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The map label for this gene is sucD [H]

Identifier: 59711433

GI number: 59711433

Start: 907384

End: 908256

Strand: Direct

Name: sucD [H]

Synonym: VF_0826

Alternate gene names: 59711433

Gene position: 907384-908256 (Clockwise)

Preceding gene: 59711432

Following gene: 59711434

Centisome position: 31.32

GC content: 43.07

Gene sequence:

>873_bases
ATGTCTGTACTAATTAATAAAGATACAAAAGTTATCTGCCAAGGTTTTACTGGTGGTCAAGGTACGTTCCACTCAGAGCA
AGCCATTGATTACGGAACACAAATGGTTGGCGGTGTATCACCAGGCAAAGGTGGTCAAGTTCACCTAGGTCTTCCAGTAT
TTAACACGGTTCGTGATGCAGTTGAAGCAACTGGTGCAACAGCTTCGGTTATTTATGTACCTGCGCCTTTCTGTAAAGAT
GCAATCCTTGAAGCAATCGATGCGGGTATTAAGCTTATCGTAACGATTACAGAAGGCATTCCAACGCTTGATCTTTTAGA
CGTTAAAGTTCGTCTAGATGCAGAAGGTGTAGTGATGATTGGTCCTAACTGTCCGGGTGTTATTACTCCTGATGAATGTA
AGATTGGTATCATGCCGGGCCACATTCATAAGAAAGGTAAAGTAGGTATTGTTTCTCGCTCTGGTACATTAACGTATGAA
GCAGTTAAGCAGACAACTGACGAAGGCTTTGGCCAATCAACGTGTGTTGGTATTGGTGGTGATCCAATTCCGGGTTCAAA
CTTTATTGATATTCTAAAACTGTTCCAAGAAGATCCAGAAACAGAAGCAATCGTAATGATTGGTGAGATCGGTGGTACAG
CAGAAGAAGAAGCGGCTGCATATATTAAAGCGAATGTAACTAAACCTGTGGTTTCTTATATTGCAGGTGTTACTGCGCCT
CCAGGTAAACGTATGGGCCATGCTGGTGCCATTATCTCTGGTGGTAAAGGCACGGCAGAAGATAAGTTTGCAGCGCTAGA
AGAAGCGGGCGTTAAGACAGTAAAAAGTCTTGCAGACATCGGTAAAGCACTAAGAGAAGTGACTGGTTGGTAA

Upstream 100 bases:

>100_bases
TAGGTTCACAAAAACTGGCTGAAAGTGGCCTAAATATCATTGCGGCTACTTCATTAACTGAAGCGGCTGAAAAAGTTGTT
GCTGCAGCGGAGGGCAAATA

Downstream 100 bases:

>100_bases
TAAGTTAAACCAATACATGAATAACTCAGAAGCCATTTATAGAAATATGAATGGCTTTTTTAATATGTGACATTATGAAA
TGTTTAGTTACATTTAGAGT

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSVLINKDTKVICQGFTGGQGTFHSEQAIDYGTQMVGGVSPGKGGQVHLGLPVFNTVRDAVEATGATASVIYVPAPFCKD
AILEAIDAGIKLIVTITEGIPTLDLLDVKVRLDAEGVVMIGPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYE
AVKQTTDEGFGQSTCVGIGGDPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAAYIKANVTKPVVSYIAGVTAP
PGKRMGHAGAIISGGKGTAEDKFAALEEAGVKTVKSLADIGKALREVTGW

Sequences:

>Translated_290_residues
MSVLINKDTKVICQGFTGGQGTFHSEQAIDYGTQMVGGVSPGKGGQVHLGLPVFNTVRDAVEATGATASVIYVPAPFCKD
AILEAIDAGIKLIVTITEGIPTLDLLDVKVRLDAEGVVMIGPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYE
AVKQTTDEGFGQSTCVGIGGDPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAAYIKANVTKPVVSYIAGVTAP
PGKRMGHAGAIISGGKGTAEDKFAALEEAGVKTVKSLADIGKALREVTGW
>Mature_289_residues
SVLINKDTKVICQGFTGGQGTFHSEQAIDYGTQMVGGVSPGKGGQVHLGLPVFNTVRDAVEATGATASVIYVPAPFCKDA
ILEAIDAGIKLIVTITEGIPTLDLLDVKVRLDAEGVVMIGPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYEA
VKQTTDEGFGQSTCVGIGGDPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAAYIKANVTKPVVSYIAGVTAPP
GKRMGHAGAIISGGKGTAEDKFAALEEAGVKTVKSLADIGKALREVTGW

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=287, Percent_Identity=65.1567944250871, Blast_Score=320, Evalue=9e-88,
Organism=Homo sapiens, GI38569421, Length=260, Percent_Identity=33.8461538461538, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI38569423, Length=260, Percent_Identity=33.8461538461538, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1786949, Length=287, Percent_Identity=85.7142857142857, Blast_Score=496, Evalue=1e-141,
Organism=Caenorhabditis elegans, GI17550194, Length=288, Percent_Identity=64.5833333333333, Blast_Score=348, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17553126, Length=290, Percent_Identity=62.0689655172414, Blast_Score=335, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17557344, Length=259, Percent_Identity=31.2741312741313, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17551266, Length=260, Percent_Identity=32.6923076923077, Blast_Score=98, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6324716, Length=292, Percent_Identity=53.4246575342466, Blast_Score=284, Evalue=1e-77,
Organism=Drosophila melanogaster, GI21356559, Length=290, Percent_Identity=59.6551724137931, Blast_Score=338, Evalue=2e-93,
Organism=Drosophila melanogaster, GI28574296, Length=288, Percent_Identity=61.8055555555556, Blast_Score=324, Evalue=5e-89,
Organism=Drosophila melanogaster, GI281363477, Length=259, Percent_Identity=30.1158301158301, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI281363475, Length=259, Percent_Identity=30.1158301158301, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI281363473, Length=259, Percent_Identity=30.1158301158301, Blast_Score=107, Evalue=7e-24,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 29946; Mature: 29815

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLINKDTKVICQGFTGGQGTFHSEQAIDYGTQMVGGVSPGKGGQVHLGLPVFNTVRDA
CEEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHH
VEATGATASVIYVPAPFCKDAILEAIDAGIKLIVTITEGIPTLDLLDVKVRLDAEGVVMI
HHHCCCCEEEEEECCCHHHHHHHHHHHCCEEEEEEEECCCCCEEEEEEEEEECCCCEEEE
GPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYEAVKQTTDEGFGQSTCVGIGG
CCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAAYIKANVTKPVVSYIAGVTAP
CCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHEEEEECCHHHHHHHHHCCCCC
PGKRMGHAGAIISGGKGTAEDKFAALEEAGVKTVKSLADIGKALREVTGW
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SVLINKDTKVICQGFTGGQGTFHSEQAIDYGTQMVGGVSPGKGGQVHLGLPVFNTVRDA
EEEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHH
VEATGATASVIYVPAPFCKDAILEAIDAGIKLIVTITEGIPTLDLLDVKVRLDAEGVVMI
HHHCCCCEEEEEECCCHHHHHHHHHHHCCEEEEEEEECCCCCEEEEEEEEEECCCCEEEE
GPNCPGVITPDECKIGIMPGHIHKKGKVGIVSRSGTLTYEAVKQTTDEGFGQSTCVGIGG
CCCCCCCCCCCCCEEEEECCCCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIPGSNFIDILKLFQEDPETEAIVMIGEIGGTAEEEAAAYIKANVTKPVVSYIAGVTAP
CCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHEEEEECCHHHHHHHHHCCCCC
PGKRMGHAGAIISGGKGTAEDKFAALEEAGVKTVKSLADIGKALREVTGW
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 8581173 [H]