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The map label for this gene is uvrC [H]

Identifier: 59712233

GI number: 59712233

Start: 1826322

End: 1828148

Strand: Reverse

Name: uvrC [H]

Synonym: VF_1626

Alternate gene names: 59712233

Gene position: 1828148-1826322 (Counterclockwise)

Preceding gene: 59712234

Following gene: 59712232

Centisome position: 63.09

GC content: 37.88

Gene sequence:

>1827_bases
GTGCCTTCCTTTGATTCAAAAGCGTTCCTAAAATCTGTAACACATCAGCCTGGCGTTTATCGAATGTATAACGCCGAGGC
TGACGTTATTTATGTAGGTAAAGCAAAAGACTTAAAAAAACGTTTATCCAGTTATTTTCGTAGTAATGTACCTTCGGAAA
AAACTAAGGCGTTAGTTAGCCATATTCATCAAGTTGACGTTACTGTCACTCACTCTGAAACAGAAGCTCTCATCCTTGAA
CACAATTATATTAAGCAATACTTACCTAAATATAATGTGCTTCTTCGAGATGATAAATCGTATCCTTATATTTTCATTTC
ACAACATAAGCATCCAAGGATCTCTATCCACCGTGGTGTGAAACGTAAAAAAGGTGAGTACTTTGGCCCTTATCCTGATT
CTGGAGCCGTTAGAGAAAGTCTTCACCTCATCCAAAAGTTATTCCCTATTCGCCAATGCGAAGATTCGGTATATGCAAAT
CGTCATAGACCATGCTTAATGCACCAAATTGGACGCTGCTTAGCCCCTTGTGTTAAAGGGATTGTTAGTGATGAAGAATA
TAAAGAACAGACTGATTTTATTCGCTTGTTTTTGCAAGGTAAGGATAGGCAAGTTATTCAAACACTGGTCAAACAAATGG
AGTCAGCCAGTCAATCCTTGAATTTTGAAAAAGCAGCGATCATTCGAGATCAAATTCAAGCCATGAGACGAGTGCAGGAG
CAACAATATGTCTCTGATGACAGTGGTGATGATCTTGATGTTTTAGGGTTTGCAATTGAAAATGGCTTGGCGTGTGTTCA
CTTATTGATGATTCGCCAAGGGAAGATTTTAGGTAGTCGCAGTTTTTTCCCGAAGATACCAGCTAACACAGACAAAGAAG
AAGTCTTTTTAAGCTTTCTGACTCAATACTACTTAAATCATACACAGGGTAGAACGATTCCTAATCGAGTGGTCACTAGT
TTTGAATTTAATAGTGAAGATTTAGAAAGAGCACTCACTGAGTTATCTGGGCGAAAAGTTATTTTTCAATTAAATCCTAA
AGGGATAAAAGGGCGTTATTTAAAATTAGCAGATACCAATGCATTAACAGCTTTAACCAGTAAATCAAATCATAAACTCA
CAATGTATCAGCGCTTTAAACAATTAGAAGAAGCGTTAGTATTATCTTCTATTCAGCGTATGGAATGTTTCGATATTAGT
CATACCATGGGAGAGAAAACAGTTGCATCGTGTGTTGTTTTTAATCAGGAAGGACCAGTAAAATCAGAGTATCGACGTTA
TAATATAGCAGGAATTACTGGTGGTGATGATTATGCTGCTATGGCGCAAGTTCTTGAACGACGCTACAGTAAACAATTAG
ATATTGATAAAATCCCTGATATTATTTTTATTGATGGTGGTAAAGGGCAATTGAATCGAGCTTATGAGGTTATCAGTAAG
CATTGGGAAGATTGGCCTAAGCAGCCATTATTACTAGGTATCGCAAAAGGTGTTACTCGTAAACATGGGTTAGAAACACT
AGTGAAAATTAGTGGAGAAGAGTTTTCAATGCCAAGTGATTCTCCTGCTTTGCATTTGATACAGCATATTCGTGATGAGA
GTCACAACCATGCTATTGGTGGACACCGAGCACAGCGTGCTAAAGTAAGAAAAACGAGTACCCTTCAAAATATTGATGGG
GTTGGTCCAAAACGAAGACAAGCATTGTTGCAATATTTAGGTGGCCTACAAGAATTAAAAAGTGCAAGTGTCGAAGAAAT
AGCCAAAGTGCCAGGCATTAGCCATTCTTTGGCAGAAAAAATACATGATGCGTTGAAACACGGATAA

Upstream 100 bases:

>100_bases
GCTATCGTTACCGTTTATTCAGTAAGTTAAATATAAGTGGAGACGTTGAATTAACTCATCTAGCTATTCGTCATGGTATT
TTAGATGCTGAGACGCTGTA

Downstream 100 bases:

>100_bases
AAAAAGCGCACCATACACTCGCGGACCAAAACTTAAGAATTATTTATGCGATTAACAATACCAAATATACTCACGTTTAT
CCGACTAGCACTGATCCCTG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MPSFDSKAFLKSVTHQPGVYRMYNAEADVIYVGKAKDLKKRLSSYFRSNVPSEKTKALVSHIHQVDVTVTHSETEALILE
HNYIKQYLPKYNVLLRDDKSYPYIFISQHKHPRISIHRGVKRKKGEYFGPYPDSGAVRESLHLIQKLFPIRQCEDSVYAN
RHRPCLMHQIGRCLAPCVKGIVSDEEYKEQTDFIRLFLQGKDRQVIQTLVKQMESASQSLNFEKAAIIRDQIQAMRRVQE
QQYVSDDSGDDLDVLGFAIENGLACVHLLMIRQGKILGSRSFFPKIPANTDKEEVFLSFLTQYYLNHTQGRTIPNRVVTS
FEFNSEDLERALTELSGRKVIFQLNPKGIKGRYLKLADTNALTALTSKSNHKLTMYQRFKQLEEALVLSSIQRMECFDIS
HTMGEKTVASCVVFNQEGPVKSEYRRYNIAGITGGDDYAAMAQVLERRYSKQLDIDKIPDIIFIDGGKGQLNRAYEVISK
HWEDWPKQPLLLGIAKGVTRKHGLETLVKISGEEFSMPSDSPALHLIQHIRDESHNHAIGGHRAQRAKVRKTSTLQNIDG
VGPKRRQALLQYLGGLQELKSASVEEIAKVPGISHSLAEKIHDALKHG

Sequences:

>Translated_608_residues
MPSFDSKAFLKSVTHQPGVYRMYNAEADVIYVGKAKDLKKRLSSYFRSNVPSEKTKALVSHIHQVDVTVTHSETEALILE
HNYIKQYLPKYNVLLRDDKSYPYIFISQHKHPRISIHRGVKRKKGEYFGPYPDSGAVRESLHLIQKLFPIRQCEDSVYAN
RHRPCLMHQIGRCLAPCVKGIVSDEEYKEQTDFIRLFLQGKDRQVIQTLVKQMESASQSLNFEKAAIIRDQIQAMRRVQE
QQYVSDDSGDDLDVLGFAIENGLACVHLLMIRQGKILGSRSFFPKIPANTDKEEVFLSFLTQYYLNHTQGRTIPNRVVTS
FEFNSEDLERALTELSGRKVIFQLNPKGIKGRYLKLADTNALTALTSKSNHKLTMYQRFKQLEEALVLSSIQRMECFDIS
HTMGEKTVASCVVFNQEGPVKSEYRRYNIAGITGGDDYAAMAQVLERRYSKQLDIDKIPDIIFIDGGKGQLNRAYEVISK
HWEDWPKQPLLLGIAKGVTRKHGLETLVKISGEEFSMPSDSPALHLIQHIRDESHNHAIGGHRAQRAKVRKTSTLQNIDG
VGPKRRQALLQYLGGLQELKSASVEEIAKVPGISHSLAEKIHDALKHG
>Mature_607_residues
PSFDSKAFLKSVTHQPGVYRMYNAEADVIYVGKAKDLKKRLSSYFRSNVPSEKTKALVSHIHQVDVTVTHSETEALILEH
NYIKQYLPKYNVLLRDDKSYPYIFISQHKHPRISIHRGVKRKKGEYFGPYPDSGAVRESLHLIQKLFPIRQCEDSVYANR
HRPCLMHQIGRCLAPCVKGIVSDEEYKEQTDFIRLFLQGKDRQVIQTLVKQMESASQSLNFEKAAIIRDQIQAMRRVQEQ
QYVSDDSGDDLDVLGFAIENGLACVHLLMIRQGKILGSRSFFPKIPANTDKEEVFLSFLTQYYLNHTQGRTIPNRVVTSF
EFNSEDLERALTELSGRKVIFQLNPKGIKGRYLKLADTNALTALTSKSNHKLTMYQRFKQLEEALVLSSIQRMECFDISH
TMGEKTVASCVVFNQEGPVKSEYRRYNIAGITGGDDYAAMAQVLERRYSKQLDIDKIPDIIFIDGGKGQLNRAYEVISKH
WEDWPKQPLLLGIAKGVTRKHGLETLVKISGEEFSMPSDSPALHLIQHIRDESHNHAIGGHRAQRAKVRKTSTLQNIDGV
GPKRRQALLQYLGGLQELKSASVEEIAKVPGISHSLAEKIHDALKHG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=607, Percent_Identity=64.9093904448105, Blast_Score=826, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 69143; Mature: 69012

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSFDSKAFLKSVTHQPGVYRMYNAEADVIYVGKAKDLKKRLSSYFRSNVPSEKTKALVS
CCCCCHHHHHHHHCCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHH
HIHQVDVTVTHSETEALILEHNYIKQYLPKYNVLLRDDKSYPYIFISQHKHPRISIHRGV
HHHHHEEEEEECCCCEEEEEHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCHHHHCH
KRKKGEYFGPYPDSGAVRESLHLIQKLFPIRQCEDSVYANRHRPCLMHQIGRCLAPCVKG
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IVSDEEYKEQTDFIRLFLQGKDRQVIQTLVKQMESASQSLNFEKAAIIRDQIQAMRRVQE
HCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QQYVSDDSGDDLDVLGFAIENGLACVHLLMIRQGKILGSRSFFPKIPANTDKEEVFLSFL
HHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TQYYLNHTQGRTIPNRVVTSFEFNSEDLERALTELSGRKVIFQLNPKGIKGRYLKLADTN
HHHHHHHCCCCCCHHHHHEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCC
ALTALTSKSNHKLTMYQRFKQLEEALVLSSIQRMECFDISHTMGEKTVASCVVFNQEGPV
HHEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEEEECCCCCC
KSEYRRYNIAGITGGDDYAAMAQVLERRYSKQLDIDKIPDIIFIDGGKGQLNRAYEVISK
HHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCCHHHHHHHHHHH
HWEDWPKQPLLLGIAKGVTRKHGLETLVKISGEEFSMPSDSPALHLIQHIRDESHNHAIG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
GHRAQRAKVRKTSTLQNIDGVGPKRRQALLQYLGGLQELKSASVEEIAKVPGISHSLAEK
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHCCCCCHHHHHH
IHDALKHG
HHHHHHCC
>Mature Secondary Structure 
PSFDSKAFLKSVTHQPGVYRMYNAEADVIYVGKAKDLKKRLSSYFRSNVPSEKTKALVS
CCCCHHHHHHHHCCCCCCEEEECCCCCEEEECCHHHHHHHHHHHHHCCCCCHHHHHHHH
HIHQVDVTVTHSETEALILEHNYIKQYLPKYNVLLRDDKSYPYIFISQHKHPRISIHRGV
HHHHHEEEEEECCCCEEEEEHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCHHHHCH
KRKKGEYFGPYPDSGAVRESLHLIQKLFPIRQCEDSVYANRHRPCLMHQIGRCLAPCVKG
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
IVSDEEYKEQTDFIRLFLQGKDRQVIQTLVKQMESASQSLNFEKAAIIRDQIQAMRRVQE
HCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QQYVSDDSGDDLDVLGFAIENGLACVHLLMIRQGKILGSRSFFPKIPANTDKEEVFLSFL
HHHCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHH
TQYYLNHTQGRTIPNRVVTSFEFNSEDLERALTELSGRKVIFQLNPKGIKGRYLKLADTN
HHHHHHHCCCCCCHHHHHEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCC
ALTALTSKSNHKLTMYQRFKQLEEALVLSSIQRMECFDISHTMGEKTVASCVVFNQEGPV
HHEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHEEEECCCCCC
KSEYRRYNIAGITGGDDYAAMAQVLERRYSKQLDIDKIPDIIFIDGGKGQLNRAYEVISK
HHHHHEEEEEEECCCCHHHHHHHHHHHHHHCCCCHHHCCCEEEEECCCCHHHHHHHHHHH
HWEDWPKQPLLLGIAKGVTRKHGLETLVKISGEEFSMPSDSPALHLIQHIRDESHNHAIG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCC
GHRAQRAKVRKTSTLQNIDGVGPKRRQALLQYLGGLQELKSASVEEIAKVPGISHSLAEK
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHCCHHHHHHCCCCCHHHHHH
IHDALKHG
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA