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The map label for this gene is cah [H]

Identifier: 59712258

GI number: 59712258

Start: 1860145

End: 1860852

Strand: Direct

Name: cah [H]

Synonym: VF_1651

Alternate gene names: 59712258

Gene position: 1860145-1860852 (Clockwise)

Preceding gene: 59712257

Following gene: 59712259

Centisome position: 64.2

GC content: 39.97

Gene sequence:

>708_bases
ATGAAAAAATTATTTACTACATTAGCTGTTCTAAGCGCTCTTTCAGCAACGCCATTCGCTTCTGCATCAGAATGGGGTTA
TACAGGAGATACAGGCCCTAACCACTGGCATGGCGTTTGCCAAACAGGCGTAAACCAATCTCCAATTGACATTACCAATG
CCATTGAGAGCGAATTAGAGCCGATTACGTTTAATTATGGTCAGGCTGGTGAAAACATCGTTAATAATGGCCATACGGTG
CAGGTAAACATAAAAAGCCCACAATCAATTCAAGTTGAAGGTAAGACATTTAGCCTACTGCAACTGCACTTCCATGCTCC
AAGTGAGAATTTAATTGCAGGACACTCATATCCGTTAGAGATGCACTTAGTTCATGCTGATAAAGATGGAAACTTAGCCG
TTGTTGGTGTGATGTTTAAAGAAGGCAAAGCAAATCCAGAACTTGCTAAAATCTGGTCGCAAATGCCTGGATCAGGAGAA
GTCACTCTTGATAAGAAATTAACACTAACGAACTTATTACCAAATGATCAAGCCTACTATCGTTTTAATGGCTCATTAAC
GACACCACCTTGTTCTGAAGGAGTAACTTGGCTAGTAATGAAAAATCCTATTGAGATTTCATCTGAACAATTAGCTCAAT
TTAGAGAACTCTACAACGGTAATAACCGTCCAACCCAGGCTATTAATGCTCGCCCTATCTTAAAATGA

Upstream 100 bases:

>100_bases
AGAAGCAGGTTGCGAAACTTCATTCAAACCATTATTAACCAAGGTACATTTGTATTAGCCTAAACTCGATTTTATAAAAT
AATAAGGCTAGATAAATACC

Downstream 100 bases:

>100_bases
TAACGAAAATGCCGTAAATCCACACAAAATGCTCGAATTTACGGCAAACAGTACTTAATTTTAAAAGAGTGCTTTACATG
AAGGTGGGGAACGCCTATTA

Product: A-type carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MKKLFTTLAVLSALSATPFASASEWGYTGDTGPNHWHGVCQTGVNQSPIDITNAIESELEPITFNYGQAGENIVNNGHTV
QVNIKSPQSIQVEGKTFSLLQLHFHAPSENLIAGHSYPLEMHLVHADKDGNLAVVGVMFKEGKANPELAKIWSQMPGSGE
VTLDKKLTLTNLLPNDQAYYRFNGSLTTPPCSEGVTWLVMKNPIEISSEQLAQFRELYNGNNRPTQAINARPILK

Sequences:

>Translated_235_residues
MKKLFTTLAVLSALSATPFASASEWGYTGDTGPNHWHGVCQTGVNQSPIDITNAIESELEPITFNYGQAGENIVNNGHTV
QVNIKSPQSIQVEGKTFSLLQLHFHAPSENLIAGHSYPLEMHLVHADKDGNLAVVGVMFKEGKANPELAKIWSQMPGSGE
VTLDKKLTLTNLLPNDQAYYRFNGSLTTPPCSEGVTWLVMKNPIEISSEQLAQFRELYNGNNRPTQAINARPILK
>Mature_235_residues
MKKLFTTLAVLSALSATPFASASEWGYTGDTGPNHWHGVCQTGVNQSPIDITNAIESELEPITFNYGQAGENIVNNGHTV
QVNIKSPQSIQVEGKTFSLLQLHFHAPSENLIAGHSYPLEMHLVHADKDGNLAVVGVMFKEGKANPELAKIWSQMPGSGE
VTLDKKLTLTNLLPNDQAYYRFNGSLTTPPCSEGVTWLVMKNPIEISSEQLAQFRELYNGNNRPTQAINARPILK

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI258679498, Length=258, Percent_Identity=34.8837209302326, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI192447434, Length=258, Percent_Identity=34.8837209302326, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI192447432, Length=258, Percent_Identity=34.8837209302326, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI192447430, Length=258, Percent_Identity=34.8837209302326, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4502517, Length=258, Percent_Identity=34.8837209302326, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4557395, Length=245, Percent_Identity=37.1428571428571, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI4885101, Length=253, Percent_Identity=33.9920948616601, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI38348436, Length=252, Percent_Identity=32.5396825396825, Blast_Score=115, Evalue=2e-26,
Organism=Homo sapiens, GI45935383, Length=238, Percent_Identity=33.6134453781513, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI4502515, Length=238, Percent_Identity=33.6134453781513, Blast_Score=114, Evalue=7e-26,
Organism=Homo sapiens, GI4885099, Length=253, Percent_Identity=32.0158102766798, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI6005723, Length=224, Percent_Identity=31.6964285714286, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI169636420, Length=251, Percent_Identity=30.6772908366534, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI62240989, Length=200, Percent_Identity=33, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI4502521, Length=224, Percent_Identity=30.3571428571429, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI194097398, Length=261, Percent_Identity=29.1187739463602, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4502519, Length=246, Percent_Identity=28.8617886178862, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI22027500, Length=241, Percent_Identity=29.045643153527, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI70167127, Length=257, Percent_Identity=30.3501945525292, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI6912284, Length=256, Percent_Identity=30.078125, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI91208428, Length=231, Percent_Identity=29.8701298701299, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI130979954, Length=239, Percent_Identity=23.8493723849372, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI130979679, Length=239, Percent_Identity=23.8493723849372, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI9910366, Length=239, Percent_Identity=23.8493723849372, Blast_Score=73, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17568715, Length=242, Percent_Identity=35.5371900826446, Blast_Score=120, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71995280, Length=252, Percent_Identity=35.7142857142857, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17569163, Length=224, Percent_Identity=27.6785714285714, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17569165, Length=224, Percent_Identity=27.6785714285714, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17737413, Length=228, Percent_Identity=35.9649122807018, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21358169, Length=284, Percent_Identity=32.3943661971831, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24645604, Length=265, Percent_Identity=29.0566037735849, Blast_Score=107, Evalue=5e-24,
Organism=Drosophila melanogaster, GI161079354, Length=257, Percent_Identity=31.1284046692607, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI20130189, Length=250, Percent_Identity=28.8, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI161079350, Length=260, Percent_Identity=30, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24650523, Length=255, Percent_Identity=30.5882352941176, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221329761, Length=279, Percent_Identity=24.7311827956989, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24649809, Length=279, Percent_Identity=27.9569892473118, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI18858185, Length=264, Percent_Identity=25.7575757575758, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI116008410, Length=235, Percent_Identity=31.063829787234, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 25727; Mature: 25727

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00162 ALPHA_CA_1 ; PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLFTTLAVLSALSATPFASASEWGYTGDTGPNHWHGVCQTGVNQSPIDITNAIESELE
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHCCC
PITFNYGQAGENIVNNGHTVQVNIKSPQSIQVEGKTFSLLQLHFHAPSENLIAGHSYPLE
CEEEECCCCCCHHHCCCCEEEEEECCCCEEEECCCEEEEEEEEEECCCCCEEECCCCCEE
MHLVHADKDGNLAVVGVMFKEGKANPELAKIWSQMPGSGEVTLDKKLTLTNLLPNDQAYY
EEEEEECCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCEEECCEEEEEECCCCCCEEE
RFNGSLTTPPCSEGVTWLVMKNPIEISSEQLAQFRELYNGNNRPTQAINARPILK
EECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKKLFTTLAVLSALSATPFASASEWGYTGDTGPNHWHGVCQTGVNQSPIDITNAIESELE
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHCCC
PITFNYGQAGENIVNNGHTVQVNIKSPQSIQVEGKTFSLLQLHFHAPSENLIAGHSYPLE
CEEEECCCCCCHHHCCCCEEEEEECCCCEEEECCCEEEEEEEEEECCCCCEEECCCCCEE
MHLVHADKDGNLAVVGVMFKEGKANPELAKIWSQMPGSGEVTLDKKLTLTNLLPNDQAYY
EEEEEECCCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCEEECCEEEEEECCCCCCEEE
RFNGSLTTPPCSEGVTWLVMKNPIEISSEQLAQFRELYNGNNRPTQAINARPILK
EECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9811652 [H]