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The map label for this gene is aqpZ [H]

Identifier: 59712086

GI number: 59712086

Start: 1636658

End: 1637344

Strand: Reverse

Name: aqpZ [H]

Synonym: VF_1479

Alternate gene names: 59712086

Gene position: 1637344-1636658 (Counterclockwise)

Preceding gene: 59712087

Following gene: 59712082

Centisome position: 56.51

GC content: 42.65

Gene sequence:

>687_bases
ATGAATAAATACATGGCAGAGTTTATTGGTACATTTTGGCTTGTACTGGGTGGTTGTGGTAGTGCAGTACTGGCGGCAGC
GTTTCCTGAACTTGGTATCGGGTTTGTTGGTGTATCACTGGCATTTGGTCTAACAGTATTAACCATGGCGTTTGCCATTG
GTCACATTTCAGGTTGTCACTTAAACCCAGCAGTATCAGTTGGTTTATGGGTAGGTGGCCGTTTTGATGCTAAAGACTTA
GTTCCATACATCGTATCTCAAGTTCTTGGTGGTATTGCGGCAGGTGGTATTTTATACCTAATCGCAAGCGGTCAAGCAGG
TTTTGATCTAGCTGGTGGTTTTGCATCAAATGGTTTTGGTGAACACTCTCCAGGTGGTTACACAATGACAGCTGCACTTA
TTACAGAAGTAGTACTAACTGCAATGTTCTTAATTGTGATTATGGGTGCAACAGATAGTCGTGCTCCAGCAGGTTTTGCT
CCAATTGCAATTGGTCTGTGTTTAACACTTATCCACCTTATCAGTATCCCTGTAACAAATACATCAGTTAACCCAGCTCG
TAGTACAGCAGTAGCGGTTTATGTTGGTGATTGGGCAACATCACAACTTTGGTTGTTCTGGGTTGCTCCGATTGTAGGTG
CGGTAATTGGTGCACTTATCTATAAAGTAATGGCGAAAGAATCATAA

Upstream 100 bases:

>100_bases
TGTCTAATTTGTTAACCATCACCTATATTTATTTTCAATGAAACTTGGTTCGTATAAAAAATTAATACTGAAATCAAGAC
ATAACAACATAGGAATAATT

Downstream 100 bases:

>100_bases
TCGCTGTTTCATTATAAACACATACAAAAATGCCGATGATTAACGTCATCGGCATTTTTATTTTTACTTCTGGTTCATCT
TTTCCATTTCTGCTAAATCA

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MNKYMAEFIGTFWLVLGGCGSAVLAAAFPELGIGFVGVSLAFGLTVLTMAFAIGHISGCHLNPAVSVGLWVGGRFDAKDL
VPYIVSQVLGGIAAGGILYLIASGQAGFDLAGGFASNGFGEHSPGGYTMTAALITEVVLTAMFLIVIMGATDSRAPAGFA
PIAIGLCLTLIHLISIPVTNTSVNPARSTAVAVYVGDWATSQLWLFWVAPIVGAVIGALIYKVMAKES

Sequences:

>Translated_228_residues
MNKYMAEFIGTFWLVLGGCGSAVLAAAFPELGIGFVGVSLAFGLTVLTMAFAIGHISGCHLNPAVSVGLWVGGRFDAKDL
VPYIVSQVLGGIAAGGILYLIASGQAGFDLAGGFASNGFGEHSPGGYTMTAALITEVVLTAMFLIVIMGATDSRAPAGFA
PIAIGLCLTLIHLISIPVTNTSVNPARSTAVAVYVGDWATSQLWLFWVAPIVGAVIGALIYKVMAKES
>Mature_228_residues
MNKYMAEFIGTFWLVLGGCGSAVLAAAFPELGIGFVGVSLAFGLTVLTMAFAIGHISGCHLNPAVSVGLWVGGRFDAKDL
VPYIVSQVLGGIAAGGILYLIASGQAGFDLAGGFASNGFGEHSPGGYTMTAALITEVVLTAMFLIVIMGATDSRAPAGFA
PIAIGLCLTLIHLISIPVTNTSVNPARSTAVAVYVGDWATSQLWLFWVAPIVGAVIGALIYKVMAKES

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502183, Length=224, Percent_Identity=37.5, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI4502179, Length=219, Percent_Identity=35.1598173515982, Blast_Score=117, Evalue=7e-27,
Organism=Homo sapiens, GI37694062, Length=233, Percent_Identity=36.0515021459227, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI4755125, Length=224, Percent_Identity=34.375, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4502181, Length=224, Percent_Identity=34.375, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI6912506, Length=221, Percent_Identity=32.579185520362, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI86792455, Length=218, Percent_Identity=29.8165137614679, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI157266307, Length=239, Percent_Identity=30.5439330543933, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI45446752, Length=204, Percent_Identity=31.8627450980392, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI22538420, Length=242, Percent_Identity=27.2727272727273, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4826645, Length=249, Percent_Identity=26.1044176706827, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI4502187, Length=244, Percent_Identity=26.6393442622951, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1787101, Length=229, Percent_Identity=71.6157205240175, Blast_Score=306, Evalue=5e-85,
Organism=Escherichia coli, GI1790362, Length=253, Percent_Identity=29.6442687747036, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71993722, Length=235, Percent_Identity=30.6382978723404, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17558372, Length=234, Percent_Identity=29.0598290598291, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71992966, Length=241, Percent_Identity=27.8008298755187, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24652747, Length=224, Percent_Identity=33.9285714285714, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI45551084, Length=224, Percent_Identity=33.9285714285714, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24652751, Length=218, Percent_Identity=33.4862385321101, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19922038, Length=218, Percent_Identity=33.4862385321101, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45550503, Length=229, Percent_Identity=27.5109170305677, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24762346, Length=230, Percent_Identity=29.1304347826087, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24762348, Length=230, Percent_Identity=29.1304347826087, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI20130305, Length=230, Percent_Identity=29.1304347826087, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24762344, Length=230, Percent_Identity=29.1304347826087, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI17136672, Length=225, Percent_Identity=26.2222222222222, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24762342, Length=195, Percent_Identity=28.7179487179487, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23372; Mature: 23372

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKYMAEFIGTFWLVLGGCGSAVLAAAFPELGIGFVGVSLAFGLTVLTMAFAIGHISGCH
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LNPAVSVGLWVGGRFDAKDLVPYIVSQVLGGIAAGGILYLIASGQAGFDLAGGFASNGFG
CCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
EHSPGGYTMTAALITEVVLTAMFLIVIMGATDSRAPAGFAPIAIGLCLTLIHLISIPVTN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
TSVNPARSTAVAVYVGDWATSQLWLFWVAPIVGAVIGALIYKVMAKES
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKYMAEFIGTFWLVLGGCGSAVLAAAFPELGIGFVGVSLAFGLTVLTMAFAIGHISGCH
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LNPAVSVGLWVGGRFDAKDLVPYIVSQVLGGIAAGGILYLIASGQAGFDLAGGFASNGFG
CCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
EHSPGGYTMTAALITEVVLTAMFLIVIMGATDSRAPAGFAPIAIGLCLTLIHLISIPVTN
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
TSVNPARSTAVAVYVGDWATSQLWLFWVAPIVGAVIGALIYKVMAKES
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]