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The map label for this gene is grxB [H]

Identifier: 59712191

GI number: 59712191

Start: 1775139

End: 1775789

Strand: Direct

Name: grxB [H]

Synonym: VF_1584

Alternate gene names: 59712191

Gene position: 1775139-1775789 (Clockwise)

Preceding gene: 59712190

Following gene: 59712196

Centisome position: 61.26

GC content: 34.72

Gene sequence:

>651_bases
ATGAAATTATTCATCTTTGATCACTGTCCATTTTGTATGAAAGCAAAAATGGTTGCAGGTATAAAAAAGCTACCCGTTGA
ATTTGTTTATCTTCAAAATGATGATGTGAATGCTCGCATTGAAAAAGTAGGAGCTAATATGGTGCCTATTTTAGAGAAAA
ATGATGGTAGCTATATGGCAGAAAGTCTTGATATTGCAAGATATTTAGATGAGCATGATCACCATCCAATCATTGAAAAA
TCAACACACGAAGAAGAGATCTCTGAGTGGCTAAACGCAGCAAGACCACTGTTTGCTAAACTCACTTTTTCTCGTTGGAC
TCAACTTGATTTACCTGAATTCGCTCGACCTGAAGCGATTACATGGTTTACAGAGAAAAAAGAAGAATTCATTGAGATGA
GCTTTGAACAAGCATTAACGAACAGTAATGAATATATCAATGCATTAAATCCACTATTAGTTAATGCGAACTTCATTACT
CTTCCTTCGGAGAAAGGAAATCAAATCACATGGGATGATATTAACTTTTTCCCATTTATCCGTAATTTGACTGTTGTTAA
AGGACTAGATTTTCCACCACACTTAAAAAACTATCTGGAAGAGATAAGTGACTTAACGGGTGTTCATCTATTTTTTGATG
TTGCTGTGTAA

Upstream 100 bases:

>100_bases
CACCAATTTGGTCAACATTCAAATAATATGTTTAGCCCTCACCTATTTGTGAGGGCTTTTTTATCCCAATCAATGGCACG
ATTGGTATTAAGGAAATACA

Downstream 100 bases:

>100_bases
TCACCATCTATTTTTAACAATAAAAAAGAGCACGTTAATGTGCTCTTTTTCTTATCAAAATCATGAAAACCAACGTTGAT
ACCAAAGTATTTCCCCATGT

Product: glutaredoxin 2

Products: NA

Alternate protein names: Grx2 [H]

Number of amino acids: Translated: 216; Mature: 216

Protein sequence:

>216_residues
MKLFIFDHCPFCMKAKMVAGIKKLPVEFVYLQNDDVNARIEKVGANMVPILEKNDGSYMAESLDIARYLDEHDHHPIIEK
STHEEEISEWLNAARPLFAKLTFSRWTQLDLPEFARPEAITWFTEKKEEFIEMSFEQALTNSNEYINALNPLLVNANFIT
LPSEKGNQITWDDINFFPFIRNLTVVKGLDFPPHLKNYLEEISDLTGVHLFFDVAV

Sequences:

>Translated_216_residues
MKLFIFDHCPFCMKAKMVAGIKKLPVEFVYLQNDDVNARIEKVGANMVPILEKNDGSYMAESLDIARYLDEHDHHPIIEK
STHEEEISEWLNAARPLFAKLTFSRWTQLDLPEFARPEAITWFTEKKEEFIEMSFEQALTNSNEYINALNPLLVNANFIT
LPSEKGNQITWDDINFFPFIRNLTVVKGLDFPPHLKNYLEEISDLTGVHLFFDVAV
>Mature_216_residues
MKLFIFDHCPFCMKAKMVAGIKKLPVEFVYLQNDDVNARIEKVGANMVPILEKNDGSYMAESLDIARYLDEHDHHPIIEK
STHEEEISEWLNAARPLFAKLTFSRWTQLDLPEFARPEAITWFTEKKEEFIEMSFEQALTNSNEYINALNPLLVNANFIT
LPSEKGNQITWDDINFFPFIRNLTVVKGLDFPPHLKNYLEEISDLTGVHLFFDVAV

Specific function: Involved in reducing some disulfides in a coupled system with glutathione reductase. Does not act as hydrogen donor for ribonucleotide reductase [H]

COG id: COG2999

COG function: function code O; Glutaredoxin 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GST N-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI1787303, Length=217, Percent_Identity=35.9447004608295, Blast_Score=149, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR007494
- InterPro:   IPR010987
- InterPro:   IPR004045
- InterPro:   IPR011901
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF04399 Glutaredoxin2_C [H]

EC number: NA

Molecular weight: Translated: 25056; Mature: 25056

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFIFDHCPFCMKAKMVAGIKKLPVEFVYLQNDDVNARIEKVGANMVPILEKNDGSYMA
CEEEEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHCCCCEEEEEECCCCCHHH
ESLDIARYLDEHDHHPIIEKSTHEEEISEWLNAARPLFAKLTFSRWTQLDLPEFARPEAI
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
TWFTEKKEEFIEMSFEQALTNSNEYINALNPLLVNANFITLPSEKGNQITWDDINFFPFI
EEHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEECCEEEEECCCCCCEEEECCCCHHHHH
RNLTVVKGLDFPPHLKNYLEEISDLTGVHLFFDVAV
HCCHHEECCCCCHHHHHHHHHHHHCCCEEEEEEECC
>Mature Secondary Structure
MKLFIFDHCPFCMKAKMVAGIKKLPVEFVYLQNDDVNARIEKVGANMVPILEKNDGSYMA
CEEEEECCCCHHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHCCCCEEEEEECCCCCHHH
ESLDIARYLDEHDHHPIIEKSTHEEEISEWLNAARPLFAKLTFSRWTQLDLPEFARPEAI
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
TWFTEKKEEFIEMSFEQALTNSNEYINALNPLLVNANFITLPSEKGNQITWDDINFFPFI
EEHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEECCEEEEECCCCCCEEEECCCCHHHHH
RNLTVVKGLDFPPHLKNYLEEISDLTGVHLFFDVAV
HCCHHEECCCCCHHHHHHHHHHHHCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]