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The map label for this gene is tesB [H]

Identifier: 59712184

GI number: 59712184

Start: 1765088

End: 1765951

Strand: Direct

Name: tesB [H]

Synonym: VF_1577

Alternate gene names: 59712184

Gene position: 1765088-1765951 (Clockwise)

Preceding gene: 59712182

Following gene: 59712186

Centisome position: 60.92

GC content: 40.97

Gene sequence:

>864_bases
ATGAACCAACCACTTAACGAATTACTTAACTTGCTACAGCTAGAGCAATTAGAGCAGGATCTTTTCCGAGGACAAAGCGA
ACATTTAGGTCTACCACAAGTTTATGGTGGTCAAGTTATTGGACAAGCACTTTCAGCAGCTCGCTATACGGTTGATAATG
ATAGAACTGTTCATTCATTTCATAGCTACTTTCTTTACCCTGGTGACCCTGAAAAAGCTATTATCTATGATGTTGAAAAC
TTACGAGATGGCCGAAGTTTCAGTACTCGTCGTGTAAAAGCCATTCAAAATGGTCGCCCTATTTTCTATCTAACGGCTTC
TTATCATGGAGATGAGCCTGGGTTTGAGCATCAATCTCACATGCCTGAAATCGCAGGTCCTGAAAACTTTGCATCAGAAA
CTCAATTAGCTGAGGCGATCAAACACGTTTTACCACCAGCGGTACAAAAAATATTCTGTGGTGAAAAACCAATCGAAGTT
CGTCCAGTCAACATTGTGAATCCACTTGCTCCGAAAAAAGCGGCACCAACTCAGCATCTCTGGATTAAAGCAAACGGTGA
ATTACCTGATAACCAATTAATTCATCAATACTTATTAGCTTATGCATCTGATTGGGGCTTTTTACCAACGGCTCTTCACC
CACATGAAGTGAGCTTATTAACTCCTAACTTCCAAGTGGCTACGATTGATCACTCAATGTGGTTCCACCGTCCATTCAAA
ATGGATGAATGGCTGCTTTATTCAATTGAAAGCACTAATGCAAGTGGCTCTCGTGGACTAGTAAGAGGGGAAATATTCAA
TCAGAAAGGCCAACTTGTTGCTTCTGCTATGCAAGAAGGCGTGATGAGAATGAAGAAAAAATAG

Upstream 100 bases:

>100_bases
TAAACTTATCTTTAATTAACATTATATTTAACTTATTGAACTCAATCTGAATATCTTTAAAATAGAGTTATTATTTGAGA
GTGATCATACAGGCCAAAAA

Downstream 100 bases:

>100_bases
GCATTCGCATCTTTTCTATTGGTCAGGCTATCGTTGCCTGACCTGCTTATTTGAATATCAGATTATAACGGTAATTCAGT
CGTGTATTTCAACGGCTCCA

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MNQPLNELLNLLQLEQLEQDLFRGQSEHLGLPQVYGGQVIGQALSAARYTVDNDRTVHSFHSYFLYPGDPEKAIIYDVEN
LRDGRSFSTRRVKAIQNGRPIFYLTASYHGDEPGFEHQSHMPEIAGPENFASETQLAEAIKHVLPPAVQKIFCGEKPIEV
RPVNIVNPLAPKKAAPTQHLWIKANGELPDNQLIHQYLLAYASDWGFLPTALHPHEVSLLTPNFQVATIDHSMWFHRPFK
MDEWLLYSIESTNASGSRGLVRGEIFNQKGQLVASAMQEGVMRMKKK

Sequences:

>Translated_287_residues
MNQPLNELLNLLQLEQLEQDLFRGQSEHLGLPQVYGGQVIGQALSAARYTVDNDRTVHSFHSYFLYPGDPEKAIIYDVEN
LRDGRSFSTRRVKAIQNGRPIFYLTASYHGDEPGFEHQSHMPEIAGPENFASETQLAEAIKHVLPPAVQKIFCGEKPIEV
RPVNIVNPLAPKKAAPTQHLWIKANGELPDNQLIHQYLLAYASDWGFLPTALHPHEVSLLTPNFQVATIDHSMWFHRPFK
MDEWLLYSIESTNASGSRGLVRGEIFNQKGQLVASAMQEGVMRMKKK
>Mature_287_residues
MNQPLNELLNLLQLEQLEQDLFRGQSEHLGLPQVYGGQVIGQALSAARYTVDNDRTVHSFHSYFLYPGDPEKAIIYDVEN
LRDGRSFSTRRVKAIQNGRPIFYLTASYHGDEPGFEHQSHMPEIAGPENFASETQLAEAIKHVLPPAVQKIFCGEKPIEV
RPVNIVNPLAPKKAAPTQHLWIKANGELPDNQLIHQYLLAYASDWGFLPTALHPHEVSLLTPNFQVATIDHSMWFHRPFK
MDEWLLYSIESTNASGSRGLVRGEIFNQKGQLVASAMQEGVMRMKKK

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=287, Percent_Identity=41.4634146341463, Blast_Score=216, Evalue=1e-56,
Organism=Escherichia coli, GI1786657, Length=283, Percent_Identity=61.4840989399293, Blast_Score=357, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71988741, Length=304, Percent_Identity=35.8552631578947, Blast_Score=190, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI17558508, Length=309, Percent_Identity=37.5404530744337, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17531889, Length=301, Percent_Identity=34.21926910299, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI115532456, Length=301, Percent_Identity=34.21926910299, Blast_Score=171, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17531885, Length=300, Percent_Identity=34.3333333333333, Blast_Score=171, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI71982224, Length=271, Percent_Identity=29.1512915129151, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI212645202, Length=287, Percent_Identity=27.1777003484321, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322480, Length=306, Percent_Identity=24.8366013071895, Blast_Score=83, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32449; Mature: 32449

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQPLNELLNLLQLEQLEQDLFRGQSEHLGLPQVYGGQVIGQALSAARYTVDNDRTVHSF
CCCHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEH
HSYFLYPGDPEKAIIYDVENLRDGRSFSTRRVKAIQNGRPIFYLTASYHGDEPGFEHQSH
HCEEEECCCCCCEEEEEHHHCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHC
MPEIAGPENFASETQLAEAIKHVLPPAVQKIFCGEKPIEVRPVNIVNPLAPKKAAPTQHL
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCEE
WIKANGELPDNQLIHQYLLAYASDWGFLPTALHPHEVSLLTPNFQVATIDHSMWFHRPFK
EEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEEEECHHHCCCCCC
MDEWLLYSIESTNASGSRGLVRGEIFNQKGQLVASAMQEGVMRMKKK
CCCEEEEEEECCCCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNQPLNELLNLLQLEQLEQDLFRGQSEHLGLPQVYGGQVIGQALSAARYTVDNDRTVHSF
CCCHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHHHHHHHHEECCCCCEEEEH
HSYFLYPGDPEKAIIYDVENLRDGRSFSTRRVKAIQNGRPIFYLTASYHGDEPGFEHQSH
HCEEEECCCCCCEEEEEHHHCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHC
MPEIAGPENFASETQLAEAIKHVLPPAVQKIFCGEKPIEVRPVNIVNPLAPKKAAPTQHL
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCEE
WIKANGELPDNQLIHQYLLAYASDWGFLPTALHPHEVSLLTPNFQVATIDHSMWFHRPFK
EEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCEEEEEEECHHHCCCCCC
MDEWLLYSIESTNASGSRGLVRGEIFNQKGQLVASAMQEGVMRMKKK
CCCEEEEEEECCCCCCCCCEEEHHHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]