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The map label for this gene is fabD [H]

Identifier: 59712348

GI number: 59712348

Start: 1964332

End: 1965246

Strand: Reverse

Name: fabD [H]

Synonym: VF_1741

Alternate gene names: 59712348

Gene position: 1965246-1964332 (Counterclockwise)

Preceding gene: 59712349

Following gene: 59712347

Centisome position: 67.82

GC content: 41.42

Gene sequence:

>915_bases
TTGCTATCGTTTTTCCCAGGCCAAGGCTCTCAAGCTGTTGGCATGCTTGCTGAATTAGGTGAGCAACACGAAGTGGTAAC
TCAAACATTTGCAGAAGCATCTGACGCATTAGGTTATGACTTATGGTCTTTAGTTCAAAATGGACCAGCAGAAGATTTAA
ATCAAACTTTCCGTACGCAGCCTGCATTGTTAGCAACGTCTGTTGCATTATGGCGTGTATGGCAAGAACAAGGTTTGGCT
CAACCATCAGTATTAGCTGGTCATAGCCTTGGTGAATATTCAGCGCTTGTTTGTGCGGGTGTCATTGACTTTAAAGAAGC
AATTAAATTAGTAGAATTGCGTGGCCAATTAATGCAAGAAGCGGTTCCTGCAGGTGTTGGTGCAATGTATGCAATTATTG
GTTTAGATAATGAATCAATTGCTAAAGCATGTGAAGAAGCGGCACAAGGTGAAGTAGTTTCACCTGTAAACTTTAACTCT
CCAGGCCAAGTGGTTATCGCTGGTAACAAAGATGCAGTTGAACGTGCAGGCGTATTATGTAAAGAAGCGGGTGCAAAACG
TGCTCTTCCTTTACCTGTATCAGTACCTTCACACTGTGCACTAATGAAACCAGCAGCAGATAAATTGGCTGTTGCATTAG
AAAATATCGAATTCAACACACCAACATTACCAGTAATTAATAATGTTGATGTTATTGCAGAAACTGATCCTGCAAAAATT
AAAGATGCACTAGTTCGTCAATTATACGGCCCAGTTCGTTGGACTGAAGTTGTTGAAAAAATGGCAGAACAAGGCGTTGA
AACGTTATACGAAGTTGGTCCAGGTAAAGTATTAACTGGTCTAACGAAACGCATCGTTAAGTCACTTAGCGCAGCAGCGG
TAAATGATGCTGCTTCACTTGAAGCTGCTAAGTAA

Upstream 100 bases:

>100_bases
GGCTCGGCTCTGGTTAAGTTTTAAATTTAGAGGTTAATCCTATGTGTGGTTAACCCTCTTAAATAAGCTTATTTAAAGGA
AATAATATTCATGAGCAATT

Downstream 100 bases:

>100_bases
TTAAAGGGAAAATAAAATGATGAATCTAGAGGGCAAAATTGCCTTAGTTACTGGTGCAAGCCGTGGTATCGGTCGTTCAA
TCGCTGAACTACTTGTATCT

Product: malonyl-CoA:(acyl carrier protein) S-malonyltransferase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MLSFFPGQGSQAVGMLAELGEQHEVVTQTFAEASDALGYDLWSLVQNGPAEDLNQTFRTQPALLATSVALWRVWQEQGLA
QPSVLAGHSLGEYSALVCAGVIDFKEAIKLVELRGQLMQEAVPAGVGAMYAIIGLDNESIAKACEEAAQGEVVSPVNFNS
PGQVVIAGNKDAVERAGVLCKEAGAKRALPLPVSVPSHCALMKPAADKLAVALENIEFNTPTLPVINNVDVIAETDPAKI
KDALVRQLYGPVRWTEVVEKMAEQGVETLYEVGPGKVLTGLTKRIVKSLSAAAVNDAASLEAAK

Sequences:

>Translated_304_residues
MLSFFPGQGSQAVGMLAELGEQHEVVTQTFAEASDALGYDLWSLVQNGPAEDLNQTFRTQPALLATSVALWRVWQEQGLA
QPSVLAGHSLGEYSALVCAGVIDFKEAIKLVELRGQLMQEAVPAGVGAMYAIIGLDNESIAKACEEAAQGEVVSPVNFNS
PGQVVIAGNKDAVERAGVLCKEAGAKRALPLPVSVPSHCALMKPAADKLAVALENIEFNTPTLPVINNVDVIAETDPAKI
KDALVRQLYGPVRWTEVVEKMAEQGVETLYEVGPGKVLTGLTKRIVKSLSAAAVNDAASLEAAK
>Mature_304_residues
MLSFFPGQGSQAVGMLAELGEQHEVVTQTFAEASDALGYDLWSLVQNGPAEDLNQTFRTQPALLATSVALWRVWQEQGLA
QPSVLAGHSLGEYSALVCAGVIDFKEAIKLVELRGQLMQEAVPAGVGAMYAIIGLDNESIAKACEEAAQGEVVSPVNFNS
PGQVVIAGNKDAVERAGVLCKEAGAKRALPLPVSVPSHCALMKPAADKLAVALENIEFNTPTLPVINNVDVIAETDPAKI
KDALVRQLYGPVRWTEVVEKMAEQGVETLYEVGPGKVLTGLTKRIVKSLSAAAVNDAASLEAAK

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=298, Percent_Identity=33.8926174496644, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI27477045, Length=109, Percent_Identity=42.2018348623853, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1787334, Length=299, Percent_Identity=73.2441471571906, Blast_Score=427, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI71984332, Length=294, Percent_Identity=29.5918367346939, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=291, Percent_Identity=29.553264604811, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24665753, Length=307, Percent_Identity=32.2475570032573, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 32085; Mature: 32085

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSFFPGQGSQAVGMLAELGEQHEVVTQTFAEASDALGYDLWSLVQNGPAEDLNQTFRTQ
CCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
PALLATSVALWRVWQEQGLAQPSVLAGHSLGEYSALVCAGVIDFKEAIKLVELRGQLMQE
HHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVPAGVGAMYAIIGLDNESIAKACEEAAQGEVVSPVNFNSPGQVVIAGNKDAVERAGVLC
HHCCCHHHHHHEEECCCHHHHHHHHHHHCCCEECCCCCCCCCCEEEECCHHHHHHHHHHH
KEAGAKRALPLPVSVPSHCALMKPAADKLAVALENIEFNTPTLPVINNVDVIAETDPAKI
HHCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCHHHH
KDALVRQLYGPVRWTEVVEKMAEQGVETLYEVGPGKVLTGLTKRIVKSLSAAAVNDAASL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHC
EAAK
CCCC
>Mature Secondary Structure
MLSFFPGQGSQAVGMLAELGEQHEVVTQTFAEASDALGYDLWSLVQNGPAEDLNQTFRTQ
CCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCC
PALLATSVALWRVWQEQGLAQPSVLAGHSLGEYSALVCAGVIDFKEAIKLVELRGQLMQE
HHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVPAGVGAMYAIIGLDNESIAKACEEAAQGEVVSPVNFNSPGQVVIAGNKDAVERAGVLC
HHCCCHHHHHHEEECCCHHHHHHHHHHHCCCEECCCCCCCCCCEEEECCHHHHHHHHHHH
KEAGAKRALPLPVSVPSHCALMKPAADKLAVALENIEFNTPTLPVINNVDVIAETDPAKI
HHCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCHHHH
KDALVRQLYGPVRWTEVVEKMAEQGVETLYEVGPGKVLTGLTKRIVKSLSAAAVNDAASL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCHHHC
EAAK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]