| Definition | Vibrio fischeri ES114 chromosome I, complete genome. |
|---|---|
| Accession | NC_006840 |
| Length | 2,897,536 |
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The map label for this gene is menD [H]
Identifier: 59712278
GI number: 59712278
Start: 1879842
End: 1881575
Strand: Reverse
Name: menD [H]
Synonym: VF_1671
Alternate gene names: 59712278
Gene position: 1881575-1879842 (Counterclockwise)
Preceding gene: 59712279
Following gene: 59712277
Centisome position: 64.94
GC content: 41.46
Gene sequence:
>1734_bases ATGATGCAACCTGAGCAGCAAGTAATGCTAAATCAAGTTTGGGCTGAGTTAATTATTGAGGAGTTAGTTCGAAATGGAGT AAAGCATATTTGCATCGCTCCGGGCTCGCGTTCAACCCCACTAACTCTTGCCGCTTCTGAACATGCTCTTTTATCCATCC ATACCCATTTTGATGAGCGTGGCTTGGGCTTCTTAGCTTTAGGTATTGCTAAAGCATCCAATGATCCTGTTGCTGTTATT GTCACTTCAGGTACTGCAGTCGCTAATTTATTGCCATCAGTTGCTGAATCAGGATTAACCAAAGAAAAACTCGTCTTACT TACTGCAGATCGCCCTGTTGAATTGATTAATTGTGGAGCGAACCAAGCAATTAATCAGCAGGGTATTTTTTCGTCACACG TTTGCCATTCGCTTCAATTGCCTTCTCCAAGTCAAAACGTGCCGGCACAGTGGTTATTAAGCCGTCTTGATCAAGCGTGC TTTGTTCAACAAGAGCAGGGTGGCGCTATCCATATTAATTGCCCTTTCCCTGAGCCGTTTTATGGCAAAAAAGACGATAG CCTTCTTGTTGATTATTTAGCACCAATTCAGAACTGGAAAGCGGATACTTCTTCTTATATACAACAAACACCTTACTTTT CTCATGTAACGTTATCACCTAACTGGATGCAAACGGCACGTAAGAAAGGGGTTGTTATTATCGGTAAAGTCTCTTTAGAA GAAGCAAATTGCGCAGCACAGTTAGCAAAAGAACTTGGTTGGCCAGTATTGGCAGATCCACAATCAGGTTATTATTCAGA GTGGGCACATTACGATTTGTGGCTACAAAATAGTGCGTGTTTTGAGTTGTTATCCGAAGTTGAGTGCGTTTTGCAATTTG GTGCTCGATTAGTATCAAAACGTTTGGGTGCATGGTTGAAAAACTACCAACAGGCCTATTATTTAATAGATCCTCATAGT GAGTTATTAAACGAAAGTTGTCATGCACATGTTCGTTATCGTGCTGATATTTCAACTTGGTGCCAAACACACGCAGACAG CCTTGCTGATAGAGATTGTGTATTTGACCATGCGCCATCTGTTCATTGGAGTGAATCTCTTAAAGTGGCATCACAAAATG CATTGGCGCTGGCTCGTTCTATGGCGTGCAATAGCGAAACATTATCTGAATTAAGCTTTGCGCTTACCGTAGGCCAAAAA GCCAATGATTGCGATTGGTTTGTTGGTAACAGCTTGATAGTTCGCTTATTAGACATGACCGGTGAGCTTAATCAAAAAAA TGTATATACCAATCGTGGCGCTTCAGGTATTGATGGTTTAGTGGCTACAGCCGTTGGGGTTCAGTTAGCTAATGATAAAC CGTTACTCGCTTTAGTTGGGGATACGTCATTACTTTATGATTTGAATTCTTTAGCGTTATTAAAGCAAGCGACGCAACCT ATGGTTGTTGTGGTGATGAATAACGATGGCGGTGGTATTTTTGATTTATTACCCGTGAATGAAAAAAAGAAAGATGATTT CTATCGTATGCCTCATCAGCTAGAGTTCAGCCATGCTGCTGCGATGTTTGGTTTGTCCTACCATAGGCCAGAAACTCTAA GCTGTGCCATGTCAATGATTAACGATGGCTTAGAAAAGGGTATTCATTTAATTGAGATCAATACACCAGCAGGTCAATCT GGTGAAGAGCTAACACGTCTTTTTCAGACCATTCAGCATGCCGCTTTATTCTAA
Upstream 100 bases:
>100_bases GCAGTGAATGGGACGAGTTAGATAGAAAAACCTCTACTTTATGTACCTTATTAGAATCTGATACTAATGTGAGTTCAGAT ATCACGGAGTCGCAAGTCGC
Downstream 100 bases:
>100_bases TCAATTGGAAACCATGAAAAATACCACTCAACCTTGCGTGGTATTTTTACATGGATTGTTAGGATCAACGAAAGACTGGT CAAGCATTGCTGCAAAGGTT
Product: 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase
Products: NA
Alternate protein names: SEPHCHC synthase; Menaquinone biosynthesis protein menD [H]
Number of amino acids: Translated: 577; Mature: 577
Protein sequence:
>577_residues MMQPEQQVMLNQVWAELIIEELVRNGVKHICIAPGSRSTPLTLAASEHALLSIHTHFDERGLGFLALGIAKASNDPVAVI VTSGTAVANLLPSVAESGLTKEKLVLLTADRPVELINCGANQAINQQGIFSSHVCHSLQLPSPSQNVPAQWLLSRLDQAC FVQQEQGGAIHINCPFPEPFYGKKDDSLLVDYLAPIQNWKADTSSYIQQTPYFSHVTLSPNWMQTARKKGVVIIGKVSLE EANCAAQLAKELGWPVLADPQSGYYSEWAHYDLWLQNSACFELLSEVECVLQFGARLVSKRLGAWLKNYQQAYYLIDPHS ELLNESCHAHVRYRADISTWCQTHADSLADRDCVFDHAPSVHWSESLKVASQNALALARSMACNSETLSELSFALTVGQK ANDCDWFVGNSLIVRLLDMTGELNQKNVYTNRGASGIDGLVATAVGVQLANDKPLLALVGDTSLLYDLNSLALLKQATQP MVVVVMNNDGGGIFDLLPVNEKKKDDFYRMPHQLEFSHAAAMFGLSYHRPETLSCAMSMINDGLEKGIHLIEINTPAGQS GEELTRLFQTIQHAALF
Sequences:
>Translated_577_residues MMQPEQQVMLNQVWAELIIEELVRNGVKHICIAPGSRSTPLTLAASEHALLSIHTHFDERGLGFLALGIAKASNDPVAVI VTSGTAVANLLPSVAESGLTKEKLVLLTADRPVELINCGANQAINQQGIFSSHVCHSLQLPSPSQNVPAQWLLSRLDQAC FVQQEQGGAIHINCPFPEPFYGKKDDSLLVDYLAPIQNWKADTSSYIQQTPYFSHVTLSPNWMQTARKKGVVIIGKVSLE EANCAAQLAKELGWPVLADPQSGYYSEWAHYDLWLQNSACFELLSEVECVLQFGARLVSKRLGAWLKNYQQAYYLIDPHS ELLNESCHAHVRYRADISTWCQTHADSLADRDCVFDHAPSVHWSESLKVASQNALALARSMACNSETLSELSFALTVGQK ANDCDWFVGNSLIVRLLDMTGELNQKNVYTNRGASGIDGLVATAVGVQLANDKPLLALVGDTSLLYDLNSLALLKQATQP MVVVVMNNDGGGIFDLLPVNEKKKDDFYRMPHQLEFSHAAAMFGLSYHRPETLSCAMSMINDGLEKGIHLIEINTPAGQS GEELTRLFQTIQHAALF >Mature_577_residues MMQPEQQVMLNQVWAELIIEELVRNGVKHICIAPGSRSTPLTLAASEHALLSIHTHFDERGLGFLALGIAKASNDPVAVI VTSGTAVANLLPSVAESGLTKEKLVLLTADRPVELINCGANQAINQQGIFSSHVCHSLQLPSPSQNVPAQWLLSRLDQAC FVQQEQGGAIHINCPFPEPFYGKKDDSLLVDYLAPIQNWKADTSSYIQQTPYFSHVTLSPNWMQTARKKGVVIIGKVSLE EANCAAQLAKELGWPVLADPQSGYYSEWAHYDLWLQNSACFELLSEVECVLQFGARLVSKRLGAWLKNYQQAYYLIDPHS ELLNESCHAHVRYRADISTWCQTHADSLADRDCVFDHAPSVHWSESLKVASQNALALARSMACNSETLSELSFALTVGQK ANDCDWFVGNSLIVRLLDMTGELNQKNVYTNRGASGIDGLVATAVGVQLANDKPLLALVGDTSLLYDLNSLALLKQATQP MVVVVMNNDGGGIFDLLPVNEKKKDDFYRMPHQLEFSHAAAMFGLSYHRPETLSCAMSMINDGLEKGIHLIEINTPAGQS GEELTRLFQTIQHAALF
Specific function: Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-ca
COG id: COG1165
COG function: function code H; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the TPP enzyme family. MenD subfamily [H]
Homologues:
Organism=Escherichia coli, GI1788599, Length=531, Percent_Identity=45.7627118644068, Blast_Score=450, Evalue=1e-127,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004433 - InterPro: IPR012001 - InterPro: IPR011766 [H]
Pfam domain/function: PF02775 TPP_enzyme_C; PF02776 TPP_enzyme_N [H]
EC number: =2.2.1.9 [H]
Molecular weight: Translated: 63438; Mature: 63438
Theoretical pI: Translated: 5.51; Mature: 5.51
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.4 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 4.5 %Cys+Met (Translated Protein) 2.4 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 4.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MMQPEQQVMLNQVWAELIIEELVRNGVKHICIAPGSRSTPLTLAASEHALLSIHTHFDER CCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCEEEEEEECCCCC GLGFLALGIAKASNDPVAVIVTSGTAVANLLPSVAESGLTKEKLVLLTADRPVELINCGA CCCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCC NQAINQQGIFSSHVCHSLQLPSPSQNVPAQWLLSRLDQACFVQQEQGGAIHINCPFPEPF CCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCEEEEECCCCCCC YGKKDDSLLVDYLAPIQNWKADTSSYIQQTPYFSHVTLSPNWMQTARKKGVVIIGKVSLE CCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEECCHHHHHHHHCCEEEEEEEECC EANCAAQLAKELGWPVLADPQSGYYSEWAHYDLWLQNSACFELLSEVECVLQFGARLVSK HHHHHHHHHHHCCCCEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH RLGAWLKNYQQAYYLIDPHSELLNESCHAHVRYRADISTWCQTHADSLADRDCVFDHAPS HHHHHHHHHCCEEEEECCHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCC VHWSESLKVASQNALALARSMACNSETLSELSFALTVGQKANDCDWFVGNSLIVRLLDMT CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCCCCCEECCCHHHHHHHHHC GELNQKNVYTNRGASGIDGLVATAVGVQLANDKPLLALVGDTSLLYDLNSLALLKQATQP CCCCCCCEECCCCCCCHHHHHHHHHCEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCCC MVVVVMNNDGGGIFDLLPVNEKKKDDFYRMPHQLEFSHAAAMFGLSYHRPETLSCAMSMI EEEEEEECCCCCEEEEECCCCCCCCHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHH NDGLEKGIHLIEINTPAGQSGEELTRLFQTIQHAALF HHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCC >Mature Secondary Structure MMQPEQQVMLNQVWAELIIEELVRNGVKHICIAPGSRSTPLTLAASEHALLSIHTHFDER CCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCEEEEECCCEEEEEEECCCCC GLGFLALGIAKASNDPVAVIVTSGTAVANLLPSVAESGLTKEKLVLLTADRPVELINCGA CCCEEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEECCC NQAINQQGIFSSHVCHSLQLPSPSQNVPAQWLLSRLDQACFVQQEQGGAIHINCPFPEPF CCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHEEEECCCCEEEEECCCCCCC YGKKDDSLLVDYLAPIQNWKADTSSYIQQTPYFSHVTLSPNWMQTARKKGVVIIGKVSLE CCCCCCCHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEECCHHHHHHHHCCEEEEEEEECC EANCAAQLAKELGWPVLADPQSGYYSEWAHYDLWLQNSACFELLSEVECVLQFGARLVSK HHHHHHHHHHHCCCCEEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH RLGAWLKNYQQAYYLIDPHSELLNESCHAHVRYRADISTWCQTHADSLADRDCVFDHAPS HHHHHHHHHCCEEEEECCHHHHHCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCCCCC VHWSESLKVASQNALALARSMACNSETLSELSFALTVGQKANDCDWFVGNSLIVRLLDMT CCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCCCCCEECCCHHHHHHHHHC GELNQKNVYTNRGASGIDGLVATAVGVQLANDKPLLALVGDTSLLYDLNSLALLKQATQP CCCCCCCEECCCCCCCHHHHHHHHHCEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCCC MVVVVMNNDGGGIFDLLPVNEKKKDDFYRMPHQLEFSHAAAMFGLSYHRPETLSCAMSMI EEEEEEECCCCCEEEEECCCCCCCCHHHCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHH NDGLEKGIHLIEINTPAGQSGEELTRLFQTIQHAALF HHHHHCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA