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The map label for this gene is thiK [H]

Identifier: 59711748

GI number: 59711748

Start: 1264037

End: 1264873

Strand: Direct

Name: thiK [H]

Synonym: VF_1141

Alternate gene names: 59711748

Gene position: 1264037-1264873 (Clockwise)

Preceding gene: 59711746

Following gene: 59711749

Centisome position: 43.62

GC content: 36.8

Gene sequence:

>837_bases
ATGGATAAACAATTTAAAGGTTTTGGTTTAACTATTTCCCATGTTTCTGCTTTAAGTGGTGGATTAACCAATGCGTGTTT
AAAAGTTGAAGCAAAAGAAGGCTCGTTTGTGTGGCGTCCAATATCCTTGCAGGCAAAGATTCTAGGAGCGGATAGAGCGA
AAGAACATGAGATTCTACAAGCGTTATCTGATGAATCCTTTTCTCCGAATGTATATGGAGAAAATGAAGAGGGGATATTA
GTTGAGTGGCTTGAAGGTGAGGTTATTGCGCTTGATAAAGCTCAAGATGTCGCTGTTGATTTATTGTGTTCGGTTCATCA
AATTTCATTAGATAAGTTAAGTGAACAAATAAAAAATAAGCCGATGAGTTTAAAAGATCGAATTATTGATTATTGGAATT
CAATTACGCCAGAAAATCAAACACCAGAGATGGAAGCGTATTTTGAGTATTTCTCACAGCAAGATGAGCAAGCTTTCTTC
TCTCATTGCTTATGCCATTACGATATTGGTGCATATAATATTGTTGTTAAAGAGGATGGCTATGGTCTCATTGATTGGGA
ATACGCTTCGATGGGTGACCCAAGCCAAGACCTCACATCTATGATTATTGCTAACCAATTTGATATGGATGATGTTATTT
CATTGTATTGTCAAAAACGTCGTTTAAATATTGATGAGTGGAAGCGGGCGGTGATTCACTGGACCCCGTGGGTGACTTTT
ATGGGGGCGTTGTGGTTCTCATTAGGTTATCAATTACTCAAAAACACATGCTATCAAGAGTTAGCAGAACGAGAAATGTG
TAAATTAATAAAATTACTTCCATCAATTCATAAATAA

Upstream 100 bases:

>100_bases
ATGATTTTTTTCGGTGTCTTTTGGTCTTTTTTAAACTCAATGTCACTCTGTGTTAGACTGCGTGAAAGCTTATTCTAATG
CACTGATATAACGAGATTTT

Downstream 100 bases:

>100_bases
ATTGGCAATAATCTAGTGTAGATCACTGTTCTCAGTATTGCTTCAGTTAAGAGATTTAAAAGCACAGTTTTCGTGGTAGA
TTAAATTCACTTATATGGAA

Product: thiamine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MDKQFKGFGLTISHVSALSGGLTNACLKVEAKEGSFVWRPISLQAKILGADRAKEHEILQALSDESFSPNVYGENEEGIL
VEWLEGEVIALDKAQDVAVDLLCSVHQISLDKLSEQIKNKPMSLKDRIIDYWNSITPENQTPEMEAYFEYFSQQDEQAFF
SHCLCHYDIGAYNIVVKEDGYGLIDWEYASMGDPSQDLTSMIIANQFDMDDVISLYCQKRRLNIDEWKRAVIHWTPWVTF
MGALWFSLGYQLLKNTCYQELAEREMCKLIKLLPSIHK

Sequences:

>Translated_278_residues
MDKQFKGFGLTISHVSALSGGLTNACLKVEAKEGSFVWRPISLQAKILGADRAKEHEILQALSDESFSPNVYGENEEGIL
VEWLEGEVIALDKAQDVAVDLLCSVHQISLDKLSEQIKNKPMSLKDRIIDYWNSITPENQTPEMEAYFEYFSQQDEQAFF
SHCLCHYDIGAYNIVVKEDGYGLIDWEYASMGDPSQDLTSMIIANQFDMDDVISLYCQKRRLNIDEWKRAVIHWTPWVTF
MGALWFSLGYQLLKNTCYQELAEREMCKLIKLLPSIHK
>Mature_278_residues
MDKQFKGFGLTISHVSALSGGLTNACLKVEAKEGSFVWRPISLQAKILGADRAKEHEILQALSDESFSPNVYGENEEGIL
VEWLEGEVIALDKAQDVAVDLLCSVHQISLDKLSEQIKNKPMSLKDRIIDYWNSITPENQTPEMEAYFEYFSQQDEQAFF
SHCLCHYDIGAYNIVVKEDGYGLIDWEYASMGDPSQDLTSMIIANQFDMDDVISLYCQKRRLNIDEWKRAVIHWTPWVTF
MGALWFSLGYQLLKNTCYQELAEREMCKLIKLLPSIHK

Specific function: Catalyzes the phosphorylation of thiamine to thiamine phosphate [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002575
- InterPro:   IPR011009
- InterPro:   IPR014093 [H]

Pfam domain/function: PF01636 APH [H]

EC number: =2.7.1.89 [H]

Molecular weight: Translated: 31869; Mature: 31869

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKQFKGFGLTISHVSALSGGLTNACLKVEAKEGSFVWRPISLQAKILGADRAKEHEILQ
CCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCEEEEEECCCCHHHHHHHH
ALSDESFSPNVYGENEEGILVEWLEGEVIALDKAQDVAVDLLCSVHQISLDKLSEQIKNK
HHCCCCCCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PMSLKDRIIDYWNSITPENQTPEMEAYFEYFSQQDEQAFFSHCLCHYDIGAYNIVVKEDG
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCC
YGLIDWEYASMGDPSQDLTSMIIANQFDMDDVISLYCQKRRLNIDEWKRAVIHWTPWVTF
CEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHEECHHHHH
MGALWFSLGYQLLKNTCYQELAEREMCKLIKLLPSIHK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKQFKGFGLTISHVSALSGGLTNACLKVEAKEGSFVWRPISLQAKILGADRAKEHEILQ
CCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCEEEEECCEEEEEECCCCHHHHHHHH
ALSDESFSPNVYGENEEGILVEWLEGEVIALDKAQDVAVDLLCSVHQISLDKLSEQIKNK
HHCCCCCCCCCCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC
PMSLKDRIIDYWNSITPENQTPEMEAYFEYFSQQDEQAFFSHCLCHYDIGAYNIVVKEDG
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEEECCC
YGLIDWEYASMGDPSQDLTSMIIANQFDMDDVISLYCQKRRLNIDEWKRAVIHWTPWVTF
CEEEEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHEECHHHHH
MGALWFSLGYQLLKNTCYQELAEREMCKLIKLLPSIHK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA