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The map label for this gene is clpA [H]

Identifier: 59712372

GI number: 59712372

Start: 1990810

End: 1993062

Strand: Reverse

Name: clpA [H]

Synonym: VF_1765

Alternate gene names: 59712372

Gene position: 1993062-1990810 (Counterclockwise)

Preceding gene: 59712373

Following gene: 59712368

Centisome position: 68.78

GC content: 39.72

Gene sequence:

>2253_bases
ATGCTAAACAAAGAATTAGAAGCGAGTTTGAACACAGCGTTTGCTCGTGCGCGAGAAAAGCGTCATGAATTCATGACAGT
AGAGCACTTGCTATTCGCTCTGCTGGAGAACCCATCAGCTCACGAAGCGCTTATTGCTTGTCATACTGATTTAGATGCCT
TGGCAACTGAAATCGACGAATTTATTACACAGACAACCCCATTAATTCCTCTGGACGATGAAAGTCGTGAAACTCAGCCT
ACGCTTAGCTTTCAGCGTGTATTACAACGAGCCGTTTTTCATGTTCAATCATCTGGTCGAAGTGAAGTTACTGGTGCCAA
CGTATTGGTTGCTATTTTTAGCGAGCAAGAATCACACGCAGCATATCTCCTTAAAAAGAATGATATTAGCCGTCTAGATA
TTGTTAATTACATCTCTCATGGTGCACCAGAAAATCGAGATGAGAATAGCGAACCAAATAATGTTGAAGCGGCGGTTGAG
GCTAATGCTGAAGATAAGTTAGAGAGTTTTGCTACTAACTTAAACCAAGTTGCTAAAAATGGTGGAATTGATCCGCTTAT
TGGACGTGATCAAGAGCTTGAGCGAACCATTCAAGTATTATGTCGTCGTCGCAAAAATAACCCTCTATTAGTGGGTGAAG
CTGGTGTTGGTAAAACGGCGATTGCAGAAGGCCTTGCTTGGCGTATTGTTGAAGAACAAGTACCTGATGTAATTAAAGAT
TGTGTTATTTATTCACTAGATATTGGTTCATTACTTGCTGGCACTAAATACCGTGGTGATTTTGAAAAACGTTTTAAAGC
GATTTTAAAACAGCTTGAAAAAGAAGAACATGCGGTTTTATTTATTGATGAAATTCACACGATTATAGGAGCGGGTGCCG
CTTCTGGTGGTCAAGTTGATGCAGCTAACTTAATCAAACCGTTATTAAGTAGTGGTAAATTACGCTGTATTGGTTCTACT
ACTTATCAAGAGCACAGTACTATTTTTGAAAAAGAGCGTGCATTAGCTCGTCGTTTCCAAAAGATTGATATTTTAGAACC
ATCTTTAGACGATACGACAAAAATTCTGATCGGTTTGAAAAGTAAGTATGAAGAACATCATGAAGTGCGTTATACCAATA
AAGCGCTTCGTGCTGCGGTAGAGCTATCTGCTAAATACATTAATGAACGTCATCTTCCAGATAAAGCGATTGACGTAATT
GATGAAGCCGGTGCTCGTTGCCGCCTAACACCTGCGAGTCGCCGTAAAAAGACCATCAATGTTGCTGATATTGAGTCTAT
GGTCGCTAAAATGGCTCGAATTCCAGAAAAATCTGTATCTTCAAGTGATAAAGATGTTCTGAAAAAACTCGATGACAAAT
TGAAAATGCTGGTATTTGGGCAAGATCAGGGTATCGATGCACTATGTGAAGCAATTAAATTAAGTCGTGCTGGTCTTGGT
GCAGAGAATAAACCAGTTGGTTCATTCTTATTTGCTGGGCCGACAGGGGTTGGTAAAACAGAAGTTACTGTTCAATTAGC
AAAAGCATTAGGTATTGAATTACTGCGCTTTGATATGTCTGAATATGGTGAGCAGCATACCGTTAGTCGCTTAATTGGTG
CGCCTCCGGGTTATGTTGGTTACGAGCAAGGTGGTTTATTAACTGATGCGGTAATTAAGCACCCACATTCGGTTGTTCTT
CTTGATGAACTTGAAAAAGCACATCCAGATATCTTTAACCTACTGTTACAAGTAATGGATAATGGTACGTTGACAGATAA
CAATGGACGTAAAGCGGATTTCCGTAACGTAATTTTTGTTATGACGACCAATGCAGGTGTTCAAGAGACGGTTAAAAAAT
CGATTGGTTTGATCCAACAAGATCACTCTACTGATGCAATGGCGGCAATTAAGAAAGTATTTACGCCAGAATTTAGAAAC
CGTTTGGATAATATCATTTGGTTTGAGCATCTAAGTAAAGATGTGATTTCACTTGTTGTTGAGAAATTCATTGCAGAGCT
ACAAGCACAGTTAGATGCTCGTGGTGTATCAATGGAAGTATCCAAAGAAGCTAAAGCATGGCTTGCTGAAAAAGGCTATG
ACAAAGCGATGGGTGCACGCCCAATGGCTCGAGTTATTCAAGAAAACCTTAAAAAGCCAATGGCAAATGAATTACTGTTT
GGTGATTTAGTTGATGGTGGCACAGTACGAGTGAAACTTAAGAAAGATGAGCTTGTATTTGAATTCACGAGTGAAACTGA
AGCGGTTCATTAA

Upstream 100 bases:

>100_bases
GAATACTTACTCGCGTGATAATGAGCACCCACTGCTGTGTACAATGGAGCAAGCGTAAGTTTGTTCGTTACACCATAAAT
TGGTGTTTTGGGAGGTTCCT

Downstream 100 bases:

>100_bases
TAAACCAATTCTATTGCTGTCAGCTAGTTTGTTTTGAAAGCTAATAAAAAACCCAGTCATTGACTGGGTTTTTGTTATTG
TTTTTTTATTAGTTTAAAGC

Product: ATP-dependent Clp protease ATP-binding subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 750; Mature: 750

Protein sequence:

>750_residues
MLNKELEASLNTAFARAREKRHEFMTVEHLLFALLENPSAHEALIACHTDLDALATEIDEFITQTTPLIPLDDESRETQP
TLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHAAYLLKKNDISRLDIVNYISHGAPENRDENSEPNNVEAAVE
ANAEDKLESFATNLNQVAKNGGIDPLIGRDQELERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEEQVPDVIKD
CVIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEHAVLFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKLRCIGST
TYQEHSTIFEKERALARRFQKIDILEPSLDDTTKILIGLKSKYEEHHEVRYTNKALRAAVELSAKYINERHLPDKAIDVI
DEAGARCRLTPASRRKKTINVADIESMVAKMARIPEKSVSSSDKDVLKKLDDKLKMLVFGQDQGIDALCEAIKLSRAGLG
AENKPVGSFLFAGPTGVGKTEVTVQLAKALGIELLRFDMSEYGEQHTVSRLIGAPPGYVGYEQGGLLTDAVIKHPHSVVL
LDELEKAHPDIFNLLLQVMDNGTLTDNNGRKADFRNVIFVMTTNAGVQETVKKSIGLIQQDHSTDAMAAIKKVFTPEFRN
RLDNIIWFEHLSKDVISLVVEKFIAELQAQLDARGVSMEVSKEAKAWLAEKGYDKAMGARPMARVIQENLKKPMANELLF
GDLVDGGTVRVKLKKDELVFEFTSETEAVH

Sequences:

>Translated_750_residues
MLNKELEASLNTAFARAREKRHEFMTVEHLLFALLENPSAHEALIACHTDLDALATEIDEFITQTTPLIPLDDESRETQP
TLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHAAYLLKKNDISRLDIVNYISHGAPENRDENSEPNNVEAAVE
ANAEDKLESFATNLNQVAKNGGIDPLIGRDQELERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEEQVPDVIKD
CVIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEHAVLFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKLRCIGST
TYQEHSTIFEKERALARRFQKIDILEPSLDDTTKILIGLKSKYEEHHEVRYTNKALRAAVELSAKYINERHLPDKAIDVI
DEAGARCRLTPASRRKKTINVADIESMVAKMARIPEKSVSSSDKDVLKKLDDKLKMLVFGQDQGIDALCEAIKLSRAGLG
AENKPVGSFLFAGPTGVGKTEVTVQLAKALGIELLRFDMSEYGEQHTVSRLIGAPPGYVGYEQGGLLTDAVIKHPHSVVL
LDELEKAHPDIFNLLLQVMDNGTLTDNNGRKADFRNVIFVMTTNAGVQETVKKSIGLIQQDHSTDAMAAIKKVFTPEFRN
RLDNIIWFEHLSKDVISLVVEKFIAELQAQLDARGVSMEVSKEAKAWLAEKGYDKAMGARPMARVIQENLKKPMANELLF
GDLVDGGTVRVKLKKDELVFEFTSETEAVH
>Mature_750_residues
MLNKELEASLNTAFARAREKRHEFMTVEHLLFALLENPSAHEALIACHTDLDALATEIDEFITQTTPLIPLDDESRETQP
TLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHAAYLLKKNDISRLDIVNYISHGAPENRDENSEPNNVEAAVE
ANAEDKLESFATNLNQVAKNGGIDPLIGRDQELERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEEQVPDVIKD
CVIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEHAVLFIDEIHTIIGAGAASGGQVDAANLIKPLLSSGKLRCIGST
TYQEHSTIFEKERALARRFQKIDILEPSLDDTTKILIGLKSKYEEHHEVRYTNKALRAAVELSAKYINERHLPDKAIDVI
DEAGARCRLTPASRRKKTINVADIESMVAKMARIPEKSVSSSDKDVLKKLDDKLKMLVFGQDQGIDALCEAIKLSRAGLG
AENKPVGSFLFAGPTGVGKTEVTVQLAKALGIELLRFDMSEYGEQHTVSRLIGAPPGYVGYEQGGLLTDAVIKHPHSVVL
LDELEKAHPDIFNLLLQVMDNGTLTDNNGRKADFRNVIFVMTTNAGVQETVKKSIGLIQQDHSTDAMAAIKKVFTPEFRN
RLDNIIWFEHLSKDVISLVVEKFIAELQAQLDARGVSMEVSKEAKAWLAEKGYDKAMGARPMARVIQENLKKPMANELLF
GDLVDGGTVRVKLKKDELVFEFTSETEAVH

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=322, Percent_Identity=31.055900621118, Blast_Score=146, Evalue=7e-35,
Organism=Escherichia coli, GI1787109, Length=761, Percent_Identity=76.7411300919842, Blast_Score=1207, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=328, Percent_Identity=42.6829268292683, Blast_Score=291, Evalue=8e-80,
Organism=Saccharomyces cerevisiae, GI6320464, Length=329, Percent_Identity=47.4164133738602, Blast_Score=297, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6323002, Length=326, Percent_Identity=41.1042944785276, Blast_Score=242, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83097; Mature: 83097

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKELEASLNTAFARAREKRHEFMTVEHLLFALLENPSAHEALIACHTDLDALATEIDE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCHHHHHHHHHH
FITQTTPLIPLDDESRETQPTLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHA
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCC
AYLLKKNDISRLDIVNYISHGAPENRDENSEPNNVEAAVEANAEDKLESFATNLNQVAKN
EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHC
GGIDPLIGRDQELERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEEQVPDVIKD
CCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
CVIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEHAVLFIDEIHTIIGAGAASGGQVD
HHEEECCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCC
AANLIKPLLSSGKLRCIGSTTYQEHSTIFEKERALARRFQKIDILEPSLDDTTKILIGLK
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
SKYEEHHEVRYTNKALRAAVELSAKYINERHLPDKAIDVIDEAGARCRLTPASRRKKTIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCHHHCCCCCC
VADIESMVAKMARIPEKSVSSSDKDVLKKLDDKLKMLVFGQDQGIDALCEAIKLSRAGLG
HHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCCCC
AENKPVGSFLFAGPTGVGKTEVTVQLAKALGIELLRFDMSEYGEQHTVSRLIGAPPGYVG
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCC
YEQGGLLTDAVIKHPHSVVLLDELEKAHPDIFNLLLQVMDNGTLTDNNGRKADFRNVIFV
CCCCCCHHHHHHHCCCCEEEHHHHHHHCHHHHHHHHHHHCCCCEECCCCCCCCCCCEEEE
MTTNAGVQETVKKSIGLIQQDHSTDAMAAIKKVFTPEFRNRLDNIIWFEHLSKDVISLVV
EECCCCHHHHHHHHHCCHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
EKFIAELQAQLDARGVSMEVSKEAKAWLAEKGYDKAMGARPMARVIQENLKKPMANELLF
HHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCHHHHHHH
GDLVDGGTVRVKLKKDELVFEFTSETEAVH
HCCCCCCEEEEEEECCCEEEEECCCCCCCC
>Mature Secondary Structure
MLNKELEASLNTAFARAREKRHEFMTVEHLLFALLENPSAHEALIACHTDLDALATEIDE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHEEECCCHHHHHHHHHH
FITQTTPLIPLDDESRETQPTLSFQRVLQRAVFHVQSSGRSEVTGANVLVAIFSEQESHA
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCC
AYLLKKNDISRLDIVNYISHGAPENRDENSEPNNVEAAVEANAEDKLESFATNLNQVAKN
EEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHC
GGIDPLIGRDQELERTIQVLCRRRKNNPLLVGEAGVGKTAIAEGLAWRIVEEQVPDVIKD
CCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
CVIYSLDIGSLLAGTKYRGDFEKRFKAILKQLEKEEHAVLFIDEIHTIIGAGAASGGQVD
HHEEECCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCCC
AANLIKPLLSSGKLRCIGSTTYQEHSTIFEKERALARRFQKIDILEPSLDDTTKILIGLK
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
SKYEEHHEVRYTNKALRAAVELSAKYINERHLPDKAIDVIDEAGARCRLTPASRRKKTIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEECCHHHCCCCCC
VADIESMVAKMARIPEKSVSSSDKDVLKKLDDKLKMLVFGQDQGIDALCEAIKLSRAGLG
HHHHHHHHHHHHHCCCHHCCCCHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHCCCC
AENKPVGSFLFAGPTGVGKTEVTVQLAKALGIELLRFDMSEYGEQHTVSRLIGAPPGYVG
CCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCC
YEQGGLLTDAVIKHPHSVVLLDELEKAHPDIFNLLLQVMDNGTLTDNNGRKADFRNVIFV
CCCCCCHHHHHHHCCCCEEEHHHHHHHCHHHHHHHHHHHCCCCEECCCCCCCCCCCEEEE
MTTNAGVQETVKKSIGLIQQDHSTDAMAAIKKVFTPEFRNRLDNIIWFEHLSKDVISLVV
EECCCCHHHHHHHHHCCHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
EKFIAELQAQLDARGVSMEVSKEAKAWLAEKGYDKAMGARPMARVIQENLKKPMANELLF
HHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCHHHHHHH
GDLVDGGTVRVKLKKDELVFEFTSETEAVH
HCCCCCCEEEEEEECCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]