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The map label for this gene is dnaX [H]

Identifier: 59712294

GI number: 59712294

Start: 1897972

End: 1900098

Strand: Reverse

Name: dnaX [H]

Synonym: VF_1687

Alternate gene names: 59712294

Gene position: 1900098-1897972 (Counterclockwise)

Preceding gene: 59712295

Following gene: 59712293

Centisome position: 65.58

GC content: 42.88

Gene sequence:

>2127_bases
ATGAGCTATCAAGTATTGGCACGGAAGTGGCGACCACATCATTTTAAAGATGTTGTTGGCCAACCCCATGTGCTTACTGC
GTTGGAAAACGCACTTGACCATAATCGACTTCATCACGCTTATCTATTTAGCGGAACACGTGGTGTGGGTAAAACCACGA
TTGCGCGTTTATTTGCTAAAGGTTTGAACTGTGAAGAAGGGATCACATCAACACCGTGTGGTGTGTGTTCTACATGTAAA
GAAATCGACGAAGGACGTTTTGTTGATTTACTTGAAATCGATGCTGCTTCTAGAACGAAAGTGGAAGATACACGTGAACT
ATTAGATAACGTTCAATACAAGCCTGCGCGTGGTCGCTTTAAGGTTTATTTGATCGATGAAGTTCATATGTTATCTCGCC
ACAGTTTCAATGCTTTATTAAAGACATTGGAAGAGCCGCCTGAATACGTAAAATTCTTACTAGCAACAACGGATCCACAG
AAGCTACCTGTAACGATCCTTTCTCGCTGTTTACAGTTTCACCTTAAGCACATCAGTGTTGACCAAATTCATGAGCAGCT
AGACTTTGTTCTTGATAAAGAAGAAGTCTCAAAAGAAGCTCGAGCTCTTGGGCTTATAGCTCATGCGGCTGATGGTAGTA
TGCGTGATGCATTAAGTTTAACTGATCAAGCTATTGCGCTTGGTAACGGTTCAGTGACGGCTGAAATTGTATCGGCAATG
CTCGGAACCTTAGATACCGATCAGGCAATTCGTATTCTAGAAGCGATTAGCACTAAGAATATGCAGACACTCATGAATTG
TGTAAATGATCTTGCTGATATTGGTGTTGAATGGGATGGATTAGCGAAAGAGTTAGCTAACCAGCTTCATAAATTAGCTA
TGTATCAAGCGTTGCCTGCAACTCTAGATAAAACACAGCCAGATGCTGAACGTATTGAGCTTTTAAGTACACAATTATCG
CCTCAAGAAGTGCAGCTGTTTTATCAAATTGTACTGCAAAGTCGTAAGGACTTGCCATTAGCTCCAAATGAGCGAACTGG
TGCAGAGATGATGTTATTGAGAATGGTAGCATTCCGCCCTGTACATGCTCAGGCATTAGAAGCACAGCCAATTGCAGTAC
CATCAACAGAGCCTCAAACAACAAATGCGGCACCAAGGGTACAACAAGCCCCTTCAGCTCCTGTTAATGTTGCGCCTCAA
GCACAAAGACCAATGGCGTCTCAACAACGCCCTACAACGCCACAGCAAACACAGCAAGGTTATGCGCCAGCGAATGTGCC
ACCAATGCAAACTGAGCAGCCACCAGTGTATGATGCGCCTCCTATGGGAACGCCGTCAGGTGAATCTGCGTCACAAGCAC
CTCAACATTCTTCTTCAGCGCAGTCTCCTATGCAAGAGACGCCAGCCCCACGAAGTGGACTATTAGGTGTTCGTAACCAA
TTGCGTAGTGCAAAAAACAATTTGACCAATACAGGTACTGGCTCAAAAAAGGCTAGTGCGGCATCCGATAAGAAAAAAAC
GAGTTCAGTGTTAGAGCGTATTGCTGAAAAGCAACATTTAGCGCCTCGTGCTCAGGTGTCGCAAATTGGAAATTCCGCAA
CACAAGAGAAAAAACCAGAAGAGCCGTATCGCTGGAAATCAACTCAACCAGAAATGAAAAAAGTGGTGAGTGATGTTACT
CCAACGAAACTAAAACAAGCGCTAGAGCATGAAAAAACGCCTGAAATGGTGAAATTGCTTGTTGAAGAGTCATCAAAACA
AGATACTTGGTCTGCTTTAGCAATGTCATTAACATTACCAAAGTTAGTACAGCAGCTTGTTTTAAATTCAGCATTTGTTG
AGCAAGATAACCAAGTTAAGTTACATTTACGAGCAGCACAATCGCATTTAAATGGCGACAAAGCCAATGAGCTGATCACT
CAAGCGCTAACACAAACATTAAATCGAGAAGTGACGGTAACAATCGATATTAGTGACGAAGGAACAACACCTTTAGAGCT
GCGTGAGCAAATGTATCAAACTAAACTGCAAACGGCTTATCAGAGTTTGCAGCAAGATCCACATGTCAATTTCTTTATTC
AGCGATTTGGCGCAGAGATGGATCAAGAAAGTGTGAGACCTATTTAA

Upstream 100 bases:

>100_bases
TTCATATACACAGTTAATTACGTGAGATCTCTCTATCAAGGAAGATCTCATTTTTTTGCTGTGCTACGATTTAGAACTAT
TTTATTTTGGGCTGTATTCT

Downstream 100 bases:

>100_bases
CATAAGCGTTCATACAATCTAATTTAAAATTTAGAGTGGGTTGAAAACAAAAATTTAACCCCCATTTTTTTAGTAACAAA
GAAGTAAACTTAAGAGAGAA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 708; Mature: 707

Protein sequence:

>708_residues
MSYQVLARKWRPHHFKDVVGQPHVLTALENALDHNRLHHAYLFSGTRGVGKTTIARLFAKGLNCEEGITSTPCGVCSTCK
EIDEGRFVDLLEIDAASRTKVEDTRELLDNVQYKPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQ
KLPVTILSRCLQFHLKHISVDQIHEQLDFVLDKEEVSKEARALGLIAHAADGSMRDALSLTDQAIALGNGSVTAEIVSAM
LGTLDTDQAIRILEAISTKNMQTLMNCVNDLADIGVEWDGLAKELANQLHKLAMYQALPATLDKTQPDAERIELLSTQLS
PQEVQLFYQIVLQSRKDLPLAPNERTGAEMMLLRMVAFRPVHAQALEAQPIAVPSTEPQTTNAAPRVQQAPSAPVNVAPQ
AQRPMASQQRPTTPQQTQQGYAPANVPPMQTEQPPVYDAPPMGTPSGESASQAPQHSSSAQSPMQETPAPRSGLLGVRNQ
LRSAKNNLTNTGTGSKKASAASDKKKTSSVLERIAEKQHLAPRAQVSQIGNSATQEKKPEEPYRWKSTQPEMKKVVSDVT
PTKLKQALEHEKTPEMVKLLVEESSKQDTWSALAMSLTLPKLVQQLVLNSAFVEQDNQVKLHLRAAQSHLNGDKANELIT
QALTQTLNREVTVTIDISDEGTTPLELREQMYQTKLQTAYQSLQQDPHVNFFIQRFGAEMDQESVRPI

Sequences:

>Translated_708_residues
MSYQVLARKWRPHHFKDVVGQPHVLTALENALDHNRLHHAYLFSGTRGVGKTTIARLFAKGLNCEEGITSTPCGVCSTCK
EIDEGRFVDLLEIDAASRTKVEDTRELLDNVQYKPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQ
KLPVTILSRCLQFHLKHISVDQIHEQLDFVLDKEEVSKEARALGLIAHAADGSMRDALSLTDQAIALGNGSVTAEIVSAM
LGTLDTDQAIRILEAISTKNMQTLMNCVNDLADIGVEWDGLAKELANQLHKLAMYQALPATLDKTQPDAERIELLSTQLS
PQEVQLFYQIVLQSRKDLPLAPNERTGAEMMLLRMVAFRPVHAQALEAQPIAVPSTEPQTTNAAPRVQQAPSAPVNVAPQ
AQRPMASQQRPTTPQQTQQGYAPANVPPMQTEQPPVYDAPPMGTPSGESASQAPQHSSSAQSPMQETPAPRSGLLGVRNQ
LRSAKNNLTNTGTGSKKASAASDKKKTSSVLERIAEKQHLAPRAQVSQIGNSATQEKKPEEPYRWKSTQPEMKKVVSDVT
PTKLKQALEHEKTPEMVKLLVEESSKQDTWSALAMSLTLPKLVQQLVLNSAFVEQDNQVKLHLRAAQSHLNGDKANELIT
QALTQTLNREVTVTIDISDEGTTPLELREQMYQTKLQTAYQSLQQDPHVNFFIQRFGAEMDQESVRPI
>Mature_707_residues
SYQVLARKWRPHHFKDVVGQPHVLTALENALDHNRLHHAYLFSGTRGVGKTTIARLFAKGLNCEEGITSTPCGVCSTCKE
IDEGRFVDLLEIDAASRTKVEDTRELLDNVQYKPARGRFKVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQK
LPVTILSRCLQFHLKHISVDQIHEQLDFVLDKEEVSKEARALGLIAHAADGSMRDALSLTDQAIALGNGSVTAEIVSAML
GTLDTDQAIRILEAISTKNMQTLMNCVNDLADIGVEWDGLAKELANQLHKLAMYQALPATLDKTQPDAERIELLSTQLSP
QEVQLFYQIVLQSRKDLPLAPNERTGAEMMLLRMVAFRPVHAQALEAQPIAVPSTEPQTTNAAPRVQQAPSAPVNVAPQA
QRPMASQQRPTTPQQTQQGYAPANVPPMQTEQPPVYDAPPMGTPSGESASQAPQHSSSAQSPMQETPAPRSGLLGVRNQL
RSAKNNLTNTGTGSKKASAASDKKKTSSVLERIAEKQHLAPRAQVSQIGNSATQEKKPEEPYRWKSTQPEMKKVVSDVTP
TKLKQALEHEKTPEMVKLLVEESSKQDTWSALAMSLTLPKLVQQLVLNSAFVEQDNQVKLHLRAAQSHLNGDKANELITQ
ALTQTLNREVTVTIDISDEGTTPLELREQMYQTKLQTAYQSLQQDPHVNFFIQRFGAEMDQESVRPI

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=302, Percent_Identity=23.841059602649, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI31881687, Length=302, Percent_Identity=23.841059602649, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1786676, Length=712, Percent_Identity=48.314606741573, Blast_Score=619, Evalue=1e-178,
Organism=Escherichia coli, GI1787341, Length=269, Percent_Identity=28.2527881040892, Blast_Score=63, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322528, Length=303, Percent_Identity=23.7623762376238, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 78395; Mature: 78264

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPHHFKDVVGQPHVLTALENALDHNRLHHAYLFSGTRGVGKTTIARLFAK
CCHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHH
GLNCEEGITSTPCGVCSTCKEIDEGRFVDLLEIDAASRTKVEDTRELLDNVQYKPARGRF
CCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQKLPVTILSRCLQFHLKHISV
EEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCH
DQIHEQLDFVLDKEEVSKEARALGLIAHAADGSMRDALSLTDQAIALGNGSVTAEIVSAM
HHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEECCCCHHHHHHHHH
LGTLDTDQAIRILEAISTKNMQTLMNCVNDLADIGVEWDGLAKELANQLHKLAMYQALPA
HCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
TLDKTQPDAERIELLSTQLSPQEVQLFYQIVLQSRKDLPLAPNERTGAEMMLLRMVAFRP
HHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCC
VHAQALEAQPIAVPSTEPQTTNAAPRVQQAPSAPVNVAPQAQRPMASQQRPTTPQQTQQG
HHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCC
YAPANVPPMQTEQPPVYDAPPMGTPSGESASQAPQHSSSAQSPMQETPAPRSGLLGVRNQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHCCCCCCHHHHHHHH
LRSAKNNLTNTGTGSKKASAASDKKKTSSVLERIAEKQHLAPRAQVSQIGNSATQEKKPE
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHCCCCC
EPYRWKSTQPEMKKVVSDVTPTKLKQALEHEKTPEMVKLLVEESSKQDTWSALAMSLTLP
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
KLVQQLVLNSAFVEQDNQVKLHLRAAQSHLNGDKANELITQALTQTLNREVTVTIDISDE
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCC
GTTPLELREQMYQTKLQTAYQSLQQDPHVNFFIQRFGAEMDQESVRPI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHCCCC
>Mature Secondary Structure 
SYQVLARKWRPHHFKDVVGQPHVLTALENALDHNRLHHAYLFSGTRGVGKTTIARLFAK
CHHHHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHH
GLNCEEGITSTPCGVCSTCKEIDEGRFVDLLEIDAASRTKVEDTRELLDNVQYKPARGRF
CCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCE
KVYLIDEVHMLSRHSFNALLKTLEEPPEYVKFLLATTDPQKLPVTILSRCLQFHLKHISV
EEEEECHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCH
DQIHEQLDFVLDKEEVSKEARALGLIAHAADGSMRDALSLTDQAIALGNGSVTAEIVSAM
HHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEECCCCHHHHHHHHH
LGTLDTDQAIRILEAISTKNMQTLMNCVNDLADIGVEWDGLAKELANQLHKLAMYQALPA
HCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
TLDKTQPDAERIELLSTQLSPQEVQLFYQIVLQSRKDLPLAPNERTGAEMMLLRMVAFRP
HHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCC
VHAQALEAQPIAVPSTEPQTTNAAPRVQQAPSAPVNVAPQAQRPMASQQRPTTPQQTQQG
HHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCC
YAPANVPPMQTEQPPVYDAPPMGTPSGESASQAPQHSSSAQSPMQETPAPRSGLLGVRNQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHHCCCCCCHHHHHHHH
LRSAKNNLTNTGTGSKKASAASDKKKTSSVLERIAEKQHLAPRAQVSQIGNSATQEKKPE
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHCCCCC
EPYRWKSTQPEMKKVVSDVTPTKLKQALEHEKTPEMVKLLVEESSKQDTWSALAMSLTLP
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHH
KLVQQLVLNSAFVEQDNQVKLHLRAAQSHLNGDKANELITQALTQTLNREVTVTIDISDE
HHHHHHHHHHHHHCCCCCEEEEEHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEECCC
GTTPLELREQMYQTKLQTAYQSLQQDPHVNFFIQRFGAEMDQESVRPI
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]