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The map label for this gene is fadH [H]

Identifier: 59712249

GI number: 59712249

Start: 1846273

End: 1848276

Strand: Reverse

Name: fadH [H]

Synonym: VF_1642

Alternate gene names: 59712249

Gene position: 1848276-1846273 (Counterclockwise)

Preceding gene: 59712252

Following gene: 59712248

Centisome position: 63.79

GC content: 39.32

Gene sequence:

>2004_bases
ATGAGCTACCCACATCTGTTTCAGCCGTTAGATTTAGGATTTACTCAATTAAAAAATCGAGTACTGATGGGCTCCATGCA
TACAGGTCTTGAAGAGAGTAATGATGGATTTAAAAAGTTATCTGCTTTTTATGCCGCAAGAGCAAAAGGTGGTGTTGGGC
TCATTGTCACAGGCGGTTTTGCTCCAAATTTTCGAGGGCGGTTAACTCCATTTAGTGCACAGTTTAGCTCGTCTCGTGCA
GCAGAAAAACATAAAGTGTTAACGCAAGCTGTGCATGATAACGGTGGTAAGATAGCCCTTCAGTTATTGCATGCAGGTCG
CTATGCCATGCATCCACTTGCATTAAGTGCTTCAGACATTAGAGCCCCCATTGGGATGTTTACTCCATCGCAAATGAGTG
AGCGTCAAATTCAAAAAACAATCCGTGATTTTGCCAATAGCGCTTATTTTGCTAAACAGGCAAATTATGATGGTGTTGAA
ATCATGGGATCTGAAGGGTACTTAATTAATCAATTCATCTGTGCCCGTACTAATGTTCGTTATGACAATTGGGGAGGGAG
TTATCAAAATAGAATTCGTTTTCCTCTCGAAATCATTAAAGCCATAAGAGAAAAAGTAGGTGCAGATTTCATTATTATTT
TTCGTTTATCTATGCTTGATTTAGTTGAGCAAGGTAGCACATTTGATGAAGTCGTTGAGCTTGCACAAGAATTAGAAAAA
GCAGGCGTTACTATATTAAATACCGGAATAGGTTGGCATGAAGCTCGTATTCCAACCATCGCCACCCAAGTACCAAGAGC
CGCGTTTAGTTGGGTAACTGAAAAATTAAAAAATAAAGTATCGATACCTTTGGTTACTTGTAATCGAATTAATACGCCAG
AAGTAGCAGAAAATATATTAGCAACAGGTCAGGCTGATATGGTGTCAATGGCTCGTCCATTTTTAGCGGATCCTGAGTTT
GTAAATAAAGCGGAACAAAATAAAACCGAGCTTATCAATACGTGTATCGGATGTAACCAAGCCTGCCTAGATCACGTGTT
TAAGGCGAAAAGAGCGACGTGTTTAGTTAATCCGCAAGCGTGTTATGAAACAGAATTAGTCTTAGAACCAAGTGATAAAA
CGAAATCTATAGGTGTCATTGGTGCAGGAATGGCAGGATTATCTTGTGCGGTTTCATTAGCAGAGAGAGGTTATCAGGTC
ACGGTTTTCGAGCGTAATGAGCGTATTGGTGGTCAATTTAATTTAGCGATGCAAATCCCAGGTAAAGAAGAGTTTAAAGA
GACCATTCGTTATTTTACTAATAAGCTCGATCACCAGAACATTGTCGTGAAGTTAAATTACAGCGTTGAAATGGATGAAT
TACGTCAATTTGATGAAGTGATTGTGGCAACAGGTGTGAAACCAAGAGCTCCTCAATTGGAAGGAAGTGAACATCCTAAA
GTGATTGATTATCAAACTTACATTAAAAACCAACCGACATTAGGGCAAAAAGTAGCAGTGGTTGGTGCTGGTGGTATTGG
TATCGATGTTGCGACAATGATAACTGAACCGGAAAATCAAACATTAGATACTTGGTTGCAAGACTGGGATATTGATAAAA
ATATTGAATTTGAAGGTGGATTAAAGCCCCAAGATACCTATAAACCAACTCGAGAAGTATGGTTAATGCAACGTAAAAAA
GGAAGTATCGGTAAAGGCCCAGGCAAAACAACTGGTTGGATTCATAAGCGCACATTAGAAAAACGTGGCGTGAATATGTT
AGCAGGTGTTGAATACTTAAAGGTGAATGATGATGGTCTTTATATTCGACATAATGAAGAGGTTAAGTTGTTAGATGTCG
ACCATGTCATTATGTGTGCAGGGCAGGTGTCTGTTAATGAGCTAGCTGAAGCATTAACAATAAATGAAATCAATTATCAT
GTTATTGGTGGCGCTGATTATGCAGGTGAACTGGATGCAAAAAGAGCGATTCGTCAAGGAGTAGAGTTGGCTTCAAAGTT
ATAG

Upstream 100 bases:

>100_bases
AGATTTGATGAATGTTGCATAATTGTAAAAAGGCAATTGTAACAAACGTATATTGATACTATTCTGGTCAGACCACAATA
ATTATAAGCGATGGATTGAT

Downstream 100 bases:

>100_bases
CCTCTTAATAAACAAAAACTTGATAACTGTCTATTCATACAGGTATAGTGCTGATGTTATTCACAACATCAGCATTTTTT
ATGTCACGATTATTTATTGC

Product: 2,4-dienoyl-CoA reductase, NADH and FMN-linked

Products: NA

Alternate protein names: 2,4-dienoyl coenzyme A reductase [H]

Number of amino acids: Translated: 667; Mature: 666

Protein sequence:

>667_residues
MSYPHLFQPLDLGFTQLKNRVLMGSMHTGLEESNDGFKKLSAFYAARAKGGVGLIVTGGFAPNFRGRLTPFSAQFSSSRA
AEKHKVLTQAVHDNGGKIALQLLHAGRYAMHPLALSASDIRAPIGMFTPSQMSERQIQKTIRDFANSAYFAKQANYDGVE
IMGSEGYLINQFICARTNVRYDNWGGSYQNRIRFPLEIIKAIREKVGADFIIIFRLSMLDLVEQGSTFDEVVELAQELEK
AGVTILNTGIGWHEARIPTIATQVPRAAFSWVTEKLKNKVSIPLVTCNRINTPEVAENILATGQADMVSMARPFLADPEF
VNKAEQNKTELINTCIGCNQACLDHVFKAKRATCLVNPQACYETELVLEPSDKTKSIGVIGAGMAGLSCAVSLAERGYQV
TVFERNERIGGQFNLAMQIPGKEEFKETIRYFTNKLDHQNIVVKLNYSVEMDELRQFDEVIVATGVKPRAPQLEGSEHPK
VIDYQTYIKNQPTLGQKVAVVGAGGIGIDVATMITEPENQTLDTWLQDWDIDKNIEFEGGLKPQDTYKPTREVWLMQRKK
GSIGKGPGKTTGWIHKRTLEKRGVNMLAGVEYLKVNDDGLYIRHNEEVKLLDVDHVIMCAGQVSVNELAEALTINEINYH
VIGGADYAGELDAKRAIRQGVELASKL

Sequences:

>Translated_667_residues
MSYPHLFQPLDLGFTQLKNRVLMGSMHTGLEESNDGFKKLSAFYAARAKGGVGLIVTGGFAPNFRGRLTPFSAQFSSSRA
AEKHKVLTQAVHDNGGKIALQLLHAGRYAMHPLALSASDIRAPIGMFTPSQMSERQIQKTIRDFANSAYFAKQANYDGVE
IMGSEGYLINQFICARTNVRYDNWGGSYQNRIRFPLEIIKAIREKVGADFIIIFRLSMLDLVEQGSTFDEVVELAQELEK
AGVTILNTGIGWHEARIPTIATQVPRAAFSWVTEKLKNKVSIPLVTCNRINTPEVAENILATGQADMVSMARPFLADPEF
VNKAEQNKTELINTCIGCNQACLDHVFKAKRATCLVNPQACYETELVLEPSDKTKSIGVIGAGMAGLSCAVSLAERGYQV
TVFERNERIGGQFNLAMQIPGKEEFKETIRYFTNKLDHQNIVVKLNYSVEMDELRQFDEVIVATGVKPRAPQLEGSEHPK
VIDYQTYIKNQPTLGQKVAVVGAGGIGIDVATMITEPENQTLDTWLQDWDIDKNIEFEGGLKPQDTYKPTREVWLMQRKK
GSIGKGPGKTTGWIHKRTLEKRGVNMLAGVEYLKVNDDGLYIRHNEEVKLLDVDHVIMCAGQVSVNELAEALTINEINYH
VIGGADYAGELDAKRAIRQGVELASKL
>Mature_666_residues
SYPHLFQPLDLGFTQLKNRVLMGSMHTGLEESNDGFKKLSAFYAARAKGGVGLIVTGGFAPNFRGRLTPFSAQFSSSRAA
EKHKVLTQAVHDNGGKIALQLLHAGRYAMHPLALSASDIRAPIGMFTPSQMSERQIQKTIRDFANSAYFAKQANYDGVEI
MGSEGYLINQFICARTNVRYDNWGGSYQNRIRFPLEIIKAIREKVGADFIIIFRLSMLDLVEQGSTFDEVVELAQELEKA
GVTILNTGIGWHEARIPTIATQVPRAAFSWVTEKLKNKVSIPLVTCNRINTPEVAENILATGQADMVSMARPFLADPEFV
NKAEQNKTELINTCIGCNQACLDHVFKAKRATCLVNPQACYETELVLEPSDKTKSIGVIGAGMAGLSCAVSLAERGYQVT
VFERNERIGGQFNLAMQIPGKEEFKETIRYFTNKLDHQNIVVKLNYSVEMDELRQFDEVIVATGVKPRAPQLEGSEHPKV
IDYQTYIKNQPTLGQKVAVVGAGGIGIDVATMITEPENQTLDTWLQDWDIDKNIEFEGGLKPQDTYKPTREVWLMQRKKG
SIGKGPGKTTGWIHKRTLEKRGVNMLAGVEYLKVNDDGLYIRHNEEVKLLDVDHVIMCAGQVSVNELAEALTINEINYHV
IGGADYAGELDAKRAIRQGVELASKL

Specific function: Catalyzes the NADP-dependent reduction of 2,4-dienoyl- CoA to yield trans-2- enoyl-CoA [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789463, Length=672, Percent_Identity=54.1666666666667, Blast_Score=772, Evalue=0.0,
Organism=Escherichia coli, GI1787939, Length=360, Percent_Identity=27.2222222222222, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17565138, Length=261, Percent_Identity=27.9693486590038, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559802, Length=271, Percent_Identity=29.1512915129151, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17559804, Length=274, Percent_Identity=28.1021897810219, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17564188, Length=247, Percent_Identity=27.9352226720648, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17566914, Length=296, Percent_Identity=26.6891891891892, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17540738, Length=254, Percent_Identity=27.5590551181102, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI72001454, Length=296, Percent_Identity=25.3378378378378, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6325086, Length=235, Percent_Identity=29.3617021276596, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321973, Length=237, Percent_Identity=27.8481012658228, Blast_Score=78, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR001155 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF07992 Pyr_redox_2 [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 73966; Mature: 73834

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYPHLFQPLDLGFTQLKNRVLMGSMHTGLEESNDGFKKLSAFYAARAKGGVGLIVTGGF
CCCCCCCCCHHCCHHHHHCEEEECHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCC
APNFRGRLTPFSAQFSSSRAAEKHKVLTQAVHDNGGKIALQLLHAGRYAMHPLALSASDI
CCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCEEECHHHH
RAPIGMFTPSQMSERQIQKTIRDFANSAYFAKQANYDGVEIMGSEGYLINQFICARTNVR
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCEEHHHHHHHCCCE
YDNWGGSYQNRIRFPLEIIKAIREKVGADFIIIFRLSMLDLVEQGSTFDEVVELAQELEK
ECCCCCCCCCCEECHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHH
AGVTILNTGIGWHEARIPTIATQVPRAAFSWVTEKLKNKVSIPLVTCNRINTPEVAENIL
CCCEEEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
ATGQADMVSMARPFLADPEFVNKAEQNKTELINTCIGCNQACLDHVFKAKRATCLVNPQA
HCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCHH
CYETELVLEPSDKTKSIGVIGAGMAGLSCAVSLAERGYQVTVFERNERIGGQFNLAMQIP
HCCEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECC
GKEEFKETIRYFTNKLDHQNIVVKLNYSVEMDELRQFDEVIVATGVKPRAPQLEGSEHPK
CHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VIDYQTYIKNQPTLGQKVAVVGAGGIGIDVATMITEPENQTLDTWLQDWDIDKNIEFEGG
EEEHHHHHCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCC
LKPQDTYKPTREVWLMQRKKGSIGKGPGKTTGWIHKRTLEKRGVNMLAGVEYLKVNDDGL
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCEEEEECCCEE
YIRHNEEVKLLDVDHVIMCAGQVSVNELAEALTINEINYHVIGGADYAGELDAKRAIRQG
EEEECCCEEEEECCEEEEEECCCCHHHHHHHHEEECCEEEEECCCCCCCCHHHHHHHHHH
VELASKL
HHHHHCC
>Mature Secondary Structure 
SYPHLFQPLDLGFTQLKNRVLMGSMHTGLEESNDGFKKLSAFYAARAKGGVGLIVTGGF
CCCCCCCCHHCCHHHHHCEEEECHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCC
APNFRGRLTPFSAQFSSSRAAEKHKVLTQAVHDNGGKIALQLLHAGRYAMHPLALSASDI
CCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHCCEEECHHHH
RAPIGMFTPSQMSERQIQKTIRDFANSAYFAKQANYDGVEIMGSEGYLINQFICARTNVR
CCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCEEHHHHHHHCCCE
YDNWGGSYQNRIRFPLEIIKAIREKVGADFIIIFRLSMLDLVEQGSTFDEVVELAQELEK
ECCCCCCCCCCEECHHHHHHHHHHHHCCCEEEEHHHHHHHHHHCCCCHHHHHHHHHHHHH
AGVTILNTGIGWHEARIPTIATQVPRAAFSWVTEKLKNKVSIPLVTCNRINTPEVAENIL
CCCEEEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHH
ATGQADMVSMARPFLADPEFVNKAEQNKTELINTCIGCNQACLDHVFKAKRATCLVNPQA
HCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEECCHH
CYETELVLEPSDKTKSIGVIGAGMAGLSCAVSLAERGYQVTVFERNERIGGQFNLAMQIP
HCCEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECC
GKEEFKETIRYFTNKLDHQNIVVKLNYSVEMDELRQFDEVIVATGVKPRAPQLEGSEHPK
CHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VIDYQTYIKNQPTLGQKVAVVGAGGIGIDVATMITEPENQTLDTWLQDWDIDKNIEFEGG
EEEHHHHHCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCCCC
LKPQDTYKPTREVWLMQRKKGSIGKGPGKTTGWIHKRTLEKRGVNMLAGVEYLKVNDDGL
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCEEEEECCCEE
YIRHNEEVKLLDVDHVIMCAGQVSVNELAEALTINEINYHVIGGADYAGELDAKRAIRQG
EEEECCCEEEEECCEEEEEECCCCHHHHHHHHEEECCEEEEECCCCCCCCHHHHHHHHHH
VELASKL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9346310; 9278503 [H]