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The map label for this gene is moaE [H]

Identifier: 59711550

GI number: 59711550

Start: 1038261

End: 1038707

Strand: Direct

Name: moaE [H]

Synonym: VF_0943

Alternate gene names: 59711550

Gene position: 1038261-1038707 (Clockwise)

Preceding gene: 59711549

Following gene: 59711556

Centisome position: 35.83

GC content: 40.49

Gene sequence:

>447_bases
ATGATTTCTGTTCAAGAGCATGATTTTAATGTTGGCGATGAATATCAATTACTAGCAGAAGGTACAGCTGCTGGCGCTGT
GGTTACTTTCATTGGTAAAGTTCGTGATATGAACCTAGGTGATGATGTTACAGGTCTATCCTTAGAACATTACCCTGGAA
TGACTGAGAAGTCTCTTAACGATATCGTGGCACAAGCTAAAGAGCGCTGGCCTCTACTTAAAGTGAAGGTAATTCATAGA
GTTGGTGACTTAGAACTTGGCGATCAAATTGTATTTGTAGGTGTATCAAGTGCTCACCGTGGTGCTGCGTTTGATTCTTG
TGAATTCATTATGGATTACTTGAAAACCAATGCTCCGTTCTGGAAAAAAGAACGAACAACAAAAGAAGTACGTTGGGTTG
AATCTCGTGATACGGATAAAACAGCGGCAGAGCGTTGGGAAAAATAA

Upstream 100 bases:

>100_bases
AAGCTGCTTGTTGCTATTAATCAAACGATTTCAAGCTTAGATTCTACTGTTTCTGATGGCGATGAAGTTGCTTTTTTCCC
ACCAGTAACAGGTGGTTAAT

Downstream 100 bases:

>100_bases
ACGTATAAGAACTGAATTATATCGGTATAAAGAAAAAGGGAAGATAGCATAAGCTCTCTTCCCTTTTTTAATGTTATAGA
CCCTACAAACAAGTAGGGCT

Product: molybdopterin synthase, large subunit

Products: NA

Alternate protein names: MPT synthase subunit 2; Molybdenum cofactor biosynthesis protein E; Molybdopterin-converting factor large subunit; Molybdopterin-converting factor subunit 2 [H]

Number of amino acids: Translated: 148; Mature: 148

Protein sequence:

>148_residues
MISVQEHDFNVGDEYQLLAEGTAAGAVVTFIGKVRDMNLGDDVTGLSLEHYPGMTEKSLNDIVAQAKERWPLLKVKVIHR
VGDLELGDQIVFVGVSSAHRGAAFDSCEFIMDYLKTNAPFWKKERTTKEVRWVESRDTDKTAAERWEK

Sequences:

>Translated_148_residues
MISVQEHDFNVGDEYQLLAEGTAAGAVVTFIGKVRDMNLGDDVTGLSLEHYPGMTEKSLNDIVAQAKERWPLLKVKVIHR
VGDLELGDQIVFVGVSSAHRGAAFDSCEFIMDYLKTNAPFWKKERTTKEVRWVESRDTDKTAAERWEK
>Mature_148_residues
MISVQEHDFNVGDEYQLLAEGTAAGAVVTFIGKVRDMNLGDDVTGLSLEHYPGMTEKSLNDIVAQAKERWPLLKVKVIHR
VGDLELGDQIVFVGVSSAHRGAAFDSCEFIMDYLKTNAPFWKKERTTKEVRWVESRDTDKTAAERWEK

Specific function: Converts molybdopterin precursor Z into molybdopterin. This requires the incorporation of two sulfur atoms into precursor Z to generate a dithiolene group. The sulfur is provided by moaD [H]

COG id: COG0314

COG function: function code H; Molybdopterin converting factor, large subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaE family [H]

Homologues:

Organism=Homo sapiens, GI4758732, Length=120, Percent_Identity=31.6666666666667, Blast_Score=83, Evalue=9e-17,
Organism=Escherichia coli, GI1787003, Length=145, Percent_Identity=62.0689655172414, Blast_Score=190, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17509279, Length=108, Percent_Identity=35.1851851851852, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356259, Length=112, Percent_Identity=41.0714285714286, Blast_Score=79, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003448 [H]

Pfam domain/function: PF02391 MoaE [H]

EC number: NA

Molecular weight: Translated: 16702; Mature: 16702

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVQEHDFNVGDEYQLLAEGTAAGAVVTFIGKVRDMNLGDDVTGLSLEHYPGMTEKSLN
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHH
DIVAQAKERWPLLKVKVIHRVGDLELGDQIVFVGVSSAHRGAAFDSCEFIMDYLKTNAPF
HHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCC
WKKERTTKEVRWVESRDTDKTAAERWEK
CCCCCCHHHHHHCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MISVQEHDFNVGDEYQLLAEGTAAGAVVTFIGKVRDMNLGDDVTGLSLEHYPGMTEKSLN
CCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHH
DIVAQAKERWPLLKVKVIHRVGDLELGDQIVFVGVSSAHRGAAFDSCEFIMDYLKTNAPF
HHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCC
WKKERTTKEVRWVESRDTDKTAAERWEK
CCCCCCHHHHHHCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]