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The map label for this gene is maeA [H]

Identifier: 59712165

GI number: 59712165

Start: 1743452

End: 1745140

Strand: Direct

Name: maeA [H]

Synonym: VF_1558

Alternate gene names: 59712165

Gene position: 1743452-1745140 (Clockwise)

Preceding gene: 59712161

Following gene: 59712166

Centisome position: 60.17

GC content: 40.85

Gene sequence:

>1689_bases
ATGAATAACAACAAACGTCCCCTATATATCCCTTATGCAGGTCCTGCACTTCTAAGTACTCCTCTACTCAATAAAGGTAG
CGCATTCAGTACTACAGAGCGTAAATATTTTAACTTAGAAGGTTTGCTTCCTGAGGCGATTGAGAGTATCGAAGAACAAA
CAGGTCGTGCTTACAAGCAATATCAAAATTTTGAAAATGATATGGATAAGCATATTTACCTACGTAATATTCAAGATACA
AACGAGACTCTTTTCTACCGTTTAGTACAAAACCACATTAGTGAAATGATGCCAATCATTTATACACCAACGGTAGGTGC
AGCTTGTGAGAACTTCTCAAATATATACCGACGTGGCCGTGGTTTGTTTATCTCTTATGAAAACAAAAACCGCATTGATG
ATTTATTGAATAATGCCGCTAACCAAAACGTTAAAGTAATTGTAGTTACTGATGGTGAACGAATTCTTGGTCTTGGTGAT
CAGGGGATCGGCGGTATGGGTATTCCTATCGGGAAACTGGCATTATATACCGCATGTGGTGGTATCAGCCCTGCTCATAC
ATTACCTATCGTACTTGATGTAGGTACAAATAACCCTCAACGTCTTGCTGATCCTATGTATATGGGCTGGCGTCACCCTC
GTGTTACTGGCGACGAATACGCTGATTTTGTTGAAGATTTCATTCAAGCTGTACAACGTCGTTGGCCTGAAGCCCTAGTT
CAATTTGAAGATTTTGCACAAAAAAATGCAATGCCTTTACTTGAGCGTTACAAAAACCGAATTTGTTGTTTTAATGATGA
TATTCAAGGTACTGCAGCAGTTACTGTTGGTTCATTACTTGCCGCTTGTAAAGCTGCTGGCAGTTCTTTATCAGAACAAC
GAGTTACTTTCCTAGGCGCAGGCTCTGCTGGTTGTGGTATTGCTGAGGCAATCATTGCACAGATGGTATCAGAAGGAATT
TCTGATGCACAAGCTCGCTCACAAGTATATATGGTTGACCGTTGGGGTCTATTACAAGAAGGTATGCCGAATCTATTAGA
TTTCCAACAGCGTCTTGTACAAAAAGCTGAAAACACAAAAGATTGGGTTTCTGAGGAACCTAACTTCTCACTTGTTGATG
TTATGCGTAATGCAAAACCAACCGTATTAATTGGTGTATCTGGTGCTCCTGGCTTATTTAGTAAAGAAGTAATCCAAGAG
ATGCACAAGCATTGTGAACGACCAATTGTTTTCCCTCTATCAAACCCAACAAGCCGTGTAGAGGCTACACCAAACGATAT
TATTCGTTGGACTGATGGTCAGGCACTAGTAGCAACAGGAAGCCCGTTTGATCCTGTTGCACACAATGGCCAAACTTATC
CAATTGCTCAGTGTAATAATAGCTTTATCTTCCCAGGTATTGGCTTAGGTGTATTAGCTATTAAAGCAACTCGTGTAACG
GATGAAATGCTGATGGAATCAAGTCGAGCACTAGCTGAATGCTCTCCACTGGCTATTCACGGTACTGGTGCATTACTTCC
ACCACTGGAAGAAATTCACAGCGTATCAAAACGAATCGCATTTGCTGTAGCTAAAAAAGCAATTGAACAAGGCCATGCGC
TTGAAATCACAGATGAAGCGCTTCAGCAAAAAATTGAAAGCTACTTTTGGAAACCGGTATACCGTCGTTACAAACGAACA
GCATTCTAA

Upstream 100 bases:

>100_bases
AACATGACTCTATTCGCACTTTATTTTCAATCACGCTTTGATATTTGCTTAAAGTAGGCATAGGATCTGTGGTTCATTCT
CGATTTGAAGAAGCCTAACG

Downstream 100 bases:

>100_bases
TAAGTACATGATTTAACTATAAACCAGAGTAACTATTGCTCTGGTTTTTTTTCAACTTTTGCTAAGCCTGGCCGATATAT
TTAATATGAATAAATAATCT

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MNNNKRPLYIPYAGPALLSTPLLNKGSAFSTTERKYFNLEGLLPEAIESIEEQTGRAYKQYQNFENDMDKHIYLRNIQDT
NETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGRGLFISYENKNRIDDLLNNAANQNVKVIVVTDGERILGLGD
QGIGGMGIPIGKLALYTACGGISPAHTLPIVLDVGTNNPQRLADPMYMGWRHPRVTGDEYADFVEDFIQAVQRRWPEALV
QFEDFAQKNAMPLLERYKNRICCFNDDIQGTAAVTVGSLLAACKAAGSSLSEQRVTFLGAGSAGCGIAEAIIAQMVSEGI
SDAQARSQVYMVDRWGLLQEGMPNLLDFQQRLVQKAENTKDWVSEEPNFSLVDVMRNAKPTVLIGVSGAPGLFSKEVIQE
MHKHCERPIVFPLSNPTSRVEATPNDIIRWTDGQALVATGSPFDPVAHNGQTYPIAQCNNSFIFPGIGLGVLAIKATRVT
DEMLMESSRALAECSPLAIHGTGALLPPLEEIHSVSKRIAFAVAKKAIEQGHALEITDEALQQKIESYFWKPVYRRYKRT
AF

Sequences:

>Translated_562_residues
MNNNKRPLYIPYAGPALLSTPLLNKGSAFSTTERKYFNLEGLLPEAIESIEEQTGRAYKQYQNFENDMDKHIYLRNIQDT
NETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGRGLFISYENKNRIDDLLNNAANQNVKVIVVTDGERILGLGD
QGIGGMGIPIGKLALYTACGGISPAHTLPIVLDVGTNNPQRLADPMYMGWRHPRVTGDEYADFVEDFIQAVQRRWPEALV
QFEDFAQKNAMPLLERYKNRICCFNDDIQGTAAVTVGSLLAACKAAGSSLSEQRVTFLGAGSAGCGIAEAIIAQMVSEGI
SDAQARSQVYMVDRWGLLQEGMPNLLDFQQRLVQKAENTKDWVSEEPNFSLVDVMRNAKPTVLIGVSGAPGLFSKEVIQE
MHKHCERPIVFPLSNPTSRVEATPNDIIRWTDGQALVATGSPFDPVAHNGQTYPIAQCNNSFIFPGIGLGVLAIKATRVT
DEMLMESSRALAECSPLAIHGTGALLPPLEEIHSVSKRIAFAVAKKAIEQGHALEITDEALQQKIESYFWKPVYRRYKRT
AF
>Mature_562_residues
MNNNKRPLYIPYAGPALLSTPLLNKGSAFSTTERKYFNLEGLLPEAIESIEEQTGRAYKQYQNFENDMDKHIYLRNIQDT
NETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGRGLFISYENKNRIDDLLNNAANQNVKVIVVTDGERILGLGD
QGIGGMGIPIGKLALYTACGGISPAHTLPIVLDVGTNNPQRLADPMYMGWRHPRVTGDEYADFVEDFIQAVQRRWPEALV
QFEDFAQKNAMPLLERYKNRICCFNDDIQGTAAVTVGSLLAACKAAGSSLSEQRVTFLGAGSAGCGIAEAIIAQMVSEGI
SDAQARSQVYMVDRWGLLQEGMPNLLDFQQRLVQKAENTKDWVSEEPNFSLVDVMRNAKPTVLIGVSGAPGLFSKEVIQE
MHKHCERPIVFPLSNPTSRVEATPNDIIRWTDGQALVATGSPFDPVAHNGQTYPIAQCNNSFIFPGIGLGVLAIKATRVT
DEMLMESSRALAECSPLAIHGTGALLPPLEEIHSVSKRIAFAVAKKAIEQGHALEITDEALQQKIESYFWKPVYRRYKRT
AF

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=522, Percent_Identity=43.6781609195402, Blast_Score=452, Evalue=1e-127,
Organism=Homo sapiens, GI62420882, Length=549, Percent_Identity=41.1657559198543, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI62420880, Length=549, Percent_Identity=41.1657559198543, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI239049447, Length=549, Percent_Identity=41.1657559198543, Blast_Score=438, Evalue=1e-123,
Organism=Homo sapiens, GI4505145, Length=524, Percent_Identity=41.9847328244275, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI270265879, Length=465, Percent_Identity=43.6559139784946, Blast_Score=389, Evalue=1e-108,
Organism=Escherichia coli, GI87081919, Length=558, Percent_Identity=68.9964157706093, Blast_Score=802, Evalue=0.0,
Organism=Escherichia coli, GI1788806, Length=356, Percent_Identity=24.1573033707865, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17537199, Length=516, Percent_Identity=43.4108527131783, Blast_Score=417, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322823, Length=559, Percent_Identity=43.2915921288014, Blast_Score=452, Evalue=1e-128,
Organism=Drosophila melanogaster, GI21356279, Length=519, Percent_Identity=43.1599229287091, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI281362674, Length=519, Percent_Identity=43.1599229287091, Blast_Score=434, Evalue=1e-122,
Organism=Drosophila melanogaster, GI281362672, Length=519, Percent_Identity=43.1599229287091, Blast_Score=434, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24646388, Length=513, Percent_Identity=41.3255360623782, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24646386, Length=513, Percent_Identity=41.3255360623782, Blast_Score=416, Evalue=1e-116,
Organism=Drosophila melanogaster, GI78707242, Length=534, Percent_Identity=37.8277153558052, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707238, Length=534, Percent_Identity=37.8277153558052, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707232, Length=509, Percent_Identity=37.9174852652259, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI78707240, Length=529, Percent_Identity=37.8071833648393, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281363505, Length=508, Percent_Identity=37.7952755905512, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI78707236, Length=508, Percent_Identity=37.7952755905512, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281363503, Length=506, Percent_Identity=37.5494071146245, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19922384, Length=544, Percent_Identity=29.0441176470588, Blast_Score=256, Evalue=4e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 62300; Mature: 62300

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNNKRPLYIPYAGPALLSTPLLNKGSAFSTTERKYFNLEGLLPEAIESIEEQTGRAYKQ
CCCCCCEEEEECCCHHHHHCCCCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHH
YQNFENDMDKHIYLRNIQDTNETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGR
HHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHCCC
GLFISYENKNRIDDLLNNAANQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLALYTACG
CEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHC
GISPAHTLPIVLDVGTNNPQRLADPMYMGWRHPRVTGDEYADFVEDFIQAVQRRWPEALV
CCCCCCCEEEEEECCCCCHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QFEDFAQKNAMPLLERYKNRICCFNDDIQGTAAVTVGSLLAACKAAGSSLSEQRVTFLGA
HHHHHHHHCCCHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
GSAGCGIAEAIIAQMVSEGISDAQARSQVYMVDRWGLLQEGMPNLLDFQQRLVQKAENTK
CCCCCHHHHHHHHHHHHHCCCHHHHHCEEEEEECCCHHHHCCCHHHHHHHHHHHHHCCCH
DWVSEEPNFSLVDVMRNAKPTVLIGVSGAPGLFSKEVIQEMHKHCERPIVFPLSNPTSRV
HHHCCCCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCC
EATPNDIIRWTDGQALVATGSPFDPVAHNGQTYPIAQCNNSFIFPGIGLGVLAIKATRVT
CCCCCCCEEECCCCEEEECCCCCCCCCCCCCCCEEEECCCCEECCCCCHHHHEEEHHHHH
DEMLMESSRALAECSPLAIHGTGALLPPLEEIHSVSKRIAFAVAKKAIEQGHALEITDEA
HHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHH
LQQKIESYFWKPVYRRYKRTAF
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNNNKRPLYIPYAGPALLSTPLLNKGSAFSTTERKYFNLEGLLPEAIESIEEQTGRAYKQ
CCCCCCEEEEECCCHHHHHCCCCCCCCCCCCCCHHEECCCCCCHHHHHHHHHHHHHHHHH
YQNFENDMDKHIYLRNIQDTNETLFYRLVQNHISEMMPIIYTPTVGAACENFSNIYRRGR
HHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHCCC
GLFISYENKNRIDDLLNNAANQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLALYTACG
CEEEEECCCCHHHHHHHHHCCCCEEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHHHHC
GISPAHTLPIVLDVGTNNPQRLADPMYMGWRHPRVTGDEYADFVEDFIQAVQRRWPEALV
CCCCCCCEEEEEECCCCCHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QFEDFAQKNAMPLLERYKNRICCFNDDIQGTAAVTVGSLLAACKAAGSSLSEQRVTFLGA
HHHHHHHHCCCHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEC
GSAGCGIAEAIIAQMVSEGISDAQARSQVYMVDRWGLLQEGMPNLLDFQQRLVQKAENTK
CCCCCHHHHHHHHHHHHHCCCHHHHHCEEEEEECCCHHHHCCCHHHHHHHHHHHHHCCCH
DWVSEEPNFSLVDVMRNAKPTVLIGVSGAPGLFSKEVIQEMHKHCERPIVFPLSNPTSRV
HHHCCCCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCC
EATPNDIIRWTDGQALVATGSPFDPVAHNGQTYPIAQCNNSFIFPGIGLGVLAIKATRVT
CCCCCCCEEECCCCEEEECCCCCCCCCCCCCCCEEEECCCCEECCCCCHHHHEEEHHHHH
DEMLMESSRALAECSPLAIHGTGALLPPLEEIHSVSKRIAFAVAKKAIEQGHALEITDEA
HHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHH
LQQKIESYFWKPVYRRYKRTAF
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA