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The map label for this gene is tmk [H]

Identifier: 59712342

GI number: 59712342

Start: 1959321

End: 1959953

Strand: Reverse

Name: tmk [H]

Synonym: VF_1735

Alternate gene names: 59712342

Gene position: 1959953-1959321 (Counterclockwise)

Preceding gene: 59712343

Following gene: 59712341

Centisome position: 67.64

GC content: 40.28

Gene sequence:

>633_bases
ATGTCTAAATTTATTGTAATCGAAGGCCTAGAAGGCGCAGGCAAAAGTACAGCAATTAAGAACGTACTAGCTACATTGGC
AAAACACGGTATTACGTCACCAGTTACAACGCGTGAGCCAGGAGGAACCCCTCTTGCTGAGAAAATGCGTGAACTGGTTA
AACAAGGTCATCCTGATGAGCCACTAACGGATATGGCAGAATTGCTTCTTCTTTATGCTGCACGTGCTCAGTTAGTAGGT
AACGTGATTAAGCCTGCTCTTGCAAGAGGTGAATGGGTTGTTGGTGATCGTCATGATTTATCTTCACAAGCATACCAAGG
TGGTGGCCGTGGATTTGATCGTGAGTTAATGATGACCATGAGAAATACAGTATTAGGTGACTTTAAGCCTGATTTAACTA
TTTACATGGATATTGACCCTAAACTAGGTTTGCAGAGAGCATCTGCTCGCGGTGAGCTTGATAGAATTGAACAAATGAAG
TTAGATTTTTTTGAGAGAAGTCGTGAACGTTATTTAGAATTTGCAAATAGTGATGAAAGTATTATTACTATTGATGCAGG
GCAAGATTTAGAAACCGTGACAAATTCAATTATTACCGCTTTAGAAGCTTGGCTAGTTAAGAATGGCAACTAA

Upstream 100 bases:

>100_bases
ATTTTGTCGCTGATGGTACTGGCGGTCATAAATTCACTAAATCATTAGTTGAGCATAACAAAGCGGTTAGAGCTTACTTA
AGAACTTTAAGAAATTAATC

Downstream 100 bases:

>100_bases
ACTTTATCCATGGCAGGAAAATTTGTGGCAACAATGGCAGCAGTTGATTCAGGCAGATCGGCTTCCTCATGCCATATTGT
GTGCTATGCCTGTAGGGGCA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSKFIVIEGLEGAGKSTAIKNVLATLAKHGITSPVTTREPGGTPLAEKMRELVKQGHPDEPLTDMAELLLLYAARAQLVG
NVIKPALARGEWVVGDRHDLSSQAYQGGGRGFDRELMMTMRNTVLGDFKPDLTIYMDIDPKLGLQRASARGELDRIEQMK
LDFFERSRERYLEFANSDESIITIDAGQDLETVTNSIITALEAWLVKNGN

Sequences:

>Translated_210_residues
MSKFIVIEGLEGAGKSTAIKNVLATLAKHGITSPVTTREPGGTPLAEKMRELVKQGHPDEPLTDMAELLLLYAARAQLVG
NVIKPALARGEWVVGDRHDLSSQAYQGGGRGFDRELMMTMRNTVLGDFKPDLTIYMDIDPKLGLQRASARGELDRIEQMK
LDFFERSRERYLEFANSDESIITIDAGQDLETVTNSIITALEAWLVKNGN
>Mature_209_residues
SKFIVIEGLEGAGKSTAIKNVLATLAKHGITSPVTTREPGGTPLAEKMRELVKQGHPDEPLTDMAELLLLYAARAQLVGN
VIKPALARGEWVVGDRHDLSSQAYQGGGRGFDRELMMTMRNTVLGDFKPDLTIYMDIDPKLGLQRASARGELDRIEQMKL
DFFERSRERYLEFANSDESIITIDAGQDLETVTNSIITALEAWLVKNGN

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=206, Percent_Identity=62.1359223300971, Blast_Score=256, Evalue=6e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23190; Mature: 23059

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFIVIEGLEGAGKSTAIKNVLATLAKHGITSPVTTREPGGTPLAEKMRELVKQGHPDE
CCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
PLTDMAELLLLYAARAQLVGNVIKPALARGEWVVGDRHDLSSQAYQGGGRGFDRELMMTM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCCCHHHHHHHH
RNTVLGDFKPDLTIYMDIDPKLGLQRASARGELDRIEQMKLDFFERSRERYLEFANSDES
HHHHHCCCCCCEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IITIDAGQDLETVTNSIITALEAWLVKNGN
EEEEECCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SKFIVIEGLEGAGKSTAIKNVLATLAKHGITSPVTTREPGGTPLAEKMRELVKQGHPDE
CCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCC
PLTDMAELLLLYAARAQLVGNVIKPALARGEWVVGDRHDLSSQAYQGGGRGFDRELMMTM
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHCCCCCCCHHHHHHHH
RNTVLGDFKPDLTIYMDIDPKLGLQRASARGELDRIEQMKLDFFERSRERYLEFANSDES
HHHHHCCCCCCEEEEEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
IITIDAGQDLETVTNSIITALEAWLVKNGN
EEEEECCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA