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The map label for this gene is pcp

Identifier: 59711977

GI number: 59711977

Start: 1517042

End: 1517680

Strand: Reverse

Name: pcp

Synonym: VF_1370

Alternate gene names: 59711977

Gene position: 1517680-1517042 (Counterclockwise)

Preceding gene: 59711978

Following gene: 59711976

Centisome position: 52.38

GC content: 41.16

Gene sequence:

>639_bases
ATGAAAAAGATTTTAATTACGGGTTTTGAACCATTTGGTAACGATAAAATCAATCCTGCATTGGAAGCGGTTAAGTTAAT
TGCAGGGCGCAAGCTTAATGGTGGTGAGATTGTTATTTGTCAGGTTCCAGTGGTTCGATACAAATCTATTGAAACAGTAA
AACAAGCAATTGAAGAGCAACAACCGTATGCGGTTATTACTGTGGGTCAAGCATCAGGACGTGCTGCCATTACACCAGAA
CGTATTGCCATTAATGTAGACGATTTTAGAATCCCTGATAACGAGGGTATCCAAGTTATTGATGAACCTGTTGTCGCTGG
TGGGCCTGACGCTTACTTTACGACACTTCCTATCAAAGCAATGGTCAGTGAAATTCAAGCGCAAGGCATACCTGCCACGG
TTTCAAATACCGCAGGGACATTTGTGTGTAACCACCTGTTTTATGGAATACAACATTACTTAAAAGACACGAATGTTCGT
CATGGTTTTGTACATATTCCATTATTACCAGAGCAATCGGTTGATGGTTCACAACCAACGATGAAACTTGAGCAAATTGC
AGAAGGTTTAGCAATAGCGGCGCAAGCCATCATTGATAACGATTCTGATATCCAACAAGGTGCGGGAACGATCTGTTAA

Upstream 100 bases:

>100_bases
ATAAAAACCAAGTGATTATTACTCAGTTTATTCCTGGTTTTATCATGTTACTTATTAATACTACATTTATGTATCTGTTT
GCGTTTTAGGGAATTAGGCA

Downstream 100 bases:

>100_bases
GATAATTAGCCTCACTTTTTAAAGCCTAAGAATAATGTTAATTGTTCTTAGGTTTTTTTATGCCTGAAGAAATTATAAGA
GATTTAACGAGATAGACAGT

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKKILITGFEPFGNDKINPALEAVKLIAGRKLNGGEIVICQVPVVRYKSIETVKQAIEEQQPYAVITVGQASGRAAITPE
RIAINVDDFRIPDNEGIQVIDEPVVAGGPDAYFTTLPIKAMVSEIQAQGIPATVSNTAGTFVCNHLFYGIQHYLKDTNVR
HGFVHIPLLPEQSVDGSQPTMKLEQIAEGLAIAAQAIIDNDSDIQQGAGTIC

Sequences:

>Translated_212_residues
MKKILITGFEPFGNDKINPALEAVKLIAGRKLNGGEIVICQVPVVRYKSIETVKQAIEEQQPYAVITVGQASGRAAITPE
RIAINVDDFRIPDNEGIQVIDEPVVAGGPDAYFTTLPIKAMVSEIQAQGIPATVSNTAGTFVCNHLFYGIQHYLKDTNVR
HGFVHIPLLPEQSVDGSQPTMKLEQIAEGLAIAAQAIIDNDSDIQQGAGTIC
>Mature_212_residues
MKKILITGFEPFGNDKINPALEAVKLIAGRKLNGGEIVICQVPVVRYKSIETVKQAIEEQQPYAVITVGQASGRAAITPE
RIAINVDDFRIPDNEGIQVIDEPVVAGGPDAYFTTLPIKAMVSEIQAQGIPATVSNTAGTFVCNHLFYGIQHYLKDTNVR
HGFVHIPLLPEQSVDGSQPTMKLEQIAEGLAIAAQAIIDNDSDIQQGAGTIC

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP_VIBF1 (Q5E531)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_204753.1
- HSSP:   P46107
- ProteinModelPortal:   Q5E531
- SMR:   Q5E531
- STRING:   Q5E531
- MEROPS:   C15.001
- GeneID:   3278693
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_1370
- NMPDR:   fig|312309.3.peg.1370
- eggNOG:   COG2039
- HOGENOM:   HBG360405
- OMA:   NTAGTYV
- ProtClustDB:   PRK13197
- BioCyc:   VFIS312309:VF1370-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 22804; Mature: 22804

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 80-80 ACT_SITE 143-143 ACT_SITE 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILITGFEPFGNDKINPALEAVKLIAGRKLNGGEIVICQVPVVRYKSIETVKQAIEEQ
CCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHC
QPYAVITVGQASGRAAITPERIAINVDDFRIPDNEGIQVIDEPVVAGGPDAYFTTLPIKA
CCEEEEEEECCCCCEEECCCEEEEECCCEECCCCCCCEEECCCEECCCCCCEEEECCHHH
MVSEIQAQGIPATVSNTAGTFVCNHLFYGIQHYLKDTNVRHGFVHIPLLPEQSVDGSQPT
HHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCC
MKLEQIAEGLAIAAQAIIDNDSDIQQGAGTIC
HHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCC
>Mature Secondary Structure
MKKILITGFEPFGNDKINPALEAVKLIAGRKLNGGEIVICQVPVVRYKSIETVKQAIEEQ
CCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHC
QPYAVITVGQASGRAAITPERIAINVDDFRIPDNEGIQVIDEPVVAGGPDAYFTTLPIKA
CCEEEEEEECCCCCEEECCCEEEEECCCEECCCCCCCEEECCCEECCCCCCEEEECCHHH
MVSEIQAQGIPATVSNTAGTFVCNHLFYGIQHYLKDTNVRHGFVHIPLLPEQSVDGSQPT
HHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCC
MKLEQIAEGLAIAAQAIIDNDSDIQQGAGTIC
HHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA