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The map label for this gene is irlR [H]

Identifier: 59712003

GI number: 59712003

Start: 1543763

End: 1544419

Strand: Direct

Name: irlR [H]

Synonym: VF_1396

Alternate gene names: 59712003

Gene position: 1543763-1544419 (Clockwise)

Preceding gene: 59712002

Following gene: 59712004

Centisome position: 53.28

GC content: 39.12

Gene sequence:

>657_bases
ATGAAAATTTTAGTTGTAGAAGATGACTTACGTTTAGGCGCACAAATTGTAGAAACCCTAGAGTCTGCCGATTGGGTTCC
TGAGTTATCACAAGATGGTGTTGATGCATTATATAGAGCAACAACTGAGGAATGGGATGCTATTGTTCTTGATTTGGGCT
TACCAAAATTAAATGGCCTAACGGTACTAAAAAGCATTCGTGATGAAAACATTAACACGCCCGTTATTATTTTAAGTGCT
CGTGATACGTTATCACAACGTGTTGAAGGCTTAAATGCAGGCGCAGATGACTACTTAACTAAACCGTTTGAAATGGTGGA
ATTGATTGCTCGCATTCGTGCTCAATTACGTCGAGCCTCTGGCAATGCCTCCCCTATTTTAAAAATTGGTGATTTAAGCT
TAGATACCCGCAGTTCCAAAGTTCTGTGGCAAGACCAAGCTGTAAGCCTGACAGCATTGGAATACAAGGTCGTTGCTTAT
TTCATGCACAATCCAGATAAGGTGATCTCTAGAACGACACTTGTTGAACATATCTATAAGCAAGATTTTGATCGTGATTC
AAATACCGTTGAAGTATTTATTGGCCGAATTCGTAAAAAAATAGCGCCAAATATCATCAAAACCGTACGTGGTCTTGGTT
ATCAATTAAACTCATAG

Upstream 100 bases:

>100_bases
ATGCGGCTAACCTTGCGATCACAGAAATTAAAGGTCGTGATATTCGAGCAGCACTTAAATAGATCAACCCACAATTATAT
AAATAGAGATAACAATAATA

Downstream 100 bases:

>100_bases
AGCAAATCAAGGATAACGATGAAAAAGGCACCCCGTCGTCTTCAACATACATTAAAAAAATTAAGTTTAAAAAGCCGCTT
GCTTCTTGCTGCGGCTTTTT

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MKILVVEDDLRLGAQIVETLESADWVPELSQDGVDALYRATTEEWDAIVLDLGLPKLNGLTVLKSIRDENINTPVIILSA
RDTLSQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRASGNASPILKIGDLSLDTRSSKVLWQDQAVSLTALEYKVVAY
FMHNPDKVISRTTLVEHIYKQDFDRDSNTVEVFIGRIRKKIAPNIIKTVRGLGYQLNS

Sequences:

>Translated_218_residues
MKILVVEDDLRLGAQIVETLESADWVPELSQDGVDALYRATTEEWDAIVLDLGLPKLNGLTVLKSIRDENINTPVIILSA
RDTLSQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRASGNASPILKIGDLSLDTRSSKVLWQDQAVSLTALEYKVVAY
FMHNPDKVISRTTLVEHIYKQDFDRDSNTVEVFIGRIRKKIAPNIIKTVRGLGYQLNS
>Mature_218_residues
MKILVVEDDLRLGAQIVETLESADWVPELSQDGVDALYRATTEEWDAIVLDLGLPKLNGLTVLKSIRDENINTPVIILSA
RDTLSQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRASGNASPILKIGDLSLDTRSSKVLWQDQAVSLTALEYKVVAY
FMHNPDKVISRTTLVEHIYKQDFDRDSNTVEVFIGRIRKKIAPNIIKTVRGLGYQLNS

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=36.7713004484305, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=39.3665158371041, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=38.1818181818182, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=35.3211009174312, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1790552, Length=216, Percent_Identity=37.962962962963, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=35.5555555555556, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=30.9417040358744, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1786911, Length=188, Percent_Identity=33.5106382978723, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=32.5991189427313, Blast_Score=111, Evalue=3e-26,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=30.9417040358744, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=32.7433628318584, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=30.2631578947368, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787229, Length=223, Percent_Identity=27.8026905829596, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=25.3275109170306, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=28.9719626168224, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24449; Mature: 24449

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVVEDDLRLGAQIVETLESADWVPELSQDGVDALYRATTEEWDAIVLDLGLPKLNGL
CEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHCEEEEECCCCCCCHH
TVLKSIRDENINTPVIILSARDTLSQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRAS
HHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCC
GNASPILKIGDLSLDTRSSKVLWQDQAVSLTALEYKVVAYFMHNPDKVISRTTLVEHIYK
CCCCCEEEECCCCCCCCCCEEEECCCCEEEHHHHHEEHHHHHCCCHHHHHHHHHHHHHHH
QDFDRDSNTVEVFIGRIRKKIAPNIIKTVRGLGYQLNS
HHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKILVVEDDLRLGAQIVETLESADWVPELSQDGVDALYRATTEEWDAIVLDLGLPKLNGL
CEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHCEEEEECCCCCCCHH
TVLKSIRDENINTPVIILSARDTLSQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRAS
HHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCC
GNASPILKIGDLSLDTRSSKVLWQDQAVSLTALEYKVVAYFMHNPDKVISRTTLVEHIYK
CCCCCEEEECCCCCCCCCCEEEECCCCEEEHHHHHEEHHHHHCCCHHHHHHHHHHHHHHH
QDFDRDSNTVEVFIGRIRKKIAPNIIKTVRGLGYQLNS
HHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]