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The map label for this gene is aroA [H]

Identifier: 59712368

GI number: 59712368

Start: 1987504

End: 1988784

Strand: Reverse

Name: aroA [H]

Synonym: VF_1761

Alternate gene names: 59712368

Gene position: 1988784-1987504 (Counterclockwise)

Preceding gene: 59712372

Following gene: 59712367

Centisome position: 68.64

GC content: 39.5

Gene sequence:

>1281_bases
ATGGAAAGCTTAACTCTTCAACCTATCTCAAAAATTAATGGGCAAATCAATTTGCCTGGTTCAAAAAGTGTATCTAACCG
AGCGCTACTTTTAGCTGCATTAGCTTCAGGAACTACAAAATTAACGAATCTACTAGATAGCGATGATATTCGTCATATGT
TGAATGCACTTAAAGCATTGGGCGTTGAATATAAATTATCAGCAAATAAAACAGAATGTGAAGTAACAGGATTAGGACGA
GCGTTTGAACCTAATGAAGCATTAGAGCTTTTTTTAGGTAATGCTGGAACGGCGATGCGCCCATTGGCTGCGGCACTATG
TTTAGGCCAAGGTGAGTTTGTTCTAACAGGCGAACCTCGCATGAAAGAGCGTCCAATCGGTCACCTTGTAACCGCTCTTA
AAGCTGCTGGAGCAGATGTAGAATATTTAGAAAATGAAAATTATCCACCGCTGAAAATTAAAGGTACTGGCCTACATGGT
GGAACAGTGGAAATTGATGGCTCGATCTCTAGCCAATTTCTTACTGCATTTTTAATGGCAGCGCCATTATCTACACAAGA
AACAACGATTAAGATTGTTGGTGATTTAGTATCAAAACCATACATTGATATCACATTAGATATTATGGCAACATTTGGTG
TAAAAATTGAGAATCAGAACTATCAAACGTTTGTCGTTCCTGCGAATCAAACTTATGTAGCTCCTGGGGATTTTCTTGTA
GAAGGTGATGCTTCATCGGCATCATATTTTCTTGCTGCCGCTGCAATTAAGGGCGGAGAAGTAAAAGTAACGGGTATTGG
TAAAAAGAGTATTCAAGGCGATGTTCAATTTGCAGATGCATTAGCTGCAATGGGGACTGAAATTGAATGGGGCGATGATT
ATGTTATCGCTCGTAAAGGTGAACTTAATGCCATTGATATGGATTTCAACCATATTCCTGATGCTGCAATGACAATAGCA
ACCGCTGCATTATTTGCAAAAGGAACGACCTCGATTCGTAACGTATACAATTGGCGTGTAAAAGAAACTGATCGTTTGGC
TGCGATGGCAACCGAGTTAAGAAAAGTGGGTGCAGTAGTGGAGGAAGGGGAAGATTATATTACAATTACACCGCCTGCTT
CATTACAGCATGCATCGATTGACACTTATGATGACCACCGCATGGCGATGTGTTTTTCTTTAGTTGCATTGAGTGATACT
CCTGTAACGATTAATGATCCAGGTTGTACATCGAAAACATTCCCTGATTATTTTGATAAATTAAAAGAATTAAGCTGCTA
A

Upstream 100 bases:

>100_bases
AGTATTGAAGAATAACAAAAAATAACAATTAAAGCTGAAGCAGTCATGAAATATTGATCATGACATTATTATTTATTTGT
ACAGGAATTTTTACGCAAAC

Downstream 100 bases:

>100_bases
TTTATTGTATTTTAAATTATTACCTTACTATGCAATGAAAGCTCTGTATCAAAATTCAGAGCTTTTTTAGTTTTTCATAA
TCAAGAGTATATAAATAATC

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MESLTLQPISKINGQINLPGSKSVSNRALLLAALASGTTKLTNLLDSDDIRHMLNALKALGVEYKLSANKTECEVTGLGR
AFEPNEALELFLGNAGTAMRPLAAALCLGQGEFVLTGEPRMKERPIGHLVTALKAAGADVEYLENENYPPLKIKGTGLHG
GTVEIDGSISSQFLTAFLMAAPLSTQETTIKIVGDLVSKPYIDITLDIMATFGVKIENQNYQTFVVPANQTYVAPGDFLV
EGDASSASYFLAAAAIKGGEVKVTGIGKKSIQGDVQFADALAAMGTEIEWGDDYVIARKGELNAIDMDFNHIPDAAMTIA
TAALFAKGTTSIRNVYNWRVKETDRLAAMATELRKVGAVVEEGEDYITITPPASLQHASIDTYDDHRMAMCFSLVALSDT
PVTINDPGCTSKTFPDYFDKLKELSC

Sequences:

>Translated_426_residues
MESLTLQPISKINGQINLPGSKSVSNRALLLAALASGTTKLTNLLDSDDIRHMLNALKALGVEYKLSANKTECEVTGLGR
AFEPNEALELFLGNAGTAMRPLAAALCLGQGEFVLTGEPRMKERPIGHLVTALKAAGADVEYLENENYPPLKIKGTGLHG
GTVEIDGSISSQFLTAFLMAAPLSTQETTIKIVGDLVSKPYIDITLDIMATFGVKIENQNYQTFVVPANQTYVAPGDFLV
EGDASSASYFLAAAAIKGGEVKVTGIGKKSIQGDVQFADALAAMGTEIEWGDDYVIARKGELNAIDMDFNHIPDAAMTIA
TAALFAKGTTSIRNVYNWRVKETDRLAAMATELRKVGAVVEEGEDYITITPPASLQHASIDTYDDHRMAMCFSLVALSDT
PVTINDPGCTSKTFPDYFDKLKELSC
>Mature_426_residues
MESLTLQPISKINGQINLPGSKSVSNRALLLAALASGTTKLTNLLDSDDIRHMLNALKALGVEYKLSANKTECEVTGLGR
AFEPNEALELFLGNAGTAMRPLAAALCLGQGEFVLTGEPRMKERPIGHLVTALKAAGADVEYLENENYPPLKIKGTGLHG
GTVEIDGSISSQFLTAFLMAAPLSTQETTIKIVGDLVSKPYIDITLDIMATFGVKIENQNYQTFVVPANQTYVAPGDFLV
EGDASSASYFLAAAAIKGGEVKVTGIGKKSIQGDVQFADALAAMGTEIEWGDDYVIARKGELNAIDMDFNHIPDAAMTIA
TAALFAKGTTSIRNVYNWRVKETDRLAAMATELRKVGAVVEEGEDYITITPPASLQHASIDTYDDHRMAMCFSLVALSDT
PVTINDPGCTSKTFPDYFDKLKELSC

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=425, Percent_Identity=74.1176470588235, Blast_Score=641, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320332, Length=445, Percent_Identity=38.2022471910112, Blast_Score=249, Evalue=6e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 45644; Mature: 45644

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00104 EPSP_SYNTHASE_1 ; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESLTLQPISKINGQINLPGSKSVSNRALLLAALASGTTKLTNLLDSDDIRHMLNALKAL
CCCCCCCCHHHCCCEEECCCCCCCCCCEEEEEEHHCCHHHHHHHHCCHHHHHHHHHHHHC
GVEYKLSANKTECEVTGLGRAFEPNEALELFLGNAGTAMRPLAAALCLGQGEFVLTGEPR
CCEEEECCCCCEEEEEECCCCCCCCHHEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCC
MKERPIGHLVTALKAAGADVEYLENENYPPLKIKGTGLHGGTVEIDGSISSQFLTAFLMA
CCCCCHHHHHHHHHHCCCCHHHHCCCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHH
APLSTQETTIKIVGDLVSKPYIDITLDIMATFGVKIENQNYQTFVVPANQTYVAPGDFLV
CCCCCCCHHHEEEHHHHCCCEEEEEEEEEEEECEEEECCCEEEEEEECCCEEECCCCEEE
EGDASSASYFLAAAAIKGGEVKVTGIGKKSIQGDVQFADALAAMGTEIEWGDDYVIARKG
ECCCCCCEEEEEEEEECCCEEEEEECCCHHCCCCHHHHHHHHHHCCCEECCCCEEEEECC
ELNAIDMDFNHIPDAAMTIATAALFAKGTTSIRNVYNWRVKETDRLAAMATELRKVGAVV
CCEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHEEEEECCHHHHHHHHHHHHHHHHHH
EEGEDYITITPPASLQHASIDTYDDHRMAMCFSLVALSDTPVTINDPGCTSKTFPDYFDK
HCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCEEECCCCCCCCCCHHHHHH
LKELSC
HHHCCC
>Mature Secondary Structure
MESLTLQPISKINGQINLPGSKSVSNRALLLAALASGTTKLTNLLDSDDIRHMLNALKAL
CCCCCCCCHHHCCCEEECCCCCCCCCCEEEEEEHHCCHHHHHHHHCCHHHHHHHHHHHHC
GVEYKLSANKTECEVTGLGRAFEPNEALELFLGNAGTAMRPLAAALCLGQGEFVLTGEPR
CCEEEECCCCCEEEEEECCCCCCCCHHEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCC
MKERPIGHLVTALKAAGADVEYLENENYPPLKIKGTGLHGGTVEIDGSISSQFLTAFLMA
CCCCCHHHHHHHHHHCCCCHHHHCCCCCCCEEEEECCCCCCEEEECCCHHHHHHHHHHHH
APLSTQETTIKIVGDLVSKPYIDITLDIMATFGVKIENQNYQTFVVPANQTYVAPGDFLV
CCCCCCCHHHEEEHHHHCCCEEEEEEEEEEEECEEEECCCEEEEEEECCCEEECCCCEEE
EGDASSASYFLAAAAIKGGEVKVTGIGKKSIQGDVQFADALAAMGTEIEWGDDYVIARKG
ECCCCCCEEEEEEEEECCCEEEEEECCCHHCCCCHHHHHHHHHHCCCEECCCCEEEEECC
ELNAIDMDFNHIPDAAMTIATAALFAKGTTSIRNVYNWRVKETDRLAAMATELRKVGAVV
CCEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHEEEEECCHHHHHHHHHHHHHHHHHH
EEGEDYITITPPASLQHASIDTYDDHRMAMCFSLVALSDTPVTINDPGCTSKTFPDYFDK
HCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCEEECCCCCCCCCCHHHHHH
LKELSC
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA