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The map label for this gene is ycfH [H]

Identifier: 59712340

GI number: 59712340

Start: 1957586

End: 1958356

Strand: Reverse

Name: ycfH [H]

Synonym: VF_1733

Alternate gene names: 59712340

Gene position: 1958356-1957586 (Counterclockwise)

Preceding gene: 59712341

Following gene: 59712339

Centisome position: 67.59

GC content: 36.71

Gene sequence:

>771_bases
GTGTTAATTGATTCACACTGTCATTTAGATAAATTAAATTATGATGACTTACATGTAAATGTTGCTGATGTACTTGATAA
AGCGAAGAAACAAGGAGTTGAGCAGTTTTTAACTGTAGGTGTTACCTTAGATGCTTTTCCAAATATGATGAACATGATAG
CAGAACACCCAGAAGTTCATGCATCTTGTGGTATTCATCCATTGGATGTGGATTCTGCATTTGATTTATCACTTTTTCGT
CAATATGCAGCACATGAACGTGTGGTAGCCATTGGTGAAACGGGGTTAGATTATTTTTATCAACCAGAAAGTGCGCCGCG
TCAGAGAGAGCTATTTGAGCAACAAGTTGAGGTTGCTGTTGAGTATAATAAGCCTTTAATTATTCATACCAGACAAGCAA
GAGAAGATACTCTAGCCATCCTAAAAAATGGTAAAGCAGATAAATGTGGTGGAGTAATTCATTGCTTTACAGAAGATTGG
GCATTTGCAGAAGCTGCAATGGAACTTGGTTTTTACATTTCAATTTCTGGAATTGTGACTTTTAATAAAGCATCTGAGTT
GAAGGATGTGGTTCGTCGTCTTCCTCTTGAACGCTTATTGGTAGAAACGGATTCTCCTTATTTAGCACCTGTACCATTTC
GAGGCAAAGAAAATCAACCGGCTTACGTTAAAGAAGTCGCTGCTTATATTGCTTTACTTAAAGGGAAAAGTGTCGAAGAA
GTAGCACAAACTACCACCACTAATTTCAAAAATCTTTTTTTGAACAAATAA

Upstream 100 bases:

>100_bases
ATTGCACTGAATTCGTTACAAGAGCAATTGGATAGTTTCCCTGGTTTAAATAAAGAATTACTACTAACTCAATGGATGTT
TGAGTTTACTGGAGAGTTGA

Downstream 100 bases:

>100_bases
TTAGATATTGGTTGTAAAGTAATCGATAAAGGAGGCTTAGGTCTCCTTTTTTTTTATTTTACGGATTTAACCCTGTTTTT
TATACCGATCACGATACGTA

Product: metallodependent hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MLIDSHCHLDKLNYDDLHVNVADVLDKAKKQGVEQFLTVGVTLDAFPNMMNMIAEHPEVHASCGIHPLDVDSAFDLSLFR
QYAAHERVVAIGETGLDYFYQPESAPRQRELFEQQVEVAVEYNKPLIIHTRQAREDTLAILKNGKADKCGGVIHCFTEDW
AFAEAAMELGFYISISGIVTFNKASELKDVVRRLPLERLLVETDSPYLAPVPFRGKENQPAYVKEVAAYIALLKGKSVEE
VAQTTTTNFKNLFLNK

Sequences:

>Translated_256_residues
MLIDSHCHLDKLNYDDLHVNVADVLDKAKKQGVEQFLTVGVTLDAFPNMMNMIAEHPEVHASCGIHPLDVDSAFDLSLFR
QYAAHERVVAIGETGLDYFYQPESAPRQRELFEQQVEVAVEYNKPLIIHTRQAREDTLAILKNGKADKCGGVIHCFTEDW
AFAEAAMELGFYISISGIVTFNKASELKDVVRRLPLERLLVETDSPYLAPVPFRGKENQPAYVKEVAAYIALLKGKSVEE
VAQTTTTNFKNLFLNK
>Mature_256_residues
MLIDSHCHLDKLNYDDLHVNVADVLDKAKKQGVEQFLTVGVTLDAFPNMMNMIAEHPEVHASCGIHPLDVDSAFDLSLFR
QYAAHERVVAIGETGLDYFYQPESAPRQRELFEQQVEVAVEYNKPLIIHTRQAREDTLAILKNGKADKCGGVIHCFTEDW
AFAEAAMELGFYISISGIVTFNKASELKDVVRRLPLERLLVETDSPYLAPVPFRGKENQPAYVKEVAAYIALLKGKSVEE
VAQTTTTNFKNLFLNK

Specific function: Unknown

COG id: COG0084

COG function: function code L; Mg-dependent DNase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tatD DNase family [H]

Homologues:

Organism=Homo sapiens, GI110349730, Length=271, Percent_Identity=30.9963099630996, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI110349734, Length=271, Percent_Identity=31.3653136531365, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI226061853, Length=279, Percent_Identity=31.8996415770609, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI225903424, Length=223, Percent_Identity=30.9417040358744, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI226061614, Length=257, Percent_Identity=29.9610894941634, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI14042943, Length=268, Percent_Identity=25.3731343283582, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI226061595, Length=236, Percent_Identity=30.0847457627119, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI225903439, Length=193, Percent_Identity=27.4611398963731, Blast_Score=75, Evalue=4e-14,
Organism=Escherichia coli, GI1787342, Length=253, Percent_Identity=56.1264822134387, Blast_Score=296, Evalue=1e-81,
Organism=Escherichia coli, GI87082439, Length=256, Percent_Identity=30.859375, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI48994985, Length=238, Percent_Identity=31.0924369747899, Blast_Score=115, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17559024, Length=271, Percent_Identity=28.7822878228782, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71980746, Length=264, Percent_Identity=27.6515151515151, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17565396, Length=298, Percent_Identity=26.8456375838926, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17543026, Length=190, Percent_Identity=30.5263157894737, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221330018, Length=212, Percent_Identity=32.0754716981132, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24586117, Length=212, Percent_Identity=32.0754716981132, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24648690, Length=275, Percent_Identity=29.0909090909091, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015992
- InterPro:   IPR001130
- InterPro:   IPR018228
- InterPro:   IPR012278
- InterPro:   IPR015991 [H]

Pfam domain/function: PF01026 TatD_DNase [H]

EC number: 3.1.21.- [C]

Molecular weight: Translated: 28785; Mature: 28785

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS01137 TATD_1 ; PS01090 TATD_2 ; PS01091 TATD_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDSHCHLDKLNYDDLHVNVADVLDKAKKQGVEQFLTVGVTLDAFPNMMNMIAEHPEVH
CEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCH
ASCGIHPLDVDSAFDLSLFRQYAAHERVVAIGETGLDYFYQPESAPRQRELFEQQVEVAV
HHCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHE
EYNKPLIIHTRQAREDTLAILKNGKADKCGGVIHCFTEDWAFAEAAMELGFYISISGIVT
ECCCCEEEEECCCCHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHCEEEEEEEEEE
FNKASELKDVVRRLPLERLLVETDSPYLAPVPFRGKENQPAYVKEVAAYIALLKGKSVEE
ECCHHHHHHHHHHCCHHHHHEECCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHH
VAQTTTTNFKNLFLNK
HHHHHHCCHHHHHCCC
>Mature Secondary Structure
MLIDSHCHLDKLNYDDLHVNVADVLDKAKKQGVEQFLTVGVTLDAFPNMMNMIAEHPEVH
CEECCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCH
ASCGIHPLDVDSAFDLSLFRQYAAHERVVAIGETGLDYFYQPESAPRQRELFEQQVEVAV
HHCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHE
EYNKPLIIHTRQAREDTLAILKNGKADKCGGVIHCFTEDWAFAEAAMELGFYISISGIVT
ECCCCEEEEECCCCHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHCEEEEEEEEEE
FNKASELKDVVRRLPLERLLVETDSPYLAPVPFRGKENQPAYVKEVAAYIALLKGKSVEE
ECCHHHHHHHHHHCCHHHHHEECCCCEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCHHH
VAQTTTTNFKNLFLNK
HHHHHHCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]