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The map label for this gene is phoQ [H]

Identifier: 59712004

GI number: 59712004

Start: 1544438

End: 1545802

Strand: Direct

Name: phoQ [H]

Synonym: VF_1397

Alternate gene names: 59712004

Gene position: 1544438-1545802 (Clockwise)

Preceding gene: 59712003

Following gene: 172087705

Centisome position: 53.3

GC content: 37.58

Gene sequence:

>1365_bases
ATGAAAAAGGCACCCCGTCGTCTTCAACATACATTAAAAAAATTAAGTTTAAAAAGCCGCTTGCTTCTTGCTGCGGCTTT
TTGGCTATCTTCAATGATTTTAGCGGCTGGCATTGGTATTCCAAAACTAGTCAATGATTATCTGATTAAAGATGTAAAAC
AACAATTAGCCTTATCTATGGATGAAATCACGGCTAATTTAGAAACCAACGAACAAGGAAAGTTAGTTTTATTCTCTCGA
CTTTCTGATCCTCGTTTTAATCAGCCTTATAGCGGTCTATACTGGACTGCAAGTACCAAAAAAGATGAACTGCGTTCTCG
TTCTTTATGGGATAAGAAGCTAAAATTTAAAGACAATTCTTTAGATATCGCTCCTACAGTAAAGGGAGCAAAAGACGAAA
AACTTATCTATATTCAAAAACACATATACCTTCCAGAAATTAAAGCACCAATAACAATAACCATTGGTGTGGATGAAAAT
CCCTTAGAAAAAACATTACACCAATTAACAGGACAAGTTTGGGTTATCTTAGGATTACTATTTAGCGGTGTTTTATTCCT
TATTGGTATTCAAGTCAGTTGGTCTTTACGCCCACTTGCTAAAATGCAATCTGAACTTATTCAACTGCGCAAAGGAGAAC
AACAAAATTTAAGCCAACACTACCCTCAAGAAATAGCCCCTTTGGTTTCGGATCTCAATGCGCTTTTATTTCATTATCAA
GAATTACTGGATCGTGCTCGTAACCATGCAGGCAACTTATCTCATTCTTTAAAAACACCACTATCCGTCCTTAAAAATGA
GTTAGAGCATTTAAGCGAAGAGGATAAAAAGCGCTTATCTCTGCCTATTAATAAACTTCAAGAGCACATCGACTACCATT
TAGGCCGTGCTCGCATGGCTGGATCAATGAATATTTTATCTGTTTCAACCTCTCCATCCGATCGTGTTGATGCCATATCA
ATGGCTTTTGATAAAGTCTATGCTGTTCGTGAAATCATGTTAATTAACGAACTTAATAGTGATGACAATATTGCCGTAGA
AGCAACAGATCTTGATGAAATGCTTGGTAATTTACTCGAAAATGGCTATAAGTGGGCAAGTTCTATGATTCGTGTTCATT
CAAAATACGCTGCTGACAATCTCATTGAAATCACGATCGAAGATGATGGAAATGGCATACCAGAAGATAAACTAGAGCAC
GTAATTCGACGAGGTGTACGTCTGGATGAATCAACCCCAGGTACAGGGCTTGGTTTAAATATTGTAGACGAAATGGCACA
CAGCTACCGCGGTTCATTGCTTTTAGATAGAAGTAAAATGGGCGGCTTAAAAGCAACCCTCACCTTTCCACTGGTGACTA
ATTAA

Upstream 100 bases:

>100_bases
ATTTATTGGCCGAATTCGTAAAAAAATAGCGCCAAATATCATCAAAACCGTACGTGGTCTTGGTTATCAATTAAACTCAT
AGAGCAAATCAAGGATAACG

Downstream 100 bases:

>100_bases
CAATAAATAACCTCGTACGTTATCCATTATTACCAATAGGTAACGTACGAGTACTGATAACCAATATCTCTCCATCAGAA
TAATAATCATGCTCTTCATC

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MKKAPRRLQHTLKKLSLKSRLLLAAAFWLSSMILAAGIGIPKLVNDYLIKDVKQQLALSMDEITANLETNEQGKLVLFSR
LSDPRFNQPYSGLYWTASTKKDELRSRSLWDKKLKFKDNSLDIAPTVKGAKDEKLIYIQKHIYLPEIKAPITITIGVDEN
PLEKTLHQLTGQVWVILGLLFSGVLFLIGIQVSWSLRPLAKMQSELIQLRKGEQQNLSQHYPQEIAPLVSDLNALLFHYQ
ELLDRARNHAGNLSHSLKTPLSVLKNELEHLSEEDKKRLSLPINKLQEHIDYHLGRARMAGSMNILSVSTSPSDRVDAIS
MAFDKVYAVREIMLINELNSDDNIAVEATDLDEMLGNLLENGYKWASSMIRVHSKYAADNLIEITIEDDGNGIPEDKLEH
VIRRGVRLDESTPGTGLGLNIVDEMAHSYRGSLLLDRSKMGGLKATLTFPLVTN

Sequences:

>Translated_454_residues
MKKAPRRLQHTLKKLSLKSRLLLAAAFWLSSMILAAGIGIPKLVNDYLIKDVKQQLALSMDEITANLETNEQGKLVLFSR
LSDPRFNQPYSGLYWTASTKKDELRSRSLWDKKLKFKDNSLDIAPTVKGAKDEKLIYIQKHIYLPEIKAPITITIGVDEN
PLEKTLHQLTGQVWVILGLLFSGVLFLIGIQVSWSLRPLAKMQSELIQLRKGEQQNLSQHYPQEIAPLVSDLNALLFHYQ
ELLDRARNHAGNLSHSLKTPLSVLKNELEHLSEEDKKRLSLPINKLQEHIDYHLGRARMAGSMNILSVSTSPSDRVDAIS
MAFDKVYAVREIMLINELNSDDNIAVEATDLDEMLGNLLENGYKWASSMIRVHSKYAADNLIEITIEDDGNGIPEDKLEH
VIRRGVRLDESTPGTGLGLNIVDEMAHSYRGSLLLDRSKMGGLKATLTFPLVTN
>Mature_454_residues
MKKAPRRLQHTLKKLSLKSRLLLAAAFWLSSMILAAGIGIPKLVNDYLIKDVKQQLALSMDEITANLETNEQGKLVLFSR
LSDPRFNQPYSGLYWTASTKKDELRSRSLWDKKLKFKDNSLDIAPTVKGAKDEKLIYIQKHIYLPEIKAPITITIGVDEN
PLEKTLHQLTGQVWVILGLLFSGVLFLIGIQVSWSLRPLAKMQSELIQLRKGEQQNLSQHYPQEIAPLVSDLNALLFHYQ
ELLDRARNHAGNLSHSLKTPLSVLKNELEHLSEEDKKRLSLPINKLQEHIDYHLGRARMAGSMNILSVSTSPSDRVDAIS
MAFDKVYAVREIMLINELNSDDNIAVEATDLDEMLGNLLENGYKWASSMIRVHSKYAADNLIEITIEDDGNGIPEDKLEH
VIRRGVRLDESTPGTGLGLNIVDEMAHSYRGSLLLDRSKMGGLKATLTFPLVTN

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=317, Percent_Identity=29.6529968454259, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1790551, Length=280, Percent_Identity=28.2142857142857, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787894, Length=234, Percent_Identity=28.6324786324786, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788393, Length=244, Percent_Identity=25.4098360655738, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789808, Length=289, Percent_Identity=26.643598615917, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1790346, Length=280, Percent_Identity=26.4285714285714, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51115; Mature: 51115

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKAPRRLQHTLKKLSLKSRLLLAAAFWLSSMILAAGIGIPKLVNDYLIKDVKQQLALSM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
DEITANLETNEQGKLVLFSRLSDPRFNQPYSGLYWTASTKKDELRSRSLWDKKLKFKDNS
HHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCC
LDIAPTVKGAKDEKLIYIQKHIYLPEIKAPITITIGVDENPLEKTLHQLTGQVWVILGLL
EEECCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
FSGVLFLIGIQVSWSLRPLAKMQSELIQLRKGEQQNLSQHYPQEIAPLVSDLNALLFHYQ
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHH
ELLDRARNHAGNLSHSLKTPLSVLKNELEHLSEEDKKRLSLPINKLQEHIDYHLGRARMA
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
GSMNILSVSTSPSDRVDAISMAFDKVYAVREIMLINELNSDDNIAVEATDLDEMLGNLLE
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHH
NGYKWASSMIRVHSKYAADNLIEITIEDDGNGIPEDKLEHVIRRGVRLDESTPGTGLGLN
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHH
IVDEMAHSYRGSLLLDRSKMGGLKATLTFPLVTN
HHHHHHHHHCCCEEEEHHHCCCEEEEEEECEECC
>Mature Secondary Structure
MKKAPRRLQHTLKKLSLKSRLLLAAAFWLSSMILAAGIGIPKLVNDYLIKDVKQQLALSM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
DEITANLETNEQGKLVLFSRLSDPRFNQPYSGLYWTASTKKDELRSRSLWDKKLKFKDNS
HHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCCC
LDIAPTVKGAKDEKLIYIQKHIYLPEIKAPITITIGVDENPLEKTLHQLTGQVWVILGLL
EEECCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHH
FSGVLFLIGIQVSWSLRPLAKMQSELIQLRKGEQQNLSQHYPQEIAPLVSDLNALLFHYQ
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHH
ELLDRARNHAGNLSHSLKTPLSVLKNELEHLSEEDKKRLSLPINKLQEHIDYHLGRARMA
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHC
GSMNILSVSTSPSDRVDAISMAFDKVYAVREIMLINELNSDDNIAVEATDLDEMLGNLLE
CCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHH
NGYKWASSMIRVHSKYAADNLIEITIEDDGNGIPEDKLEHVIRRGVRLDESTPGTGLGLN
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCHH
IVDEMAHSYRGSLLLDRSKMGGLKATLTFPLVTN
HHHHHHHHHCCCEEEEHHHCCCEEEEEEECEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA