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The map label for this gene is yfbQ [H]

Identifier: 59712280

GI number: 59712280

Start: 1883278

End: 1884492

Strand: Direct

Name: yfbQ [H]

Synonym: VF_1673

Alternate gene names: 59712280

Gene position: 1883278-1884492 (Clockwise)

Preceding gene: 59712272

Following gene: 172087718

Centisome position: 65.0

GC content: 40.74

Gene sequence:

>1215_bases
ATGCAAAATATTGGAATGTCATCAAAACTTAGCAGTGTATGCTACGACATCCGTGGTCCAGTTCTTAAACATGCTAAGCG
AATGGAAGAAGAAGGCCACAAAATTCTTAAGTTAAATATTGGGAATCCAGCCCCATTTGGCTTTGACGCCCCTGATGAAA
TCCTTGTTGATGTGATTAAAAATCTACCAACATCGCAAGGTTACTGTGATTCAAAAGGCATTTACTCAGCACGTAAAGCT
GTTGTTCAACATTATCAACGTCGTGGTCTATTAGATTTGGACGTAGAAGATGTTTACATCGGTAATGGTGCATCTGAGCT
GATCGTTATGGCAATGCAAGCATTGTTAAATAATGGCGATGAAATGCTAGTTCCTGCTCCTGATTACCCATTATGGACAG
CTGCAGTGTCACTTTCAGGTGGTAAACCTGTGCATTACATGTGTGATGAAGGGGCAGATTGGTACCCAGATTTAGACGAC
ATTAAAAAGAAAATCACACCAAACACTAAAGGTATCGTGTTAATTAACCCGAATAACCCAACAGGTGCGGTATACAGTCG
TGATTTCTTACTACAAGTTGTCGAAATTGCACGTCAAAACAACCTAATCATTTTTGCTGATGAAATTTATGACAAAGTAC
TTTATGACGGTGCAGTTCATACTACATTGGCAACATTAGCACCTGATATCTTAACGGTAACATTCAACGGTCTATCTAAA
GCGTATCGAGTATGTGGTTTCCGTGGTGGTTGGATGTTCTTAAACGGCCCTAAAGATCACGCTCAAGGTTACATTGCTGG
GTTGGATATGCTTGCTTCAATGCGCTTATGTGCAAACGTACCTATGCAACATGCGATTCAAACAGCGTTAGGTGGTTATC
AAAGCATTAATGAGCTTCTGCTTCCTGGCGGTCGTCTATTAGAGCAGCGTGATAAAGCGTATGATCTTATTACACAAATT
CCGGGTGTAAGTTGTGTGAAACCAAAAGGCGCAATGTATCTGTTCCCTAAACTTGATCCTAAGATGTACAAGATTAAAGA
TGATCAGAAGTTTGTGCTGGATTTCTTAATCAAAGAGAAGGTTCTACTAGTTCAAGGAACTGGCTTTAACTGGCCAACAC
CTGATCATTTCCGTATCGTGACATTACCACGAGTTGATGATCTAGAGACTGCGATTGGTCGCCTAGAGCGCTTCCTACAC
ACTTACAAACAATAA

Upstream 100 bases:

>100_bases
AAGATGTTTTTACATGATTTTTTTCTAAAAATTGGTTCTCAGCCTATTAGAAATAGTGTAATTTGAATCTATATCGTTTT
TATATCATCAGGGTTTCACC

Downstream 100 bases:

>100_bases
ATTGTTCTTGTTATAAAAATTCAAAAGCCTGCTCACTTGCAGGCTTTTTTATACTCACTAATCTTCAGACCACACATCTC
GAATTGCAGGCCACCCCCAC

Product: aminotransferase AlaT

Products: oxaloacetate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MQNIGMSSKLSSVCYDIRGPVLKHAKRMEEEGHKILKLNIGNPAPFGFDAPDEILVDVIKNLPTSQGYCDSKGIYSARKA
VVQHYQRRGLLDLDVEDVYIGNGASELIVMAMQALLNNGDEMLVPAPDYPLWTAAVSLSGGKPVHYMCDEGADWYPDLDD
IKKKITPNTKGIVLINPNNPTGAVYSRDFLLQVVEIARQNNLIIFADEIYDKVLYDGAVHTTLATLAPDILTVTFNGLSK
AYRVCGFRGGWMFLNGPKDHAQGYIAGLDMLASMRLCANVPMQHAIQTALGGYQSINELLLPGGRLLEQRDKAYDLITQI
PGVSCVKPKGAMYLFPKLDPKMYKIKDDQKFVLDFLIKEKVLLVQGTGFNWPTPDHFRIVTLPRVDDLETAIGRLERFLH
TYKQ

Sequences:

>Translated_404_residues
MQNIGMSSKLSSVCYDIRGPVLKHAKRMEEEGHKILKLNIGNPAPFGFDAPDEILVDVIKNLPTSQGYCDSKGIYSARKA
VVQHYQRRGLLDLDVEDVYIGNGASELIVMAMQALLNNGDEMLVPAPDYPLWTAAVSLSGGKPVHYMCDEGADWYPDLDD
IKKKITPNTKGIVLINPNNPTGAVYSRDFLLQVVEIARQNNLIIFADEIYDKVLYDGAVHTTLATLAPDILTVTFNGLSK
AYRVCGFRGGWMFLNGPKDHAQGYIAGLDMLASMRLCANVPMQHAIQTALGGYQSINELLLPGGRLLEQRDKAYDLITQI
PGVSCVKPKGAMYLFPKLDPKMYKIKDDQKFVLDFLIKEKVLLVQGTGFNWPTPDHFRIVTLPRVDDLETAIGRLERFLH
TYKQ
>Mature_404_residues
MQNIGMSSKLSSVCYDIRGPVLKHAKRMEEEGHKILKLNIGNPAPFGFDAPDEILVDVIKNLPTSQGYCDSKGIYSARKA
VVQHYQRRGLLDLDVEDVYIGNGASELIVMAMQALLNNGDEMLVPAPDYPLWTAAVSLSGGKPVHYMCDEGADWYPDLDD
IKKKITPNTKGIVLINPNNPTGAVYSRDFLLQVVEIARQNNLIIFADEIYDKVLYDGAVHTTLATLAPDILTVTFNGLSK
AYRVCGFRGGWMFLNGPKDHAQGYIAGLDMLASMRLCANVPMQHAIQTALGGYQSINELLLPGGRLLEQRDKAYDLITQI
PGVSCVKPKGAMYLFPKLDPKMYKIKDDQKFVLDFLIKEKVLLVQGTGFNWPTPDHFRIVTLPRVDDLETAIGRLERFLH
TYKQ

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI19263340, Length=465, Percent_Identity=25.3763440860215, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI215599424, Length=368, Percent_Identity=27.445652173913, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI4507369, Length=377, Percent_Identity=28.1167108753316, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI4885351, Length=451, Percent_Identity=25.2771618625277, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI95147551, Length=183, Percent_Identity=29.5081967213115, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI169881279, Length=183, Percent_Identity=29.5081967213115, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI56713254, Length=282, Percent_Identity=24.822695035461, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI56713256, Length=282, Percent_Identity=24.822695035461, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI169881281, Length=156, Percent_Identity=28.8461538461538, Blast_Score=76, Evalue=7e-14,
Organism=Escherichia coli, GI1788627, Length=404, Percent_Identity=76.2376237623762, Blast_Score=670, Evalue=0.0,
Organism=Escherichia coli, GI1788722, Length=380, Percent_Identity=27.8947368421053, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1786816, Length=232, Percent_Identity=23.7068965517241, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17567663, Length=372, Percent_Identity=29.8387096774194, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71981209, Length=469, Percent_Identity=26.4392324093817, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71981215, Length=297, Percent_Identity=28.2828282828283, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71994472, Length=172, Percent_Identity=34.3023255813954, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71994476, Length=172, Percent_Identity=34.3023255813954, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17567369, Length=165, Percent_Identity=29.0909090909091, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323118, Length=362, Percent_Identity=26.7955801104972, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320317, Length=362, Percent_Identity=28.4530386740331, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322401, Length=352, Percent_Identity=26.9886363636364, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI18859735, Length=374, Percent_Identity=27.2727272727273, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI45551451, Length=468, Percent_Identity=25.4273504273504, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24641770, Length=468, Percent_Identity=25.4273504273504, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24641760, Length=468, Percent_Identity=25.4273504273504, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24641768, Length=468, Percent_Identity=25.4273504273504, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24641766, Length=468, Percent_Identity=25.4273504273504, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24641764, Length=468, Percent_Identity=25.4273504273504, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI28573069, Length=267, Percent_Identity=26.2172284644195, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646114, Length=267, Percent_Identity=26.2172284644195, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28573067, Length=267, Percent_Identity=26.2172284644195, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28573065, Length=267, Percent_Identity=26.2172284644195, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.1

Molecular weight: Translated: 45006; Mature: 45006

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNIGMSSKLSSVCYDIRGPVLKHAKRMEEEGHKILKLNIGNPAPFGFDAPDEILVDVIK
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHH
NLPTSQGYCDSKGIYSARKAVVQHYQRRGLLDLDVEDVYIGNGASELIVMAMQALLNNGD
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCEEEECCCHHHHHHHHHHHHHCCCC
EMLVPAPDYPLWTAAVSLSGGKPVHYMCDEGADWYPDLDDIKKKITPNTKGIVLINPNNP
EEEEECCCCCEEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEECCCCC
TGAVYSRDFLLQVVEIARQNNLIIFADEIYDKVLYDGAVHTTLATLAPDILTVTFNGLSK
CCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCHHHHHHHHHCCCEEEEEEHHHHH
AYRVCGFRGGWMFLNGPKDHAQGYIAGLDMLASMRLCANVPMQHAIQTALGGYQSINELL
HHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHH
LPGGRLLEQRDKAYDLITQIPGVSCVKPKGAMYLFPKLDPKMYKIKDDQKFVLDFLIKEK
CCCHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCEEEECCCHHHHHHHHHHCC
VLLVQGTGFNWPTPDHFRIVTLPRVDDLETAIGRLERFLHTYKQ
EEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQNIGMSSKLSSVCYDIRGPVLKHAKRMEEEGHKILKLNIGNPAPFGFDAPDEILVDVIK
CCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHHHHHHH
NLPTSQGYCDSKGIYSARKAVVQHYQRRGLLDLDVEDVYIGNGASELIVMAMQALLNNGD
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEECCCCEEEECCCHHHHHHHHHHHHHCCCC
EMLVPAPDYPLWTAAVSLSGGKPVHYMCDEGADWYPDLDDIKKKITPNTKGIVLINPNNP
EEEEECCCCCEEEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEECCCCC
TGAVYSRDFLLQVVEIARQNNLIIFADEIYDKVLYDGAVHTTLATLAPDILTVTFNGLSK
CCCHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHCCHHHHHHHHHCCCEEEEEEHHHHH
AYRVCGFRGGWMFLNGPKDHAQGYIAGLDMLASMRLCANVPMQHAIQTALGGYQSINELL
HHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHH
LPGGRLLEQRDKAYDLITQIPGVSCVKPKGAMYLFPKLDPKMYKIKDDQKFVLDFLIKEK
CCCHHHHHHHHHHHHHHHHCCCCEEECCCCCEEEEECCCCCEEEECCCHHHHHHHHHHCC
VLLVQGTGFNWPTPDHFRIVTLPRVDDLETAIGRLERFLHTYKQ
EEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate; 2-oxoglutarate

Specific reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]