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The map label for this gene is hisG [H]

Identifier: 59711619

GI number: 59711619

Start: 1118853

End: 1119749

Strand: Direct

Name: hisG [H]

Synonym: VF_1012

Alternate gene names: 59711619

Gene position: 1118853-1119749 (Clockwise)

Preceding gene: 172087684

Following gene: 59711620

Centisome position: 38.61

GC content: 40.91

Gene sequence:

>897_bases
ATGTCATCACAACGATTACGCATTGCGATTCAAAAGAAGGGTCGCCTATCTAAAGAGTGCCAAGAATTATTTAAACGCTG
CGGCATGAAATTTAACATTTCGGGTGAGCGTTTAGTGGTTCATTCTGAAAATATGCCGATTGATCTATTGTTAGTTCGTG
ACGATGACATCCCAAGTCTAATTATGGATGGGGTAGTTGATTTAGGTGTGATTGGTGAAAATGAACTTGAAGAAGTACGT
TTAGAGCGTAAAGCGCTTGGTGAGCCTTCAGCATTTACTACTCTACGTCGTTTGGATTTCGGTGGCTGTCGTTTATCTAT
TGCGATTGACAAAGATGAAGTATACAACGGCCCACAAGATTTAGCCGGAAAACGTATCGCAACAACCTACCCACAATTAC
TTAAAAGTTTTATGGATGAGCAGGGTATTCCGTTTTCAACCTGTATTTTAAATGGTTCTGTAGAAGTTGCTCCACGCGCA
GGTCTTGCGGATGCGATTGCCGATTTAGTATCAACAGGTGCGACACTTGAAGCTAATGGTCTTAAAGAAGCTGAAGTAAT
TTTTCGATCAAAAGCGACATTAATTCAGCGTGAAGGTGAATTTGATGCAGATAAGGCCGCGTTGATCAATAAGCTATTAA
CCCGTATGCAAGGTTGTATTCAAGCAAAAGAATCAAAATATATTATGCTGCACGCACCAACAGATAAGCTTGATGCTATT
AAAGACTTGCTTCCGGGGGCGGAAGATCCAACGGTTTTACCTCTGTCGCGTGATGGAGCAAAGGTCGCAGTTCACTTAGT
AAGTACAGAAAATCTATTTTGGGAAACAATGGAACAGTTAAAAGCATTAGGGGCGAGTTCTATTCTAGTATTGCCAATTG
AGAAAATGATGGAGTAG

Upstream 100 bases:

>100_bases
TTAGATTATTTATTGATTTATAAGAGTTTAAAATTAGCCGATTGCATTGTTTGCTTAAAAAACGATTTAATTGGAATCAC
ATTTTTACAAGGAAGAAATT

Downstream 100 bases:

>100_bases
CCATTATGAAAACGTTAGTTTGGCAATCATTGAGCGATTCGCAGCAAGATACGGTTCTACAACGTCCTGCGATTACGGAA
GGTGCGAATATTACCGCAGC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MSSQRLRIAIQKKGRLSKECQELFKRCGMKFNISGERLVVHSENMPIDLLLVRDDDIPSLIMDGVVDLGVIGENELEEVR
LERKALGEPSAFTTLRRLDFGGCRLSIAIDKDEVYNGPQDLAGKRIATTYPQLLKSFMDEQGIPFSTCILNGSVEVAPRA
GLADAIADLVSTGATLEANGLKEAEVIFRSKATLIQREGEFDADKAALINKLLTRMQGCIQAKESKYIMLHAPTDKLDAI
KDLLPGAEDPTVLPLSRDGAKVAVHLVSTENLFWETMEQLKALGASSILVLPIEKMME

Sequences:

>Translated_298_residues
MSSQRLRIAIQKKGRLSKECQELFKRCGMKFNISGERLVVHSENMPIDLLLVRDDDIPSLIMDGVVDLGVIGENELEEVR
LERKALGEPSAFTTLRRLDFGGCRLSIAIDKDEVYNGPQDLAGKRIATTYPQLLKSFMDEQGIPFSTCILNGSVEVAPRA
GLADAIADLVSTGATLEANGLKEAEVIFRSKATLIQREGEFDADKAALINKLLTRMQGCIQAKESKYIMLHAPTDKLDAI
KDLLPGAEDPTVLPLSRDGAKVAVHLVSTENLFWETMEQLKALGASSILVLPIEKMME
>Mature_297_residues
SSQRLRIAIQKKGRLSKECQELFKRCGMKFNISGERLVVHSENMPIDLLLVRDDDIPSLIMDGVVDLGVIGENELEEVRL
ERKALGEPSAFTTLRRLDFGGCRLSIAIDKDEVYNGPQDLAGKRIATTYPQLLKSFMDEQGIPFSTCILNGSVEVAPRAG
LADAIADLVSTGATLEANGLKEAEVIFRSKATLIQREGEFDADKAALINKLLTRMQGCIQAKESKYIMLHAPTDKLDAIK
DLLPGAEDPTVLPLSRDGAKVAVHLVSTENLFWETMEQLKALGASSILVLPIEKMME

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=296, Percent_Identity=68.9189189189189, Blast_Score=424, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6320896, Length=297, Percent_Identity=29.6296296296296, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 32768; Mature: 32637

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQRLRIAIQKKGRLSKECQELFKRCGMKFNISGERLVVHSENMPIDLLLVRDDDIPSL
CCCCEEEEEEECCCCCHHHHHHHHHHCCCEEECCCCEEEEECCCCCEEEEEEECCCCHHH
IMDGVVDLGVIGENELEEVRLERKALGEPSAFTTLRRLDFGGCRLSIAIDKDEVYNGPQD
HHHHHHHEECCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECHHHHCCCHHH
LAGKRIATTYPQLLKSFMDEQGIPFSTCILNGSVEVAPRAGLADAIADLVSTGATLEANG
HCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEECCCCCHHHHHHHHHHCCCEEECCC
LKEAEVIFRSKATLIQREGEFDADKAALINKLLTRMQGCIQAKESKYIMLHAPTDKLDAI
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
KDLLPGAEDPTVLPLSRDGAKVAVHLVSTENLFWETMEQLKALGASSILVLPIEKMME
HHHCCCCCCCEEEEECCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure 
SSQRLRIAIQKKGRLSKECQELFKRCGMKFNISGERLVVHSENMPIDLLLVRDDDIPSL
CCCEEEEEEECCCCCHHHHHHHHHHCCCEEECCCCEEEEECCCCCEEEEEEECCCCHHH
IMDGVVDLGVIGENELEEVRLERKALGEPSAFTTLRRLDFGGCRLSIAIDKDEVYNGPQD
HHHHHHHEECCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEEECHHHHCCCHHH
LAGKRIATTYPQLLKSFMDEQGIPFSTCILNGSVEVAPRAGLADAIADLVSTGATLEANG
HCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCEEECCCCCHHHHHHHHHHCCCEEECCC
LKEAEVIFRSKATLIQREGEFDADKAALINKLLTRMQGCIQAKESKYIMLHAPTDKLDAI
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHH
KDLLPGAEDPTVLPLSRDGAKVAVHLVSTENLFWETMEQLKALGASSILVLPIEKMME
HHHCCCCCCCEEEEECCCCCEEEEEEEECCHHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA