Click here to switch to the map view.

The map label for this gene is fabB [H]

Identifier: 59712307

GI number: 59712307

Start: 1916165

End: 1917376

Strand: Reverse

Name: fabB [H]

Synonym: VF_1700

Alternate gene names: 59712307

Gene position: 1917376-1916165 (Counterclockwise)

Preceding gene: 59712309

Following gene: 59712306

Centisome position: 66.17

GC content: 44.31

Gene sequence:

>1212_bases
ATGAAAAGAGCCGTAATTACAGGCATGGGCATTGTTTCAAGTATCGGTAACAATGCAGAAGAAGTATTAGAGTCTCTGAA
AGCAGGTAAATCAGGCATTAACTTCTCTGAGCAGTTTGCTGAAAAAGGTCTGCGCAGTAATGTTTGGGGCGATTTGAAAA
TGAACCCTGCTGATCACATTGACCGCAAAAAAATGCGTTTCATGGGTGATGCGGCTGCATTTGCTTACATCTCAATGGAG
CAAGCAGTAGCGGATTCTGGCTTAACAGAAGATCAAGTTTCAAATGAACGTACAGGTATTGTTGCGGGTTCTGGTGGTGC
ATCATCACTAAACCAAGTAAACGCAGTTGATATCTTGCGTGAGAAAGGCGTTAAGCGTGTTGGTCCTTACATGGTTCCAC
GTACAATGGCGTCAACGGTTTCTGCATGTCTTGCAACACCGTTTAAAATTAAAGGCGTGAACTACTCAATGAGTTCAGCT
TGTGCAACATCTGCACACTGTATTGGCCACGCAGTAGAGCTTATCCAACTAGGTAAACAAGACGTAATGTTTGCTGGTGG
CGGTGAAGAGCTAGATTGGTCTCTTACTATGATGTTTGATGCAATGGGAGCATTATCATCTAAGTATAACGATACTCCAG
AAAAAGCATCACGTACTTATGATGCAGACCGCGATGGTTTCGTAATTTCTGGTGGTGGCGGTATGCTAGTTATCGAAGAA
CTTGAGCACGCACTTGCTCGTGGCGCTAAAATTTACGGTGAAATCGTAGGTTACGGTGCAACATCTGATGGTTACGACAT
GGTAGCTCCATCAGGCGAAGGTGCAGTTCGTTGTATGAAAATGGCAATGCAAAACGTAGACAGCGTTGATTACGTGAACA
CTCACGGCACATCAACACCTGTAGGTGATGCAAAAGAGCTAGGCGCAATCCAAGAAGTATTTGGTGCTAACAGCCCTGCA
ATTTCTGCAACTAAAGCAATGACAGGTCACGCACTAGGCGCGGCTGGTGTTCATGAAGCGATTTACTCAACACTAATGTT
AGAGCACGGTTTCATTGCACCAAGCATCAACGTTGAAACGCTAGACCCAGCAGCTGAAGGTCTTGATATCGTAACTGAAA
AACGTGATCAAGCACTGAACACAGTAATGTCAAACAGCTTCGGTTTTGGTGGTACAAACGCAACGCTAGTTATTAAGAAA
TACGAAGCGTAA

Upstream 100 bases:

>100_bases
AATCTACGTCGGATTTTAACGACTTATAGGAAAGCTGACCACTTTGTTGTGCTATCTTCGCTATTATCTACCAAGATTTA
TGACTTATTAGGAAAGAATC

Downstream 100 bases:

>100_bases
TAGCGTCATCACTGAAAACAAATAGTAAAAGCCCAGTCACTTAAATTGACTGGGTTTTTTTATACCTATTTTCTGTTATG
GAAGTGATGATACCAATTCC

Product: 3-oxoacyl-(acyl-carrier-protein)-synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase I; Beta-ketoacyl-ACP synthase I; KAS I [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MKRAVITGMGIVSSIGNNAEEVLESLKAGKSGINFSEQFAEKGLRSNVWGDLKMNPADHIDRKKMRFMGDAAAFAYISME
QAVADSGLTEDQVSNERTGIVAGSGGASSLNQVNAVDILREKGVKRVGPYMVPRTMASTVSACLATPFKIKGVNYSMSSA
CATSAHCIGHAVELIQLGKQDVMFAGGGEELDWSLTMMFDAMGALSSKYNDTPEKASRTYDADRDGFVISGGGGMLVIEE
LEHALARGAKIYGEIVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDSVDYVNTHGTSTPVGDAKELGAIQEVFGANSPA
ISATKAMTGHALGAAGVHEAIYSTLMLEHGFIAPSINVETLDPAAEGLDIVTEKRDQALNTVMSNSFGFGGTNATLVIKK
YEA

Sequences:

>Translated_403_residues
MKRAVITGMGIVSSIGNNAEEVLESLKAGKSGINFSEQFAEKGLRSNVWGDLKMNPADHIDRKKMRFMGDAAAFAYISME
QAVADSGLTEDQVSNERTGIVAGSGGASSLNQVNAVDILREKGVKRVGPYMVPRTMASTVSACLATPFKIKGVNYSMSSA
CATSAHCIGHAVELIQLGKQDVMFAGGGEELDWSLTMMFDAMGALSSKYNDTPEKASRTYDADRDGFVISGGGGMLVIEE
LEHALARGAKIYGEIVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDSVDYVNTHGTSTPVGDAKELGAIQEVFGANSPA
ISATKAMTGHALGAAGVHEAIYSTLMLEHGFIAPSINVETLDPAAEGLDIVTEKRDQALNTVMSNSFGFGGTNATLVIKK
YEA
>Mature_403_residues
MKRAVITGMGIVSSIGNNAEEVLESLKAGKSGINFSEQFAEKGLRSNVWGDLKMNPADHIDRKKMRFMGDAAAFAYISME
QAVADSGLTEDQVSNERTGIVAGSGGASSLNQVNAVDILREKGVKRVGPYMVPRTMASTVSACLATPFKIKGVNYSMSSA
CATSAHCIGHAVELIQLGKQDVMFAGGGEELDWSLTMMFDAMGALSSKYNDTPEKASRTYDADRDGFVISGGGGMLVIEE
LEHALARGAKIYGEIVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDSVDYVNTHGTSTPVGDAKELGAIQEVFGANSPA
ISATKAMTGHALGAAGVHEAIYSTLMLEHGFIAPSINVETLDPAAEGLDIVTEKRDQALNTVMSNSFGFGGTNATLVIKK
YEA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Specific for elongation from C-10 to unsaturated C-16 and C-18 fatty acids [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=424, Percent_Identity=35.377358490566, Blast_Score=224, Evalue=7e-59,
Organism=Homo sapiens, GI223972627, Length=171, Percent_Identity=40.9356725146199, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI41872631, Length=426, Percent_Identity=24.8826291079812, Blast_Score=102, Evalue=7e-22,
Organism=Escherichia coli, GI1788663, Length=405, Percent_Identity=72.0987654320988, Blast_Score=594, Evalue=1e-171,
Organism=Escherichia coli, GI1787337, Length=411, Percent_Identity=39.9026763990268, Blast_Score=261, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI71983541, Length=417, Percent_Identity=35.2517985611511, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=39.3822393822394, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17550940, Length=338, Percent_Identity=27.5147928994083, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI212642053, Length=353, Percent_Identity=25.7790368271955, Blast_Score=104, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=30.4054054054054, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=38.8095238095238, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI19920632, Length=406, Percent_Identity=24.6305418719212, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI221330659, Length=406, Percent_Identity=24.6305418719212, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24581345, Length=364, Percent_Identity=23.0769230769231, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: 24024 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 30,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 42375; Mature: 42375

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRAVITGMGIVSSIGNNAEEVLESLKAGKSGINFSEQFAEKGLRSNVWGDLKMNPADHI
CCCEEEEHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCHHCCCCCCEECCCHHHH
DRKKMRFMGDAAAFAYISMEQAVADSGLTEDQVSNERTGIVAGSGGASSLNQVNAVDILR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCCCCHHHHHHHHHHHH
EKGVKRVGPYMVPRTMASTVSACLATPFKIKGVNYSMSSACATSAHCIGHAVELIQLGKQ
HCCHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DVMFAGGGEELDWSLTMMFDAMGALSSKYNDTPEKASRTYDADRDGFVISGGGGMLVIEE
CEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCEEEECCCCEEEHHH
LEHALARGAKIYGEIVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDSVDYVNTHGTSTP
HHHHHHCCHHHHHHHEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCEECCCCCCCC
VGDAKELGAIQEVFGANSPAISATKAMTGHALGAAGVHEAIYSTLMLEHGFIAPSINVET
CCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEE
LDPAAEGLDIVTEKRDQALNTVMSNSFGFGGTNATLVIKKYEA
CCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MKRAVITGMGIVSSIGNNAEEVLESLKAGKSGINFSEQFAEKGLRSNVWGDLKMNPADHI
CCCEEEEHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHCCHHCCCCCCEECCCHHHH
DRKKMRFMGDAAAFAYISMEQAVADSGLTEDQVSNERTGIVAGSGGASSLNQVNAVDILR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEECCCCCCHHHHHHHHHHHH
EKGVKRVGPYMVPRTMASTVSACLATPFKIKGVNYSMSSACATSAHCIGHAVELIQLGKQ
HCCHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DVMFAGGGEELDWSLTMMFDAMGALSSKYNDTPEKASRTYDADRDGFVISGGGGMLVIEE
CEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCEEEECCCCEEEHHH
LEHALARGAKIYGEIVGYGATSDGYDMVAPSGEGAVRCMKMAMQNVDSVDYVNTHGTSTP
HHHHHHCCHHHHHHHEECCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCCEECCCCCCCC
VGDAKELGAIQEVFGANSPAISATKAMTGHALGAAGVHEAIYSTLMLEHGFIAPSINVET
CCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEE
LDPAAEGLDIVTEKRDQALNTVMSNSFGFGGTNATLVIKKYEA
CCHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]