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The map label for this gene is asd [H]

Identifier: 59712252

GI number: 59712252

Start: 1851538

End: 1852653

Strand: Reverse

Name: asd [H]

Synonym: VF_1645

Alternate gene names: 59712252

Gene position: 1852653-1851538 (Counterclockwise)

Preceding gene: 59712254

Following gene: 59712249

Centisome position: 63.94

GC content: 41.76

Gene sequence:

>1116_bases
ATGAGAGTAGGTTTAGTTGGTTGGCGCGGTATGGTTGGTTCTGTATTGATGCAACGTATGGTTGAAGAGCGCGATTTCGA
TCATATCGAACCTGTATTTTACACCACATCGCAAGTTGGGATTCCAGCTCCAAACCTTGGTAAAGATGCAGGGCTATTAC
AAGATGCATTTGATATTCAATCACTATCAAAATTAGATGCCATCATTACGTGTCAGGGTGGCAGTTATACTGAAAAAGTG
TACCCAGCACTTAGACAAGCAGGTTGGAAAGGTTACTGGATTGATGCTGCATCGACATTACGTATGAAAGATGATGCCAT
TATTACCCTTGATCCTGTCAACTTTGAGCAAATTCAGCAAGGCATCCATGCCGGAACCAATACATACGTAGGTGGTAACT
GTACCGTTAGTTTAATGCTAATGGGATTAGGTGGTTTGTATAAAGCGGGTCTAGTTGAATGGATGAGTGCAATGACATAC
CAAGCTGCTTCAGGTGCTGGTGCGAAAAATATGCGTGAGCTGATTTCACAAATGGGCGTGGTTAATGATTGTGTGACTTC
TGAGTTGGCAAATCCTGCGAGTTCAATTTTAGATATTGATAGAAAAGTGGCTGAAACCATTCGTTCTAGTTCTTTTCCTA
CCTCTGAATTTGGTGCTCCATTAGCGGGTTCTTTGATCCCATGGATTGATGTAAAGCGTGAAAATGGTCAAAGTAAAGAA
GAATGGAAAGCAACAGTAGAAACGAACAAGATTCTAGGGCTTGAAAACACTCCTGTACCAATTGATGGTACGTGTGTGCG
TATTGGGGCAATGCGTTGTCACTCGCAAGCATTAACGATTAAGTTAAAGCAAGATGTTCCAATGGATGAAATTGAAGAGA
TCATCGCAACGCATAATGATTGGGTTAAAGTGATCCCTAATGAGCGTGATATTACGGCACAGGAATTAACTCCGGCAAAA
GTAACAGGGACATTATCTGTTCCAGTTGGTCGCTTACGTAAAATGTCGATGGGTAATGAGTTTTTAAATGCCTTTACGGT
TGGTGACCAATTACTATGGGGCGCAGCAGAGCCACTTCGTCGTACCCTACGTATTATTTTGAACGAAAAAAGATAA

Upstream 100 bases:

>100_bases
TTTATTTCAAATCATATAAAAATAGTGCTTGAGATTTTATTCTGTTCATCATATAGATGGAGGAAGCGTATTTATTTTTT
AAGATTACAGGGAGAGTAAA

Downstream 100 bases:

>100_bases
TTTACGGTTAATTATCTAGAATTAAAAAAGGCTTCCCATGAGAATTCAGGGAAGCCTTTTTTGTATTACGTAAATCGAAA
TTAATGCGTTAGTTCACCAC

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MRVGLVGWRGMVGSVLMQRMVEERDFDHIEPVFYTTSQVGIPAPNLGKDAGLLQDAFDIQSLSKLDAIITCQGGSYTEKV
YPALRQAGWKGYWIDAASTLRMKDDAIITLDPVNFEQIQQGIHAGTNTYVGGNCTVSLMLMGLGGLYKAGLVEWMSAMTY
QAASGAGAKNMRELISQMGVVNDCVTSELANPASSILDIDRKVAETIRSSSFPTSEFGAPLAGSLIPWIDVKRENGQSKE
EWKATVETNKILGLENTPVPIDGTCVRIGAMRCHSQALTIKLKQDVPMDEIEEIIATHNDWVKVIPNERDITAQELTPAK
VTGTLSVPVGRLRKMSMGNEFLNAFTVGDQLLWGAAEPLRRTLRIILNEKR

Sequences:

>Translated_371_residues
MRVGLVGWRGMVGSVLMQRMVEERDFDHIEPVFYTTSQVGIPAPNLGKDAGLLQDAFDIQSLSKLDAIITCQGGSYTEKV
YPALRQAGWKGYWIDAASTLRMKDDAIITLDPVNFEQIQQGIHAGTNTYVGGNCTVSLMLMGLGGLYKAGLVEWMSAMTY
QAASGAGAKNMRELISQMGVVNDCVTSELANPASSILDIDRKVAETIRSSSFPTSEFGAPLAGSLIPWIDVKRENGQSKE
EWKATVETNKILGLENTPVPIDGTCVRIGAMRCHSQALTIKLKQDVPMDEIEEIIATHNDWVKVIPNERDITAQELTPAK
VTGTLSVPVGRLRKMSMGNEFLNAFTVGDQLLWGAAEPLRRTLRIILNEKR
>Mature_371_residues
MRVGLVGWRGMVGSVLMQRMVEERDFDHIEPVFYTTSQVGIPAPNLGKDAGLLQDAFDIQSLSKLDAIITCQGGSYTEKV
YPALRQAGWKGYWIDAASTLRMKDDAIITLDPVNFEQIQQGIHAGTNTYVGGNCTVSLMLMGLGGLYKAGLVEWMSAMTY
QAASGAGAKNMRELISQMGVVNDCVTSELANPASSILDIDRKVAETIRSSSFPTSEFGAPLAGSLIPWIDVKRENGQSKE
EWKATVETNKILGLENTPVPIDGTCVRIGAMRCHSQALTIKLKQDVPMDEIEEIIATHNDWVKVIPNERDITAQELTPAK
VTGTLSVPVGRLRKMSMGNEFLNAFTVGDQLLWGAAEPLRRTLRIILNEKR

Specific function: Second step in the common biosynthetic pathway leading from Asp to the cell wall precursor meso-diaminopimelate, to Lys, to Met, to Ile and to Thr. [C]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789841, Length=362, Percent_Identity=66.0220994475138, Blast_Score=514, Evalue=1e-147,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR011534
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 40646; Mature: 40646

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGLVGWRGMVGSVLMQRMVEERDFDHIEPVFYTTSQVGIPAPNLGKDAGLLQDAFDIQ
CCEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHH
SLSKLDAIITCQGGSYTEKVYPALRQAGWKGYWIDAASTLRMKDDAIITLDPVNFEQIQQ
HHHHCCEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCEEEECCCEEEEECCCCHHHHHH
GIHAGTNTYVGGNCTVSLMLMGLGGLYKAGLVEWMSAMTYQAASGAGAKNMRELISQMGV
HHHCCCCCEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCH
VNDCVTSELANPASSILDIDRKVAETIRSSSFPTSEFGAPLAGSLIPWIDVKRENGQSKE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCEEEECCCCCCHH
EWKATVETNKILGLENTPVPIDGTCVRIGAMRCHSQALTIKLKQDVPMDEIEEIIATHND
HHHHHHHCCEEECCCCCCCCCCCCEEEEHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCC
WVKVIPNERDITAQELTPAKVTGTLSVPVGRLRKMSMGNEFLNAFTVGDQLLWGAAEPLR
EEEECCCCCCCCHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RTLRIILNEKR
HHHHHHHCCCC
>Mature Secondary Structure
MRVGLVGWRGMVGSVLMQRMVEERDFDHIEPVFYTTSQVGIPAPNLGKDAGLLQDAFDIQ
CCEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHH
SLSKLDAIITCQGGSYTEKVYPALRQAGWKGYWIDAASTLRMKDDAIITLDPVNFEQIQQ
HHHHCCEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCEEEECCCEEEEECCCCHHHHHH
GIHAGTNTYVGGNCTVSLMLMGLGGLYKAGLVEWMSAMTYQAASGAGAKNMRELISQMGV
HHHCCCCCEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCH
VNDCVTSELANPASSILDIDRKVAETIRSSSFPTSEFGAPLAGSLIPWIDVKRENGQSKE
HHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCEEEECCCCCCHH
EWKATVETNKILGLENTPVPIDGTCVRIGAMRCHSQALTIKLKQDVPMDEIEEIIATHND
HHHHHHHCCEEECCCCCCCCCCCCEEEEHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCC
WVKVIPNERDITAQELTPAKVTGTLSVPVGRLRKMSMGNEFLNAFTVGDQLLWGAAEPLR
EEEECCCCCCCCHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RTLRIILNEKR
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9084174; 10984043 [H]