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The map label for this gene is hisC [H]

Identifier: 59711621

GI number: 59711621

Start: 1121084

End: 1122124

Strand: Direct

Name: hisC [H]

Synonym: VF_1014

Alternate gene names: 59711621

Gene position: 1121084-1122124 (Clockwise)

Preceding gene: 59711620

Following gene: 59711622

Centisome position: 38.69

GC content: 40.92

Gene sequence:

>1041_bases
ATGGAAAAGTTAGCCAGAAAACAAGTACAAGCATTAACACCTTATCTTTCTGCTCGTCGAATCGGTGGTTCAGGGGATGT
ATGGTTGAATGCCAATGAATCCCCATTTGATAACGAATATCAGTTTAATTTTGCTCGTCTTAATCGCTATAGCGAATGTC
AACCGCCTGAGTTAATTAATGCTTATGCGGCTTATGCAAAGGTAAAGCCTGAGCAGGTTTTAACTTCCCGCGGAGCAGAT
GAAGGTATTGAATTACTGGTTCGTGCTTTTTGTGAACCGAACCAAGATGCCATTTTATATTGCCCGCCAACTTATGGAAT
GTACTCAATCAGTGCAGAAACCATTGGTGTAGAGACGAAAACGGTTCCACTTACATCCAATTGGCAGCTAGATCTTCCTG
CAATAGAAGCAAGCTTAGAAAACGTCAAAGTTGTGTTTGTGTGTAGCCCAAATAATCCAACGGGTAATATCGTTGATCGT
AAAGATATTCTTTCATTATTAGAAATGACAAAAGATCGTGCCATTGTTGTAATGGATGAGGCTTACATCGATTTTTGTAT
GGAGAAATCGACAGTTGATTTACTGGTTGACTACCCACACCTTGCGATTTTACGTACTTTATCTAAAGCGTTTGCATTAG
CTGGGCTTCGTTGTGGTTTCACTCTCGCCAATGAAGAGTTAATTAACGTATTACTGAAAGTGATTGCACCCTACCCAGTG
CCAGTACCTGTGGCTGAGATTGCTACTCAAGCTTTATCAGAAGCAGGTCTAGCTCGTATGAAATACCAAATGCTTGACTT
AAGTGCTAACCGTGCTTATTTACAAGCAGGATTAATGGTCTTGCCGGGGGTTACCGTTTTTGAAGGTTGGGGCAACTACT
TGTTAGTGAAGTTTCCCGATGGTGACTCGGTATTTAAAGCTGCGTGGGATCACGGCATTATTTTACGTAACTCACCAATT
GAAAATTGCGTACGCATTAGTGTTGGCAATCGTGAAGAGTGTGAAAAAACATTGGGCTTTATTCGCAATCAATTAATCTA
A

Upstream 100 bases:

>100_bases
GGAAGGGCTTGATGCTCATAAAAGAGCCGTAACGATTCGAATTGAAAAGCTCGCTCAGTTAGACGTTAATAAACAAGAAG
TGAATCAGTAGGAATTCATT

Downstream 100 bases:

>100_bases
TACCAATCGTAGTAAATAACTGATCATCCTAGCTAGTTAAAATACTCGATAACTGCGTTAAAATTTTTGATTGTAGAATA
ACTACTTATCGAAAAATTTT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYQFNFARLNRYSECQPPELINAYAAYAKVKPEQVLTSRGAD
EGIELLVRAFCEPNQDAILYCPPTYGMYSISAETIGVETKTVPLTSNWQLDLPAIEASLENVKVVFVCSPNNPTGNIVDR
KDILSLLEMTKDRAIVVMDEAYIDFCMEKSTVDLLVDYPHLAILRTLSKAFALAGLRCGFTLANEELINVLLKVIAPYPV
PVPVAEIATQALSEAGLARMKYQMLDLSANRAYLQAGLMVLPGVTVFEGWGNYLLVKFPDGDSVFKAAWDHGIILRNSPI
ENCVRISVGNREECEKTLGFIRNQLI

Sequences:

>Translated_346_residues
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYQFNFARLNRYSECQPPELINAYAAYAKVKPEQVLTSRGAD
EGIELLVRAFCEPNQDAILYCPPTYGMYSISAETIGVETKTVPLTSNWQLDLPAIEASLENVKVVFVCSPNNPTGNIVDR
KDILSLLEMTKDRAIVVMDEAYIDFCMEKSTVDLLVDYPHLAILRTLSKAFALAGLRCGFTLANEELINVLLKVIAPYPV
PVPVAEIATQALSEAGLARMKYQMLDLSANRAYLQAGLMVLPGVTVFEGWGNYLLVKFPDGDSVFKAAWDHGIILRNSPI
ENCVRISVGNREECEKTLGFIRNQLI
>Mature_346_residues
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYQFNFARLNRYSECQPPELINAYAAYAKVKPEQVLTSRGAD
EGIELLVRAFCEPNQDAILYCPPTYGMYSISAETIGVETKTVPLTSNWQLDLPAIEASLENVKVVFVCSPNNPTGNIVDR
KDILSLLEMTKDRAIVVMDEAYIDFCMEKSTVDLLVDYPHLAILRTLSKAFALAGLRCGFTLANEELINVLLKVIAPYPV
PVPVAEIATQALSEAGLARMKYQMLDLSANRAYLQAGLMVLPGVTVFEGWGNYLLVKFPDGDSVFKAAWDHGIILRNSPI
ENCVRISVGNREECEKTLGFIRNQLI

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=348, Percent_Identity=60.3448275862069, Blast_Score=430, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322075, Length=378, Percent_Identity=32.2751322751323, Blast_Score=166, Evalue=5e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38436; Mature: 38436

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYQFNFARLNRYSECQPPELIN
CCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEHHHHCCCCCCCCHHHHH
AYAAYAKVKPEQVLTSRGADEGIELLVRAFCEPNQDAILYCPPTYGMYSISAETIGVETK
HHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCEECCEEE
TVPLTSNWQLDLPAIEASLENVKVVFVCSPNNPTGNIVDRKDILSLLEMTKDRAIVVMDE
EEECCCCCEEECHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEH
AYIDFCMEKSTVDLLVDYPHLAILRTLSKAFALAGLRCGFTLANEELINVLLKVIAPYPV
HHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHCCCCC
PVPVAEIATQALSEAGLARMKYQMLDLSANRAYLQAGLMVLPGVTVFEGWGNYLLVKFPD
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHCCCEEEECCCCEEEEEECC
GDSVFKAAWDHGIILRNSPIENCVRISVGNREECEKTLGFIRNQLI
CCCHHHHHCCCCEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYQFNFARLNRYSECQPPELIN
CCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEHHHHCCCCCCCCHHHHH
AYAAYAKVKPEQVLTSRGADEGIELLVRAFCEPNQDAILYCPPTYGMYSISAETIGVETK
HHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEECCCCCEEEEECCEECCEEE
TVPLTSNWQLDLPAIEASLENVKVVFVCSPNNPTGNIVDRKDILSLLEMTKDRAIVVMDE
EEECCCCCEEECHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEH
AYIDFCMEKSTVDLLVDYPHLAILRTLSKAFALAGLRCGFTLANEELINVLLKVIAPYPV
HHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHHHCCCCC
PVPVAEIATQALSEAGLARMKYQMLDLSANRAYLQAGLMVLPGVTVFEGWGNYLLVKFPD
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHHHHCCCEEEECCCCEEEEEECC
GDSVFKAAWDHGIILRNSPIENCVRISVGNREECEKTLGFIRNQLI
CCCHHHHHCCCCEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA