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The map label for this gene is clcA [H]

Identifier: 59712405

GI number: 59712405

Start: 2030291

End: 2031697

Strand: Reverse

Name: clcA [H]

Synonym: VF_1798

Alternate gene names: 59712405

Gene position: 2031697-2030291 (Counterclockwise)

Preceding gene: 59712406

Following gene: 59712402

Centisome position: 70.12

GC content: 41.44

Gene sequence:

>1407_bases
ATGCCAAAATCACCCAATTTTCGTTTCTTTCAAGGTGGGATGCTCAAACATCGCACAACTCCAAAATTTTTAACCACACA
AACTGATTACTATGCACTGCTGCTTTTATCTGCTTTAGTTGGCGGTATTGCTGGTTCCGTTGTTGCCATGTTTGAAGCGT
CTATTCGACTCATTGGTGAACAGCGCTTACATTTTCTTGATTCACTTCCTTATTCTGAATTTATTGCTCCAATTGGTGCT
GTAGTTGCTGGTGCTGCAATGGCTGCGTTAGGTTTTTGGTTAACGTTTAAGTTTGCTCCAGAAGTAGCAGGTAGTGGTAT
TCCACACATTGAAGGCGCATTGGATGGCACGCATGAAATTCGTTGGCATCGAGTTCTACCTGTTAAATTTATTGCAGGTA
CATTAACTATTGGATCTGGAATGGTATTGGGGCGTGAAGGGCCTTCTATACAAATTGGTGGTGCGGTAGGGCGAATGGTT
GCGAGTAAAGGAAAGCGATTTAGTCACTCTTCTCATATTTTGACTGCTGCGGGTGCTGCTGCTGGCTTGGCTGCTGCCTT
TAATGCGCCACTAGCAGGTATTCTTTTTATTGTAGAAGAGATGCGACCACAATTTAGATATAACATTACTTCAATTAAAT
GCGTGACATTAGCAACAGCGGTTGCAACGATCGTTATGCGTTCATTACATGGACAGGAAGCCTTTTTAACCATCCCTAGT
TTTGAAGTTCCACCACTAAGATCCCTTATCTTGTTTGCTATTTTAGGGATTATCTTTGGCATTATTGGAGTAAACTTTAA
TAAATGGATTCTTAAAGGAACAAGTAAAGTTAAGAAATTTCATCAGAACAAATTATCTCGAATTGTTCTGATGGGGGCGG
CTTTTGGTGCTACCTTCTCATTCTTACATTTAGTTGCTCCCGAACTTTCAGGCAGTGGCATGGCGATCATTACTGAAATG
TTTCATAGCCCAATGGCTTGGATTCTTATGGTTGGCTTCTTTGTTCTTCGAGTGATTGTGACTGTTGCTTGTTTTTCATC
GGGTGCACCAGGGGGGATTTTTGCCCCAATGTTAGCTTTAGGCACTTTGCTTGGCTTATCTTATGGTATGGTGATGTCAG
CTTGGTTCCCTGGTTGGATAGCGGAACCTGGTGTTTATGCGATTGCTGGCATGGGCGCACTGTTTGCAGCAACGGTTAGA
GCACCAGTAACTGGGGTGATTCTTGTTGTAGAAATGACCAATAATTATCAATTAATTTTACCTTTATTGGTTACAACATT
AGGCGCAACGTTTATTGCTCAAGCTTTAGGTGGTCAACCCCTTTATTCTGCCTTATTGAAACAATCATTAGTTAAAGACA
AAGAGTTAAGAGCAGATCACCAAGCTCCTTTAAAAGACGTAACTTAA

Upstream 100 bases:

>100_bases
AAATGGTTAGGGTCTATCGGCTGCTGAAGCGTATAATTATTTGTGATCTTATTCTAATAAATGTTGCCAATGCTCTTTAC
GTGCTAAGTTGATTCGATAA

Downstream 100 bases:

>100_bases
TGTAACCTGACTGGTAATGAAATCGATTCCAATTCCATTAGCTATAATACGTCCCATCGTATAACTCGCTGCAATATTTA
GAGAGTAGGGCAGCGAGTAT

Product: chloride channel protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MPKSPNFRFFQGGMLKHRTTPKFLTTQTDYYALLLLSALVGGIAGSVVAMFEASIRLIGEQRLHFLDSLPYSEFIAPIGA
VVAGAAMAALGFWLTFKFAPEVAGSGIPHIEGALDGTHEIRWHRVLPVKFIAGTLTIGSGMVLGREGPSIQIGGAVGRMV
ASKGKRFSHSSHILTAAGAAAGLAAAFNAPLAGILFIVEEMRPQFRYNITSIKCVTLATAVATIVMRSLHGQEAFLTIPS
FEVPPLRSLILFAILGIIFGIIGVNFNKWILKGTSKVKKFHQNKLSRIVLMGAAFGATFSFLHLVAPELSGSGMAIITEM
FHSPMAWILMVGFFVLRVIVTVACFSSGAPGGIFAPMLALGTLLGLSYGMVMSAWFPGWIAEPGVYAIAGMGALFAATVR
APVTGVILVVEMTNNYQLILPLLVTTLGATFIAQALGGQPLYSALLKQSLVKDKELRADHQAPLKDVT

Sequences:

>Translated_468_residues
MPKSPNFRFFQGGMLKHRTTPKFLTTQTDYYALLLLSALVGGIAGSVVAMFEASIRLIGEQRLHFLDSLPYSEFIAPIGA
VVAGAAMAALGFWLTFKFAPEVAGSGIPHIEGALDGTHEIRWHRVLPVKFIAGTLTIGSGMVLGREGPSIQIGGAVGRMV
ASKGKRFSHSSHILTAAGAAAGLAAAFNAPLAGILFIVEEMRPQFRYNITSIKCVTLATAVATIVMRSLHGQEAFLTIPS
FEVPPLRSLILFAILGIIFGIIGVNFNKWILKGTSKVKKFHQNKLSRIVLMGAAFGATFSFLHLVAPELSGSGMAIITEM
FHSPMAWILMVGFFVLRVIVTVACFSSGAPGGIFAPMLALGTLLGLSYGMVMSAWFPGWIAEPGVYAIAGMGALFAATVR
APVTGVILVVEMTNNYQLILPLLVTTLGATFIAQALGGQPLYSALLKQSLVKDKELRADHQAPLKDVT
>Mature_467_residues
PKSPNFRFFQGGMLKHRTTPKFLTTQTDYYALLLLSALVGGIAGSVVAMFEASIRLIGEQRLHFLDSLPYSEFIAPIGAV
VAGAAMAALGFWLTFKFAPEVAGSGIPHIEGALDGTHEIRWHRVLPVKFIAGTLTIGSGMVLGREGPSIQIGGAVGRMVA
SKGKRFSHSSHILTAAGAAAGLAAAFNAPLAGILFIVEEMRPQFRYNITSIKCVTLATAVATIVMRSLHGQEAFLTIPSF
EVPPLRSLILFAILGIIFGIIGVNFNKWILKGTSKVKKFHQNKLSRIVLMGAAFGATFSFLHLVAPELSGSGMAIITEMF
HSPMAWILMVGFFVLRVIVTVACFSSGAPGGIFAPMLALGTLLGLSYGMVMSAWFPGWIAEPGVYAIAGMGALFAATVRA
PVTGVILVVEMTNNYQLILPLLVTTLGATFIAQALGGQPLYSALLKQSLVKDKELRADHQAPLKDVT

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Homo sapiens, GI189217923, Length=408, Percent_Identity=26.2254901960784, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI189217921, Length=408, Percent_Identity=26.2254901960784, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI4557473, Length=408, Percent_Identity=26.2254901960784, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI55770838, Length=411, Percent_Identity=25.0608272506083, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI55770840, Length=411, Percent_Identity=25.0608272506083, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI153252026, Length=409, Percent_Identity=24.2053789731051, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI156104869, Length=408, Percent_Identity=26.4705882352941, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI283806618, Length=408, Percent_Identity=26.4705882352941, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI283806622, Length=408, Percent_Identity=25.9803921568627, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1786350, Length=428, Percent_Identity=49.7663551401869, Blast_Score=350, Evalue=8e-98,
Organism=Escherichia coli, GI87081943, Length=321, Percent_Identity=29.595015576324, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17532615, Length=424, Percent_Identity=24.5283018867925, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71996455, Length=502, Percent_Identity=23.7051792828685, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71996452, Length=502, Percent_Identity=23.7051792828685, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71980824, Length=503, Percent_Identity=22.0675944333996, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980828, Length=503, Percent_Identity=22.0675944333996, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71980820, Length=508, Percent_Identity=21.8503937007874, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71985148, Length=188, Percent_Identity=32.4468085106383, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71985141, Length=188, Percent_Identity=32.4468085106383, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322500, Length=360, Percent_Identity=23.0555555555556, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24665008, Length=436, Percent_Identity=26.8348623853211, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45551566, Length=423, Percent_Identity=25.7683215130024, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI161078208, Length=423, Percent_Identity=25.2955082742317, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281361606, Length=423, Percent_Identity=25.2955082742317, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281361608, Length=454, Percent_Identity=24.8898678414097, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573073, Length=423, Percent_Identity=25.2955082742317, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573075, Length=423, Percent_Identity=25.2955082742317, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573071, Length=423, Percent_Identity=25.2955082742317, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 49847; Mature: 49716

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKSPNFRFFQGGMLKHRTTPKFLTTQTDYYALLLLSALVGGIAGSVVAMFEASIRLIGE
CCCCCCCEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRLHFLDSLPYSEFIAPIGAVVAGAAMAALGFWLTFKFAPEVAGSGIPHIEGALDGTHEI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHCCCCCCCCCCCCCCCCCE
RWHRVLPVKFIAGTLTIGSGMVLGREGPSIQIGGAVGRMVASKGKRFSHSSHILTAAGAA
EEEEECHHHHHHHHEEECCCEEEECCCCCEEECHHHHHHHHHCCCCCCCCCCCEEHHHHH
AGLAAAFNAPLAGILFIVEEMRPQFRYNITSIKCVTLATAVATIVMRSLHGQEAFLTIPS
HHHHHHHCCCHHHHHHHHHHHCHHHEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
FEVPPLRSLILFAILGIIFGIIGVNFNKWILKGTSKVKKFHQNKLSRIVLMGAAFGATFS
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLHLVAPELSGSGMAIITEMFHSPMAWILMVGFFVLRVIVTVACFSSGAPGGIFAPMLAL
HHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GTLLGLSYGMVMSAWFPGWIAEPGVYAIAGMGALFAATVRAPVTGVILVVEMTNNYQLIL
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEEHH
PLLVTTLGATFIAQALGGQPLYSALLKQSLVKDKELRADHQAPLKDVT
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PKSPNFRFFQGGMLKHRTTPKFLTTQTDYYALLLLSALVGGIAGSVVAMFEASIRLIGE
CCCCCCEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRLHFLDSLPYSEFIAPIGAVVAGAAMAALGFWLTFKFAPEVAGSGIPHIEGALDGTHEI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHCCCCCCCCCCCCCCCCCE
RWHRVLPVKFIAGTLTIGSGMVLGREGPSIQIGGAVGRMVASKGKRFSHSSHILTAAGAA
EEEEECHHHHHHHHEEECCCEEEECCCCCEEECHHHHHHHHHCCCCCCCCCCCEEHHHHH
AGLAAAFNAPLAGILFIVEEMRPQFRYNITSIKCVTLATAVATIVMRSLHGQEAFLTIPS
HHHHHHHCCCHHHHHHHHHHHCHHHEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
FEVPPLRSLILFAILGIIFGIIGVNFNKWILKGTSKVKKFHQNKLSRIVLMGAAFGATFS
CCCCHHHHHHHHHHHHHHHHHHCCCCCHHEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLHLVAPELSGSGMAIITEMFHSPMAWILMVGFFVLRVIVTVACFSSGAPGGIFAPMLAL
HHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
GTLLGLSYGMVMSAWFPGWIAEPGVYAIAGMGALFAATVRAPVTGVILVVEMTNNYQLIL
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCEEHH
PLLVTTLGATFIAQALGGQPLYSALLKQSLVKDKELRADHQAPLKDVT
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA