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The map label for this gene is mobB [H]

Identifier: 59712013

GI number: 59712013

Start: 1555060

End: 1556841

Strand: Direct

Name: mobB [H]

Synonym: VF_1406

Alternate gene names: 59712013

Gene position: 1555060-1556841 (Clockwise)

Preceding gene: 59712012

Following gene: 59712014

Centisome position: 53.67

GC content: 42.99

Gene sequence:

>1782_bases
ATGAGCTTAACGTCTGCGTCTATCCCTCTATTGGGTTTTGCTGCTTATAGCGGCACAGGTAAAACAACATTACTTGAAAA
ACTGCTGCCTAAACTGACTGATATGGGACTAAAAGTCGCAGTCATTAAACACGCTCATCATAATTTTGATATCGACCAAG
AAGGCAAAGACAGCTACCGCTTACGTAAAGCGGGCGCTAGCCAAATGTTGATCAGTTCACGTTTTCGCAATGCCTTGATC
ACTGAAACCCCCGATGAAGAAACAACATGTCAGCAGTTAATCAATAAACTCGATCAAACTGAATTAGACTTAATTCTTAT
TGAAGGGTTTAAACAACTACCATCCACCAAGATTGAATTGCATCGTAATGAAATCGGCAAGCCTTGGATTTTCCCAGAAG
ATGAAAACATCATTGCGATTGCCTCGGATTTAAAAGCCGACTCTGAACTGCCTCAAATGGACATCAATGATACCGATTCA
ATCACGCAATTCATTGTTGACTACGTCAAACAACATCAGCATAAACAGCAAAGTGACCTATCCGCCAACTGCGATGAGTT
ATCCCCTGCGTTTTTATCTGTTAGTCAAGGCAGAGCTAAGATTTTAGAGGCGATCACTCCACTAAATTCACAAAGTGATG
TCTCTTTAGTTGAGTCGATTAATGCATTAGCCGCTCAAGATATTTTATCACCGATTAATGTTCCCCAACATAACAATTCA
GCAATGGATGGCTATGTGATTTGTGGTGATGATTTAGAGTGTGAAAGCTATACGGTCGTTGCCGAAATCATGGCAGGTCA
CAGCTATGATCGCCCTCTTCAACATGGTGAAGCAGCTAAAATCATGACGGGGGCGCCAGTACCTGAAAATGGTCATGCCG
TGATCATGCGAGAACAAGCGACTCAAGAAGGTGATCAAGTACGCTTCGATGCGGGTAAATCAGGCATTCGTAAAGGCCAA
AATGTTCGTCTAGCCGGTGAAGATCTGGCTATCGATCAGATCTGTGTGGCTAAAGGTTCACGTATTACAGCACCTGAAGT
GGGTATGCTTGCGTCTTTAGGCATTGCTTCTGTTCCTGTTATCGCTAAAACAAAAGTAGCTATCTTCTCGACTGGCGATG
AAGTTCAAGCACCAGGTGAAGCACAAAAAGCCAACTCTATTTACGACTCAAACCGTTTTACTTTAACGGCATTACTGCAA
AAATTAGGCTGTGAAGTGATTGATTTCGGTATCATTGAAGACAGTGAAGCCGCTTTAGAATCAACGCTTTCTCAAGCATC
ACAACAAGCAGATATGATTTTATCTTCTGGTGGTGTGTCGGTTGGTGATGCGGACTACATCAAAACGATTTTAGACAAAC
TGGGCAATATTAATTTCTGGCGTATCAATATGCGTCCGGGACGCCCTCTTGCCTTTGGTCATATTGGTGATACGCCATTC
TTCGGTTTACCGGGTAACCCTGTAGCAGTAATGGTGGCGTTCTTACAGTTTGTCGAGCCTGCACTTCGCAAACTTCAAGG
CGAAGATAATTGGCAGCCTGAAACCTTTACTGCAATTGCAAAAGAGTTTATTCGTTCTCGCACTGGCCGAACTGAATACA
GCCGTGGTATTTACTCTATTAACCAAAATGGTCAAATGGAAGTCGTAACCACAGGCAAACAAGGCTCTGGTATTTTACGT
TCAATGAGTGAAGCCAACTGCTTAATTGAAGTGCAACCAGAAGTTGAGTCGGTAGATATTGGTCAGAAAGTGACGATCAT
TCCGTTGAGTTCGAGAGTGTAG

Upstream 100 bases:

>100_bases
ACAAAGAGTGTAATACTGTATTTGCTGATTTCTCTGACTACCCTAACGCGTTTATCAATTTGAATAGTCCTCAAGAACTT
GAACAATTTGGAACTTTATT

Downstream 100 bases:

>100_bases
ATACCTCTTATCCAAATGATTATAAACAGGCCTATTTTACAACTAGGCCTGTTTTCTTTTCTAATCACTTTATCCAATCC
CATGTTGATGGTATAAAGTG

Product: putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MSLTSASIPLLGFAAYSGTGKTTLLEKLLPKLTDMGLKVAVIKHAHHNFDIDQEGKDSYRLRKAGASQMLISSRFRNALI
TETPDEETTCQQLINKLDQTELDLILIEGFKQLPSTKIELHRNEIGKPWIFPEDENIIAIASDLKADSELPQMDINDTDS
ITQFIVDYVKQHQHKQQSDLSANCDELSPAFLSVSQGRAKILEAITPLNSQSDVSLVESINALAAQDILSPINVPQHNNS
AMDGYVICGDDLECESYTVVAEIMAGHSYDRPLQHGEAAKIMTGAPVPENGHAVIMREQATQEGDQVRFDAGKSGIRKGQ
NVRLAGEDLAIDQICVAKGSRITAPEVGMLASLGIASVPVIAKTKVAIFSTGDEVQAPGEAQKANSIYDSNRFTLTALLQ
KLGCEVIDFGIIEDSEAALESTLSQASQQADMILSSGGVSVGDADYIKTILDKLGNINFWRINMRPGRPLAFGHIGDTPF
FGLPGNPVAVMVAFLQFVEPALRKLQGEDNWQPETFTAIAKEFIRSRTGRTEYSRGIYSINQNGQMEVVTTGKQGSGILR
SMSEANCLIEVQPEVESVDIGQKVTIIPLSSRV

Sequences:

>Translated_593_residues
MSLTSASIPLLGFAAYSGTGKTTLLEKLLPKLTDMGLKVAVIKHAHHNFDIDQEGKDSYRLRKAGASQMLISSRFRNALI
TETPDEETTCQQLINKLDQTELDLILIEGFKQLPSTKIELHRNEIGKPWIFPEDENIIAIASDLKADSELPQMDINDTDS
ITQFIVDYVKQHQHKQQSDLSANCDELSPAFLSVSQGRAKILEAITPLNSQSDVSLVESINALAAQDILSPINVPQHNNS
AMDGYVICGDDLECESYTVVAEIMAGHSYDRPLQHGEAAKIMTGAPVPENGHAVIMREQATQEGDQVRFDAGKSGIRKGQ
NVRLAGEDLAIDQICVAKGSRITAPEVGMLASLGIASVPVIAKTKVAIFSTGDEVQAPGEAQKANSIYDSNRFTLTALLQ
KLGCEVIDFGIIEDSEAALESTLSQASQQADMILSSGGVSVGDADYIKTILDKLGNINFWRINMRPGRPLAFGHIGDTPF
FGLPGNPVAVMVAFLQFVEPALRKLQGEDNWQPETFTAIAKEFIRSRTGRTEYSRGIYSINQNGQMEVVTTGKQGSGILR
SMSEANCLIEVQPEVESVDIGQKVTIIPLSSRV
>Mature_592_residues
SLTSASIPLLGFAAYSGTGKTTLLEKLLPKLTDMGLKVAVIKHAHHNFDIDQEGKDSYRLRKAGASQMLISSRFRNALIT
ETPDEETTCQQLINKLDQTELDLILIEGFKQLPSTKIELHRNEIGKPWIFPEDENIIAIASDLKADSELPQMDINDTDSI
TQFIVDYVKQHQHKQQSDLSANCDELSPAFLSVSQGRAKILEAITPLNSQSDVSLVESINALAAQDILSPINVPQHNNSA
MDGYVICGDDLECESYTVVAEIMAGHSYDRPLQHGEAAKIMTGAPVPENGHAVIMREQATQEGDQVRFDAGKSGIRKGQN
VRLAGEDLAIDQICVAKGSRITAPEVGMLASLGIASVPVIAKTKVAIFSTGDEVQAPGEAQKANSIYDSNRFTLTALLQK
LGCEVIDFGIIEDSEAALESTLSQASQQADMILSSGGVSVGDADYIKTILDKLGNINFWRINMRPGRPLAFGHIGDTPFF
GLPGNPVAVMVAFLQFVEPALRKLQGEDNWQPETFTAIAKEFIRSRTGRTEYSRGIYSINQNGQMEVVTTGKQGSGILRS
MSEANCLIEVQPEVESVDIGQKVTIIPLSSRV

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=407, Percent_Identity=31.9410319410319, Blast_Score=180, Evalue=3e-45,
Organism=Homo sapiens, GI66932975, Length=406, Percent_Identity=32.0197044334975, Blast_Score=180, Evalue=3e-45,
Organism=Escherichia coli, GI1787049, Length=389, Percent_Identity=42.6735218508997, Blast_Score=325, Evalue=4e-90,
Organism=Escherichia coli, GI145693204, Length=166, Percent_Identity=48.7951807228916, Blast_Score=162, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI25147659, Length=303, Percent_Identity=31.023102310231, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17562606, Length=319, Percent_Identity=24.1379310344828, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17136978, Length=373, Percent_Identity=31.6353887399464, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24638841, Length=373, Percent_Identity=31.6353887399464, Blast_Score=148, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 64470; Mature: 64339

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLTSASIPLLGFAAYSGTGKTTLLEKLLPKLTDMGLKVAVIKHAHHNFDIDQEGKDSYR
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEEHHCCCCCCCCCCCHHHH
LRKAGASQMLISSRFRNALITETPDEETTCQQLINKLDQTELDLILIEGFKQLPSTKIEL
HHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECHHHCCCCEEEE
HRNEIGKPWIFPEDENIIAIASDLKADSELPQMDINDTDSITQFIVDYVKQHQHKQQSDL
EHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
SANCDELSPAFLSVSQGRAKILEAITPLNSQSDVSLVESINALAAQDILSPINVPQHNNS
CCCCHHCCHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
AMDGYVICGDDLECESYTVVAEIMAGHSYDRPLQHGEAAKIMTGAPVPENGHAVIMREQA
CCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEECCC
TQEGDQVRFDAGKSGIRKGQNVRLAGEDLAIDQICVAKGSRITAPEVGMLASLGIASVPV
CCCCCEEEECCCCHHHCCCCCEEEECCCCCHHHHHHCCCCCCCCCCHHHHHHCCHHHCCE
IAKTKVAIFSTGDEVQAPGEAQKANSIYDSNRFTLTALLQKLGCEVIDFGIIEDSEAALE
EEECEEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCHHHHHH
STLSQASQQADMILSSGGVSVGDADYIKTILDKLGNINFWRINMRPGRPLAFGHIGDTPF
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCC
FGLPGNPVAVMVAFLQFVEPALRKLQGEDNWQPETFTAIAKEFIRSRTGRTEYSRGIYSI
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEE
NQNGQMEVVTTGKQGSGILRSMSEANCLIEVQPEVESVDIGQKVTIIPLSSRV
CCCCCEEEEECCCCCCHHHHHHCCCCEEEEECCCCCEECCCCEEEEEECCCCC
>Mature Secondary Structure 
SLTSASIPLLGFAAYSGTGKTTLLEKLLPKLTDMGLKVAVIKHAHHNFDIDQEGKDSYR
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCEEEEEEEHHCCCCCCCCCCCHHHH
LRKAGASQMLISSRFRNALITETPDEETTCQQLINKLDQTELDLILIEGFKQLPSTKIEL
HHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECHHHCCCCEEEE
HRNEIGKPWIFPEDENIIAIASDLKADSELPQMDINDTDSITQFIVDYVKQHQHKQQSDL
EHHHCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
SANCDELSPAFLSVSQGRAKILEAITPLNSQSDVSLVESINALAAQDILSPINVPQHNNS
CCCCHHCCHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
AMDGYVICGDDLECESYTVVAEIMAGHSYDRPLQHGEAAKIMTGAPVPENGHAVIMREQA
CCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCCEEEEECCC
TQEGDQVRFDAGKSGIRKGQNVRLAGEDLAIDQICVAKGSRITAPEVGMLASLGIASVPV
CCCCCEEEECCCCHHHCCCCCEEEECCCCCHHHHHHCCCCCCCCCCHHHHHHCCHHHCCE
IAKTKVAIFSTGDEVQAPGEAQKANSIYDSNRFTLTALLQKLGCEVIDFGIIEDSEAALE
EEECEEEEEECCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCCCHHHHHH
STLSQASQQADMILSSGGVSVGDADYIKTILDKLGNINFWRINMRPGRPLAFGHIGDTPF
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCEEEECCCCCCC
FGLPGNPVAVMVAFLQFVEPALRKLQGEDNWQPETFTAIAKEFIRSRTGRTEYSRGIYSI
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEE
NQNGQMEVVTTGKQGSGILRSMSEANCLIEVQPEVESVDIGQKVTIIPLSSRV
CCCCCEEEEECCCCCCHHHHHHCCCCEEEEECCCCCEECCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]