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The map label for this gene is ndh [H]

Identifier: 59711750

GI number: 59711750

Start: 1265915

End: 1267204

Strand: Direct

Name: ndh [H]

Synonym: VF_1143

Alternate gene names: 59711750

Gene position: 1265915-1267204 (Clockwise)

Preceding gene: 59711749

Following gene: 59711751

Centisome position: 43.69

GC content: 41.09

Gene sequence:

>1290_bases
ATGACTAAAATTGTTATTGTTGGTGGTGGAGCTGGTGGTTTAGAGCTCGCTACAAAATTTGGTCGTACATTAGGTCGCAA
GGGCCGTGCTGAAGTTACATTAGTAGATCGTAAAGCAAGTCACTTATGGAAACCATTACTACACGAAGTAGCAACGGGCT
CACTGGACGAAGGTGTTGATGCTATCAGCTACCGTGCACATGCAAAAAATCACTCTTTCGAATTTCAAATGGGTAGCTTG
TGCGATATTAATCGTGAGAAGAAGTTTATTACTCTTGCAGAAATTAAAGACGAACATGGCGATTTAATTATTCCTACTCG
TCACATTGATTATGATTACCTAATTCTTGCAATTGGTTCTACATCAAATGATTTCAATACTCCGGGTGTTCGTGAAAATT
GTATTTTCCTTGATAGCCCAGAGCAAGCACACCGTTTCCGTACAGAAATGAATAACCAGTTCTTGAAACTGCACGCACAT
CCAACTCAAAAGACGGTTGATATTGCGATTGTTGGTGCTGGTGCAACGGGTGTTGAATTATCAGCTGAGCTTCATAACGC
AGTTAAAGAACTTCGTTCATACGGTTTTGGTGATTTAGATTCGGCAAAACTGAATGTGAACTTGGTAGAAGCGGGTGAGC
GTATTCTTCCTGCATTACCTCCTCGTATTTCATCTGCTGCACACAGCGAGTTAACTAAGCTGGGTGTGAATGTTCGTACA
GCAACAATGGTAACAAAAGCGGATTCAGAAGGTCTTCATACGAAAGATGGCGATGTGATCCCTGCGCAAATCATGGTTTG
GGCTGCTGGTATTAAAGCGCCTGATTTTATGAAAGACATTGCAGGTCTTGAAACTAACCGCATTAATCAGTTAGTTGTTA
AGCCGACACTGCAAACTACGCGTGATGATGATATTTTTGTTATTGGTGATTTAGCTTCGTGCGAAAAAGCAGACGGTGGT
TTTGTTCCACCTCGTGCACAAGCAGCACACCAAATGGCAAGTCATGCGTTTAAAAACATCGTAGCCAAGATGCGAAACCA
AGAAATGAAACCTTATGTGTATAAAGATCATGGTTCGTTAGTTTCTTTAAGTAACTTCTCAACAGTAGGTAGCTTAATGG
GCAACTTAACCAAAGGTTCTATGATGGTTGAAGGTCGTATAGCTCGTGTTGTTTACATCTCACTGTATCGTATGCACCAA
ATTGCACTTCATGGCGTATTTAAGACGGCATTAATGATGCTTGTTGGTCGTATTAACCGTGTATTACGTCCAAACTTGAA
GCTACATTAA

Upstream 100 bases:

>100_bases
CATTTCAGACAATCTAGATATTGCATTGTGAGGTAAGCACAAATTTTTTAATTCGAATGTGCGGGTTAAAACCTTTTTTA
TTTTTTAGAGGATAATTGTA

Downstream 100 bases:

>100_bases
TCCAATAGATAAACATAAATAGATTTAAAAGCAGAAATACTCCGGTGTTTCTGCTTTTTTTGTACCTAAATATGAAAAAA
TGTGCGCTAACTCACCGTAA

Product: respiratory NADH dehydrogenase 2/cupric reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTKIVIVGGGAGGLELATKFGRTLGRKGRAEVTLVDRKASHLWKPLLHEVATGSLDEGVDAISYRAHAKNHSFEFQMGSL
CDINREKKFITLAEIKDEHGDLIIPTRHIDYDYLILAIGSTSNDFNTPGVRENCIFLDSPEQAHRFRTEMNNQFLKLHAH
PTQKTVDIAIVGAGATGVELSAELHNAVKELRSYGFGDLDSAKLNVNLVEAGERILPALPPRISSAAHSELTKLGVNVRT
ATMVTKADSEGLHTKDGDVIPAQIMVWAAGIKAPDFMKDIAGLETNRINQLVVKPTLQTTRDDDIFVIGDLASCEKADGG
FVPPRAQAAHQMASHAFKNIVAKMRNQEMKPYVYKDHGSLVSLSNFSTVGSLMGNLTKGSMMVEGRIARVVYISLYRMHQ
IALHGVFKTALMMLVGRINRVLRPNLKLH

Sequences:

>Translated_429_residues
MTKIVIVGGGAGGLELATKFGRTLGRKGRAEVTLVDRKASHLWKPLLHEVATGSLDEGVDAISYRAHAKNHSFEFQMGSL
CDINREKKFITLAEIKDEHGDLIIPTRHIDYDYLILAIGSTSNDFNTPGVRENCIFLDSPEQAHRFRTEMNNQFLKLHAH
PTQKTVDIAIVGAGATGVELSAELHNAVKELRSYGFGDLDSAKLNVNLVEAGERILPALPPRISSAAHSELTKLGVNVRT
ATMVTKADSEGLHTKDGDVIPAQIMVWAAGIKAPDFMKDIAGLETNRINQLVVKPTLQTTRDDDIFVIGDLASCEKADGG
FVPPRAQAAHQMASHAFKNIVAKMRNQEMKPYVYKDHGSLVSLSNFSTVGSLMGNLTKGSMMVEGRIARVVYISLYRMHQ
IALHGVFKTALMMLVGRINRVLRPNLKLH
>Mature_428_residues
TKIVIVGGGAGGLELATKFGRTLGRKGRAEVTLVDRKASHLWKPLLHEVATGSLDEGVDAISYRAHAKNHSFEFQMGSLC
DINREKKFITLAEIKDEHGDLIIPTRHIDYDYLILAIGSTSNDFNTPGVRENCIFLDSPEQAHRFRTEMNNQFLKLHAHP
TQKTVDIAIVGAGATGVELSAELHNAVKELRSYGFGDLDSAKLNVNLVEAGERILPALPPRISSAAHSELTKLGVNVRTA
TMVTKADSEGLHTKDGDVIPAQIMVWAAGIKAPDFMKDIAGLETNRINQLVVKPTLQTTRDDDIFVIGDLASCEKADGGF
VPPRAQAAHQMASHAFKNIVAKMRNQEMKPYVYKDHGSLVSLSNFSTVGSLMGNLTKGSMMVEGRIARVVYISLYRMHQI
ALHGVFKTALMMLVGRINRVLRPNLKLH

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=430, Percent_Identity=73.953488372093, Blast_Score=642, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323515, Length=445, Percent_Identity=26.7415730337079, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323794, Length=351, Percent_Identity=29.6296296296296, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320118, Length=367, Percent_Identity=26.4305177111717, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 47047; Mature: 46916

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIVIVGGGAGGLELATKFGRTLGRKGRAEVTLVDRKASHLWKPLLHEVATGSLDEGVD
CEEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHCCCHHCCCH
AISYRAHAKNHSFEFQMGSLCDINREKKFITLAEIKDEHGDLIIPTRHIDYDYLILAIGS
HHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCEEEEEEEEC
TSNDFNTPGVRENCIFLDSPEQAHRFRTEMNNQFLKLHAHPTQKTVDIAIVGAGATGVEL
CCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCEE
SAELHNAVKELRSYGFGDLDSAKLNVNLVEAGERILPALPPRISSAAHSELTKLGVNVRT
HHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHCCCCCCCCCHHHHHHHHHHCCCEEE
ATMVTKADSEGLHTKDGDVIPAQIMVWAAGIKAPDFMKDIAGLETNRINQLVVKPTLQTT
EEEEEECCCCCCCCCCCCCCHHEEEEEECCCCCHHHHHHHHCCCCCCCCEEEEECCCCCC
RDDDIFVIGDLASCEKADGGFVPPRAQAAHQMASHAFKNIVAKMRNQEMKPYVYKDHGSL
CCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCE
VSLSNFSTVGSLMGNLTKGSMMVEGRIARVVYISLYRMHQIALHGVFKTALMMLVGRINR
EEECCHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLRPNLKLH
HHCCCCCCC
>Mature Secondary Structure 
TKIVIVGGGAGGLELATKFGRTLGRKGRAEVTLVDRKASHLWKPLLHEVATGSLDEGVD
EEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHHHHCCCHHCCCH
AISYRAHAKNHSFEFQMGSLCDINREKKFITLAEIKDEHGDLIIPTRHIDYDYLILAIGS
HHHHHHHCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCCCEEEEEECCCCEEEEEEEEC
TSNDFNTPGVRENCIFLDSPEQAHRFRTEMNNQFLKLHAHPTQKTVDIAIVGAGATGVEL
CCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEECCCCCCEE
SAELHNAVKELRSYGFGDLDSAKLNVNLVEAGERILPALPPRISSAAHSELTKLGVNVRT
HHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCHHCCCCCCCCCHHHHHHHHHHCCCEEE
ATMVTKADSEGLHTKDGDVIPAQIMVWAAGIKAPDFMKDIAGLETNRINQLVVKPTLQTT
EEEEEECCCCCCCCCCCCCCHHEEEEEECCCCCHHHHHHHHCCCCCCCCEEEEECCCCCC
RDDDIFVIGDLASCEKADGGFVPPRAQAAHQMASHAFKNIVAKMRNQEMKPYVYKDHGSL
CCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCE
VSLSNFSTVGSLMGNLTKGSMMVEGRIARVVYISLYRMHQIALHGVFKTALMMLVGRINR
EEECCHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLRPNLKLH
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]