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The map label for this gene is chuR [H]

Identifier: 59712024

GI number: 59712024

Start: 1567986

End: 1569302

Strand: Reverse

Name: chuR [H]

Synonym: VF_1417

Alternate gene names: 59712024

Gene position: 1569302-1567986 (Counterclockwise)

Preceding gene: 59712026

Following gene: 59712023

Centisome position: 54.16

GC content: 36.75

Gene sequence:

>1317_bases
ATGATCATTACTCAAGGCCCACAATTTCAAGGTAAAGCATCAAAACGATTACATGTTATGGCCAAGCCTATTGGTGCTGT
ATGTAATATTGATTGTTCTTATTGTTATTACTTAAGTAAAGAAGATTTACTTGAGTATAAAAAGGGTTGTTCACCGCAAA
TGGATGACGAAACGCTTGAAACTTATATTCGTCAATATATTGAAGGACAAAACACGCCAGAGATTATCTTCTCATGGCAA
GGTGGTGAACCGACGTTATTAGGTCTTGATTACTTTAAAAAAATTGTTGAATTTCAAAAAAAATATCAGCCTGAAGGGAT
CTTGATTTCTAATGATTTACAGACAAACGGTACGTTATTAACCGATAAATGGTGTGAGTTTCTTGCTGAAAACAATTTTT
TAGTTGGTTTGAGTATTGATGGACCTGAAATGCTACACAATGCTTATCGCACCAACAAAGCGGGGCGCGGTACGTTTAAG
CAAGTAATGAACGCTGTTGAATTATTGCATAAACATAATGTGAAATTTGCCACGTTAACGTGTGTGAATAATTTAACGAG
TCGAAACCCTCTTGAGGTATATCGATTCTTACGTGATGTGGTGAAATCGCCACAAATGCAGTTTATTCCAATCGTTGAGC
AAAAAACGTTTAGAACAGTTGCTCCTCAAACTGAGCAAATTGCAGCACAGCTACGTCAAGGCGATAAACGTTTAATTCCA
GGTAATAAAGAATCCATTATGGAACCTTGGTGTGTTTCAGATGAAGCATGGGGTAATTTCTTAATTGCTGTATTTGATGA
ATGGACTCAGCATGACCTAGGTAAAGTATTTGTTCAGTATTTTGAAGCCAGTGTTGAAACATGGATGGGGCGTAAAAACC
CATTATGTACATTAGGTGAGATTTGCGGAAAAGGCTTAGCAATGGAACACAATGGAGATGTGTTTGCTTGTGACCATTAT
GTGTACCCTGAATATAAAATCGGAAATATTCATAATGAAGAGTTGGATACATTAGCGTTTAGCCGCAAGCAACAAGAGTT
TGGTTTTGCAAAATCAAAAACGTTAACGACTCAATGTCAGAAGTGTGAATATAAATTTGCGTGTCATGGTGAATGTCCTA
AAAACCGTTTTATTAAAACACGTGATGGTGAACCTGGATTAAATTATCTGTGTGCAGGTTGGAAGAAGTTTTTTGCTCAT
GCTGATAAATCCATCGCTTATATATTGAAAATGCTAGGGAATCCTGTTCAGCACGGTAAATACAGTGATGCGAAGATGCA
GCAAGTTCACCAAAATGCTTTTCCTACTAAGTTTTAA

Upstream 100 bases:

>100_bases
ATAGAGTTAGAACTTACTTAGCAGCAAAACTATAAGGGTGGTTTTCTCTTTGGCTAGGTAAGTTCTACTTAACCAAATTC
GTAAAATAATAGGAATCAAT

Downstream 100 bases:

>100_bases
TAATCTAAATTTTAATTATTTAATCTTTAAGATCGTACGTTTAAGAGTACCTTATGAAAAAAATAGTCTGCATTAGTTTG
TTATCCATATTGGGATTTTC

Product: arylsulfatase regulator (Fe-S oxidoreductase)

Products: NA

Alternate protein names: AnSME; Chondroitin sulfate/heparin utilization regulation protein; Ser-type sulfatase-activating enzyme [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MIITQGPQFQGKASKRLHVMAKPIGAVCNIDCSYCYYLSKEDLLEYKKGCSPQMDDETLETYIRQYIEGQNTPEIIFSWQ
GGEPTLLGLDYFKKIVEFQKKYQPEGILISNDLQTNGTLLTDKWCEFLAENNFLVGLSIDGPEMLHNAYRTNKAGRGTFK
QVMNAVELLHKHNVKFATLTCVNNLTSRNPLEVYRFLRDVVKSPQMQFIPIVEQKTFRTVAPQTEQIAAQLRQGDKRLIP
GNKESIMEPWCVSDEAWGNFLIAVFDEWTQHDLGKVFVQYFEASVETWMGRKNPLCTLGEICGKGLAMEHNGDVFACDHY
VYPEYKIGNIHNEELDTLAFSRKQQEFGFAKSKTLTTQCQKCEYKFACHGECPKNRFIKTRDGEPGLNYLCAGWKKFFAH
ADKSIAYILKMLGNPVQHGKYSDAKMQQVHQNAFPTKF

Sequences:

>Translated_438_residues
MIITQGPQFQGKASKRLHVMAKPIGAVCNIDCSYCYYLSKEDLLEYKKGCSPQMDDETLETYIRQYIEGQNTPEIIFSWQ
GGEPTLLGLDYFKKIVEFQKKYQPEGILISNDLQTNGTLLTDKWCEFLAENNFLVGLSIDGPEMLHNAYRTNKAGRGTFK
QVMNAVELLHKHNVKFATLTCVNNLTSRNPLEVYRFLRDVVKSPQMQFIPIVEQKTFRTVAPQTEQIAAQLRQGDKRLIP
GNKESIMEPWCVSDEAWGNFLIAVFDEWTQHDLGKVFVQYFEASVETWMGRKNPLCTLGEICGKGLAMEHNGDVFACDHY
VYPEYKIGNIHNEELDTLAFSRKQQEFGFAKSKTLTTQCQKCEYKFACHGECPKNRFIKTRDGEPGLNYLCAGWKKFFAH
ADKSIAYILKMLGNPVQHGKYSDAKMQQVHQNAFPTKF
>Mature_438_residues
MIITQGPQFQGKASKRLHVMAKPIGAVCNIDCSYCYYLSKEDLLEYKKGCSPQMDDETLETYIRQYIEGQNTPEIIFSWQ
GGEPTLLGLDYFKKIVEFQKKYQPEGILISNDLQTNGTLLTDKWCEFLAENNFLVGLSIDGPEMLHNAYRTNKAGRGTFK
QVMNAVELLHKHNVKFATLTCVNNLTSRNPLEVYRFLRDVVKSPQMQFIPIVEQKTFRTVAPQTEQIAAQLRQGDKRLIP
GNKESIMEPWCVSDEAWGNFLIAVFDEWTQHDLGKVFVQYFEASVETWMGRKNPLCTLGEICGKGLAMEHNGDVFACDHY
VYPEYKIGNIHNEELDTLAFSRKQQEFGFAKSKTLTTQCQKCEYKFACHGECPKNRFIKTRDGEPGLNYLCAGWKKFFAH
ADKSIAYILKMLGNPVQHGKYSDAKMQQVHQNAFPTKF

Specific function: Involved in 'Ser-type' sulfatase maturation under anaerobic conditions. Links the heparin and the chondroitin sulfate utilization pathways which contribute to the colonization of the intestinal tract. May catalyze the activation of chondro-6- sulfatase, i

COG id: COG0641

COG function: function code R; Arylsulfatase regulator (Fe-S oxidoreductase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family [H]

Homologues:

Organism=Escherichia coli, GI48994973, Length=422, Percent_Identity=44.7867298578199, Blast_Score=374, Evalue=1e-105,
Organism=Escherichia coli, GI87081923, Length=402, Percent_Identity=38.8059701492537, Blast_Score=300, Evalue=1e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 50187; Mature: 50187

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIITQGPQFQGKASKRLHVMAKPIGAVCNIDCSYCYYLSKEDLLEYKKGCSPQMDDETLE
CCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCEEEEECHHHHHHHHHCCCCCCCHHHHH
TYIRQYIEGQNTPEIIFSWQGGEPTLLGLDYFKKIVEFQKKYQPEGILISNDLQTNGTLL
HHHHHHHCCCCCCEEEEEECCCCCEEECHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEE
TDKWCEFLAENNFLVGLSIDGPEMLHNAYRTNKAGRGTFKQVMNAVELLHKHNVKFATLT
HHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
CVNNLTSRNPLEVYRFLRDVVKSPQMQFIPIVEQKTFRTVAPQTEQIAAQLRQGDKRLIP
EHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHCCCCHHHHHHHHHCCCCCCCC
GNKESIMEPWCVSDEAWGNFLIAVFDEWTQHDLGKVFVQYFEASVETWMGRKNPLCTLGE
CCHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHH
ICGKGLAMEHNGDVFACDHYVYPEYKIGNIHNEELDTLAFSRKQQEFGFAKSKTLTTQCQ
HHCCCEEEECCCCEEEECCEECCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
KCEYKFACHGECPKNRFIKTRDGEPGLNYLCAGWKKFFAHADKSIAYILKMLGNPVQHGK
HCCCEEEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHCCC
YSDAKMQQVHQNAFPTKF
CCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIITQGPQFQGKASKRLHVMAKPIGAVCNIDCSYCYYLSKEDLLEYKKGCSPQMDDETLE
CCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCEEEEECHHHHHHHHHCCCCCCCHHHHH
TYIRQYIEGQNTPEIIFSWQGGEPTLLGLDYFKKIVEFQKKYQPEGILISNDLQTNGTLL
HHHHHHHCCCCCCEEEEEECCCCCEEECHHHHHHHHHHHHHCCCCCEEEECCCCCCCCEE
TDKWCEFLAENNFLVGLSIDGPEMLHNAYRTNKAGRGTFKQVMNAVELLHKHNVKFATLT
HHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
CVNNLTSRNPLEVYRFLRDVVKSPQMQFIPIVEQKTFRTVAPQTEQIAAQLRQGDKRLIP
EHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHCCCCHHHHHHHHHCCCCCCCC
GNKESIMEPWCVSDEAWGNFLIAVFDEWTQHDLGKVFVQYFEASVETWMGRKNPLCTLGE
CCHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHH
ICGKGLAMEHNGDVFACDHYVYPEYKIGNIHNEELDTLAFSRKQQEFGFAKSKTLTTQCQ
HHCCCEEEECCCCEEEECCEECCCEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHH
KCEYKFACHGECPKNRFIKTRDGEPGLNYLCAGWKKFFAHADKSIAYILKMLGNPVQHGK
HCCCEEEECCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHCCC
YSDAKMQQVHQNAFPTKF
CCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1429442; 12663928 [H]