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The map label for this gene is dctB [H]

Identifier: 59711660

GI number: 59711660

Start: 1162399

End: 1163739

Strand: Direct

Name: dctB [H]

Synonym: VF_1053

Alternate gene names: 59711660

Gene position: 1162399-1163739 (Clockwise)

Preceding gene: 59711659

Following gene: 59711661

Centisome position: 40.12

GC content: 41.54

Gene sequence:

>1341_bases
ATGAATCAAGAAAAATTACAGCGATTAATTGGAGCGTATTTTTCTCAACCTGAGCGTCGGGTGACGCTTCCTGCAGGTGA
AACACTACTTGAGCAAGGAGAAGATAACGATCGTTTGTATTATGTCTGCTCTGGTGAACTTGAAGGGTTTTATCAAGAAG
AAAATAGCGAAGCGCAAGTCAAAGTGTTCAGTGCAGGAGAAGGGGCATTTATTGGCGTTCACAGCTTTTTCTCTGAAACC
TTAATTGCGTCGTCGACGGTTATTACTAAAACAGAAACTGAATTAGGGTGGATTGACTCTAAAACAACGGCCATTGATTT
GGATAGATATGGTCCTTTGACGGCGCAATTTACTCCAATTATTGTTAATGAGCTTTCACGTCGTCAGCGACGAGCAATGC
ATGAATCTATAGAAAAAGAGAAAGCGTTACAAAAGTTATATACCGCAGAGCAAATGACAACGTTAGGGCAACTTGCCGCA
GGTATTGCTCATGAGTTGAATAATGCTGTTGGAGTATTGAGTAGTAAAACCGAAAGACTTCAAAGTATTATTTTAGAGCT
ACTCGAAGAGATTCATCCCGAAGCGAGCAGTTTTGTTGACCAAGGTTTAATGTTTGGACAAAACATCAGTTCAGCGGAGG
TGAGAAAGCGTGGACGTGAGTTGGAAGTGACTTATGGTATAGAAAGAGATACTGCAAGAGAACTCGCTCGTGCGGTTCCT
GAAGGAGAACTTTCAAAGTATTGGTTAAAAAGCCCAGAGCAAGCAGTGCGGTATTGGAATATAGGACGAGATCTTCACGA
TATGCGTCTTGCTGCAAGGCACTCGGTTGGGATTGTTCGTTCCGTTAAGCAACTAGGACGCACTGATATTGATACCGATG
AAGTCTTAGACGTTAACGACAGCATAAATAAAGCCCTTGTGTTATTGCAAAGTGATTTACGACGAGTGTCGGTTCATTTA
AGTCCTGCAGCAATGCCTATGGTAAGAGCATCGGCGACTGAGCTCGTCCAAATTTGGGCAAACATAATTAAGAATGCCAG
TGATGCCATGAAGCATACACAGGAGCCGGAAATTGAAATATCAACTCGGGTATCGAATCGATTTGTTTTGGTTACGATTG
CTAATAATGGCCCTGAGATTGATGAAGCGACAAGAAGAAAAATTTTCAGACCAAACTTTACCACTAAAAAAGGTGGGCTT
TCGTTTGGCTTAGGGCTTGGTTTAGCTATAGTTAAACGAATTATCAGTGGATATGGTGGTTCGATAGCGGTGAAAAGTAA
CCAAGAGAAAACCATTTTTAGAATTAAACTACCTGTCGAGGACAGTCATGGAAAAACTTAA

Upstream 100 bases:

>100_bases
CCAAATGGCGAAAACCGGTGTTATTTTAGGGATTGTCGGGGTTTTATTAAGTTTTGTTATGGTGTGGGTTCTTCATTCAG
TAGGTCATATTGGATAGTTT

Downstream 100 bases:

>100_bases
TCTGATTTGTGTGGACGACCAAAGAGAAGTTCTGAGTGCCGTTTTACAAGATTTGGCACCACTTAAAACTTGGGTGAATA
TTGAAGAGTGCGAGTCTGCG

Product: sensory transduction protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MNQEKLQRLIGAYFSQPERRVTLPAGETLLEQGEDNDRLYYVCSGELEGFYQEENSEAQVKVFSAGEGAFIGVHSFFSET
LIASSTVITKTETELGWIDSKTTAIDLDRYGPLTAQFTPIIVNELSRRQRRAMHESIEKEKALQKLYTAEQMTTLGQLAA
GIAHELNNAVGVLSSKTERLQSIILELLEEIHPEASSFVDQGLMFGQNISSAEVRKRGRELEVTYGIERDTARELARAVP
EGELSKYWLKSPEQAVRYWNIGRDLHDMRLAARHSVGIVRSVKQLGRTDIDTDEVLDVNDSINKALVLLQSDLRRVSVHL
SPAAMPMVRASATELVQIWANIIKNASDAMKHTQEPEIEISTRVSNRFVLVTIANNGPEIDEATRRKIFRPNFTTKKGGL
SFGLGLGLAIVKRIISGYGGSIAVKSNQEKTIFRIKLPVEDSHGKT

Sequences:

>Translated_446_residues
MNQEKLQRLIGAYFSQPERRVTLPAGETLLEQGEDNDRLYYVCSGELEGFYQEENSEAQVKVFSAGEGAFIGVHSFFSET
LIASSTVITKTETELGWIDSKTTAIDLDRYGPLTAQFTPIIVNELSRRQRRAMHESIEKEKALQKLYTAEQMTTLGQLAA
GIAHELNNAVGVLSSKTERLQSIILELLEEIHPEASSFVDQGLMFGQNISSAEVRKRGRELEVTYGIERDTARELARAVP
EGELSKYWLKSPEQAVRYWNIGRDLHDMRLAARHSVGIVRSVKQLGRTDIDTDEVLDVNDSINKALVLLQSDLRRVSVHL
SPAAMPMVRASATELVQIWANIIKNASDAMKHTQEPEIEISTRVSNRFVLVTIANNGPEIDEATRRKIFRPNFTTKKGGL
SFGLGLGLAIVKRIISGYGGSIAVKSNQEKTIFRIKLPVEDSHGKT
>Mature_446_residues
MNQEKLQRLIGAYFSQPERRVTLPAGETLLEQGEDNDRLYYVCSGELEGFYQEENSEAQVKVFSAGEGAFIGVHSFFSET
LIASSTVITKTETELGWIDSKTTAIDLDRYGPLTAQFTPIIVNELSRRQRRAMHESIEKEKALQKLYTAEQMTTLGQLAA
GIAHELNNAVGVLSSKTERLQSIILELLEEIHPEASSFVDQGLMFGQNISSAEVRKRGRELEVTYGIERDTARELARAVP
EGELSKYWLKSPEQAVRYWNIGRDLHDMRLAARHSVGIVRSVKQLGRTDIDTDEVLDVNDSINKALVLLQSDLRRVSVHL
SPAAMPMVRASATELVQIWANIIKNASDAMKHTQEPEIEISTRVSNRFVLVTIANNGPEIDEATRRKIFRPNFTTKKGGL
SFGLGLGLAIVKRIISGYGGSIAVKSNQEKTIFRIKLPVEDSHGKT

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=150, Percent_Identity=32, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49757; Mature: 49757

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50042 CNMP_BINDING_3 ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQEKLQRLIGAYFSQPERRVTLPAGETLLEQGEDNDRLYYVCSGELEGFYQEENSEAQV
CCHHHHHHHHHHHHCCCCCEEECCCCHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCEE
KVFSAGEGAFIGVHSFFSETLIASSTVITKTETELGWIDSKTTAIDLDRYGPLTAQFTPI
EEEECCCCCEEEHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCHHH
IVNELSRRQRRAMHESIEKEKALQKLYTAEQMTTLGQLAAGIAHELNNAVGVLSSKTERL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSIILELLEEIHPEASSFVDQGLMFGQNISSAEVRKRGRELEVTYGIERDTARELARAVP
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEECCCHHHHHHHHHHCC
EGELSKYWLKSPEQAVRYWNIGRDLHDMRLAARHSVGIVRSVKQLGRTDIDTDEVLDVND
CCCHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCC
SINKALVLLQSDLRRVSVHLSPAAMPMVRASATELVQIWANIIKNASDAMKHTQEPEIEI
HHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCEEE
STRVSNRFVLVTIANNGPEIDEATRRKIFRPNFTTKKGGLSFGLGLGLAIVKRIISGYGG
EEEECCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
SIAVKSNQEKTIFRIKLPVEDSHGKT
EEEEECCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure
MNQEKLQRLIGAYFSQPERRVTLPAGETLLEQGEDNDRLYYVCSGELEGFYQEENSEAQV
CCHHHHHHHHHHHHCCCCCEEECCCCHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCEE
KVFSAGEGAFIGVHSFFSETLIASSTVITKTETELGWIDSKTTAIDLDRYGPLTAQFTPI
EEEECCCCCEEEHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCHHH
IVNELSRRQRRAMHESIEKEKALQKLYTAEQMTTLGQLAAGIAHELNNAVGVLSSKTERL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSIILELLEEIHPEASSFVDQGLMFGQNISSAEVRKRGRELEVTYGIERDTARELARAVP
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHCCCEEEEEECCCHHHHHHHHHHCC
EGELSKYWLKSPEQAVRYWNIGRDLHDMRLAARHSVGIVRSVKQLGRTDIDTDEVLDVND
CCCHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCC
SINKALVLLQSDLRRVSVHLSPAAMPMVRASATELVQIWANIIKNASDAMKHTQEPEIEI
HHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCEEE
STRVSNRFVLVTIANNGPEIDEATRRKIFRPNFTTKKGGLSFGLGLGLAIVKRIISGYGG
EEEECCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
SIAVKSNQEKTIFRIKLPVEDSHGKT
EEEEECCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2134335; 2793824; 11481431; 2551890; 2695394 [H]