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The map label for this gene is 59711868

Identifier: 59711868

GI number: 59711868

Start: 1402973

End: 1403353

Strand: Direct

Name: 59711868

Synonym: VF_1261

Alternate gene names: NA

Gene position: 1402973-1403353 (Clockwise)

Preceding gene: 59711867

Following gene: 59711869

Centisome position: 48.42

GC content: 39.9

Gene sequence:

>381_bases
ATGAAAGTTGCACGTTTAGATCATCTTGTTTTAACGGTTAACAGCATTGAAGTGACGAGTCAATTTTATTCAAACGTGCT
CGGAATGGATATCGTTACCTTTGGTGAGGGCAGGGTCGCCCTTACTTTTGGTGAGCAAAAGATAAACCTTCATCAATTGG
GAAATGAGTTTGAACCTAAAGCGGCACAGGTTAAAAGCGGCAGTGCGGATCTGTGTTTTATTACTCATATGCCTATTCAT
GAAGTTCAAAGCCATATTGAATCACAAGGCGTGACTATCATTGATGGTCCAATTCAACGAACAGGTGCGATGGGCAAGAT
TATCTCAGTCTATTTACGAGATCCCGACGGTAATTTAATTGAACTCTCTAACTATTTATAA

Upstream 100 bases:

>100_bases
AAAAGATGCAGAGCTGATTGAACTCGCTCACCAAATGTTTTTAGGGATCATCTTTAAATCTGAATAATGTTTTACGTTTT
AATTTCATAGGGAATGAATC

Downstream 100 bases:

>100_bases
CACCTAATTAAGTAAGACATATTACTTACATCTCAAAACCATTTTCTTAGCATATACTTATATCGTGTAGCGATAAGATC
AATCATAAAGGTTGACTTAA

Product: lactoylglutathione lyase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 126; Mature: 126

Protein sequence:

>126_residues
MKVARLDHLVLTVNSIEVTSQFYSNVLGMDIVTFGEGRVALTFGEQKINLHQLGNEFEPKAAQVKSGSADLCFITHMPIH
EVQSHIESQGVTIIDGPIQRTGAMGKIISVYLRDPDGNLIELSNYL

Sequences:

>Translated_126_residues
MKVARLDHLVLTVNSIEVTSQFYSNVLGMDIVTFGEGRVALTFGEQKINLHQLGNEFEPKAAQVKSGSADLCFITHMPIH
EVQSHIESQGVTIIDGPIQRTGAMGKIISVYLRDPDGNLIELSNYL
>Mature_126_residues
MKVARLDHLVLTVNSIEVTSQFYSNVLGMDIVTFGEGRVALTFGEQKINLHQLGNEFEPKAAQVKSGSADLCFITHMPIH
EVQSHIESQGVTIIDGPIQRTGAMGKIISVYLRDPDGNLIELSNYL

Specific function: Is critically involved in promoting the replication of S.typhimurium cells inside host macrophages, suggesting a role in the establishment of bacterial colonization within macrophages. May be involved in the biosynthesis and modification of the peptidogly

COG id: COG0346

COG function: function code E; Lactoylglutathione lyase and related lyases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI254039722, Length=124, Percent_Identity=55.6451612903226, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: NA

Molecular weight: Translated: 13868; Mature: 13868

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVARLDHLVLTVNSIEVTSQFYSNVLGMDIVTFGEGRVALTFGEQKINLHQLGNEFEPK
CCCCCCEEEEEEEECHHHHHHHHHHHHCCEEEEECCCEEEEEECCCEEEHHHCCCCCCCC
AAQVKSGSADLCFITHMPIHEVQSHIESQGVTIIDGPIQRTGAMGKIISVYLRDPDGNLI
CEEECCCCCCEEEEECCCHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEECCCCCEE
ELSNYL
EECCCC
>Mature Secondary Structure
MKVARLDHLVLTVNSIEVTSQFYSNVLGMDIVTFGEGRVALTFGEQKINLHQLGNEFEPK
CCCCCCEEEEEEEECHHHHHHHHHHHHCCEEEEECCCEEEEEECCCEEEHHHCCCCCCCC
AAQVKSGSADLCFITHMPIHEVQSHIESQGVTIIDGPIQRTGAMGKIISVYLRDPDGNLI
CEEECCCCCCEEEEECCCHHHHHHHHHHCCEEEEECCCCCCCCCCEEEEEEEECCCCCEE
ELSNYL
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]