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The map label for this gene is tyrP [H]

Identifier: 59711804

GI number: 59711804

Start: 1329535

End: 1330707

Strand: Reverse

Name: tyrP [H]

Synonym: VF_1197

Alternate gene names: 59711804

Gene position: 1330707-1329535 (Counterclockwise)

Preceding gene: 59711806

Following gene: 59711803

Centisome position: 45.93

GC content: 35.12

Gene sequence:

>1173_bases
ATGAAGACAAAAGTACTTGGAAGCTCGTTAATTATAGCAGGAACAACCATAGGAGCTGGCATGTTAGCCCTACCTCTTGT
TTCCGCTAGTCTAGGATTCTTTACAGCAAGTTTATTAATGATTGGTATTTGGGCAATCATGAGCTATACAAGTCTACTGA
TGTTAGAAGTTCATCAATATGGAGAACAGAGCGCAACGCTTCATAGTTTAGCTCGCCAATTTTTAGGAAAACACGGACAA
AAAGTTGCAACCTTCTCTATGTTGTTTCTTTTTTACGCTTTGTGTGCGGCTTACATTGCAGGAGGAAGTGAACAATTTCA
TTCTAAATTAAATGAGCTGCTTCCTTTTGAGTTTTCAAATTTTACATCAACGATTATCTTTACCTGTATTGTTGCAACCA
TCATTACATTTGGTACGAAAACAGTTGATATTATTAACCGTGGTTTATTCACGTTAAAATTAGTTATGTTAGTTTCTATT
CTATTCTTTTTAACGCCAAGTATTACTGGAGAATACCTATTAGCACTGCCTGTTGAGCAAGGTGTATTTATTACAGCATT
ACCCGTTATTTTCACTTCGTTTGGATTTCATGGCAGTATTCCAGCAATCGTGAACTACCTTGAATTAGATGTTAAAAAGA
TCAAAATAAGTCTATTAGTGGGTTCTTCCCTACCTTTAATTGTTTACTTATTTTGGCAAGGAATGACATTAGGCTTGTTG
TCACAAAATGAATTTGGCCAAATAAACGGACTAAATCAATTCATCACTGAAATTCAAAGCACAATAGATCACCAATTTAT
TCAACAAGCACTCTCTTTATTTGCCGATCTTGCGCTATTAACTTCATTCATTGGTGTAAGTTTGGGATTATTTGAATTTT
TACGTGATTCATCTAAAAAATGGCAACAATCATCAATTGTGACCGCTTTATTAACTTACACGCCACCATTATTATTTGCT
TTGTTCTACCCACAAGGCTTTATCATGGCTTTAGGCTATGCTGCTATTGCTCTTGTTATTCTTGCTCTATTCTTACCTGT
TGCTTTAGTTATTTCAGCGAGAAAAACTAAAAAAGGATCTGAATACCAAGTAATCGGTGGTAACGGAGCACTCTTATTGG
TCGTTGCTTTTGGTGTACTTATTATTATGAGTCAACTTTTCAGTTCTCTATAA

Upstream 100 bases:

>100_bases
TAATTGTACATTTTTATTGTATTCAATTCAGAATAGTCGTACATTTCTACCATCGAAAATAAGCACCCAAATTTACTCTA
ATTTAAGAAAGAAGAAGTAT

Downstream 100 bases:

>100_bases
CAACTTAATTATTGATCTTTTATTGAGCCAGTTTGTCTACATTTAACCTAGATAAACTGGCTCTTCTTATTTTTATGTTT
TGCATTTTTTCTCGAATAGT

Product: tyrosine transporter

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKTKVLGSSLIIAGTTIGAGMLALPLVSASLGFFTASLLMIGIWAIMSYTSLLMLEVHQYGEQSATLHSLARQFLGKHGQ
KVATFSMLFLFYALCAAYIAGGSEQFHSKLNELLPFEFSNFTSTIIFTCIVATIITFGTKTVDIINRGLFTLKLVMLVSI
LFFLTPSITGEYLLALPVEQGVFITALPVIFTSFGFHGSIPAIVNYLELDVKKIKISLLVGSSLPLIVYLFWQGMTLGLL
SQNEFGQINGLNQFITEIQSTIDHQFIQQALSLFADLALLTSFIGVSLGLFEFLRDSSKKWQQSSIVTALLTYTPPLLFA
LFYPQGFIMALGYAAIALVILALFLPVALVISARKTKKGSEYQVIGGNGALLLVVAFGVLIIMSQLFSSL

Sequences:

>Translated_390_residues
MKTKVLGSSLIIAGTTIGAGMLALPLVSASLGFFTASLLMIGIWAIMSYTSLLMLEVHQYGEQSATLHSLARQFLGKHGQ
KVATFSMLFLFYALCAAYIAGGSEQFHSKLNELLPFEFSNFTSTIIFTCIVATIITFGTKTVDIINRGLFTLKLVMLVSI
LFFLTPSITGEYLLALPVEQGVFITALPVIFTSFGFHGSIPAIVNYLELDVKKIKISLLVGSSLPLIVYLFWQGMTLGLL
SQNEFGQINGLNQFITEIQSTIDHQFIQQALSLFADLALLTSFIGVSLGLFEFLRDSSKKWQQSSIVTALLTYTPPLLFA
LFYPQGFIMALGYAAIALVILALFLPVALVISARKTKKGSEYQVIGGNGALLLVVAFGVLIIMSQLFSSL
>Mature_390_residues
MKTKVLGSSLIIAGTTIGAGMLALPLVSASLGFFTASLLMIGIWAIMSYTSLLMLEVHQYGEQSATLHSLARQFLGKHGQ
KVATFSMLFLFYALCAAYIAGGSEQFHSKLNELLPFEFSNFTSTIIFTCIVATIITFGTKTVDIINRGLFTLKLVMLVSI
LFFLTPSITGEYLLALPVEQGVFITALPVIFTSFGFHGSIPAIVNYLELDVKKIKISLLVGSSLPLIVYLFWQGMTLGLL
SQNEFGQINGLNQFITEIQSTIDHQFIQQALSLFADLALLTSFIGVSLGLFEFLRDSSKKWQQSSIVTALLTYTPPLLFA
LFYPQGFIMALGYAAIALVILALFLPVALVISARKTKKGSEYQVIGGNGALLLVVAFGVLIIMSQLFSSL

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=394, Percent_Identity=44.4162436548223, Blast_Score=327, Evalue=6e-91,
Organism=Escherichia coli, GI1790145, Length=394, Percent_Identity=30.7106598984772, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1789552, Length=382, Percent_Identity=26.9633507853403, Blast_Score=140, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42442; Mature: 42442

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKVLGSSLIIAGTTIGAGMLALPLVSASLGFFTASLLMIGIWAIMSYTSLLMLEVHQY
CCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEQSATLHSLARQFLGKHGQKVATFSMLFLFYALCAAYIAGGSEQFHSKLNELLPFEFSN
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHH
FTSTIIFTCIVATIITFGTKTVDIINRGLFTLKLVMLVSILFFLTPSITGEYLLALPVEQ
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
GVFITALPVIFTSFGFHGSIPAIVNYLELDVKKIKISLLVGSSLPLIVYLFWQGMTLGLL
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCEEEC
SQNEFGQINGLNQFITEIQSTIDHQFIQQALSLFADLALLTSFIGVSLGLFEFLRDSSKK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WQQSSIVTALLTYTPPLLFALFYPQGFIMALGYAAIALVILALFLPVALVISARKTKKGS
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EYQVIGGNGALLLVVAFGVLIIMSQLFSSL
CEEEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKTKVLGSSLIIAGTTIGAGMLALPLVSASLGFFTASLLMIGIWAIMSYTSLLMLEVHQY
CCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GEQSATLHSLARQFLGKHGQKVATFSMLFLFYALCAAYIAGGSEQFHSKLNELLPFEFSN
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHH
FTSTIIFTCIVATIITFGTKTVDIINRGLFTLKLVMLVSILFFLTPSITGEYLLALPVEQ
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
GVFITALPVIFTSFGFHGSIPAIVNYLELDVKKIKISLLVGSSLPLIVYLFWQGMTLGLL
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCEEEC
SQNEFGQINGLNQFITEIQSTIDHQFIQQALSLFADLALLTSFIGVSLGLFEFLRDSSKK
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WQQSSIVTALLTYTPPLLFALFYPQGFIMALGYAAIALVILALFLPVALVISARKTKKGS
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
EYQVIGGNGALLLVVAFGVLIIMSQLFSSL
CEEEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]