEECCCHHHHHHHHCCCCCCCCCHHHHCCCCCHHCCCCEEEEECHHCCCCCHHHH
LLRVLQEREVERLGGRKSIKLDVRILATSNRDLKKYVEEGNFREDLYYRLNVFPIAWPPL
HHHHHHHHHHHHHCCCCEEEEEEEEEEECCHHHHHHHHCCCCCCCEEEEEEEEEEECCCC
KDRKGDIAPIAQHLVERHCQKQGLPVPSFSAEATQKLEAYPWPGNVRELDNVVQRALILA
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
EEHTITADDVLLEGVDWADADGLQQVVSGEAPTIRPEQQVPSINETGAPATSEESEVLVA
HCCCCCHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCCEEEE
SSGLGGELREQEFIIILETIKACDGKRKDVAEKLGISPRTLRYKLAKMRDAGIDIPS
ECCCCCCCCCCCEEEEEEHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]