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The map label for this gene is apt [H]

Identifier: 59712295

GI number: 59712295

Start: 1900202

End: 1900747

Strand: Reverse

Name: apt [H]

Synonym: VF_1688

Alternate gene names: 59712295

Gene position: 1900747-1900202 (Counterclockwise)

Preceding gene: 59712296

Following gene: 59712294

Centisome position: 65.6

GC content: 40.48

Gene sequence:

>546_bases
ATGTCTACAGAAACACTAACACTGATTAAGAACAGTATTAAATCAATTCCTGATTATCCTAAAGCTGGCATTATGTTCCG
TGATGTAACAAGCCTAATGGAAGACCCAAAAGCATACCAAGCAACAATTCAATCATTAGTTGAAAAGTATAAGCAAGGCG
GTTTTACTAAAATCGTTGGTACAGAAGCTCGTGGTTTCTTATTTGGTGCGCCATTAGCATTAGAGTTAGGTGTTGGCTTT
GTTCCTGTTCGTAAACCAGGTAAATTGCCTCGTCCAACAATCGCACAAACATATGATCTTGAATACGGTACGGATACATT
AGAAATTCATACTGATGCGATCGTTGAAGGCGACAAGGTGCTTGTTGTTGATGATCTATTAGCAACGGGTGGAACGATTG
AAGCAACGGTAAAACTGATCCGCCAACTGGGTGGTGAAGTTGAGCATGCCGCATTTGTTATTAATCTTCCAGAAATTGGT
GGCGAAACACGTTTAGAAGGCCTAGGTCTAAACGTATACAGCATTTGTGAGTTTGCTGGTCACTAA

Upstream 100 bases:

>100_bases
ACCTTGTTTGGTAATACTTGCTCATGGATAAGAAAGTGAATACCATTGCCCGGTTAATTTATTTTTAAGCCCGAATAGAG
GCAAAGCAGGTCAAATAACA

Downstream 100 bases:

>100_bases
TTCTTCATATACACAGTTAATTACGTGAGATCTCTCTATCAAGGAAGATCTCATTTTTTTGCTGTGCTACGATTTAGAAC
TATTTTATTTTGGGCTGTAT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 181; Mature: 180

Protein sequence:

>181_residues
MSTETLTLIKNSIKSIPDYPKAGIMFRDVTSLMEDPKAYQATIQSLVEKYKQGGFTKIVGTEARGFLFGAPLALELGVGF
VPVRKPGKLPRPTIAQTYDLEYGTDTLEIHTDAIVEGDKVLVVDDLLATGGTIEATVKLIRQLGGEVEHAAFVINLPEIG
GETRLEGLGLNVYSICEFAGH

Sequences:

>Translated_181_residues
MSTETLTLIKNSIKSIPDYPKAGIMFRDVTSLMEDPKAYQATIQSLVEKYKQGGFTKIVGTEARGFLFGAPLALELGVGF
VPVRKPGKLPRPTIAQTYDLEYGTDTLEIHTDAIVEGDKVLVVDDLLATGGTIEATVKLIRQLGGEVEHAAFVINLPEIG
GETRLEGLGLNVYSICEFAGH
>Mature_180_residues
STETLTLIKNSIKSIPDYPKAGIMFRDVTSLMEDPKAYQATIQSLVEKYKQGGFTKIVGTEARGFLFGAPLALELGVGFV
PVRKPGKLPRPTIAQTYDLEYGTDTLEIHTDAIVEGDKVLVVDDLLATGGTIEATVKLIRQLGGEVEHAAFVINLPEIGG
ETRLEGLGLNVYSICEFAGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=168, Percent_Identity=43.452380952381, Blast_Score=142, Evalue=1e-34,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=47.3684210526316, Blast_Score=125, Evalue=2e-29,
Organism=Escherichia coli, GI1786675, Length=180, Percent_Identity=73.8888888888889, Blast_Score=267, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17509087, Length=164, Percent_Identity=42.0731707317073, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6323619, Length=163, Percent_Identity=41.1042944785276, Blast_Score=116, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6320649, Length=161, Percent_Identity=39.1304347826087, Blast_Score=94, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17136334, Length=179, Percent_Identity=40.7821229050279, Blast_Score=128, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 19553; Mature: 19422

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTETLTLIKNSIKSIPDYPKAGIMFRDVTSLMEDPKAYQATIQSLVEKYKQGGFTKIVG
CCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEC
TEARGFLFGAPLALELGVGFVPVRKPGKLPRPTIAQTYDLEYGTDTLEIHTDAIVEGDKV
CCCCCEEEECCEEEECCCCEEECCCCCCCCCCCCCEEEECCCCCCEEEEEECEEECCCEE
LVVDDLLATGGTIEATVKLIRQLGGEVEHAAFVINLPEIGGETRLEGLGLNVYSICEFAG
EEEECHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEECCCCHHHHHHHCC
H
C
>Mature Secondary Structure 
STETLTLIKNSIKSIPDYPKAGIMFRDVTSLMEDPKAYQATIQSLVEKYKQGGFTKIVG
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEC
TEARGFLFGAPLALELGVGFVPVRKPGKLPRPTIAQTYDLEYGTDTLEIHTDAIVEGDKV
CCCCCEEEECCEEEECCCCEEECCCCCCCCCCCCCEEEECCCCCCEEEEEECEEECCCEE
LVVDDLLATGGTIEATVKLIRQLGGEVEHAAFVINLPEIGGETRLEGLGLNVYSICEFAG
EEEECHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEECCCCHHHHHHHCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA