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The map label for this gene is cysM [C]

Identifier: 59712186

GI number: 59712186

Start: 1766601

End: 1767665

Strand: Direct

Name: cysM [C]

Synonym: VF_1579

Alternate gene names: 59712186

Gene position: 1766601-1767665 (Clockwise)

Preceding gene: 59712184

Following gene: 59712187

Centisome position: 60.97

GC content: 41.03

Gene sequence:

>1065_bases
ATGTGTACCGATCATAATTGGATAAATAACGCTATTCGTAAAATTGAAGCAGATTACCAACGCTCTGCTGATACGCATCT
TATTAAACTTGATTTGCCTATGCTTGAAGGTATCGATGTATACCTAAAAGATGAAAGTACACATCCAACAGGCTCCCTTA
AACACCGTTTAGCACGCTCTCTATTTCTTTATGCTATTTCTAACGGTTGGATTGGTCCAAACACACCAATTATAGAATCA
TCATCTGGCAGCACTGCCGTATCAGAAGCGTATTTTGCGCGTTTATTAGGTTTGCCATTCATTGCCGTTGTACCTCGTAA
AACAGCAACGAAAAAAATTGAAATGATTAAGTTTTATGGCGGCCAAGCGCACTTTGTAGAACGTTCTGATGAGATCTACG
CTGAATCTCGCCGTCTAGCTGAAGAACTAAATGGTCACTACATGGACCAATTTACTTATGCTGAACGTGCCACTGACTGG
CGTGGTAACAACAACATTGCAGATAGTATTTTCCGTCAAATGAAATTAGAAGACCACCCAGAACCAACATGGGTTGTAAT
GAACCCTGGCACAGGTGGTACTTCAGCAACGATCGGTCGCTTTATCCGTTATCAAAAATACAATACAAAACTGTGCGTTG
TTGACCCTGAAAATTCCGTTTTCCATGATTTCTATAAAACAGGCAATAAAGAGCTAACATTAGATGCTGGAAGTAAAATT
GAAGGGATTGGCCGCCCTCGCGTAGAACCAAGTTTTATTCCTGGTGTTATTGATGAAATGCGTACTATCCCGGATGTTGC
GAGTGTCGCTACTGCACGTTGGTTAGAAGGCATTCTTGGTCGTAAGGCTGGCGCTTCTACAGGTACTAACCTATTTGGTG
CATTACAACTCGCTTGTGAAATGCAACAACGTGGAGAGAAAGGTTCTATTGTCACTCTATTATGTGATAGTGGTGAGCGA
TACCTTGATACCTATTATAACGATGAGTGGGTTGCGAATAATATTGGCGATTTAACACCAACTTTAGCCCTATTGGCTAA
TTTTGAGAAAACAGGTCAACTGTAA

Upstream 100 bases:

>100_bases
ATTTTTCTATTTTATTACCAATATGAAGTAAATATAGCAAAGTTTTTCTCATCGAACAGCGGTAAATTATTCACATAGTC
ACTTTTAAAGGAAAATCATT

Downstream 100 bases:

>100_bases
AGCAAAGTTATAATAATAACGTCAGTTTGGCTTAACACCATTTATTGGTATTAACCGCAAAGCCATCGATTATCGATGGC
TTTTTTATTACAATATCAAT

Product: cysteine synthase

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MCTDHNWINNAIRKIEADYQRSADTHLIKLDLPMLEGIDVYLKDESTHPTGSLKHRLARSLFLYAISNGWIGPNTPIIES
SSGSTAVSEAYFARLLGLPFIAVVPRKTATKKIEMIKFYGGQAHFVERSDEIYAESRRLAEELNGHYMDQFTYAERATDW
RGNNNIADSIFRQMKLEDHPEPTWVVMNPGTGGTSATIGRFIRYQKYNTKLCVVDPENSVFHDFYKTGNKELTLDAGSKI
EGIGRPRVEPSFIPGVIDEMRTIPDVASVATARWLEGILGRKAGASTGTNLFGALQLACEMQQRGEKGSIVTLLCDSGER
YLDTYYNDEWVANNIGDLTPTLALLANFEKTGQL

Sequences:

>Translated_354_residues
MCTDHNWINNAIRKIEADYQRSADTHLIKLDLPMLEGIDVYLKDESTHPTGSLKHRLARSLFLYAISNGWIGPNTPIIES
SSGSTAVSEAYFARLLGLPFIAVVPRKTATKKIEMIKFYGGQAHFVERSDEIYAESRRLAEELNGHYMDQFTYAERATDW
RGNNNIADSIFRQMKLEDHPEPTWVVMNPGTGGTSATIGRFIRYQKYNTKLCVVDPENSVFHDFYKTGNKELTLDAGSKI
EGIGRPRVEPSFIPGVIDEMRTIPDVASVATARWLEGILGRKAGASTGTNLFGALQLACEMQQRGEKGSIVTLLCDSGER
YLDTYYNDEWVANNIGDLTPTLALLANFEKTGQL
>Mature_354_residues
MCTDHNWINNAIRKIEADYQRSADTHLIKLDLPMLEGIDVYLKDESTHPTGSLKHRLARSLFLYAISNGWIGPNTPIIES
SSGSTAVSEAYFARLLGLPFIAVVPRKTATKKIEMIKFYGGQAHFVERSDEIYAESRRLAEELNGHYMDQFTYAERATDW
RGNNNIADSIFRQMKLEDHPEPTWVVMNPGTGGTSATIGRFIRYQKYNTKLCVVDPENSVFHDFYKTGNKELTLDAGSKI
EGIGRPRVEPSFIPGVIDEMRTIPDVASVATARWLEGILGRKAGASTGTNLFGALQLACEMQQRGEKGSIVTLLCDSGER
YLDTYYNDEWVANNIGDLTPTLALLANFEKTGQL

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=297, Percent_Identity=27.9461279461279, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI295821200, Length=297, Percent_Identity=27.9461279461279, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI4557415, Length=297, Percent_Identity=27.9461279461279, Blast_Score=89, Evalue=9e-18,
Organism=Escherichia coli, GI2367138, Length=328, Percent_Identity=27.1341463414634, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71996324, Length=355, Percent_Identity=30.9859154929577, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17539800, Length=354, Percent_Identity=32.2033898305085, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17539640, Length=369, Percent_Identity=30.3523035230352, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI17562970, Length=322, Percent_Identity=28.2608695652174, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI32566674, Length=304, Percent_Identity=27.9605263157895, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI115535073, Length=312, Percent_Identity=27.8846153846154, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17534315, Length=341, Percent_Identity=28.4457478005865, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321594, Length=330, Percent_Identity=26.6666666666667, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321449, Length=333, Percent_Identity=25.2252252252252, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24643623, Length=319, Percent_Identity=26.0188087774295, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI20129101, Length=319, Percent_Identity=26.0188087774295, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 39570; Mature: 39570

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTDHNWINNAIRKIEADYQRSADTHLIKLDLPMLEGIDVYLKDESTHPTGSLKHRLARS
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHCCCEEEEECCCCCCCHHHHHHHHHH
LFLYAISNGWIGPNTPIIESSSGSTAVSEAYFARLLGLPFIAVVPRKTATKKIEMIKFYG
HHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHEEEEEEEC
GQAHFVERSDEIYAESRRLAEELNGHYMDQFTYAERATDWRGNNNIADSIFRQMKLEDHP
CEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCC
EPTWVVMNPGTGGTSATIGRFIRYQKYNTKLCVVDPENSVFHDFYKTGNKELTLDAGSKI
CCEEEEECCCCCCCHHHHHHHHHHEECCCEEEEECCCCHHHHHHHHCCCCEEEEECCCCC
EGIGRPRVEPSFIPGVIDEMRTIPDVASVATARWLEGILGRKAGASTGTNLFGALQLACE
CCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
MQQRGEKGSIVTLLCDSGERYLDTYYNDEWVANNIGDLTPTLALLANFEKTGQL
HHHCCCCCCEEEEEECCCCHHHHHHCCCCHHHCCCCHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MCTDHNWINNAIRKIEADYQRSADTHLIKLDLPMLEGIDVYLKDESTHPTGSLKHRLARS
CCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCHHCCCEEEEECCCCCCCHHHHHHHHHH
LFLYAISNGWIGPNTPIIESSSGSTAVSEAYFARLLGLPFIAVVPRKTATKKIEMIKFYG
HHHHHHCCCCCCCCCCEEECCCCCHHHHHHHHHHHHCCCEEEEECCCHHHHHEEEEEEEC
GQAHFVERSDEIYAESRRLAEELNGHYMDQFTYAERATDWRGNNNIADSIFRQMKLEDHP
CEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCC
EPTWVVMNPGTGGTSATIGRFIRYQKYNTKLCVVDPENSVFHDFYKTGNKELTLDAGSKI
CCEEEEECCCCCCCHHHHHHHHHHEECCCEEEEECCCCHHHHHHHHCCCCEEEEECCCCC
EGIGRPRVEPSFIPGVIDEMRTIPDVASVATARWLEGILGRKAGASTGTNLFGALQLACE
CCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
MQQRGEKGSIVTLLCDSGERYLDTYYNDEWVANNIGDLTPTLALLANFEKTGQL
HHHCCCCCCEEEEEECCCCHHHHHHCCCCHHHCCCCHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]