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The map label for this gene is hisD

Identifier: 59711620

GI number: 59711620

Start: 1119755

End: 1121074

Strand: Direct

Name: hisD

Synonym: VF_1013

Alternate gene names: 59711620

Gene position: 1119755-1121074 (Clockwise)

Preceding gene: 59711619

Following gene: 59711621

Centisome position: 38.65

GC content: 41.36

Gene sequence:

>1320_bases
ATGAAAACGTTAGTTTGGCAATCATTGAGCGATTCGCAGCAAGATACGGTTCTACAACGTCCTGCGATTACGGAAGGTGC
GAATATTACCGCAGCAGTAACTAGTGTTATTAATACCGTAAAACAAGAGGGTGATGCTGGTGTATTCGCATTAACTGAAA
AGTTTGATGGCGTGAAACCTGACTCTATTCGAGTATCGAATGCTGAGATTGAAGCGGCAAGTGATCGTTTGTCTGAAGAA
ATGAAAACAGCACTTAAACAAGCTTATAGCAATATTTCTAAATTTCACCAAGCACAGAAACCACAGCCTGTAAAAGTTGA
AACACAGCCAGGTGTCATCTGTGAACAAATTACTATGCCTATAAATAAAGTAGGTTTGTATATTCCAGGTGGTAGTGCGC
CATTGCCATCAACAGTCCTAATGTTAGGTATTCCTGCTCAAATTGCAGGTTGTCATAAAGTTGTATTATGTTCGCCACCT
CCAATAGCTGATGAGATTTTGTACGTGGCAAAACTGTGTAAGATTGATGAAGTATATAACATTGGTGGGGCTCAAGCCGT
TGCTGCGATGGCGTATGGAACAGAATCTGTCTCTAAAGTAGATAAGATCTTTGGGCCAGGTAATGCCTATGTAACTGAAG
CAAAACGTCAAGTTTCGAATGATTTCCGTGGTGCGGCGATTGATATGCCTGCAGGGCCATCTGAAGTTTTAGTGATTGCT
GATGAGAGCGCAGATCCAGACTTTATTGCAGCGGATCTTCTTAGCCAAGCAGAGCATGGTCCTGATTCACAAGTAGTATT
AGTTACTCCATCGCCAATTATTGCCGATCAAGTCGCTGATGCTGTTGAAAGACAATTAAAAGAACTTAGTCGTGAAGATA
TAGCTCGCCAAGCTTTAGGTTCAAGTTTATTGATTGTTGCAGATTCACTTACTCAGTGTGTTTCAATTTCAAACTTTTAT
GGGCCTGAACACCTTATTGTTCAAACTAAGAATCCGCGAGAGTTACTCCCTCTTCTAGATAATGCGGGTTCAATTTTCTT
AGGTGATTATTCACCCGAATCGGCAGGGGATTATGCATCAGGAACTAATCACGTATTGCCGACTTATGGGTACACACGAA
CTTATTCAAGTTTAGGATTAGCAGATTTCTCTAAACGAATGACTGTGCAAGAGTTAACGGCTGATGGTTTAAAAGGTTTG
GCTCCAACGGTTGTCACAATGGCTGAAGCGGAAGGGCTTGATGCTCATAAAAGAGCCGTAACGATTCGAATTGAAAAGCT
CGCTCAGTTAGACGTTAATAAACAAGAAGTGAATCAGTAG

Upstream 100 bases:

>100_bases
GTACAGAAAATCTATTTTGGGAAACAATGGAACAGTTAAAAGCATTAGGGGCGAGTTCTATTCTAGTATTGCCAATTGAG
AAAATGATGGAGTAGCCATT

Downstream 100 bases:

>100_bases
GAATTCATTATGGAAAAGTTAGCCAGAAAACAAGTACAAGCATTAACACCTTATCTTTCTGCTCGTCGAATCGGTGGTTC
AGGGGATGTATGGTTGAATG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 439; Mature: 439

Protein sequence:

>439_residues
MKTLVWQSLSDSQQDTVLQRPAITEGANITAAVTSVINTVKQEGDAGVFALTEKFDGVKPDSIRVSNAEIEAASDRLSEE
MKTALKQAYSNISKFHQAQKPQPVKVETQPGVICEQITMPINKVGLYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPP
PIADEILYVAKLCKIDEVYNIGGAQAVAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DESADPDFIAADLLSQAEHGPDSQVVLVTPSPIIADQVADAVERQLKELSREDIARQALGSSLLIVADSLTQCVSISNFY
GPEHLIVQTKNPRELLPLLDNAGSIFLGDYSPESAGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLKGL
APTVVTMAEAEGLDAHKRAVTIRIEKLAQLDVNKQEVNQ

Sequences:

>Translated_439_residues
MKTLVWQSLSDSQQDTVLQRPAITEGANITAAVTSVINTVKQEGDAGVFALTEKFDGVKPDSIRVSNAEIEAASDRLSEE
MKTALKQAYSNISKFHQAQKPQPVKVETQPGVICEQITMPINKVGLYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPP
PIADEILYVAKLCKIDEVYNIGGAQAVAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DESADPDFIAADLLSQAEHGPDSQVVLVTPSPIIADQVADAVERQLKELSREDIARQALGSSLLIVADSLTQCVSISNFY
GPEHLIVQTKNPRELLPLLDNAGSIFLGDYSPESAGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLKGL
APTVVTMAEAEGLDAHKRAVTIRIEKLAQLDVNKQEVNQ
>Mature_439_residues
MKTLVWQSLSDSQQDTVLQRPAITEGANITAAVTSVINTVKQEGDAGVFALTEKFDGVKPDSIRVSNAEIEAASDRLSEE
MKTALKQAYSNISKFHQAQKPQPVKVETQPGVICEQITMPINKVGLYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPP
PIADEILYVAKLCKIDEVYNIGGAQAVAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
DESADPDFIAADLLSQAEHGPDSQVVLVTPSPIIADQVADAVERQLKELSREDIARQALGSSLLIVADSLTQCVSISNFY
GPEHLIVQTKNPRELLPLLDNAGSIFLGDYSPESAGDYASGTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLKGL
APTVVTMAEAEGLDAHKRAVTIRIEKLAQLDVNKQEVNQ

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=424, Percent_Identity=64.8584905660377, Blast_Score=565, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6319819, Length=420, Percent_Identity=50.4761904761905, Blast_Score=405, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_VIBF1 (Q5E638)

Other databases:

- EMBL:   CP000020
- RefSeq:   YP_204396.1
- ProteinModelPortal:   Q5E638
- SMR:   Q5E638
- STRING:   Q5E638
- GeneID:   3277807
- GenomeReviews:   CP000020_GR
- KEGG:   vfi:VF_1013
- NMPDR:   fig|312309.3.peg.862
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- PhylomeDB:   Q5E638
- ProtClustDB:   PRK00877
- BioCyc:   VFIS312309:VF1013-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46847; Mature: 46847

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 323-323 ACT_SITE 324-324 BINDING 127-127 BINDING 185-185 BINDING 208-208 BINDING 234-234 BINDING 256-256 BINDING 259-259 BINDING 324-324 BINDING 357-357 BINDING 411-411 BINDING 416-416

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLVWQSLSDSQQDTVLQRPAITEGANITAAVTSVINTVKQEGDAGVFALTEKFDGVKP
CCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHCCCCCC
DSIRVSNAEIEAASDRLSEEMKTALKQAYSNISKFHQAQKPQPVKVETQPGVICEQITMP
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHCC
INKVGLYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPPPIADEILYVAKLCKIDEVYN
HHHEEEEECCCCCCCCCEEEEEECCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHC
IGGAQAVAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
CCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEE
DESADPDFIAADLLSQAEHGPDSQVVLVTPSPIIADQVADAVERQLKELSREDIARQALG
CCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SSLLIVADSLTQCVSISNFYGPEHLIVQTKNPRELLPLLDNAGSIFLGDYSPESAGDYAS
CEEEEEHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCEEEECCCCCCCCCCCC
GTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLKGLAPTVVTMAEAEGLDAHKRAV
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHEE
TIRIEKLAQLDVNKQEVNQ
EEEEHHHHHCCCCHHHCCC
>Mature Secondary Structure
MKTLVWQSLSDSQQDTVLQRPAITEGANITAAVTSVINTVKQEGDAGVFALTEKFDGVKP
CCCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHCCCCCC
DSIRVSNAEIEAASDRLSEEMKTALKQAYSNISKFHQAQKPQPVKVETQPGVICEQITMP
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHCC
INKVGLYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPPPIADEILYVAKLCKIDEVYN
HHHEEEEECCCCCCCCCEEEEEECCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHC
IGGAQAVAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA
CCCHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEEEEE
DESADPDFIAADLLSQAEHGPDSQVVLVTPSPIIADQVADAVERQLKELSREDIARQALG
CCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SSLLIVADSLTQCVSISNFYGPEHLIVQTKNPRELLPLLDNAGSIFLGDYSPESAGDYAS
CEEEEEHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCEEEECCCCCCCCCCCC
GTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLKGLAPTVVTMAEAEGLDAHKRAV
CCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHEE
TIRIEKLAQLDVNKQEVNQ
EEEEHHHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA