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The map label for this gene is fabH

Identifier: 59712349

GI number: 59712349

Start: 1965323

End: 1966276

Strand: Reverse

Name: fabH

Synonym: VF_1742

Alternate gene names: 59712349

Gene position: 1966276-1965323 (Counterclockwise)

Preceding gene: 59712350

Following gene: 59712348

Centisome position: 67.86

GC content: 40.04

Gene sequence:

>954_bases
ATGTATAGCAAAATTTTAGGTACTGGTAGCTATTTACCAGCACAAATTCGCTCAAATGCGGATTTAGAAAAAATGGTCGA
TACTAGTGATGAGTGGATCTTAGCTCGAACTGGTATTAGTGAACGTCGCATTGCTGGTGAAGATGAATCGGTAGCTACAA
TGGCTCACCTTGCTTCTGTAAATGCAATTGAAATGGCTGGTATTGATAAGAACGATATTGATCTTATTATTTTGGCAACA
AGTACGCCTACGTACTCATTTCCATCTGCAGCGTGTGAAGTTCAAGGTTTATTAGGTATTCAAGGCTGTCCTGCATTTGA
TTTATCAGCAGCATGTTCAGGTTTTGTTTATGCATTAAGCGTTGCAGACCAACACATTAAAACTGGCATGGCAAAGAACG
TGCTTGTTATTGGTTCTGATGCTGTTTCTCATACTTGTGATCCAGAAGACCGCTCAACTATCATTTTATTTGGTGATGGT
GCAGGCGCTGTTGTCTTAGGGCAAAGTGAAGAACCTGGCATTATCTCAACACATTTACATGCTGATGGTAAGTTTGGTGA
ATTACTTTCATTACCTGTTCCTTCTCGTAAGAATGAAGAAGCAGACAAGTGGCTATATATGGCTGGTAATGAAGTATTTA
AAGTAGCAGTAACTCAACTTTCTAACTTGGTAAAAGAAACACTTCAAGAAAATCAGATGGATAAATCTGAACTTGATTGG
TTGGTTCCTCATCAAGCTAACTTACGAATTATTAAAGCGACAGCAAAGAAACTATCAATGTCGATGGATCAAGTTGTTGT
AACTCTAGACCGCCACGGTAACACTTCAGCTGCGACTGTTCCTACAGCGTTAGATGAAGCGGTACGTGATGGCCGAATTC
AACGAGGTCAAACTTTACTACTTGAAGCATTTGGTGGTGGGTTTACTTGGGGCTCGGCTCTGGTTAAGTTTTAA

Upstream 100 bases:

>100_bases
ATGCCATCAAGGAAGCGGTTCATGAGGTCAAGCGACAAATACCTAACCGTATTAGTGATCGCTTGGAGGCAGTTTTACTC
GAGAGGCATTATTAGTCTTC

Downstream 100 bases:

>100_bases
ATTTAGAGGTTAATCCTATGTGTGGTTAACCCTCTTAAATAAGCTTATTTAAAGGAAATAATATTCATGAGCAATTTTGC
TATCGTTTTTCCCAGGCCAA

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MYSKILGTGSYLPAQIRSNADLEKMVDTSDEWILARTGISERRIAGEDESVATMAHLASVNAIEMAGIDKNDIDLIILAT
STPTYSFPSAACEVQGLLGIQGCPAFDLSAACSGFVYALSVADQHIKTGMAKNVLVIGSDAVSHTCDPEDRSTIILFGDG
AGAVVLGQSEEPGIISTHLHADGKFGELLSLPVPSRKNEEADKWLYMAGNEVFKVAVTQLSNLVKETLQENQMDKSELDW
LVPHQANLRIIKATAKKLSMSMDQVVVTLDRHGNTSAATVPTALDEAVRDGRIQRGQTLLLEAFGGGFTWGSALVKF

Sequences:

>Translated_317_residues
MYSKILGTGSYLPAQIRSNADLEKMVDTSDEWILARTGISERRIAGEDESVATMAHLASVNAIEMAGIDKNDIDLIILAT
STPTYSFPSAACEVQGLLGIQGCPAFDLSAACSGFVYALSVADQHIKTGMAKNVLVIGSDAVSHTCDPEDRSTIILFGDG
AGAVVLGQSEEPGIISTHLHADGKFGELLSLPVPSRKNEEADKWLYMAGNEVFKVAVTQLSNLVKETLQENQMDKSELDW
LVPHQANLRIIKATAKKLSMSMDQVVVTLDRHGNTSAATVPTALDEAVRDGRIQRGQTLLLEAFGGGFTWGSALVKF
>Mature_317_residues
MYSKILGTGSYLPAQIRSNADLEKMVDTSDEWILARTGISERRIAGEDESVATMAHLASVNAIEMAGIDKNDIDLIILAT
STPTYSFPSAACEVQGLLGIQGCPAFDLSAACSGFVYALSVADQHIKTGMAKNVLVIGSDAVSHTCDPEDRSTIILFGDG
AGAVVLGQSEEPGIISTHLHADGKFGELLSLPVPSRKNEEADKWLYMAGNEVFKVAVTQLSNLVKETLQENQMDKSELDW
LVPHQANLRIIKATAKKLSMSMDQVVVTLDRHGNTSAATVPTALDEAVRDGRIQRGQTLLLEAFGGGFTWGSALVKF

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=317, Percent_Identity=70.9779179810726, Blast_Score=481, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_VIBF1 (Q5E409)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_205125.1
- HSSP:   P0A6R0
- ProteinModelPortal:   Q5E409
- SMR:   Q5E409
- STRING:   Q5E409
- GeneID:   3278984
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_1742
- NMPDR:   fig|312309.3.peg.1742
- eggNOG:   COG0332
- HOGENOM:   HBG649927
- OMA:   YLPAQVR
- PhylomeDB:   Q5E409
- ProtClustDB:   PRK09352
- BioCyc:   VFIS312309:VF1742-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.41

Molecular weight: Translated: 33968; Mature: 33968

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: ACT_SITE 112-112 ACT_SITE 244-244 ACT_SITE 274-274

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSKILGTGSYLPAQIRSNADLEKMVDTSDEWILARTGISERRIAGEDESVATMAHLASV
CCCCEECCCCCCCHHHCCCCCHHHHHCCCCCEEEEECCCCHHHCCCCCCHHHHHHHHHCC
NAIEMAGIDKNDIDLIILATSTPTYSFPSAACEVQGLLGIQGCPAFDLSAACSGFVYALS
CEEEECCCCCCCCEEEEEEECCCCCCCCCHHHHCCCCEECCCCCCCCHHHHHCCCEEEEH
VADQHIKTGMAKNVLVIGSDAVSHTCDPEDRSTIILFGDGAGAVVLGQSEEPGIISTHLH
HHHHHHHCCCCCCEEEEECCHHCCCCCCCCCCEEEEEECCCCEEEECCCCCCCEEEEEEE
ADGKFGELLSLPVPSRKNEEADKWLYMAGNEVFKVAVTQLSNLVKETLQENQMDKSELDW
CCCCCCCEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCE
LVPHQANLRIIKATAKKLSMSMDQVVVTLDRHGNTSAATVPTALDEAVRDGRIQRGQTLL
ECCCCCCEEEEEEHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEE
LEAFGGGFTWGSALVKF
EEECCCCCCHHHHHHCC
>Mature Secondary Structure
MYSKILGTGSYLPAQIRSNADLEKMVDTSDEWILARTGISERRIAGEDESVATMAHLASV
CCCCEECCCCCCCHHHCCCCCHHHHHCCCCCEEEEECCCCHHHCCCCCCHHHHHHHHHCC
NAIEMAGIDKNDIDLIILATSTPTYSFPSAACEVQGLLGIQGCPAFDLSAACSGFVYALS
CEEEECCCCCCCCEEEEEEECCCCCCCCCHHHHCCCCEECCCCCCCCHHHHHCCCEEEEH
VADQHIKTGMAKNVLVIGSDAVSHTCDPEDRSTIILFGDGAGAVVLGQSEEPGIISTHLH
HHHHHHHCCCCCCEEEEECCHHCCCCCCCCCCEEEEEECCCCEEEECCCCCCCEEEEEEE
ADGKFGELLSLPVPSRKNEEADKWLYMAGNEVFKVAVTQLSNLVKETLQENQMDKSELDW
CCCCCCCEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCE
LVPHQANLRIIKATAKKLSMSMDQVVVTLDRHGNTSAATVPTALDEAVRDGRIQRGQTLL
ECCCCCCEEEEEEHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEE
LEAFGGGFTWGSALVKF
EEECCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA